## PRSweb reference PRSWEB_PHECODE174.1_Onco-iCOGS-ER-positive-BRCA_P_5e-08_UKB_20200608 ## PRSweb LD reference MGI ## PRSweb date 20200608 ## GWAS source 29059683 ## GWAS reference PUBMED ## GWAS phenotype Breast cancer [female]; ER positive ## GWAS id Onco_iCOGS_ER_positive_BRCA ## GWAS URL http://bcac.ccge.medschl.cam.ac.uk/bcacdata/oncoarray/gwas-icogs-and-oncoarray-summary-results/ ## PRS method LD Clumping (MAF >= 1%, r^2 <= 0.1) of variants with P-value <= 5e-8 ## PRS tuning parameter 5e-08 ## PRS evaluation in UKB ## Genome build GRCh37/hg19 CHROM POS REF ALT EA OA PVALUE WEIGHT 1 10616505 C A A C 4.146e-08 -0.0436 1 18807339 T C C T 9.927e-16 -0.0608 1 46600917 A G G A 2.746e-09 0.0466 1 88156923 G A A G 1.885e-08 0.0576 1 114445880 G A A G 5.861e-09 0.057 1 114449829 T A A T 9.295e-09 0.0564 1 120436751 T C C T 4.87e-09 0.0937 1 120567163 C T T C 8.78e-10 0.1011 1 121280613 A G G A 4.73e-58 0.123 1 121283515 T A A T 2.409e-11 -0.0858 1 145533314 T C C T 1.322e-08 -0.0452 1 145604791 G T T G 1.705e-10 -0.0508 1 149892872 A G G A 8.38e-14 0.0562 1 155148781 G A A G 1.265e-11 0.0519 1 155876613 G A A G 3.135e-08 -0.0441 1 201437832 C T T C 2.333e-08 0.0918 1 203801249 T C C T 4.163e-08 0.0461 1 217220574 G A A G 4.06e-08 -0.05 1 242034263 A G G A 1.083e-12 0.1481 2 121155824 A T T A 4.163e-14 -0.0595 2 121160231 G A A G 8.799e-11 0.0868 2 121244272 T C C T 3.413e-12 0.0864 2 172382905 C T T C 1.56e-10 -0.0494 2 172972971 G A A G 3.219e-16 -0.0603 2 174207470 A C C A 2.583e-09 0.063 2 202123430 C T T C 2.094e-12 -0.0545 2 217858314 A T T A 3.355e-14 -0.1036 2 217858641 G A A G 5.269e-10 -0.1397 2 217896410 A G G A 2.353e-22 -0.0852 2 217905937 T G G T 1.609e-61 -0.1355 2 217907873 C T T C 8.48e-11 0.1033 2 217911696 G A A G 1.825e-09 0.1301 2 217912437 C T T C 8.594e-10 -0.1063 2 217920769 G T T G 6.65e-91 -0.1482 2 217937940 A G G A 4.396e-33 -0.1056 2 217954982 T A A T 5.964e-36 -0.2647 2 217966910 A G G A 1.609e-08 0.0466 2 218262547 G A A G 6.43e-11 0.1539 2 218303958 G A A G 7.328e-19 0.0713 2 218344355 G T T G 5.856e-11 0.0671 3 4742251 A G G A 3.18e-16 0.0618 3 4796784 A T T A 3.354e-08 0.0422 3 27253521 T C C T 4e-08 0.0983 3 27330615 G A A G 3.279e-54 0.1148 3 27428663 G A A G 7.756e-14 0.0876 3 30684097 G A A G 9.756e-16 0.0627 3 46888198 T C C T 5.277e-15 -0.0991 3 63941697 T G G T 3.179e-08 0.0589 3 71532113 T C C T 3.756e-08 -0.0407 3 99687273 G A A G 2.587e-10 -0.0547 3 141147414 T C C T 2.269e-14 0.0571 3 172283173 G A A G 4.57e-09 0.0519 4 38816338 A C C A 1.593e-10 0.055 4 106064683 G A A G 7.643e-11 0.0569 4 175828036 T C C T 6.063e-30 0.1338 4 175836048 G A A G 3.89e-23 -0.0733 4 175917268 T A A T 8.549e-13 -0.0665 4 175917928 G T T G 1.113e-08 0.0446 5 1299379 C G G C 3.533e-09 -0.0445 5 16254310 A G G A 2.829e-08 -0.0415 5 44119344 G A A G 1.847e-08 0.1025 5 44249820 A G G A 5.506e-09 -0.0614 5 44373060 C T T C 1.46e-13 0.0544 5 44533123 T C C T 8.707e-17 -0.0947 5 44604890 G A A G 3.57e-08 0.1237 5 44706498 A G G A 8.267e-78 0.1563 5 44776604 C G G C 1.17e-10 0.1582 5 44893897 T G G T 1.444e-37 -0.0967 5 44947702 T C C T 2.416e-16 0.0908 5 45057095 G A A G 2.553e-10 0.1137 5 45333860 T C C T 2.871e-18 -0.0743 5 45988038 G A A G 7.22e-10 0.1055 5 49641645 T C C T 8.043e-09 -0.079 5 50238519 C T T C 1.585e-11 -0.0546 5 55965167 C T T C 3.742e-09 0.0462 5 55989304 G A A G 2.325e-18 -0.0655 5 56005859 G C C G 4.146e-20 -0.0866 5 56011234 G T T G 1.538e-12 0.0638 5 56045081 T C C T 8.701e-24 -0.1019 5 56053723 A T T A 2.88e-96 0.2032 5 56150973 T C C T 8.185e-23 0.1534 5 56153470 T C C T 1.806e-22 0.2875 5 56156477 C T T C 1.687e-08 0.1653 5 56191200 T A A T 8.669e-55 -0.1196 5 56242614 C T T C 2.944e-10 0.1631 5 56248735 C A A C 1.288e-14 0.0645 5 56278377 G A A G 6.25e-15 0.0687 5 56324374 T C C T 2.804e-08 0.0449 5 81492643 G A A G 3.318e-12 0.0613 5 90662839 G T T G 4.796e-12 -0.074 5 132442263 T C C T 7.005e-11 -0.0595 5 158244083 C T T C 5.774e-21 -0.0695 5 158386576 C T T C 1.114e-08 0.0433 5 169568846 C T T C 9.311e-11 0.057 6 13713366 G C C G 2.284e-12 -0.0524 6 20640537 G A A G 4.211e-10 -0.0498 6 21905726 A G G A 4.42e-09 0.0439 6 27425644 G C C G 2.994e-09 -0.0889 6 82287685 G A A G 1.559e-09 -0.0451 6 149595505 T C C T 7.55e-09 -0.0538 6 151958612 G T T G 3.628e-23 0.1386 6 152020390 A C C A 4.854e-12 0.0518 6 152055978 A T T A 6.668e-14 0.1107 6 152432902 C T T C 6.143e-13 0.0532 7 91588194 T C C T 1.279e-09 0.0463 7 91692760 T C C T 2.286e-09 0.0449 7 94304344 C T T C 1.407e-10 -0.054 7 101551704 G A A G 2.852e-11 -0.0794 7 130656911 C T T C 3.371e-10 -0.0494 7 130674481 G A A G 6.786e-09 0.0478 7 139954640 C A A C 3.103e-14 0.0587 7 144074929 G A A G 3.758e-09 -0.0508 8 23647494 G A A G 3.631e-09 0.0444 8 29507094 T C C T 2.435e-18 -0.0684 8 36849946 C G G C 4.906e-14 -0.0748 8 76230301 G T T G 2.01e-15 0.0784 8 76305785 A T T A 1.372e-20 0.1187 8 76326106 A T T A 4.13e-14 -0.0556 8 102430331 A G G A 2.099e-09 0.0576 8 106357736 T C C T 5.237e-10 0.0475 8 117209548 A G G A 2.933e-08 -0.0427 8 128293916 G C C G 1.235e-12 -0.0529 8 128320138 C T T C 4.164e-09 0.0991 8 128370949 C G G C 2.99e-48 0.1093 8 128371903 C T T C 4.342e-10 0.1048 8 129204262 T C C T 1.772e-12 0.0628 9 21956230 C T T C 2.605e-10 0.079 9 22003223 C T T C 4.596e-14 -0.0576 9 110305273 G C C G 3.618e-20 0.0744 9 110837073 A G G A 1.511e-16 0.1235 9 110837176 C T T C 2.147e-18 0.0839 9 110876842 C T T C 1.085e-12 0.0546 9 110892899 C A A C 3.357e-58 0.1237 9 110919211 C T T C 1.576e-13 -0.1788 9 119296736 G T T G 8.36e-13 -0.0552 10 21824727 G A A G 6.724e-21 0.0726 10 22112717 T C C T 5.197e-15 0.2267 10 64251977 C T T C 7.785e-16 0.0593 10 64291308 T C C T 2.733e-09 -0.0491 10 64299890 A G G A 1.115e-39 -0.1379 10 64480783 C T T C 2.393e-10 -0.1257 10 64562524 G A A G 3.694e-08 -0.0634 10 80852768 T G G T 3.957e-28 -0.0828 10 80886726 A G G A 1.241e-14 0.0759 10 115128491 T C C T 3.456e-13 -0.0644 10 123095186 A G G A 9.268e-14 -0.0594 10 123148822 C T T C 2.553e-10 0.0834 10 123229626 T G G T 2.147e-09 -0.0443 10 123241122 C G G C 1.586e-24 0.1463 10 123243730 G A A G 1.855e-10 0.0636 10 123250278 C T T C 1.414e-13 0.1117 10 123277507 G A A G 3.973e-08 0.1559 10 123278914 G T T G 2.906e-25 0.0766 10 123294692 C T T C 1.929e-13 -0.1062 10 123331468 T A A T 9.6e-47 0.1148 10 123333176 G A A G 1.349e-08 -0.197 10 123337814 A G G A 1.244e-26 -0.1213 10 123342707 G A A G 2.906e-19 0.1809 10 123349324 A T T A 1.871e-43 -0.2622 10 123349430 G A A G 3.45e-10 -0.1925 10 123351302 G A A G 2.13e-300 -0.2782 10 123352130 C T T C 1.156e-14 0.1781 10 123354003 G A A G 2.742e-19 0.2068 10 123356263 C T T C 1.018e-17 -0.1177 10 123357210 C T T C 2.833e-18 0.1667 10 123371924 G A A G 1.639e-14 0.2012 10 123394874 A G G A 4.431e-14 0.066 10 123399142 C T T C 4.453e-17 0.1832 10 123422858 C T T C 3.821e-35 -0.1313 10 123436950 T C C T 9.882e-41 -0.13 10 123446164 G C C G 7.076e-33 -0.1132 10 123479366 C A A C 3.836e-10 -0.0462 10 123486724 C T T C 5.843e-09 -0.124 10 123498694 T C C T 4.301e-12 -0.059 10 123608283 G A A G 6.071e-10 -0.0534 10 123801422 A C C A 1.135e-11 0.056 11 1871813 G A A G 3.295e-10 -0.0766 11 1891284 T A A T 1.886e-29 -0.0832 11 1894163 A G G A 8.929e-13 0.0546 11 2016908 G A A G 2.067e-12 -0.0663 11 65503224 C T T C 2.1e-09 0.0562 11 65571855 A G G A 3.729e-11 -0.0489 11 69153455 C T T C 4.641e-14 0.1925 11 69245812 A C C A 1.527e-17 0.0667 11 69258074 A G G A 1.592e-10 -0.048 11 69283303 T G G T 6.201e-23 -0.0734 11 69306595 T G G T 5.517e-17 0.0659 11 69331418 C T T C 1.02e-136 0.3277 11 69332712 C T T C 1.456e-21 -0.0863 11 69348869 T C C T 1.299e-12 -0.0545 11 69378694 G A A G 6.776e-12 0.1535 11 69466115 C A A C 3.733e-08 0.0411 11 69475386 C T T C 4e-17 0.1516 11 69509669 C T T C 8.169e-17 0.2274 11 129461016 A G G A 3.332e-09 0.0445 12 14413931 G C C G 7.344e-09 0.0483 12 28132906 A G G A 9.229e-09 -0.0526 12 28174817 C T T C 3.245e-36 -0.1102 12 28372143 G A A G 1.148e-11 -0.0542 12 29140260 G A A G 1.194e-08 0.077 12 96027759 A G G A 1.69e-28 -0.0899 12 115108361 T C C T 4.009e-11 0.0556 12 115583816 G A A G 1.156e-08 0.0442 12 115712201 G A A G 2.677e-11 -0.0528 12 115789200 T C C T 3.409e-10 -0.0841 12 115835798 G A A G 3.33e-40 -0.0996 14 37136545 C A A C 1.454e-18 -0.0804 14 37228504 C T T C 5.192e-11 0.0511 14 68637906 A T T A 9.054e-15 -0.0762 14 68986157 C T T C 1.385e-33 -0.1037 14 91742924 C T T C 3.36e-11 0.0536 14 91841069 A G G A 6.368e-10 0.0477 15 75136261 C G G C 3.72e-08 0.0446 15 91538920 C T T C 4.57e-12 -0.076 16 52512456 C T T C 1.808e-10 0.0501 16 52529948 C A A C 1.373e-24 -0.0846 16 52549671 G A A G 4.801e-10 -0.0632 16 52554640 T G G T 3.924e-10 0.2361 16 52566220 A G G A 2.502e-10 0.1723 16 52584927 T G G T 1.391e-10 0.2095 16 52591719 C T T C 8.403e-11 0.2728 16 52594838 G T T G 1.633e-09 -0.1092 16 52599188 C T T C 3.93e-164 0.2296 16 52600618 A G G A 2.074e-21 -0.0888 16 53803223 G A A G 2.157e-15 -0.0593 16 54682064 G A A G 8.429e-13 0.0533 16 80648296 A G G A 2.259e-21 0.0819 17 29211667 G A A G 3.196e-08 -0.0463 17 44252468 G A A G 6.155e-09 -0.0584 17 53174966 A G G A 2.664e-29 0.0908 18 24337424 C G G C 1.374e-11 0.0515 18 24484526 C T T C 2.351e-10 0.0639 18 24500899 C A A C 2.99e-21 -0.0794 18 42411803 G C C G 6.062e-13 -0.1057 18 42888797 T C C T 1.48e-12 -0.0549 19 18593553 T C C T 8.651e-23 -0.0768 19 44283232 C T T C 1.523e-16 -0.0635 19 46166073 T C C T 6.631e-09 -0.0467 19 46182304 T A A T 5.091e-09 0.0557 20 52287610 G T T G 2.795e-08 0.0507 20 62879331 T G G T 4.129e-08 0.0564 21 16432738 T C C T 1.732e-12 0.0704 21 16523248 T C C T 4.433e-08 -0.0922 21 16574455 C A A C 2.949e-33 -0.0964 21 16574676 T C C T 1.71e-08 0.0726 21 16607789 A C C A 3.694e-08 0.0443 21 16632322 C T T C 6.229e-09 -0.137 22 29134719 G A A G 6.232e-12 0.0882 22 29272637 C T T C 5.869e-19 0.2492 22 29318724 C T T C 1.117e-08 -0.0422 22 29529148 A G G A 3.583e-09 0.1008 22 29551872 A G G A 1.598e-16 -0.2347 22 38513138 G A A G 1.524e-12 -0.0543 22 38570313 G A A G 1.103e-16 -0.0632 22 39358037 A C C A 9.898e-11 0.0942 22 40806940 A G G A 1.246e-14 0.0835 22 41009707 A T T A 2.037e-21 0.1108