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UKB PRS for Cancer of prostate(185) based on Schumacher FR et al. 2019
GWAS reference: 29892016	GWAS source: Schumacher FR et al. 2019	PRS method: PRS-CS
PRSweb LD reference: eur	GWAS phenotype: Prostate cancer	PRSweb date: 2020-06-20
GWAS ID: Pca_PRACTICAL	GWAS URL: http://practical.icr.ac.uk/blog/?page_id=8164	Genome build: GRCh37/hg19
PRS tuning parameter:	PRS evaluation in: UKB

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Figure 2: Exclusion PheWAS results Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.More Info scroll down

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.

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LEGENDS

Figure 1: PheWAS results
P-values correspond to associations between the polygenic risk score (PRS) and the electronic health record-derived phenotype obtained using Firth’s logistic regression and also adjusting for age, gender, genotyping array, and the first four genotype principal components.
Upward (downward)-pointing triangles indicate a positive (negative) association.
Additional details are available by hovering the cursor over a particular triangle and by clicking the triangle. The horizontal dashed line indicates phenome-wide significance. Results are color-coded by disease category.

Figure 2: Exclusion PheWAS results
Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.
This figure shows results for the selected phenotype in Figure 1. This figure provides the beta estimate for the adjusted association between the PRS and the selected phenotype from Firth-corrected logistic regression. The corresponding confidence intervals are also shown. Results from PRS PheWAS (blue) and Exclusion PRS PheWAS (red) are presented for models using either a continuous or a categorical version of the PRS. Q1 through Q4 represent the four quartiles of the PRS.