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UKB PRS for Breast cancer [female](174.1) based on Michailidou K et al. 2018
GWAS reference: 29059683	GWAS source: Michailidou K et al. 2018	PRS method: Lassosum
PRSweb LD reference: UKB	GWAS phenotype: Breast cancer [female], Overall	PRSweb date: 2020-06-20
GWAS ID: iCOGS_Overall_BRCA	GWAS URL: http://bcac.ccge.medschl.cam.ac.uk/bcacdata/oncoarray/oncoarray-and-combined-summary-result/gwas-summary-results-breast-cancer-risk-2017	Genome build: GRCh37/hg19
PRS tuning parameter: s=0.5;Lambda=0.006952	PRS evaluation in: UKB

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Figure 2: Exclusion PheWAS results Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.More Info scroll down

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.

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LEGENDS

Figure 1: PheWAS results
P-values correspond to associations between the polygenic risk score (PRS) and the electronic health record-derived phenotype obtained using Firth’s logistic regression and also adjusting for age, gender, genotyping array, and the first four genotype principal components.
Upward (downward)-pointing triangles indicate a positive (negative) association.
Additional details are available by hovering the cursor over a particular triangle and by clicking the triangle. The horizontal dashed line indicates phenome-wide significance. Results are color-coded by disease category.

Figure 2: Exclusion PheWAS results
Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.
This figure shows results for the selected phenotype in Figure 1. This figure provides the beta estimate for the adjusted association between the PRS and the selected phenotype from Firth-corrected logistic regression. The corresponding confidence intervals are also shown. Results from PRS PheWAS (blue) and Exclusion PRS PheWAS (red) are presented for models using either a continuous or a categorical version of the PRS. Q1 through Q4 represent the four quartiles of the PRS.