Overview

Integrating published and freely available genome-wide association studies (GWAS) summary statistics from multiple sources (published GWAS, the NHGRI-EBI GWAS Catalog, or UKB-based GWAS), we created an online repository for polygenic risk scores (PRS) for common cancer traits. Our framework condenses these summary statistics into PRS using linkage disequilibrium pruning and p-value thresholding (fixed or data-adaptively optimized thresholds) or penalized, genome-wide effect size weighting. We evaluate them in the cancer-enriched cohort of the Michigan Genomics Initiative (MGI), a longitudinal biorepository effort at Michigan Medicine, and in the population-based UK Biobank Study (UKB). For each PRS construct, measures on performance, calibration, and discrimination are provided. Beyond the cancer PRS evaluation in MGI and UKB, the PRSweb platform features construct downloads, risk evaluation in the top percentiles, and phenome-wide PRS association studies (PRS-PheWAS) for a subset of PRS that are predictive for the primary cancer.
For more information, see our latest article in The American Journal of Human Genetics here and the “Method” tab on top of this page."





Sign indicates " No predictive PRS found; weak association between PRS and trait of interest".
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Malignant neoplasm of ovary with UKB and odds ratio (top 1% versus rest)

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Association Overall Performance Discrimination/AAUC Odds Ratio
Top 1% vs Rest
GWAS

Source 		Phenotype
Description 		Method # SNPs P-value Pseudo-R2 Brier score AAUC 95%CI Odds Ratio 95 % CI PRS
PheWAS		 Download PRS
GWAS Catalog (2019-05-03) Epithelial ovarian cancer;High.. P&T 21 0.017 0.00239 0.0827 0.532 0.506, 0.559 0.923 0.347,2.45 link --
Phelan CM et al. 2017 Endometrioid ovarian cancer PRS-CS 1115189 0.022 0.00221 0.0827 0.526 0.498, 0.554 1.97 0.973,4 link --
Phelan CM et al. 2017 Epithelial ovarian cancer Lassosum 1441 0.01 0.00277 0.0826 0.538 0.512, 0.565 1.13 0.463,2.77 link --
Phelan CM et al. 2017 Invasive epithelial ovarian ca.. PRS-CS 1115189 2.3e-07 0.0113 0.0823 0.568 0.542, 0.595 1.76 0.838,3.7 link --
Phelan CM et al. 2017 Invasive epithelial ovarian ca.. P&T 12 8.6e-06 0.00819 0.0824 0.558 0.53, 0.586 1.55 0.71,3.38 link --
Phelan CM et al. 2017 Invasive epithelial ovarian ca.. Lassosum 41269 0.00028 0.00552 0.0825 0.552 0.523, 0.58 1.97 0.97,3.99 link --
Phelan CM et al. 2017 Low-grade serous and serous bo.. PRS-CS 1115189 0.032 0.00193 0.0827 0.522 0.491, 0.548 3.92 2.27,6.79 link --
Phelan CM et al. 2017 Low-grade serous and serous bo.. P&T 15 0.0099 0.00282 0.0826 0.539 0.513, 0.568 2.18 1.11,4.3 link --
Phelan CM et al. 2017 Low-grade serous and serous bo.. Lassosum 486841 0.016 0.00242 0.0826 0.516 0.489, 0.544 2.4 1.24,4.62 link --
Phelan CM et al. 2017 Low-grade serous ovarian cance.. Lassosum 1635861 0.03 0.00185 0.0826 0.498 0.471, 0.527 2.83 1.53,5.23 link --
Phelan CM et al. 2017 Ovarian clear cell cancer PRS-CS 1115187 0.0039 0.00348 0.0826 0.534 0.508, 0.562 1.55 0.71,3.38 link --
Phelan CM et al. 2017 Ovarian clear cell cancer Lassosum 1098236 5e-05 0.00676 0.0824 0.546 0.52, 0.574 1.76 0.839,3.69 link --
Phelan CM et al. 2017 Serous invasive ovarian cancer PRS-CS 1115189 8.9e-05 0.00646 0.0825 0.552 0.526, 0.58 1.55 0.708,3.38 link --
Phelan CM et al. 2017 Serous invasive ovarian cancer P&T 12 0.00023 0.00564 0.0826 0.547 0.52, 0.574 0.511 0.142,1.84 link --
Phelan CM et al. 2017 Serous invasive ovarian cancer Lassosum 110710 4.9e-05 0.00692 0.0825 0.556 0.529, 0.583 1.76 0.839,3.69 link --