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UKB PRS for Malignant neoplasm of ovary(184.11) based on Phelan CM et al. 2017
GWAS reference: 28346442	GWAS source: Phelan CM et al. 2017	PRS method: P_5e-08
PRSweb LD reference: MGI	GWAS phenotype: Epithelial ovarian cancer	PRSweb date: 2020-06-20
GWAS ID: Phelan_EPOC	GWAS URL: ftp://ftp.ebi.ac.uk/pub/databases/gwas/summary_statistics/PhelanCM_28346442_GCST004462/harmonised/28346442-GCST004462-EFO_0001075-Build37.f.tsv.gz	Genome build: GRCh37/hg19
PRS tuning parameter: P<=5e-08	PRS evaluation in: UKB

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Figure 2: Exclusion PheWAS results Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.More Info scroll down

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.

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LEGENDS

Figure 1: PheWAS results
P-values correspond to associations between the polygenic risk score (PRS) and the electronic health record-derived phenotype obtained using Firth’s logistic regression and also adjusting for age, gender, genotyping array, and the first four genotype principal components.
Upward (downward)-pointing triangles indicate a positive (negative) association.
Additional details are available by hovering the cursor over a particular triangle and by clicking the triangle. The horizontal dashed line indicates phenome-wide significance. Results are color-coded by disease category.

Figure 2: Exclusion PheWAS results
Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.
This figure shows results for the selected phenotype in Figure 1. This figure provides the beta estimate for the adjusted association between the PRS and the selected phenotype from Firth-corrected logistic regression. The corresponding confidence intervals are also shown. Results from PRS PheWAS (blue) and Exclusion PRS PheWAS (red) are presented for models using either a continuous or a categorical version of the PRS. Q1 through Q4 represent the four quartiles of the PRS.