## PRSweb reference PRSWEB_PHECODE174.1_iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608 ## PRSweb LD reference MGI ## PRSweb date 20200608 ## GWAS source 29059683 ## GWAS reference PUBMED ## GWAS phenotype Breast cancer [female]; ER positive ## GWAS id iCOGS_ER_positive_BRCA ## GWAS URL http://bcac.ccge.medschl.cam.ac.uk/bcacdata/oncoarray/gwas-icogs-and-oncoarray-summary-results/ ## PRS method LD Clumping (MAF >= 1%, r^2 <= 0.1) of variants with P-value <= 5e-8 ## PRS tuning parameter 5e-08 ## PRS evaluation in UKB ## Genome build GRCh37/hg19 CHROM POS REF ALT EA OA PVALUE WEIGHT 1 121213348 A G G A 4.2e-22 0.117409 1 145604791 G T T G 1.2e-08 -0.073789 1 149892872 A G G A 6.3e-11 0.0754325 2 172974566 C G G C 1.8e-08 -0.0646843 2 217896408 A G G A 5.5e-10 -0.0832936 2 217920769 G T T G 2.3e-40 -0.151807 2 217963060 C A A C 2e-13 -0.209191 2 218302313 T G G T 2.7e-11 0.112873 3 4744047 C T T C 6.5e-09 0.0684243 3 27327965 A C C A 2.7e-23 0.116626 3 30684097 G A A G 1.8e-08 0.06821 4 175821735 C T T C 5.3e-15 0.14315 4 175847436 C A A C 1.1e-10 0.0775534 5 44706498 A G G A 2.8e-28 0.142695 5 44947702 T C C T 1.9e-08 0.0957643 5 45333860 T C C T 7.1e-10 -0.0810432 5 56031822 C A A C 4.3e-11 -0.104552 5 56053723 A T T A 3.6e-43 0.212402 5 56153470 T C C T 1.9e-13 0.321922 5 56156477 C T T C 7.2e-09 0.30272 5 56329225 C T T C 1.5e-09 0.162853 5 81610680 G A A G 3.8e-09 0.0815412 5 158244083 C T T C 8.2e-09 -0.0663854 6 13719673 G A A G 1.7e-09 -0.0706354 6 151953765 T C C T 1.1e-09 0.137052 8 29502062 A C C A 1.1e-08 -0.0697593 8 76230943 A G G A 9.8e-10 0.0933271 8 76305785 A T T A 6.3e-10 0.124265 8 128356860 T C C T 5.1e-19 0.103296 9 110305088 C A A C 1.5e-09 0.0759782 9 110837176 C T T C 2e-11 0.098984 9 110895353 C T T C 5.9e-32 0.14061 9 110919211 C T T C 3.9e-08 -0.20284 10 21824727 G A A G 1.9e-12 0.0840902 10 22258728 T C C T 1e-11 0.277123 10 64232042 T C C T 6.3e-09 -0.0667172 10 64299890 A G G A 5.6e-24 -0.165943 10 80851257 G T T G 7.9e-16 -0.0942584 10 123093182 G A A G 3.7e-08 -0.0681765 10 123241122 C G G C 5.4e-13 0.158276 10 123271059 T G G T 1.5e-09 0.0813001 10 123311974 G A A G 7.7e-09 0.0663125 10 123337335 A G G A 9.4e-133 -0.284827 10 123338472 C T T C 3.4e-08 -0.164203 10 123342707 G A A G 6.9e-12 0.227679 10 123349324 A T T A 2.5e-17 -0.277991 10 123351629 C T T C 2e-08 -0.260972 10 123354003 G A A G 2.5e-09 0.212894 10 123357210 C T T C 3.6e-08 0.163396 10 123389837 G A A G 6.1e-22 0.213844 10 123399142 C T T C 1.1e-08 0.189125 10 123438122 C T T C 2.1e-18 -0.148058 10 123446062 G C C G 6.4e-14 -0.111255 10 123801422 A C C A 3.9e-09 0.0806048 11 1902097 C T T C 4e-14 0.0882448 11 2016908 G A A G 8.7e-09 -0.0845091 11 69245812 A C C A 4e-10 0.0807058 11 69283303 T G G T 4.3e-13 -0.0840593 11 69306595 T G G T 1.5e-08 0.0692194 11 69328130 A T T A 2.3e-13 -0.105564 11 69331418 C T T C 2.3e-66 0.342744 11 69463527 C T T C 1.3e-16 0.373538 11 69475017 G A A G 2.3e-08 0.209688 12 28174817 C T T C 2.4e-17 -0.115481 12 96027759 A G G A 1.5e-14 -0.0969931 12 115836132 T C C T 6.6e-17 -0.0976331 14 37127410 G A A G 1.4e-10 -0.091569 14 68623851 C A A C 4.5e-09 -0.0892479 14 69005887 G A A G 5.1e-14 -0.0993268 14 91841069 A G G A 3.7e-09 0.0708588 16 52549671 G A A G 3.9e-09 -0.0920703 16 52564669 T C C T 3e-09 -0.0867282 16 52574343 G A A G 2.8e-75 0.235141 16 52591719 C T T C 4.9e-08 0.329172 16 53822502 T G G T 1.4e-09 -0.0714872 16 80648048 C G G C 4.7e-11 0.0883056 17 53209774 A C C A 1.4e-14 -0.0993797 18 24530559 A G G A 1.1e-08 -0.0676345 19 18627953 A G G A 3.7e-11 -0.0809745 19 44282857 T G G T 4.4e-09 -0.0720397 21 16481934 G A A G 6.8e-09 0.127266 21 16571951 G C C G 7.5e-14 -0.0928127 22 28314612 G A A G 7.7e-17 0.466046 22 28557762 A G G A 9.6e-13 0.465482 22 40806940 A G G A 2.6e-08 0.0928664 22 41049402 G T T G 3.1e-11 0.123319