|UKB PRS for Malignant neoplasm of ovary(184.11) based on Phelan CM et al. 2017|
|GWAS reference: 28346442||GWAS source: Phelan CM et al. 2017||PRS method: Lassosum|
|PRSweb LD reference: UKB||GWAS phenotype: Low-grade serous and serous borderline ovarian cancer||PRSweb date: 2020-06-20|
|GWAS ID: Phelan_LSASBOC||GWAS URL: ftp://ftp.ebi.ac.uk/pub/databases/gwas/summary_statistics/PhelanCM_28346442_GCST004481/harmonised/28346442-GCST004481-EFO_1001516-Build37.f.tsv.gz||Genome build: GRCh37/hg19|
|PRS tuning parameter: s=0.2;Lambda=0.008859||PRS evaluation in: UKB|
Figure 2: Exclusion PheWAS results
Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.
Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.
This figure shows results for the selected phenotype in Figure 1. This figure provides the beta estimate for the adjusted association between the PRS and the selected phenotype from Firth-corrected logistic regression. The corresponding confidence intervals are also shown. Results from PRS PheWAS (blue) and Exclusion PRS PheWAS (red) are presented for models using either a continuous or a categorical version of the PRS. Q1 through Q4 represent the four quartiles of the PRS.