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UKB PRS for Malignant neoplasm of ovary(184.11) based on Phelan CM et al. 2017
GWAS reference: 28346442 GWAS source: Phelan CM et al. 2017 PRS method: P_5e-08
PRSweb LD reference: MGI GWAS phenotype: Epithelial ovarian cancer PRSweb date: 2020-06-20
GWAS ID: Phelan_EPOC GWAS URL: ftp://ftp.ebi.ac.uk/pub/databases/gwas/summary_statistics/PhelanCM_28346442_GCST004462/harmonised/28346442-GCST004462-EFO_0001075-Build37.f.tsv.gz Genome build: GRCh37/hg19
PRS tuning parameter: P<=5e-08 PRS evaluation in: UKB
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PRS PheWAS Summary Statistics Exclusion PRS PheWAS Summary Statistics
PheWAS
Code		 Description Category Sex P value Odds
Ratio 		95% CI # Cases # Controls P value Odds
Ratio		 95% CI # Cases # Controls
008 Intestinal infection infectious diseases Both 0.9705 1.0 0.979,1.02 8842 88430 0.7362 1.01 0.948,1.08 1006 10122
008.5 Bacterial enteritis infectious diseases Both 0.5483 0.988 0.949,1.03 2718 27172 0.3062 0.959 0.884,1.04 639 6511
008.52 Intestinal infection due to C. difficile infectious diseases Both 0.2075 0.95 0.877,1.03 653 6533 0.3062 0.959 0.884,1.04 639 6511
008.6 Viral Enteritis infectious diseases Both 0.9772 1.0 0.934,1.07 862 8622 0.9354 1.0 0.936,1.07 857 8585
008.7 Intestinal infection due to protozoa infectious diseases Both 0.1 1.26 0.957,1.66 55 550 0.1 1.26 0.957,1.66 55 549
010 Tuberculosis infectious diseases Both 0.8913 0.989 0.845,1.16 166 1659 0.6531 0.994 0.968,1.02 5891 59290
038 Septicemia infectious diseases Both 0.1167 1.03 0.994,1.06 4175 41776 0.4188 1.04 0.948,1.14 490 4968
038.1 Gram negative septicemia infectious diseases Both 0.2 1.05 0.976,1.12 850 8501 0.1663 1.05 0.979,1.13 839 8480
038.2 Gram positive septicemia infectious diseases Both 0.4074 1.04 0.949,1.14 494 4978 0.4188 1.04 0.948,1.14 490 4968
041 Bacterial infection NOS infectious diseases Both 0.8337 1.0 0.983,1.02 12017 120377 0.7499 0.994 0.955,1.03 2663 27221
041.1 Staphylococcus infections infectious diseases Both 0.9162 1.0 0.966,1.04 3128 31348 0.8531 1.0 0.967,1.04 3094 31292
041.2 Streptococcus infection infectious diseases Both 0.3819 0.978 0.929,1.03 1641 16433 0.4457 0.98 0.932,1.03 1623 16398
041.4 E. coli infectious diseases Both 0.9226 0.998 0.96,1.04 2730 27319 0.7499 0.994 0.955,1.03 2663 27221
053 Herpes zoster infectious diseases Both 0.2489 1.06 0.958,1.18 411 4137 0.7311 1.04 0.838,1.29 95 944
053.1 Herpes zoster with nervous system complications infectious diseases Both 0.7096 1.04 0.84,1.29 95 949 0.7311 1.04 0.838,1.29 95 944
054 Herpes simplex infectious diseases Both 0.1236 1.12 0.97,1.28 211 2107 0.1245 1.12 0.97,1.28 211 2098
070 Viral hepatitis infectious diseases Both 0.7603 0.987 0.908,1.07 590 5916 0.8453 0.99 0.896,1.09 425 4274
070.1 Viral hepatitis A infectious diseases Both 0.7211 1.05 0.812,1.35 69 690 0.7096 1.05 0.812,1.36 68 686
070.2 Viral hepatitis B infectious diseases Both 0.9204 0.991 0.835,1.18 132 1330 0.9226 0.992 0.835,1.18 132 1329
070.3 Viral hepatitis C infectious diseases Both 0.0537 0.882 0.777,1.0 255 2568 0.05129 0.881 0.776,1.0 255 2564
070.4 Chronic hepatitis infectious diseases Both 0.1592 1.09 0.966,1.23 276 2767 0.1462 1.09 0.969,1.24 274 2760
070.9 Hepatitis NOS infectious diseases Both 0.8337 0.989 0.896,1.09 428 4287 0.8453 0.99 0.896,1.09 425 4274
071 Human immunodeficiency virus [HIV] disease infectious diseases Both 0.3034 0.917 0.778,1.08 147 1467 0.317 0.91 0.756,1.09 117 1168
071.1 HIV infection, symptomatic infectious diseases Both 0.317 0.91 0.756,1.09 117 1168 0.317 0.91 0.756,1.09 117 1168
078 Viral warts & HPV infectious diseases Both 0.9078 1.0 0.941,1.07 1004 10036 0.8472 1.01 0.943,1.07 986 9999
079 Viral infection infectious diseases Both 0.7745 1.01 0.967,1.05 2769 27694 0.9268 1.01 0.792,1.29 64 637
079.1 Varicella infection infectious diseases Both 0.9268 1.01 0.792,1.29 64 640 0.9268 1.01 0.792,1.29 64 637
080 Postoperative infection infectious diseases Both 0.4721 1.01 0.981,1.04 4473 44775 0.597 1.01 0.978,1.04 4395 44638
081 Infection/inflammation of internal prosthetic device; implant; and graft infectious diseases Both 0.02399 1.05 1.01,1.09 2477 24765 0.02291 1.05 1.01,1.09 2437 24697
090 Sexually transmitted infections (not HIV or hepatitis) infectious diseases Both 0.9376 1.01 0.796,1.28 71 709 0.955 1.01 0.794,1.28 71 706
110 Dermatophytosis / Dermatomycosis infectious diseases Both 0.191 1.08 0.96,1.23 279 2810 0.6026 1.05 0.882,1.24 140 1408
110.1 Dermatophytosis infectious diseases Both 0.2547 1.07 0.949,1.22 273 2750 0.6026 1.05 0.882,1.24 140 1408
110.11 Dermatophytosis of nail infectious diseases Both 0.1854 1.18 0.925,1.5 74 756 0.191 1.17 0.923,1.49 74 754
110.12 Althete's foot infectious diseases Both 0.6368 1.04 0.878,1.24 141 1410 0.6026 1.05 0.882,1.24 140 1408
112 Candidiasis infectious diseases Both 0.03467 1.05 1.0,1.1 2126 21275 0.04365 1.05 1.0,1.1 2080 21202
117 Mycoses infectious diseases Both 0.8166 0.985 0.869,1.12 272 2719 0.1963 0.902 0.77,1.06 164 1648
117.4 Aspergillosis infectious diseases Both 0.207 0.904 0.773,1.06 165 1650 0.1963 0.902 0.77,1.06 164 1648
130 Spirochetal infection infectious diseases Both 0.2649 0.88 0.704,1.1 80 800 0.2523 0.877 0.701,1.1 80 798
133 Arthropod-borne diseases infectious diseases Both 0.5559 0.931 0.733,1.18 69 689 0.5559 0.931 0.733,1.18 69 689
134 Helminthiases infectious diseases Both 0.05248 0.835 0.697,1.0 127 1267 0.2317 0.886 0.726,1.08 106 1057
134.1 Intestinal helminthiases infectious diseases Both 0.2286 0.885 0.725,1.08 106 1058 0.2317 0.886 0.726,1.08 106 1057
136 Other infectious and parasitic diseases infectious diseases Both 0.912 0.992 0.861,1.14 205 2050 0.7638 0.978 0.848,1.13 202 2045
145 Cancer of mouth neoplasms Both 0.3926 0.965 0.889,1.05 642 6415 0.375 0.889 0.685,1.15 54 538
145.2 Cancer of tongue neoplasms Both 0.5224 1.04 0.924,1.17 310 3096 0.5248 1.04 0.924,1.17 310 3094
145.3 Cancer of major salivary glands neoplasms Both 0.873 0.984 0.806,1.2 105 1049 0.8831 0.985 0.807,1.2 105 1047
145.5 Cancer of the mouth floor neoplasms Both 0.3631 0.886 0.683,1.15 54 539 0.375 0.889 0.685,1.15 54 538
149 Cancer of larynx, pharynx, nasal cavities neoplasms Both 0.6855 0.983 0.907,1.07 635 6342 0.695 0.946 0.72,1.25 57 570
149.1 Cancer of oropharynx neoplasms Both 0.6295 0.968 0.849,1.1 252 2517 0.6339 0.969 0.849,1.1 252 2515
149.4 Cancer of larynx neoplasms Both 0.9886 0.999 0.881,1.13 265 2640 0.9727 0.998 0.88,1.13 264 2640
149.9 Cancer of of nasal cavities neoplasms Both 0.695 0.946 0.72,1.25 57 570 0.695 0.946 0.72,1.25 57 570
150 Cancer of esophagus neoplasms Both 0.1486 1.06 0.981,1.14 762 7630 0.1472 1.06 0.981,1.14 760 7614
151 Cancer of stomach neoplasms Both 0.9817 1.0 0.92,1.09 569 5696 0.9419 1.0 0.922,1.09 566 5686
153 Colorectal cancer neoplasms Both 0.5152 0.99 0.96,1.02 4580 45799 0.9954 1.0 0.956,1.05 2136 21579
153.2 Colon cancer neoplasms Both 0.3251 0.982 0.946,1.02 3105 31046 0.2624 0.979 0.943,1.02 3069 30960
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus neoplasms Both 0.863 1.0 0.96,1.05 2164 21640 0.9954 1.0 0.956,1.05 2136 21579
155 Cancer of liver and intrahepatic bile duct neoplasms Both 0.1361 0.926 0.836,1.02 400 4008 0.09772 0.871 0.74,1.03 157 1578
155.1 Malignant neoplasm of liver, primary neoplasms Both 0.1035 0.873 0.742,1.03 158 1580 0.09772 0.871 0.74,1.03 157 1578
157 Pancreatic cancer neoplasms Both 0.8279 1.01 0.931,1.09 659 6582 0.857 1.01 0.929,1.09 657 6563
158 Neoplasm of unspecified nature of digestive system neoplasms Both 0.06457 1.06 0.996,1.13 1063 10635 0.05754 1.06 0.998,1.13 1050 10608
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum neoplasms Both 0.7638 1.0 0.977,1.03 5567 55694 0.5272 1.07 0.876,1.29 99 1920
159.2 Malignant neoplasm of small intestine, including duodenum neoplasms Both 0.879 0.989 0.854,1.14 190 1900 0.8453 0.985 0.851,1.14 188 1894
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts neoplasms Both 0.7962 0.981 0.85,1.13 205 2048 0.7674 0.978 0.847,1.13 203 2045
159.4 Malignant neoplasm of retroperitoneum and peritoneum neoplasms Both 0.871 1.01 0.876,1.17 193 1925 0.5272 1.07 0.876,1.29 99 1920
164 Cancer of intrathoracic organs neoplasms Both 0.01514 0.723 0.557,0.939 60 600 0.01514 0.724 0.558,0.94 60 599
165 Cancer within the respiratory system neoplasms Both 0.03548 1.04 1.0,1.08 2824 28235 0.0537 1.04 0.999,1.09 2210 22234
165.1 Cancer of bronchus; lung neoplasms Both 0.03981 1.05 1.0,1.09 2230 22307 0.0537 1.04 0.999,1.09 2210 22234
170 Cancer of bone and connective tissue neoplasms Both 0.5675 1.03 0.933,1.14 437 4364 0.7228 1.02 0.91,1.15 323 3293
170.1 Bone cancer neoplasms Both 0.7962 1.02 0.857,1.22 131 1309 0.7278 1.03 0.864,1.23 130 1307
170.2 Cancer of connective tissue neoplasms Both 0.5781 1.03 0.922,1.16 331 3303 0.7228 1.02 0.91,1.15 323 3293
172 Skin cancer neoplasms Both 0.01122 1.02 1.01,1.04 13495 134987 0.4018 1.04 0.955,1.12 657 6634
172.1 Melanomas of skin, dx or hx neoplasms Both 0.1052 1.03 0.993,1.08 2681 26792 0.08511 1.04 0.995,1.08 2701 27007
172.11 Melanomas of skin neoplasms Both 0.09333 1.03 0.994,1.08 2713 27112 0.08511 1.04 0.995,1.08 2701 27007
172.2 Other non-epithelial cancer of skin neoplasms Both 0.03631 1.02 1.0,1.04 11000 110056 0.04677 1.02 1.0,1.04 10942 109648
172.3 Carcinoma in situ of skin neoplasms Both 0.3828 1.04 0.957,1.12 666 6656 0.4018 1.04 0.955,1.12 657 6634
173 Neoplasm of uncertain behavior of skin neoplasms Both 0.9268 0.993 0.855,1.15 181 1818 0.9268 0.993 0.855,1.15 181 1814
174 Breast cancer neoplasms Both 0.01202 1.02 1.01,1.04 12686 126597 0.9661 1.0 0.83,1.21 114 1148
174.1 Breast cancer [female] neoplasms Female 0.01148 1.02 1.01,1.04 12476 124506 0.07413 1.02 0.998,1.04 11637 117502
174.11 Malignant neoplasm of female breast neoplasms Female 0.04898 1.02 1.0,1.04 11757 117502 0.07413 1.02 0.998,1.04 11637 117502
174.3 Neoplasm of uncertain behavior of breast neoplasms Both 0.9931 1.0 0.828,1.21 115 1148 0.9661 1.0 0.83,1.21 114 1148
175 Acquired absence of breast neoplasms Female 0.004677 1.06 1.02,1.11 2400 24010 0.01122 1.06 1.01,1.1 2361 24010
180 Cervical cancer and dysplasia neoplasms Female 0.9863 1.0 0.956,1.04 2174 21747 0.8356 1.0 0.96,1.05 2032 20784
180.1 Cervical cancer neoplasms Female 0.9057 1.01 0.888,1.14 272 2720 0.7396 1.02 0.896,1.17 249 2720
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia] neoplasms Female 0.9462 1.0 0.957,1.05 2078 20784 0.8356 1.0 0.96,1.05 2032 20784
182 Malignant neoplasm of uterus neoplasms Female 0.1189 1.05 0.988,1.11 1282 12836 0.1406 1.04 0.986,1.11 1203 12836
184 Cancer of other female genital organs neoplasms Female 8.318E-6 1.13 1.07,1.2 1378 13772 ,
184.1 Malignant neoplasm of ovary and other uterine adnexa neoplasms Female 1.23E-5 1.16 1.08,1.24 967 9667 ,
184.11 Malignant neoplasm of ovary neoplasms Female 3.467E-5 1.15 1.08,1.23 939 9387 ,
184.2 Cancer of other female genital organs (excluding uterus and ovary) neoplasms Female 0.7852 0.984 0.875,1.11 305 3049 ,
185 Cancer of prostate neoplasms Male 0.06026 0.975 0.949,1.0 5974 58812 0.06026 0.975 0.949,1.0 5974 58812
187 Cancer of other male genital organs neoplasms Male 0.1352 0.929 0.843,1.02 449 4485 0.5794 1.06 0.868,1.29 110 1098
187.1 Malignant neoplasm of unspecified male genital organ neoplasms Male 0.9462 1.01 0.792,1.28 70 700 0.9462 1.01 0.792,1.28 70 700
187.2 Malignant neoplasm of testis neoplasms Male 0.1462 0.915 0.812,1.03 287 2868 0.1462 0.915 0.812,1.03 287 2868
187.8 Neoplasm of uncertain behavior of male genital organs neoplasms Male 0.5794 1.06 0.868,1.29 110 1098 0.5794 1.06 0.868,1.29 110 1098
189 Cancer of urinary organs (incl. kidney and bladder) neoplasms Both 0.2844 1.02 0.986,1.05 4160 41604 0.7211 1.03 0.872,1.22 143 1436
189.1 Cancer of kidney and renal pelvis neoplasms Both 0.8356 0.993 0.933,1.06 1073 10723 0.7362 1.05 0.806,1.36 66 660
189.11 Malignant neoplasm of kidney, except pelvis neoplasms Both 0.6745 0.986 0.926,1.05 1033 10324 0.6934 0.987 0.926,1.05 1029 10296
189.12 Malignant neoplasm of renal pelvis neoplasms Both 0.7362 1.05 0.806,1.36 66 660 0.7362 1.05 0.806,1.36 66 660
189.2 Cancer of bladder neoplasms Both 0.5433 1.01 0.971,1.06 2409 24113 0.597 1.01 0.968,1.06 2132 21399
189.21 Malignant neoplasm of bladder neoplasms Both 0.5754 1.01 0.969,1.06 2142 21447 0.597 1.01 0.968,1.06 2132 21399
189.4 Malignant neoplasm of other urinary organs neoplasms Both 0.8453 1.02 0.861,1.2 144 1439 0.7211 1.03 0.872,1.22 143 1436
190 Cancer of eye neoplasms Both 0.4581 1.06 0.909,1.24 176 1758 0.4426 1.06 0.91,1.24 175 1748
191 Manlignant and unknown neoplasms of brain and nervous system neoplasms Both 6.918E-7 1.22 1.13,1.32 689 6879 9.772E-7 1.25 1.14,1.37 525 5225
191.1 Cancer of brain and nervous system neoplasms Both 1.445E-6 1.24 1.13,1.35 566 5650 9.772E-7 1.25 1.14,1.37 525 5225
191.11 Cancer of brain neoplasms Both 7.943E-7 1.25 1.14,1.37 525 5240 9.772E-7 1.25 1.14,1.37 525 5225
193 Thyroid cancer neoplasms Both 0.7551 1.02 0.911,1.14 346 3466 0.7762 1.02 0.91,1.13 345 3451
194 Cancer of other endocrine glands neoplasms Both 0.5346 1.07 0.867,1.32 95 949 0.5754 1.06 0.861,1.31 94 946
195 Cancer, suspected or other neoplasms Both 0.1374 1.01 0.996,1.03 16967 165463 0.1581 1.01 0.995,1.03 15670 159314
195.1 Malignant neoplasm, other neoplasms Both 0.07586 1.01 0.998,1.03 16267 159497 0.1581 1.01 0.995,1.03 15670 159314
197 Chemotherapy neoplasms Both 0.1722 1.01 0.996,1.02 21433 213213 0.3656 1.01 0.992,1.02 20753 212909
198 Secondary malignant neoplasm neoplasms Both 0.2594 1.01 0.991,1.03 9552 95503 0.6442 0.966 0.832,1.12 180 1888
198.1 Secondary malignancy of lymph nodes neoplasms Both 0.8356 0.997 0.969,1.03 5368 53670 0.7145 0.995 0.967,1.02 5184 53596
198.2 Secondary malignancy of respiratory organs neoplasms Both 0.1419 1.03 0.989,1.08 2267 22670 0.2773 1.02 0.981,1.07 2138 22644
198.3 Secondary malignant neoplasm of digestive systems neoplasms Both 0.7551 0.992 0.941,1.05 1549 15496 0.2042 0.961 0.904,1.02 1123 15473
198.4 Secondary malignant neoplasm of liver neoplasms Both 0.787 0.995 0.956,1.03 2665 26648 0.8913 0.997 0.957,1.04 2528 26609
198.5 Secondary malignancy of brain/spine neoplasms Both 0.4055 1.03 0.961,1.1 848 8473 0.4656 1.03 0.956,1.1 812 8466
198.6 Secondary malignancy of bone neoplasms Both 0.9016 1.0 0.959,1.05 2161 21600 0.9931 1.0 0.956,1.05 2111 21577
198.7 Secondary malignant neoplasm of skin neoplasms Both 0.5943 0.961 0.83,1.11 188 1890 0.6442 0.966 0.832,1.12 180 1888
199 Neoplasm of uncertain behavior neoplasms Both 0.3069 1.03 0.974,1.09 1432 14313 0.5358 0.936 0.76,1.15 92 948
199.4 Neurofibromatosis neoplasms Both 0.492 0.93 0.757,1.14 95 950 0.5358 0.936 0.76,1.15 92 948
200 Myeloproliferative disease neoplasms Both 9.12E-5 1.14 1.07,1.22 991 9911 0.1419 1.08 0.974,1.2 387 3859
200.1 Polycythemia vera neoplasms Both 0.1426 1.08 0.974,1.2 387 3867 0.1419 1.08 0.974,1.2 387 3859
201 Hodgkin's disease neoplasms Both 0.6124 0.967 0.849,1.1 259 2598 0.6324 0.969 0.851,1.1 259 2592
202 Cancer of other lymphoid, histiocytic tissue neoplasms Both 0.4624 1.02 0.973,1.06 2264 22709 0.6637 1.02 0.936,1.11 579 5810
202.2 Non-Hodgkins lymphoma neoplasms Both 0.1803 1.03 0.985,1.08 1802 18073 0.6637 1.02 0.936,1.11 579 5810
202.21 Nodular lymphoma neoplasms Both 0.01995 1.13 1.02,1.26 363 3647 0.02138 1.13 1.02,1.26 363 3630
202.24 Large cell lymphoma neoplasms Both 0.7047 1.02 0.934,1.11 581 5824 0.6637 1.02 0.936,1.11 579 5810
204 Leukemia neoplasms Both 0.05129 1.05 1.0,1.11 1660 16630 0.6683 1.02 0.934,1.11 555 5543
204.1 Lymphoid leukemia neoplasms Both 0.3381 1.04 0.957,1.14 577 5784 0.3304 1.05 0.955,1.15 504 5069
204.11 Lymphoid leukemia, acute neoplasms Both 0.4395 1.12 0.843,1.48 56 560 0.4487 1.12 0.841,1.48 56 559
204.12 Lymphoid leukemia, chronic neoplasms Both 0.3097 1.05 0.957,1.15 507 5084 0.3304 1.05 0.955,1.15 504 5069
204.2 Myeloid leukemia neoplasms Both 0.02754 1.11 1.01,1.23 462 4617 0.5715 1.05 0.884,1.25 142 1435
204.21 Myeloid leukemia, acute neoplasms Both 0.1365 1.09 0.973,1.22 329 3287 0.1472 1.09 0.971,1.22 327 3280
204.22 Myeloid leukemia, chronic neoplasms Both 0.5534 1.05 0.887,1.25 144 1440 0.5715 1.05 0.884,1.25 142 1435
204.4 Multiple myeloma neoplasms Both 0.6823 1.02 0.933,1.11 555 5560 0.6683 1.02 0.934,1.11 555 5543
208 Benign neoplasm of colon neoplasms Both 0.8531 1.0 0.987,1.02 19856 191891 0.8551 1.0 0.987,1.02 19766 191332
210 Benign neoplasm of lip, oral cavity, and pharynx neoplasms Both 0.984 1.0 0.938,1.07 978 9781 0.9661 1.0 0.938,1.07 976 9751
211 Benign neoplasm of other parts of digestive system neoplasms Both 0.1574 1.02 0.992,1.05 5243 52452 0.1683 1.02 0.992,1.05 5213 52251
212 Benign neoplasm of respiratory and intrathoracic organs neoplasms Both 0.03548 0.89 0.799,0.992 347 3466 0.03802 0.892 0.8,0.994 347 3455
213 Benign neoplasm of bone and articular cartilage neoplasms Both 0.1841 0.925 0.825,1.04 318 3187 0.1914 0.926 0.826,1.04 316 3175
214 Lipoma neoplasms Both 0.5212 1.01 0.983,1.04 6231 62346 0.3524 1.01 0.984,1.05 4572 45716
214.1 Lipoma of skin and subcutaneous tissue neoplasms Both 0.3556 1.01 0.984,1.05 4585 45872 0.3524 1.01 0.984,1.05 4572 45716
215 Other benign neoplasm of connective and other soft tissue neoplasms Both 0.05248 1.06 0.999,1.13 1107 11061 0.0537 1.06 0.999,1.13 1103 11018
216 Benign neoplasm of skin neoplasms Both 0.0257 1.03 1.0,1.05 7664 76660 0.03236 1.03 1.0,1.05 7631 76365
217 Vascular hamartomas and non-neoplastic nevi neoplasms Both 0.8072 0.99 0.911,1.08 632 6313 0.7943 0.989 0.908,1.08 589 5914
217.1 Nevus, non-neoplastic neoplasms Both 0.811 0.99 0.909,1.08 595 5943 0.7943 0.989 0.908,1.08 589 5914
218 Benign neoplasm of uterus neoplasms Female 4.677E-6 1.05 1.03,1.07 10023 100200 0.1358 1.09 0.974,1.21 342 3548
218.1 Uterine leiomyoma neoplasms Female 1.259E-6 1.05 1.03,1.07 10241 102376 6.166E-6 1.05 1.03,1.07 10042 102376
218.2 Other benign neoplasm of uterus neoplasms Female 0.1084 1.09 0.981,1.22 355 3548 0.1358 1.09 0.974,1.21 342 3548
220 Benign neoplasm of ovary neoplasms Female 1.0E-11 1.21 1.14,1.27 1445 14483 3.981E-11 1.2 1.14,1.27 1396 14483
221 Benign neoplasm of other female genital organs neoplasms Female 0.2999 1.08 0.936,1.24 220 2196 0.2944 1.08 0.935,1.25 208 2196
222 Benign neoplasm of male genital organs neoplasms Male 0.7762 0.976 0.828,1.15 160 1600 0.7762 0.976 0.828,1.15 160 1600
223 Benign neoplasm of kidney and other urinary organs neoplasms Both 0.5943 1.04 0.893,1.22 173 1729 0.5358 1.05 0.899,1.23 171 1728
224 Benign neoplasm of eye neoplasms Both 0.7907 1.03 0.853,1.23 129 1299 0.1274 0.818 0.632,1.06 67 676
224.1 Benign neoplasm of eye, uveal neoplasms Both 0.13 0.819 0.633,1.06 67 680 0.1274 0.818 0.632,1.06 67 676
225 Benign neoplasm of brain and other parts of nervous system neoplasms Both 4.677E-5 1.16 1.08,1.25 816 8155 0.5546 1.08 0.841,1.38 59 584
225.1 Benign neoplasm of brain, cranial nerves, meninges neoplasms Both 5.129E-5 1.17 1.08,1.26 775 7756 6.918E-5 1.17 1.08,1.26 767 7726
225.2 Benign neoplasm of spinal cord, meninges neoplasms Both 0.5297 1.08 0.845,1.39 59 589 0.5546 1.08 0.841,1.38 59 584
226 Benign neoplasm of thyroid glands neoplasms Both 0.4887 1.05 0.922,1.19 266 2664 0.5188 1.04 0.918,1.18 262 2651
227 Benign neoplasm of other endocrine glands and related structures neoplasms Both 0.7798 1.01 0.942,1.08 861 8635 0.5943 0.969 0.861,1.09 308 3104
227.1 Benign neoplasm of adrenal gland neoplasms Both 0.4416 0.943 0.812,1.1 186 1857 0.3597 0.932 0.802,1.08 184 1852
227.2 Benign neoplasm of parathyroid gland neoplasms Both 0.2056 1.07 0.963,1.19 371 3709 0.2143 1.07 0.962,1.19 371 3689
227.3 Benign neoplasm of pituitary gland and craniopharyngeal duct (pouch) neoplasms Both 0.5768 0.967 0.86,1.09 309 3114 0.5943 0.969 0.861,1.09 308 3104
228 Hemangioma and lymphangioma, any site neoplasms Both 0.2163 1.03 0.981,1.09 1596 15966 0.2014 1.03 0.982,1.09 1588 15912
229 Benign neoplasm of unspecified sites neoplasms Both 0.9078 1.0 0.961,1.05 2397 23955 0.8974 1.0 0.961,1.05 2385 23851
860 Bone marrow or stem cell transplant neoplasms Both 0.06918 1.25 0.983,1.59 68 680 0.0871 1.23 0.969,1.57 67 679
240 Simple and unspecified goiter endocrine/metabolic Both 0.3846 1.04 0.955,1.13 600 6016 0.3141 1.04 0.961,1.13 595 5983
241 Nontoxic nodular goiter endocrine/metabolic Both 0.6124 0.984 0.926,1.05 1107 11092 0.7568 0.988 0.913,1.07 671 6751
241.1 Nontoxic uninodular goiter endocrine/metabolic Both 0.7586 0.985 0.897,1.08 471 4706 0.7228 0.983 0.895,1.08 469 4687
241.2 Nontoxic multinodular goiter endocrine/metabolic Both 0.7194 0.986 0.912,1.07 676 6784 0.7568 0.988 0.913,1.07 671 6751
242 Thyrotoxicosis with or without goiter endocrine/metabolic Both 0.5728 1.01 0.966,1.06 1854 18531 0.8279 0.981 0.824,1.17 138 1374
242.1 Graves' disease endocrine/metabolic Both 0.3062 1.05 0.955,1.16 456 4553 0.3055 1.05 0.954,1.16 452 4536
242.2 Toxic multinodular goiter endocrine/metabolic Both 0.04365 0.801 0.646,0.994 91 910 0.05754 0.81 0.651,1.01 89 904
242.3 Exophthalmos endocrine/metabolic Both 0.8356 0.982 0.824,1.17 138 1379 0.8279 0.981 0.824,1.17 138 1374
244 Hypothyroidism endocrine/metabolic Both 0.03548 1.02 1.0,1.04 14590 145053 0.03388 1.02 1.0,1.04 13776 138151
244.1 Secondary hypothyroidism endocrine/metabolic Both 0.3741 1.03 0.967,1.09 1108 11079 0.4046 1.03 0.965,1.09 1091 11030
244.2 Acquired hypothyroidism endocrine/metabolic Both 0.5585 0.939 0.762,1.16 101 1010 0.5689 0.941 0.763,1.16 101 1004
244.4 Hypothyroidism NOS endocrine/metabolic Both 0.02512 1.02 1.0,1.04 13918 138926 0.03388 1.02 1.0,1.04 13776 138151
245 Thyroiditis endocrine/metabolic Both 0.0631 1.12 0.994,1.26 288 2877 0.05012 1.15 1.0,1.32 209 2084
245.2 Chronic thyroiditis endocrine/metabolic Both 0.08318 1.13 0.984,1.29 218 2177 0.05012 1.15 1.0,1.32 209 2084
245.21 Chronic lymphocytic thyroiditis endocrine/metabolic Both 0.05248 1.15 0.998,1.32 210 2097 0.05012 1.15 1.0,1.32 209 2084
246 Other disorders of thyroid endocrine/metabolic Both 0.414 1.04 0.941,1.16 397 3975 0.4276 1.04 0.94,1.16 395 3953
250 Diabetes mellitus endocrine/metabolic Both 0.9376 0.999 0.985,1.01 19787 186006 0.2399 1.03 0.978,1.09 1325 13307
250.1 Type 1 diabetes endocrine/metabolic Both 0.9397 0.998 0.96,1.04 2758 27621 0.3296 1.08 0.924,1.27 160 1604
250.11 Type 1 diabetes with ketoacidosis endocrine/metabolic Both 0.1132 1.11 0.975,1.27 239 2389 0.0955 1.12 0.98,1.28 238 2380
250.12 Type 1 diabetes with renal manifestations endocrine/metabolic Both 0.7674 0.966 0.766,1.22 76 770 0.7674 0.966 0.766,1.22 76 770
250.13 Type 1 diabetes with ophthalmic manifestations endocrine/metabolic Both 0.507 1.03 0.94,1.13 473 4744 0.4406 1.04 0.945,1.14 471 4735
250.14 Type 1 diabetes with neurological manifestations endocrine/metabolic Both 0.3273 1.08 0.924,1.27 160 1610 0.3296 1.08 0.924,1.27 160 1604
250.2 Type 2 diabetes endocrine/metabolic Both 0.4539 0.994 0.979,1.01 17831 170202 0.6486 1.02 0.932,1.12 501 5058
250.21 Type 2 diabetes with ketoacidosis endocrine/metabolic Both 0.7709 1.03 0.843,1.26 104 1050 0.798 1.03 0.84,1.25 103 1042
250.22 Type 2 diabetes with renal manifestations endocrine/metabolic Both 0.0123 1.2 1.04,1.38 200 2018 0.01202 1.2 1.04,1.38 200 2014
250.23 Type 2 diabetes with ophthalmic manifestations endocrine/metabolic Both 0.7228 1.01 0.948,1.08 986 9907 0.6792 1.01 0.95,1.08 983 9880
250.24 Type 2 diabetes with neurological manifestations endocrine/metabolic Both 0.695 1.02 0.93,1.12 503 5066 0.6486 1.02 0.932,1.12 501 5058
250.4 Abnormal glucose endocrine/metabolic Both 0.869 0.993 0.918,1.08 680 6827 0.5284 1.03 0.934,1.14 414 4168
250.41 Impaired fasting glucose endocrine/metabolic Both 0.246 0.928 0.817,1.05 265 2659 0.2377 0.927 0.816,1.05 265 2651
250.42 Other abnormal glucose endocrine/metabolic Both 0.4898 1.04 0.937,1.15 416 4178 0.5284 1.03 0.934,1.14 414 4168
250.5 Glycosuria or Acetonuria endocrine/metabolic Both 0.7727 0.975 0.819,1.16 131 1308 0.7745 0.975 0.819,1.16 131 1307
250.6 Polyneuropathy in diabetes endocrine/metabolic Both 0.618 1.03 0.924,1.14 349 3495 0.5821 1.03 0.926,1.15 348 3489
250.7 Diabetic retinopathy endocrine/metabolic Both 0.2655 1.03 0.976,1.09 1329 13335 0.2399 1.03 0.978,1.09 1325 13307
251.1 Hypoglycemia endocrine/metabolic Both 0.9954 1.0 0.936,1.07 932 9370 0.984 1.0 0.936,1.07 931 9355
252 Disorders of parathyroid gland endocrine/metabolic Both 0.6577 0.984 0.918,1.06 873 8719 0.1042 0.864 0.724,1.03 140 1413
252.1 Hyperparathyroidism endocrine/metabolic Both 0.7261 0.987 0.917,1.06 781 7802 0.7244 0.987 0.917,1.06 777 7756
252.2 Hypoparathyroidism endocrine/metabolic Both 0.09333 0.86 0.722,1.03 142 1418 0.1042 0.864 0.724,1.03 140 1413
253 Disorders of the pituitary gland and its hypothalamic control endocrine/metabolic Both 0.7464 0.987 0.911,1.07 681 6821 0.4688 1.06 0.902,1.25 158 1568
253.1 Pituitary hyperfunction endocrine/metabolic Both 0.984 1.0 0.861,1.16 187 1867 0.389 0.911 0.736,1.13 94 944
253.11 Acromegaly and gigantism endocrine/metabolic Both 0.3614 0.906 0.733,1.12 95 949 0.389 0.911 0.736,1.13 94 944
253.2 Pituitary hypofunction endocrine/metabolic Both 0.2472 0.927 0.815,1.05 260 2618 0.25 0.927 0.816,1.05 260 2609
253.3 Diabetes insipidus endocrine/metabolic Both 0.7889 1.03 0.831,1.28 92 919 0.778 1.03 0.832,1.28 92 916
253.7 Other disorders of neurohypophysis endocrine/metabolic Both 0.471 1.06 0.902,1.25 158 1578 0.4688 1.06 0.902,1.25 158 1568
255 Disorders of adrenal glands endocrine/metabolic Both 0.3076 1.04 0.962,1.13 638 6374 0.2636 1.06 0.956,1.18 358 3595
255.1 Adrenal hyperfunction endocrine/metabolic Both 0.1702 0.899 0.771,1.05 180 1797 0.08913 0.816 0.645,1.03 76 758
255.11 Cushing's syndrome endocrine/metabolic Both 0.9441 0.993 0.814,1.21 103 1029 0.9705 0.996 0.817,1.22 103 1023
255.12 Hyperaldosteronism endocrine/metabolic Both 0.0912 0.816 0.645,1.03 76 759 0.08913 0.816 0.645,1.03 76 758
255.2 Adrenal hypofunction endocrine/metabolic Both 0.2729 1.06 0.955,1.18 362 3617 0.2636 1.06 0.956,1.18 358 3595
255.21 Glucocorticoid deficiency endocrine/metabolic Both 0.2897 1.06 0.953,1.18 361 3607 0.2636 1.06 0.956,1.18 358 3595
256 Ovarian dysfunction endocrine/metabolic Female 0.9506 0.996 0.876,1.13 240 2397 0.5902 0.962 0.836,1.11 205 2081
256.4 Polycystic ovaries endocrine/metabolic Female 0.6026 0.964 0.839,1.11 209 2088 0.5902 0.962 0.836,1.11 205 2081
257 Testicular dysfunction endocrine/metabolic Male 0.3126 0.92 0.784,1.08 160 1619 0.3334 0.922 0.782,1.09 152 1539
257.1 Testicular hypofunction endocrine/metabolic Male 0.3334 0.922 0.782,1.09 152 1539 0.3334 0.922 0.782,1.09 152 1539
258 Iatrogenic endocrine disorders endocrine/metabolic Both 0.07413 0.833 0.682,1.02 102 1020 0.07762 0.835 0.683,1.02 101 1016
259 Other endocrine disorders endocrine/metabolic Both 0.6887 0.967 0.82,1.14 149 1498 0.7047 0.969 0.822,1.14 149 1493
260 Protein-calorie malnutrition endocrine/metabolic Both 0.9141 1.01 0.876,1.16 202 2018 0.4198 0.971 0.905,1.04 822 8281
260.1 Cachexia endocrine/metabolic Both 0.2812 0.851 0.634,1.14 51 510 0.2812 0.851 0.634,1.14 51 510
260.6 Anorexia endocrine/metabolic Both 0.4178 0.971 0.905,1.04 830 8317 0.4198 0.971 0.905,1.04 822 8281
261 Vitamin deficiency endocrine/metabolic Both 0.5808 0.983 0.927,1.04 1199 11974 0.7178 0.956 0.749,1.22 71 763
261.2 Vitamin B-complex deficiencies endocrine/metabolic Both 0.9594 0.998 0.926,1.08 755 7541 0.9484 0.997 0.925,1.08 749 7510
261.4 Vitamin D deficiency endocrine/metabolic Both 0.52 0.969 0.879,1.07 447 4462 0.7178 0.956 0.749,1.22 71 763
261.41 Rickets or osteomalacia endocrine/metabolic Both 0.8492 0.977 0.772,1.24 77 769 0.7178 0.956 0.749,1.22 71 763
262 Mineral deficiency NEC endocrine/metabolic Both 0.9333 0.994 0.871,1.14 241 2407 0.9528 1.0 0.879,1.15 239 2399
269 Proteinuria endocrine/metabolic Both 0.3573 1.05 0.943,1.18 338 3378 0.3516 1.05 0.943,1.18 337 3376
270 Disorders of protein plasma/amino-acid transport and metabolism endocrine/metabolic Both 0.4207 1.05 0.933,1.18 303 3028 0.9016 1.02 0.801,1.29 68 688
270.3 Disorders of plasma protein metabolism endocrine/metabolic Both 0.6776 1.03 0.906,1.17 261 2608 0.9016 1.02 0.801,1.29 68 688
270.32 Paraproteinemia endocrine/metabolic Both 0.5702 1.04 0.9,1.21 191 1910 0.5636 1.04 0.9,1.21 191 1907
270.33 Amyloidosis endocrine/metabolic Both 0.06918 0.841 0.697,1.01 113 1129 0.0955 0.852 0.706,1.03 112 1122
270.35 Macroglobulinemia endocrine/metabolic Both 0.7745 1.04 0.818,1.31 69 689 0.9016 1.02 0.801,1.29 68 688
271 Disorders of carbohydrate transport and metabolism endocrine/metabolic Both 0.5636 1.05 0.894,1.23 160 1600 0.561 1.05 0.885,1.25 135 1386
271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption endocrine/metabolic Both 0.5164 1.06 0.892,1.25 139 1391 0.561 1.05 0.885,1.25 135 1386
272 Disorders of lipoid metabolism endocrine/metabolic Both 0.7499 0.998 0.987,1.01 34835 235433 0.6209 0.966 0.841,1.11 210 2105
272.1 Hyperlipidemia endocrine/metabolic Both 0.7328 0.998 0.987,1.01 34764 235203 0.5445 1.05 0.897,1.23 164 1635
272.11 Hypercholesterolemia endocrine/metabolic Both 0.6653 0.997 0.986,1.01 32324 228083 0.7129 0.998 0.986,1.01 32170 227335
272.12 Hyperglyceridemia endocrine/metabolic Both 0.07762 0.785 0.599,1.03 58 580 0.07762 0.785 0.599,1.03 58 580
272.13 Mixed hyperlipidemia endocrine/metabolic Both 0.5445 1.05 0.897,1.23 164 1637 0.5445 1.05 0.897,1.23 164 1635
272.9 Unspecified disorder of lipoid metabolism endocrine/metabolic Both 0.6039 0.964 0.839,1.11 211 2109 0.6209 0.966 0.841,1.11 210 2105
274 Gout and other crystal arthropathies endocrine/metabolic Both 0.4624 1.01 0.979,1.05 3724 37231 0.7295 1.02 0.931,1.11 556 5563
274.1 Gout endocrine/metabolic Both 0.3381 1.02 0.982,1.06 3171 31705 0.6761 1.04 0.861,1.26 112 1119
274.11 Gouty arthropathy endocrine/metabolic Both 0.6761 1.04 0.861,1.26 112 1119 0.6761 1.04 0.861,1.26 112 1119
274.2 Crystal arthropathies endocrine/metabolic Both 0.9817 0.999 0.921,1.08 613 6124 0.7295 1.02 0.931,1.11 556 5563
274.21 Chondrocalcinosis endocrine/metabolic Both 0.7691 1.01 0.929,1.1 558 5576 0.7295 1.02 0.931,1.11 556 5563
275 Disorders of mineral metabolism endocrine/metabolic Both 0.8831 0.997 0.953,1.04 2107 21070 0.2506 1.05 0.967,1.14 650 6522
275.3 Disorders of magnesium metabolism endocrine/metabolic Both 0.1648 0.928 0.836,1.03 375 3745 0.4083 0.956 0.858,1.06 353 3733
275.5 Disorders of calcium/phosphorus metabolism endocrine/metabolic Both 0.6902 0.988 0.931,1.05 1202 12019 0.8433 0.985 0.844,1.15 169 1714
275.53 Disorders of phosphorus metabolism endocrine/metabolic Both 0.8017 0.981 0.841,1.14 171 1717 0.8433 0.985 0.844,1.15 169 1714
276 Disorders of fluid, electrolyte, and acid-base balance endocrine/metabolic Both 0.6561 1.01 0.982,1.03 7284 72932 0.4742 1.07 0.891,1.28 127 1273
276.1 Electrolyte imbalance endocrine/metabolic Both 0.861 0.997 0.966,1.03 4086 40930 0.5521 1.02 0.962,1.07 1395 14183
276.11 Hyperosmolality and/or hypernatremia endocrine/metabolic Both 0.1057 1.11 0.978,1.27 239 2409 0.1247 1.11 0.972,1.26 237 2405
276.12 Hyposmolality and/or hyponatremia endocrine/metabolic Both 0.9162 0.997 0.95,1.05 1818 18200 0.7816 0.993 0.946,1.04 1775 18143
276.13 Hyperpotassemia endocrine/metabolic Both 0.2333 0.961 0.901,1.03 969 9728 0.2109 0.959 0.898,1.02 945 9713
276.14 Hypopotassemia endocrine/metabolic Both 0.6653 1.01 0.958,1.07 1424 14235 0.5521 1.02 0.962,1.07 1395 14183
276.4 Acid-base balance disorder endocrine/metabolic Both 0.4529 1.02 0.963,1.09 1161 11629 0.2028 0.886 0.735,1.07 112 1125
276.41 Acidosis endocrine/metabolic Both 0.2642 1.04 0.973,1.1 1056 10577 0.2716 1.04 0.972,1.1 1043 10549
276.42 Alkalosis endocrine/metabolic Both 0.246 0.896 0.743,1.08 113 1129 0.2028 0.886 0.735,1.07 112 1125
276.5 Hypovolemia endocrine/metabolic Both 0.6324 0.991 0.953,1.03 2827 28265 0.5861 0.989 0.951,1.03 2747 28191
276.6 Fluid overload endocrine/metabolic Both 0.2716 1.05 0.959,1.16 451 4535 0.2972 1.05 0.956,1.16 446 4532
276.8 Polydipsia endocrine/metabolic Both 0.5358 1.06 0.884,1.27 128 1278 0.4742 1.07 0.891,1.28 127 1273
277 Other disorders of metabolism endocrine/metabolic Both 0.3459 1.03 0.965,1.11 899 8977 0.3715 0.886 0.679,1.16 52 519
277.4 Disorders of bilirubin excretion endocrine/metabolic Both 0.3614 1.05 0.944,1.17 362 3613 0.3459 1.05 0.945,1.17 361 3603
277.5 Other disorders of lipoid metabolism endocrine/metabolic Both 0.9462 0.995 0.872,1.14 230 2298 0.3715 0.886 0.679,1.16 52 519
277.51 Lipoprotein disorders endocrine/metabolic Both 0.3758 0.887 0.68,1.16 52 520 0.3715 0.886 0.679,1.16 52 519
278 Overweight, obesity and other hyperalimentation endocrine/metabolic Both 0.865 1.0 0.982,1.02 10804 108289 0.7145 1.05 0.812,1.35 65 659
278.1 Obesity endocrine/metabolic Both 0.8831 1.0 0.982,1.02 10642 106670 0.857 1.0 0.982,1.02 10584 106281
278.3 Localized adiposity endocrine/metabolic Both 0.9462 0.993 0.801,1.23 84 838 0.9268 0.99 0.799,1.23 84 834
278.4 Abnormal weight gain endocrine/metabolic Both 0.5984 1.07 0.831,1.38 66 660 0.7145 1.05 0.812,1.35 65 659
279 Disorders involving the immune mechanism endocrine/metabolic Both 0.1866 0.917 0.807,1.04 250 2510 0.861 1.01 0.888,1.15 248 2476
279.1 Immunity deficiency endocrine/metabolic Both 0.2723 0.923 0.801,1.06 209 2100 0.2286 0.901 0.76,1.07 138 1382
279.11 Deficiency of humoral immunity endocrine/metabolic Both 0.2099 0.897 0.758,1.06 138 1390 0.2286 0.901 0.76,1.07 138 1382
279.7 Other immunological findings endocrine/metabolic Both 0.8492 1.01 0.889,1.15 248 2478 0.861 1.01 0.888,1.15 248 2476
275.1 Disorders of iron metabolism hematopoietic Both 0.2223 1.05 0.97,1.14 653 6535 0.2506 1.05 0.967,1.14 650 6522
280 Iron deficiency anemias hematopoietic Both 0.618 1.01 0.983,1.03 7610 76168 0.4477 1.04 0.942,1.15 444 4530
280.1 Iron deficiency anemias, unspecified or not due to blood loss hematopoietic Both 0.6152 1.01 0.982,1.03 7311 73153 0.5741 1.01 0.983,1.03 7266 72905
280.2 Iron deficiency anemia secondary to blood loss (chronic) hematopoietic Both 0.3508 1.05 0.951,1.15 452 4541 0.4477 1.04 0.942,1.15 444 4530
281 Other deficiency anemia hematopoietic Both 0.6501 0.986 0.927,1.05 1112 11126 0.4188 1.12 0.847,1.49 54 536
281.1 Megaloblastic anemia hematopoietic Both 0.4943 0.978 0.919,1.04 1066 10669 0.3556 0.931 0.801,1.08 181 1836
281.11 Pernicious anemia hematopoietic Both 0.8395 0.992 0.921,1.07 750 7514 0.8954 0.995 0.924,1.07 742 7487
281.12 Other vitamin B12 deficiency anemia hematopoietic Both 0.3388 0.928 0.796,1.08 177 1769 0.2858 0.92 0.789,1.07 176 1765
281.13 Folate-deficiency anemia hematopoietic Both 0.399 0.937 0.807,1.09 183 1836 0.3556 0.931 0.801,1.08 181 1836
281.9 Deficiency anemias hematopoietic Both 0.4178 1.12 0.847,1.49 54 538 0.4188 1.12 0.847,1.49 54 536
282 Hereditary hemolytic anemias hematopoietic Both 0.06761 0.861 0.734,1.01 150 1499 0.6368 0.949 0.763,1.18 84 845
282.8 Other hemoglobinopathies hematopoietic Both 0.1268 0.821 0.638,1.06 56 560 0.08128 0.797 0.617,1.03 55 557
282.9 Other hereditary hemolytic anemias hematopoietic Both 0.561 0.938 0.755,1.16 85 849 0.6368 0.949 0.763,1.18 84 845
283 Acquired hemolytic anemias hematopoietic Both 0.3715 0.923 0.773,1.1 135 1377 0.2244 0.88 0.717,1.08 101 1056
283.1 Autoimmune hemolytic anemias hematopoietic Both 0.1479 0.86 0.702,1.05 103 1059 0.2244 0.88 0.717,1.08 101 1056
284 Aplastic anemia hematopoietic Both 0.7096 1.02 0.923,1.13 435 4357 0.7278 1.02 0.921,1.12 427 4340
285 Other anemias hematopoietic Both 0.2904 1.01 0.991,1.03 12104 121094 0.2535 1.06 0.956,1.18 375 4136
285.1 Acute posthemorrhagic anemia hematopoietic Both 0.07413 1.12 0.989,1.27 271 2707 0.0955 1.11 0.981,1.26 270 2697
285.2 Anemia of chronic disease hematopoietic Both 0.984 0.999 0.926,1.08 697 6980 0.2535 1.06 0.956,1.18 375 4136
285.22 Anemia in neoplastic disease hematopoietic Both 0.6699 1.02 0.924,1.13 414 4147 0.2535 1.06 0.956,1.18 375 4136
286 Coagulation defects hematopoietic Both 0.04266 1.07 1.0,1.15 921 9218 0.03467 1.12 1.01,1.24 383 3852
286.1 Congenital coagulation defects hematopoietic Both 0.1901 1.07 0.969,1.17 459 4594 0.8472 1.02 0.801,1.31 62 628
286.11 Von willebrand's disease hematopoietic Both 0.4477 1.08 0.879,1.34 96 959 0.4634 1.08 0.876,1.34 94 953
286.12 Congenital deficiency of other clotting factors (including factor VII) hematopoietic Both 0.3258 1.06 0.943,1.19 294 2944 0.354 1.06 0.939,1.19 293 2931
286.13 Congenital factor VIII disorder hematopoietic Both 0.8831 1.02 0.798,1.3 63 630 0.8472 1.02 0.801,1.31 62 628
286.5 Hemorrhagic disorder due to intrinsic circulating anticoagulants hematopoietic Both 0.8337 1.02 0.823,1.27 86 860 0.8337 1.02 0.823,1.27 86 860
286.7 Other and unspecified coagulation defects hematopoietic Both 0.0309 1.12 1.01,1.24 386 3867 0.03467 1.12 1.01,1.24 383 3852
287 Purpura and other hemorrhagic conditions hematopoietic Both 0.9817 0.999 0.95,1.05 1652 16532 0.9886 1.0 0.783,1.28 72 748
287.1 Spontaneous ecchymoses hematopoietic Both 0.2104 0.894 0.75,1.07 129 1290 0.2113 0.894 0.75,1.07 129 1285
287.2 Allergic purpura hematopoietic Both 0.8017 1.03 0.797,1.34 51 510 ,
287.3 Thrombocytopenia hematopoietic Both 0.7112 0.99 0.94,1.04 1553 15543 0.9886 1.0 0.783,1.28 72 748
287.31 Primary thrombocytopenia hematopoietic Both 0.7889 1.01 0.918,1.12 419 4195 0.7311 1.02 0.922,1.12 417 4180
287.32 Secondary thrombocytopenia hematopoietic Both 0.9977 1.0 0.784,1.28 75 749 0.9886 1.0 0.783,1.28 72 748
288 Diseases of white blood cells hematopoietic Both 0.2535 1.02 0.986,1.05 3765 37672 0.7145 0.955 0.746,1.22 70 705
288.1 Decreased white blood cell count hematopoietic Both 0.1545 1.03 0.99,1.07 3168 31704 0.1828 1.03 0.988,1.06 3066 31677
288.11 Neutropenia hematopoietic Both 0.1396 1.03 0.991,1.07 3176 31784 0.1828 1.03 0.988,1.06 3066 31677
288.3 Eosinophilia hematopoietic Both 0.6324 0.942 0.736,1.2 71 709 0.7145 0.955 0.746,1.22 70 705
289 Other diseases of blood and blood-forming organs hematopoietic Both 0.6442 0.984 0.918,1.05 862 8625 0.3524 0.904 0.73,1.12 87 898
289.3 Personal history of diseases of blood and blood-forming organs hematopoietic Both 0.6295 1.03 0.914,1.16 290 2897 0.618 1.03 0.915,1.16 289 2887
289.4 Lymphadenitis hematopoietic Both 0.6745 1.01 0.969,1.05 2602 26061 0.7362 1.01 0.967,1.05 2564 25985
289.5 Diseases of spleen hematopoietic Both 0.01445 1.12 1.02,1.23 516 5153 0.01778 1.12 1.02,1.23 507 5142
289.8 Polycythemia, secondary hematopoietic Both 0.4036 0.95 0.841,1.07 292 2917 0.4064 0.95 0.842,1.07 292 2914
289.9 Abnormality of red blood cells hematopoietic Both 0.455 0.923 0.748,1.14 90 900 0.3524 0.904 0.73,1.12 87 898
290 Delirium dementia and amnestic and other cognitive disorders mental disorders Both 0.1059 0.962 0.918,1.01 1929 19281 0.6266 0.942 0.74,1.2 70 708
290.1 Dementias mental disorders Both 0.1995 0.959 0.899,1.02 1004 10032 0.7278 0.974 0.841,1.13 200 2005
290.11 Alzheimer's disease mental disorders Both 0.0302 0.898 0.815,0.99 431 4307 0.02692 0.896 0.812,0.987 428 4291
290.16 Vascular dementia mental disorders Both 0.6998 0.972 0.839,1.12 201 2008 0.7278 0.974 0.841,1.13 200 2005
290.2 Delirium due to conditions classified elsewhere mental disorders Both 0.5236 0.974 0.898,1.06 650 6501 0.5521 0.976 0.899,1.06 646 6482
290.3 Other persistent mental disorders due to conditions classified elsewhere mental disorders Both 0.6166 0.94 0.739,1.2 70 709 0.6266 0.942 0.74,1.2 70 708
291 Other specified nonpsychotic and/or transient mental disorders mental disorders Both 0.2123 1.05 0.974,1.12 836 8385 0.8954 1.01 0.912,1.11 433 4367
291.1 Transient mental disorders due to conditions classified elsewhere mental disorders Both 0.1968 1.13 0.94,1.35 132 1320 0.2472 1.11 0.927,1.34 130 1313
291.4 Specific nonpsychotic mental disorders due to brain damage mental disorders Both 0.1236 1.1 0.975,1.24 286 2867 0.1233 1.1 0.975,1.24 286 2861
291.8 Alteration of consciousness mental disorders Both 0.8356 1.01 0.916,1.11 436 4376 0.8954 1.01 0.912,1.11 433 4367
292 Neurological disorders mental disorders Both 0.7852 1.0 0.974,1.03 4621 46260 0.6281 1.03 0.916,1.16 302 3063
292.1 Aphasia/speech disturbance mental disorders Both 0.9462 0.998 0.946,1.05 1504 15074 0.9661 0.999 0.947,1.05 1497 15042
292.2 Mild cognitive impairment mental disorders Both 0.01259 1.21 1.04,1.41 190 1907 0.01259 1.21 1.04,1.41 190 1900
292.3 Memory loss mental disorders Both 0.2366 1.05 0.97,1.13 696 6978 0.2323 1.05 0.97,1.13 693 6966
292.4 Altered mental status mental disorders Both 0.798 0.994 0.952,1.04 2181 21827 0.8511 0.996 0.953,1.04 2159 21761
292.6 Hallucinations mental disorders Both 0.4074 1.05 0.936,1.18 307 3073 0.6281 1.03 0.916,1.16 302 3063
293 Symptoms involving head and neck mental disorders Both 0.2588 0.974 0.931,1.02 2078 20779 0.04677 1.07 1.0,1.15 898 8972
293.1 Swelling, mass, or lump in head and neck [Space-occupying lesion, intracranial NOS] mental disorders Both 0.04074 1.07 1.0,1.15 901 9010 0.04677 1.07 1.0,1.15 898 8972
295 Schizophrenia and other psychotic disorders mental disorders Both 0.7998 0.991 0.924,1.06 841 8446 0.5058 1.06 0.901,1.24 168 1705
295.1 Schizophrenia mental disorders Both 0.6194 0.979 0.898,1.07 574 5766 0.5754 0.976 0.896,1.06 572 5760
295.2 Paranoid disorders mental disorders Both 0.6442 1.04 0.891,1.2 178 1780 0.7998 1.02 0.877,1.19 176 1774
295.3 Psychosis mental disorders Both 0.5297 1.05 0.898,1.23 169 1710 0.5058 1.06 0.901,1.24 168 1705
296 Mood disorders mental disorders Both 0.4634 1.01 0.989,1.03 12372 123822 0.00912 0.867 0.779,0.965 359 3591
296.1 Bipolar mental disorders Both 0.8017 0.992 0.932,1.06 1059 10599 0.7709 0.991 0.931,1.05 1053 10564
296.2 Depression mental disorders Both 0.4416 1.01 0.989,1.03 11737 117469 0.00912 0.867 0.779,0.965 359 3591
296.22 Major depressive disorder mental disorders Both 0.01202 0.872 0.783,0.97 361 3604 0.00912 0.867 0.779,0.965 359 3591
297.2 Suicide or self-inflicted injury mental disorders Both 0.6839 1.02 0.912,1.15 311 3070 0.6839 1.02 0.912,1.15 311 3066
300 Anxiety disorders mental disorders Both 0.4236 1.01 0.985,1.04 6844 68484 0.5834 0.948 0.782,1.15 113 1126
300.1 Anxiety disorder mental disorders Both 0.3184 1.01 0.987,1.04 6324 63282 0.8017 1.01 0.923,1.11 498 4988
300.11 Generalized anxiety disorder mental disorders Both 0.03311 0.832 0.703,0.986 149 1499 0.03311 0.832 0.703,0.985 149 1495
300.12 Agorophobia, social phobia, and panic disorder mental disorders Both 0.08318 1.07 0.991,1.16 707 7065 0.08318 1.07 0.991,1.16 701 7053
300.13 Phobia mental disorders Both 0.7762 1.01 0.925,1.11 501 5013 0.8017 1.01 0.923,1.11 498 4988
300.3 Obsessive-compulsive disorders mental disorders Both 0.9099 1.01 0.854,1.19 140 1407 0.7586 1.03 0.867,1.22 138 1403
300.4 Dysthymic disorder mental disorders Both 0.695 1.06 0.798,1.4 53 530 0.7145 1.05 0.796,1.4 53 527
300.8 Acute reaction to stress mental disorders Both 0.5754 0.951 0.798,1.13 124 1238 0.6012 0.954 0.8,1.14 123 1232
300.9 Posttraumatic stress disorder mental disorders Both 0.5559 0.944 0.779,1.14 113 1129 0.5834 0.948 0.782,1.15 113 1126
301 Personality disorders mental disorders Both 0.7709 0.984 0.882,1.1 334 3338 0.7447 0.97 0.805,1.17 118 1183
301.2 Antisocial/borderline personality disorder mental disorders Both 0.859 0.983 0.817,1.18 119 1186 0.7447 0.97 0.805,1.17 118 1183
302 Sexual and gender identity disorders mental disorders Both 0.4335 0.952 0.843,1.08 283 2845 0.4335 0.952 0.843,1.08 283 2845
303 Psychogenic and somatoform disorders mental disorders Both 0.6457 1.02 0.929,1.13 467 4679 0.6295 1.05 0.869,1.26 122 1221
303.3 Psychogenic disorder mental disorders Both 0.9419 1.0 0.898,1.12 350 3510 0.881 1.01 0.902,1.13 347 3502
303.4 Somatoform disorder mental disorders Both 0.673 1.04 0.864,1.25 123 1229 0.6295 1.05 0.869,1.26 122 1221
304 Adjustment reaction mental disorders Both 0.2244 1.08 0.956,1.21 293 2936 0.2317 1.07 0.955,1.21 293 2928
305.2 Eating disorder mental disorders Both 0.2377 0.882 0.716,1.09 90 900 0.2559 0.886 0.719,1.09 90 895
306 Other mental disorder mental disorders Both 0.07943 1.01 0.999,1.02 28056 230087 0.4753 1.04 0.93,1.17 312 3142
306.9 Tension headache mental disorders Both 0.4325 1.05 0.934,1.17 315 3148 0.4753 1.04 0.93,1.17 312 3142
313 Pervasive developmental disorders mental disorders Both 0.4498 0.914 0.723,1.15 76 770 0.6823 1.06 0.798,1.41 52 538
313.3 Autism mental disorders Both 0.5458 1.09 0.824,1.44 53 539 0.6823 1.06 0.798,1.41 52 538
315 Develomental delays and disorders mental disorders Both 0.6252 1.03 0.922,1.15 351 3517 0.1282 1.18 0.952,1.47 87 877
315.1 Learning disorder mental disorders Both 0.9705 1.0 0.856,1.18 161 1610 0.8892 1.01 0.863,1.19 160 1608
315.2 Speech and language disorder mental disorders Both 0.1288 1.18 0.953,1.47 88 880 0.1282 1.18 0.952,1.47 87 877
316 Substance addiction and disorders mental disorders Both 0.4426 0.989 0.962,1.02 5313 53131 0.0302 0.744 0.57,0.972 55 597
316.1 Polyneuropathy due to drugs mental disorders Both 0.0389 0.762 0.589,0.986 60 599 0.0302 0.744 0.57,0.972 55 597
317 Alcohol-related disorders mental disorders Both 0.4436 0.993 0.975,1.01 12696 126892 0.2931 0.963 0.897,1.03 835 8379
317.1 Alcoholism mental disorders Both 0.863 0.998 0.977,1.02 8890 88923 0.2931 0.963 0.897,1.03 835 8379
317.11 Alcoholic liver damage mental disorders Both 0.302 0.964 0.898,1.03 838 8392 0.2931 0.963 0.897,1.03 835 8379
318 Tobacco use disorder mental disorders Both 0.9036 1.0 0.986,1.02 19359 185465 0.9204 1.0 0.986,1.02 19253 185022
320 Meningitis neurological Both 0.456 1.04 0.942,1.14 444 4447 0.4498 1.04 0.943,1.14 444 4437
323 Encephalitis neurological Both 0.4634 1.04 0.934,1.16 342 3422 0.5129 1.08 0.856,1.37 73 738
323.2 Acute (transverse) myelitis neurological Both 0.4498 1.09 0.867,1.38 74 739 0.5129 1.08 0.856,1.37 73 738
324 Other CNS infection and poliomyelitis neurological Both 0.6699 0.974 0.864,1.1 292 2916 0.6683 0.974 0.864,1.1 292 2910
327 Sleep disorders neurological Both 0.6592 1.01 0.954,1.08 1164 11659 0.003802 1.3 1.09,1.55 134 1380
327.3 Sleep apnea neurological Both 0.6383 0.993 0.962,1.02 4428 44318 0.6166 0.992 0.962,1.02 4420 44237
327.4 Insomnia neurological Both 0.04365 1.18 1.0,1.39 163 1660 0.003802 1.3 1.09,1.55 134 1380
327.41 Organic or persistent insomnia neurological Both 0.004467 1.29 1.08,1.54 136 1390 0.003802 1.3 1.09,1.55 134 1380
331 Other cerebral degenerations neurological Both 0.6166 0.985 0.926,1.05 1142 11416 0.8166 0.988 0.895,1.09 428 4291
331.1 Hydrocephalus neurological Both 0.7762 0.987 0.9,1.08 502 5014 0.7603 0.986 0.899,1.08 497 4999
331.9 Cerebral degeneration, unspecified neurological Both 0.778 0.986 0.893,1.09 430 4298 0.8166 0.988 0.895,1.09 428 4291
332 Parkinson's disease neurological Both 0.03548 0.937 0.882,0.996 1126 11254 0.02455 0.933 0.878,0.991 1123 11220
333 Extrapyramidal disease and abnormal movement disorders neurological Both 0.1169 1.06 0.986,1.13 894 8954 0.4159 1.06 0.925,1.21 250 2516
333.1 Essential tremor neurological Both 0.278 1.08 0.94,1.24 216 2157 0.3105 1.07 0.936,1.23 215 2154
333.2 Myoclonus neurological Both 0.2786 0.889 0.719,1.1 96 958 0.2618 0.885 0.715,1.1 95 956
333.4 Torsion dystonia neurological Both 0.369 1.06 0.931,1.21 253 2528 0.4159 1.06 0.925,1.21 250 2516
334 Degenerative disease of the spinal cord neurological Both 0.6982 1.01 0.962,1.06 1812 18130 0.2786 1.07 0.944,1.22 245 2441
334.1 Spinocerebellar disease neurological Both 0.7907 1.03 0.848,1.24 117 1169 0.7998 1.03 0.846,1.24 115 1164
334.2 Anterior horn cell disease neurological Both 0.271 1.08 0.945,1.22 245 2446 0.2786 1.07 0.944,1.22 245 2441
335 Multiple sclerosis neurological Both 0.7396 0.991 0.937,1.05 1340 13385 0.7362 0.991 0.937,1.05 1334 13331
337 Disorders of the autonomic nervous system neurological Both 0.2917 0.935 0.826,1.06 266 2668 0.07079 0.799 0.626,1.02 72 718
337.1 Peripheral autonomic neuropathy neurological Both 0.07244 0.8 0.627,1.02 72 719 0.07079 0.799 0.626,1.02 72 718
338 Pain neurological Both 0.05129 1.08 1.0,1.16 768 7692 0.1963 1.07 0.964,1.19 379 3808
338.1 Acute pain neurological Both 0.1406 1.08 0.975,1.2 394 3937 0.1422 1.08 0.974,1.2 392 3924
338.2 Chronic pain neurological Both 0.2084 1.07 0.963,1.19 380 3817 0.1963 1.07 0.964,1.19 379 3808
339 Other headache syndromes neurological Both 0.3606 1.01 0.988,1.03 7819 78241 0.3828 1.01 0.987,1.03 7760 77957
340 Migraine neurological Both 0.2208 1.02 0.986,1.06 2860 28602 0.7816 0.98 0.851,1.13 212 2108
340.1 Migrain with aura neurological Both 0.7586 0.978 0.849,1.13 212 2117 0.7816 0.98 0.851,1.13 212 2108
341 Other demyelinating diseases of central nervous system neurological Both 0.4178 0.948 0.832,1.08 252 2535 0.4426 0.95 0.834,1.08 250 2525
342 Hemiplegia neurological Both 0.4966 1.02 0.966,1.07 1494 14947 0.547 1.02 0.964,1.07 1484 14915
343 Infantile cerebral palsy neurological Both 0.9268 0.992 0.842,1.17 145 1450 0.9204 0.992 0.842,1.17 145 1448
344 Other paralytic syndromes neurological Both 0.456 0.97 0.895,1.05 658 6593 0.4753 0.971 0.896,1.05 654 6574
345 Epilepsy, recurrent seizures, convulsions neurological Both 0.2259 1.02 0.989,1.05 5023 50270 0.4898 0.985 0.942,1.03 2219 22288
345.1 Epilepsy neurological Both 0.7278 0.987 0.92,1.06 866 8661 0.5768 0.965 0.85,1.1 276 2770
345.11 Generalized convulsive epilepsy neurological Both 0.5728 0.972 0.881,1.07 439 4385 0.5508 0.97 0.879,1.07 437 4369
345.12 Partial epilepsy neurological Both 0.5728 0.964 0.849,1.09 277 2776 0.5768 0.965 0.85,1.1 276 2770
345.3 Convulsions neurological Both 0.5023 0.985 0.943,1.03 2235 22339 0.4898 0.985 0.942,1.03 2219 22288
346.1 Nonspecific abnormal findings on radiological and other examination of skull and head neurological Both 0.3784 1.08 0.913,1.27 144 1438 0.514 1.06 0.894,1.25 139 1430
348 Other conditions of brain neurological Both 0.9772 1.0 0.93,1.08 778 7808 0.0309 1.13 1.01,1.25 386 3887
348.2 Cerebral edema and compression of brain neurological Both 0.3236 0.94 0.83,1.06 268 2678 0.2761 0.933 0.824,1.06 265 2669
348.4 Cerebral cysts neurological Both 0.2547 1.11 0.929,1.32 133 1350 0.2399 1.11 0.932,1.33 132 1346
348.7 Coma neurological Both 0.871 1.01 0.906,1.12 358 3596 0.8433 1.01 0.907,1.13 356 3586
348.8 Encephalopathy, not elsewhere classified neurological Both 0.6776 1.03 0.904,1.17 249 2504 0.787 1.02 0.895,1.16 247 2499
348.9 Other conditions of brain, NOS neurological Both 0.04074 1.12 1.0,1.24 390 3899 0.0309 1.13 1.01,1.25 386 3887
349 Other and unspecified disorders of the nervous system neurological Both 0.1914 0.928 0.83,1.04 342 3414 0.1849 0.927 0.829,1.04 337 3403
350 Abnormal movement neurological Both 0.3357 0.981 0.942,1.02 2671 26722 0.7194 1.05 0.793,1.4 53 539
350.1 Abnormal involuntary movements neurological Both 0.004169 0.902 0.841,0.968 887 8852 0.003311 0.9 0.839,0.966 881 8823
350.2 Abnormality of gait neurological Both 0.9057 0.997 0.947,1.05 1596 15969 0.7621 0.992 0.942,1.04 1577 15919
350.3 Lack of coordination neurological Both 0.9247 1.01 0.9,1.12 363 3638 0.9036 1.01 0.902,1.12 362 3630
350.6 Disturbances of sensation of smell and taste neurological Both 0.6966 1.06 0.797,1.4 54 540 0.7194 1.05 0.793,1.4 53 539
351 Other peripheral nerve disorders neurological Both 0.2421 1.01 0.993,1.03 12420 124321 0.2143 1.01 0.993,1.03 12366 123773
352 Disorders of other cranial nerves neurological Both 0.4009 1.02 0.969,1.08 1370 13706 0.9795 0.999 0.931,1.07 873 8761
352.1 Trigeminal nerve disorders [CN5] neurological Both 0.04677 1.1 1.0,1.21 463 4638 0.05012 1.1 1.0,1.21 459 4622
352.2 Facial nerve disorders [CN7] neurological Both 0.8995 1.0 0.937,1.08 880 8795 0.9795 0.999 0.931,1.07 873 8761
353 Nerve root and plexus disorders neurological Both 0.3873 0.973 0.916,1.03 1131 11319 0.9441 1.01 0.767,1.33 56 566
353.1 Nerve plexus lesions neurological Both 0.309 0.904 0.745,1.1 114 1138 0.3192 0.906 0.746,1.1 113 1138
353.2 Nerve root lesions neurological Both 0.9795 1.0 0.763,1.32 57 570 0.9441 1.01 0.767,1.33 56 566
356 Hereditary and idiopathic peripheral neuropathy neurological Both 0.5495 1.05 0.89,1.25 152 1520 0.5754 1.05 0.886,1.24 151 1517
357 Inflammatory and toxic neuropathy neurological Both 0.1901 1.04 0.982,1.1 1361 13648 0.1972 1.04 0.981,1.1 1350 13615
358 Myoneural disorders neurological Both 0.542 0.957 0.833,1.1 211 2109 0.9908 0.999 0.862,1.16 192 1911
358.1 Myasthenia gravis neurological Both 0.9954 1.0 0.862,1.16 192 1919 0.9908 0.999 0.862,1.16 192 1911
359 Muscular dystrophies and other myopathies neurological Both 0.4853 0.967 0.88,1.06 465 4646 0.7745 0.985 0.885,1.1 357 3588
359.1 Muscular dystrophies neurological Both 0.3673 0.918 0.761,1.11 122 1219 0.3076 0.907 0.752,1.09 121 1217
359.2 Myopathy neurological Both 0.8072 0.987 0.887,1.1 360 3597 0.7745 0.985 0.885,1.1 357 3588
360 Disorders of the globe sense organs Both 0.826 0.988 0.884,1.1 337 3367 0.9247 0.994 0.875,1.13 251 2499
360.2 Progressive myopia sense organs Both 0.9183 0.993 0.875,1.13 251 2508 0.9247 0.994 0.875,1.13 251 2499
361 Retinal detachments and defects sense organs Both 0.9772 0.999 0.964,1.04 3246 32453 0.3126 0.886 0.7,1.12 68 678
361.1 Retinal detachment with retinal defect sense organs Both 0.798 0.993 0.939,1.05 1389 13884 0.7816 0.992 0.938,1.05 1387 13847
361.2 Retinoschisis and retinal cysts sense organs Both 0.3243 0.889 0.703,1.12 68 680 0.3126 0.886 0.7,1.12 68 678
362 Other retinal disorders sense organs Both 0.227 0.98 0.948,1.01 3836 38370 0.5284 1.06 0.879,1.28 116 1153
362.2 Degeneration of macula and posterior pole of retina sense organs Both 0.4688 0.984 0.942,1.03 2182 21813 0.5768 0.987 0.945,1.03 2160 21672
362.29 Macular degeneration (senile) of retina NOS sense organs Both 0.4842 0.984 0.942,1.03 2179 21783 0.5768 0.987 0.945,1.03 2160 21672
362.3 Other nondiabetic retinopathy sense organs Both 0.456 0.941 0.801,1.1 161 1609 0.9616 1.0 0.821,1.23 99 986
362.31 Separation of retinal layers sense organs Both 0.9397 1.01 0.824,1.23 99 990 0.9616 1.0 0.821,1.23 99 986
362.4 Retinal vascular changes and abnomalities sense organs Both 0.6457 0.984 0.917,1.06 848 8477 0.6808 0.985 0.918,1.06 847 8452
362.6 Peripheral retinal degenerations sense organs Both 0.4276 1.06 0.913,1.24 182 1827 0.4295 1.06 0.913,1.24 182 1821
362.7 Hereditary retinal dystrophies sense organs Both 0.02399 1.29 1.03,1.62 82 812 0.03311 1.28 1.02,1.6 81 810
362.8 Retinal hemorrhage/ischemia sense organs Both 0.5408 1.06 0.878,1.28 116 1159 0.5284 1.06 0.879,1.28 116 1153
363 Chorioretinal inflammations, scars, and other disorders of choroid sense organs Both 0.3334 0.925 0.79,1.08 170 1699 0.1114 0.821 0.645,1.05 69 688
363.3 Chorioretinal scars sense organs Both 0.1132 0.822 0.645,1.05 69 690 0.1114 0.821 0.645,1.05 69 688
364 Corneal opacity and other disorders of cornea sense organs Both 0.1528 0.943 0.87,1.02 647 6485 0.4198 0.921 0.753,1.13 100 998
364.1 Corneal opacity sense organs Both 0.4887 1.08 0.869,1.34 90 910 0.4764 1.08 0.871,1.35 90 908
364.2 Corneal edema sense organs Both 0.2355 0.877 0.706,1.09 79 800 0.2371 0.877 0.706,1.09 79 798
364.4 Corneal degenerations sense organs Both 0.8279 1.02 0.88,1.17 201 2017 0.04898 0.805 0.649,0.999 86 868
364.41 Keratoconus sense organs Both 0.04786 0.804 0.648,0.998 86 869 0.04898 0.805 0.649,0.999 86 868
364.5 Corneal dystrophy sense organs Both 0.1343 0.897 0.779,1.03 211 2109 0.1452 0.9 0.781,1.04 210 2101
364.9 Cornea replaced by transplant sense organs Both 0.4074 0.919 0.752,1.12 100 1000 0.4198 0.921 0.753,1.13 100 998
365 Glaucoma sense organs Both 0.4634 1.01 0.981,1.04 4408 44136 0.6383 1.02 0.943,1.1 696 6965
365.1 Open-angle glaucoma sense organs Both 0.5585 1.02 0.956,1.09 1032 10346 0.6546 1.01 0.951,1.08 1016 10252
365.11 Primary open angle glaucoma sense organs Both 0.6546 1.01 0.952,1.08 1026 10287 0.6546 1.01 0.951,1.08 1016 10252
365.2 Primary angle-closure glaucoma sense organs Both 0.7345 1.01 0.938,1.09 698 6996 0.6383 1.02 0.943,1.1 696 6965
366 Cataract sense organs Both 0.2661 0.992 0.977,1.01 19926 168711 0.3828 0.914 0.746,1.12 102 1017
366.1 Nonsenile Cataract sense organs Both 0.6792 0.948 0.736,1.22 69 700 0.6471 0.943 0.732,1.21 69 697
366.2 Senile cataract sense organs Both 0.1199 0.982 0.96,1.0 8231 81909 0.1143 0.982 0.96,1.0 8192 81550
366.3 Traumatic cataract sense organs Both 0.3776 0.913 0.745,1.12 102 1019 0.3828 0.914 0.746,1.12 102 1017
367 Disorders of refraction and accommodation; blindness and low vision sense organs Both 0.04266 0.957 0.918,0.999 2408 24092 0.3342 0.963 0.893,1.04 716 7180
367.1 Myopia sense organs Both 0.1622 0.959 0.904,1.02 1251 12519 0.2 0.962 0.907,1.02 1244 12459
367.2 Astigmatism sense organs Both 0.02951 0.849 0.733,0.984 190 1899 0.02754 0.847 0.731,0.982 190 1889
367.8 Hypermetropia sense organs Both 0.5495 0.962 0.847,1.09 253 2530 0.6053 0.967 0.851,1.1 252 2521
367.9 Blindness and low vision sense organs Both 0.335 0.963 0.893,1.04 719 7198 0.3342 0.963 0.893,1.04 716 7180
368 Visual disturbances sense organs Both 0.9183 0.998 0.961,1.04 2962 29648 0.6592 0.982 0.903,1.07 608 6090
368.1 Amblyopia sense organs Both 0.3148 0.955 0.873,1.04 532 5322 0.271 0.951 0.869,1.04 531 5296
368.2 Diplopia and disorders of binocular vision sense organs Both 0.9908 1.0 0.927,1.08 727 7288 0.8831 0.994 0.922,1.07 723 7268
368.3 Anisometropia sense organs Both 0.4188 0.934 0.792,1.1 154 1548 0.4169 0.934 0.792,1.1 154 1546
368.4 Visual field defects sense organs Both 0.7211 0.98 0.875,1.1 333 3327 0.743 0.981 0.876,1.1 330 3311
368.9 Subjective visual disturbances sense organs Both 0.6776 0.983 0.904,1.07 612 6115 0.6592 0.982 0.903,1.07 608 6090
369 Infection of the eye sense organs Both 0.8933 1.01 0.921,1.1 553 5544 0.9683 1.0 0.869,1.16 211 2121
369.2 Eye infection, viral sense organs Both 0.4656 1.07 0.895,1.28 125 1257 0.4786 1.07 0.893,1.27 124 1249
369.5 Conjunctivitis, infectious sense organs Both 0.9863 0.999 0.866,1.15 213 2128 0.9683 1.0 0.869,1.16 211 2121
370 Keratitis sense organs Both 0.5117 1.04 0.921,1.18 286 2855 0.9354 0.993 0.832,1.18 140 1403
370.1 Corneal ulcer sense organs Both 0.9594 0.995 0.835,1.19 141 1408 0.9354 0.993 0.832,1.18 140 1403
371 Inflammation of the eye sense organs Both 0.5768 1.01 0.974,1.05 3045 30480 0.354 1.02 0.978,1.06 2346 23464
371.1 Uveitis, noninfectious or NOS sense organs Both 0.9099 1.01 0.916,1.1 482 4821 0.9204 1.0 0.915,1.1 480 4808
371.3 Inflammation of eyelids sense organs Both 0.3296 1.02 0.979,1.07 2353 23555 0.354 1.02 0.978,1.06 2346 23464
372 Disorders of conjunctiva sense organs Both 0.2512 0.957 0.889,1.03 760 7602 0.2355 0.956 0.887,1.03 758 7572
374 Other disorders of eyelids sense organs Both 0.8531 0.997 0.971,1.03 5680 56807 0.2642 0.973 0.927,1.02 1818 18152
374.1 Ectropion or entropion sense organs Both 0.4677 1.02 0.961,1.09 1063 10645 0.5521 1.02 0.957,1.09 1057 10609
374.3 Ptosis of eyelid sense organs Both 0.2547 0.973 0.927,1.02 1825 18232 0.2642 0.973 0.927,1.02 1818 18152
375 Disorders of lacrimal system sense organs Both 0.52 0.986 0.944,1.03 2204 22031 0.4467 1.03 0.959,1.1 894 8928
375.2 Epiphora sense organs Both 0.4236 1.03 0.96,1.1 898 8969 0.4467 1.03 0.959,1.1 894 8928
376 Disorders of the orbit sense organs Both 0.863 0.981 0.788,1.22 86 859 0.873 0.982 0.79,1.22 86 856
377 Disorders of optic nerve and visual pathways sense organs Both 0.873 1.01 0.904,1.13 361 3618 0.389 1.08 0.903,1.3 123 1244
377.1 Optic atrophy sense organs Both 0.9268 0.988 0.756,1.29 56 570 0.9441 0.99 0.758,1.29 56 566
377.3 Optic neuritis/neuropathy sense organs Both 0.3491 1.09 0.91,1.31 125 1249 0.389 1.08 0.903,1.3 123 1244
378 Strabismus and other disorders of binocular eye movements sense organs Both 0.9594 0.999 0.946,1.05 1410 14116 0.5781 0.965 0.852,1.09 274 2749
378.1 Strabismus (not specified as paralytic) sense organs Both 0.5358 1.02 0.955,1.09 909 9082 0.5058 1.02 0.956,1.1 907 9060
378.2 Nystagmus and other irregular eye movements sense organs Both 0.3273 0.933 0.813,1.07 213 2138 0.3289 0.933 0.813,1.07 213 2137
378.5 Paralytic strabismus sense organs Both 0.5284 0.961 0.848,1.09 275 2755 0.5781 0.965 0.852,1.09 274 2749
379 Other disorders of eye sense organs Both 0.1734 0.977 0.944,1.01 3703 37063 0.6486 0.964 0.822,1.13 167 1688
379.2 Disorders of vitreous body sense organs Both 0.1303 0.957 0.905,1.01 1367 13665 0.1549 0.96 0.907,1.02 1363 13609
379.3 Aphakia and other disorders of lens sense organs Both 0.4732 0.983 0.937,1.03 1813 18134 0.4355 0.981 0.935,1.03 1808 18059
379.4 Anomalies of pupillary function sense organs Both 0.08318 0.8 0.622,1.03 71 710 0.08511 0.801 0.622,1.03 71 709
379.5 Disorders of iris and ciliary body sense organs Both 0.857 0.991 0.894,1.1 400 4028 0.9099 0.994 0.897,1.1 399 4022
379.9 Pain, swelling or discharge of eye sense organs Both 0.6324 0.962 0.821,1.13 169 1690 0.6486 0.964 0.822,1.13 167 1688
380 Disorders of external ear sense organs Both 0.5058 1.03 0.948,1.11 642 6413 0.8414 1.01 0.907,1.13 360 3599
380.1 Otitis externa sense organs Both 0.2 0.942 0.86,1.03 509 5107 0.1936 0.941 0.859,1.03 507 5088
380.4 Impacted cerumen sense organs Both 0.7396 1.02 0.914,1.13 362 3614 0.8414 1.01 0.907,1.13 360 3599
381 Otitis media and Eustachian tube disorders sense organs Both 0.5408 1.01 0.97,1.06 2150 21493 0.0302 0.87 0.767,0.987 279 2797
381.1 Otitis media sense organs Both 0.6339 1.01 0.964,1.06 1767 17668 0.1435 1.05 0.982,1.13 849 8499
381.11 Suppurative and unspecified otitis media sense organs Both 0.1422 1.05 0.982,1.13 852 8524 0.1435 1.05 0.982,1.13 849 8499
381.2 Eustachian tube disorders sense organs Both 0.2553 1.09 0.941,1.25 193 1929 0.2773 1.08 0.938,1.25 190 1923
381.3 Mastoiditis & related conditions sense organs Both 0.3589 1.08 0.92,1.26 171 1709 0.3681 1.07 0.919,1.26 171 1705
381.9 Otorrhea sense organs Both 0.02692 0.868 0.766,0.984 281 2807 0.0302 0.87 0.767,0.987 279 2797
382 Otalgia sense organs Both 0.04074 1.13 1.01,1.27 308 3084 0.05012 1.12 1.0,1.27 305 3071
383 Otosclerosis sense organs Both 0.7482 1.02 0.909,1.14 309 3090 0.695 1.02 0.913,1.15 308 3078
384 Other disorders of tympanic membrane sense organs Both 0.5943 1.02 0.959,1.08 1299 12991 0.7464 1.01 0.948,1.08 1040 10394
384.4 Perforation of tympanic membrane sense organs Both 0.6839 1.01 0.951,1.08 1043 10432 0.7464 1.01 0.948,1.08 1040 10394
385 Other disorders of middle ear and mastoid sense organs Both 0.03548 1.08 1.01,1.16 783 7837 0.2371 1.08 0.948,1.24 241 2395
385.3 Cholesteatoma sense organs Both 0.1242 1.07 0.982,1.16 607 6078 0.1256 1.07 0.982,1.16 603 6061
385.5 Tympanosclerosis and middle ear disease related to otitis media sense organs Both 0.2339 1.09 0.948,1.24 241 2409 0.2371 1.08 0.948,1.24 241 2395
386 Vertiginous syndromes and other disorders of vestibular system sense organs Both 0.2582 0.972 0.925,1.02 1736 17373 0.4645 1.01 0.981,1.04 4556 45668
386.1 Meniere's disease sense organs Both 0.984 1.0 0.919,1.09 576 5768 0.9727 0.999 0.917,1.09 572 5741
386.2 Peripheral or central vertigo sense organs Both 0.4875 0.963 0.865,1.07 377 3763 0.4508 0.96 0.862,1.07 374 3753
386.3 Labyrinthitis sense organs Both 0.1429 0.947 0.88,1.02 765 7664 0.1227 0.944 0.877,1.02 760 7635
386.9 Dizziness and giddiness (Light-headedness and vertigo) sense organs Both 0.4467 1.01 0.982,1.04 4582 45806 0.4645 1.01 0.981,1.04 4556 45668
388 Other disorders of ear sense organs Both 0.879 1.01 0.88,1.16 202 2017 0.873 1.01 0.88,1.16 201 2008
389 Hearing loss sense organs Both 0.8954 1.0 0.971,1.03 4188 41944 0.5728 0.974 0.889,1.07 505 5126
389.1 Sensorineural hearing loss sense organs Both 0.4064 0.961 0.876,1.06 456 4553 0.3428 0.956 0.87,1.05 452 4542
389.2 Conductive hearing loss sense organs Both 0.07762 0.915 0.829,1.01 450 4497 0.08511 0.917 0.83,1.01 445 4480
389.4 Tinnitus sense organs Both 0.6745 0.981 0.896,1.07 513 5134 0.5728 0.974 0.889,1.07 505 5126
394 Rheumatic disease of the heart valves circulatory system Both 0.1622 1.02 0.992,1.05 4899 48974 0.1303 1.05 0.986,1.12 1053 10537
394.2 Mitral valve disease circulatory system Both 0.3981 1.02 0.979,1.06 2993 29922 0.4198 1.02 0.978,1.05 2980 29842
394.3 Aortic valve disease circulatory system Both 0.9616 1.0 0.946,1.06 1282 12814 0.9268 1.0 0.947,1.06 1279 12774
394.7 Disease of tricuspid valve circulatory system Both 0.1009 1.05 0.99,1.12 1058 10566 0.1303 1.05 0.986,1.12 1053 10537
395 Heart valve disorders circulatory system Both 0.5929 1.01 0.977,1.04 4223 42219 0.4571 0.98 0.929,1.03 1491 14912
395.1 Nonrheumatic mitral valve disorders circulatory system Both 0.3311 1.02 0.981,1.06 2891 28900 0.354 1.02 0.98,1.06 2878 28826
395.2 Nonrheumatic aortic valve disorders circulatory system Both 0.6792 1.03 0.908,1.16 276 2766 0.6808 1.03 0.907,1.16 276 2757
395.3 Nonrheumatic tricuspid valve disorders circulatory system Both 0.182 1.14 0.942,1.37 105 1039 0.1778 1.14 0.943,1.37 105 1036
395.4 Nonrheumatic pulmonary valve disorders circulatory system Both 0.335 0.904 0.736,1.11 97 970 0.3467 0.905 0.736,1.11 96 967
395.6 Heart valve replaced circulatory system Both 0.4121 0.978 0.928,1.03 1495 14942 0.4571 0.98 0.929,1.03 1491 14912
396 Abnormal heart sounds circulatory system Both 0.2838 1.04 0.971,1.1 1048 10468 0.3499 1.03 0.967,1.1 1038 10412
401 Hypertension circulatory system Both 0.06918 1.01 0.999,1.02 73956 266957 0.4786 0.941 0.794,1.11 142 1434
401.1 Essential hypertension circulatory system Both 0.06761 1.01 0.999,1.02 73731 266739 0.06607 1.01 0.999,1.02 73348 265945
401.2 Hypertensive heart and/or renal disease circulatory system Both 0.6622 1.01 0.964,1.06 1898 19031 0.4887 1.02 0.967,1.07 1527 15432
401.21 Hypertensive heart disease circulatory system Both 0.811 0.987 0.888,1.1 370 3699 0.8222 0.988 0.888,1.1 370 3690
401.22 Hypertensive chronic kidney disease circulatory system Both 0.5572 1.02 0.964,1.07 1543 15483 0.4887 1.02 0.967,1.07 1527 15432
401.3 Other hypertensive complications circulatory system Both 0.4385 0.936 0.791,1.11 144 1438 0.4786 0.941 0.794,1.11 142 1434
402 Elevated blood pressure reading without diagnosis of hypertension circulatory system Both 0.4345 1.02 0.968,1.08 1479 14786 0.4477 1.02 0.968,1.08 1472 14747
411 Ischemic Heart Disease circulatory system Both 0.2931 1.01 0.994,1.02 31245 210714 0.7413 0.99 0.934,1.05 1213 12149
411.1 Unstable angina (intermediate coronary syndrome) circulatory system Both 0.798 1.0 0.975,1.03 5152 51498 0.8128 1.0 0.975,1.03 5139 51385
411.2 Myocardial infarction circulatory system Both 0.9528 1.0 0.982,1.02 11950 112699 0.9661 1.0 0.982,1.02 11921 112495
411.3 Angina pectoris circulatory system Both 0.2307 1.01 0.994,1.03 15888 143745 0.2163 1.01 0.994,1.03 15835 143328
411.4 Coronary atherosclerosis circulatory system Both 0.929 0.999 0.985,1.01 20171 154621 0.8395 1.01 0.932,1.09 697 6981
411.41 Aneurysm and dissection of heart circulatory system Both 0.8531 1.01 0.932,1.09 700 6997 0.8395 1.01 0.932,1.09 697 6981
411.8 Other chronic ischemic heart disease, unspecified circulatory system Both 0.5212 1.01 0.989,1.02 15290 131798 0.4887 1.01 0.989,1.02 15236 131466
411.9 Other acute and subacute forms of ischemic heart disease circulatory system Both 0.7762 0.992 0.935,1.05 1218 12166 0.7413 0.99 0.934,1.05 1213 12149
414 Other forms of chronic heart disease circulatory system Both 0.9376 1.0 0.955,1.05 1823 18228 0.7925 1.03 0.811,1.31 72 718
414.2 ASCVD circulatory system Both 0.8054 1.03 0.81,1.31 72 719 0.7925 1.03 0.811,1.31 72 718
415 Pulmonary heart disease circulatory system Both 0.9333 0.999 0.968,1.03 4476 44810 0.1866 0.937 0.852,1.03 445 4458
415.11 Pulmonary embolism and infarction, acute circulatory system Both 0.6124 1.06 0.844,1.33 75 750 0.597 1.06 0.846,1.34 75 747
415.2 Chronic pulmonary heart disease circulatory system Both 0.369 0.963 0.887,1.05 601 6002 0.1866 0.937 0.852,1.03 445 4458
415.21 Primary pulmonary hypertension circulatory system Both 0.2028 0.94 0.854,1.03 448 4475 0.1866 0.937 0.852,1.03 445 4458
416 Cardiomegaly circulatory system Both 0.8072 1.0 0.966,1.05 2680 26793 0.7798 1.01 0.967,1.05 2675 26745
418 Nonspecific chest pain circulatory system Both 0.2399 0.993 0.981,1.0 28599 270106 0.4634 0.987 0.954,1.02 3535 35427
418.1 Precordial pain circulatory system Both 0.5129 0.989 0.955,1.02 3551 35541 0.4634 0.987 0.954,1.02 3535 35427
420 Carditis circulatory system Both 0.3342 1.02 0.977,1.07 2106 21053 0.9016 1.0 0.93,1.09 711 7181
420.1 Myocarditis circulatory system Both 0.871 1.02 0.843,1.22 127 1267 0.879 1.01 0.842,1.22 127 1265
420.2 Pericarditis circulatory system Both 0.2328 1.03 0.978,1.1 1338 13371 0.5781 1.05 0.874,1.27 113 1126
420.21 Acute pericarditis circulatory system Both 0.4989 1.05 0.914,1.2 223 2227 0.4592 1.05 0.918,1.21 222 2220
420.22 Chronic pericarditis circulatory system Both 0.6012 1.05 0.871,1.27 113 1129 0.5781 1.05 0.874,1.27 113 1126
420.3 Endocarditis circulatory system Both 0.9572 0.998 0.924,1.08 719 7194 0.9016 1.0 0.93,1.09 711 7181
425 Cardiomyopathy circulatory system Both 0.6699 0.988 0.933,1.05 1271 12699 0.6194 1.06 0.832,1.36 60 600
425.1 Primary/intrinsic cardiomyopathies circulatory system Both 0.7079 0.989 0.933,1.05 1236 12349 0.1722 0.894 0.761,1.05 163 1626
425.11 Hypertrophic obstructive cardiomyopathy circulatory system Both 0.3873 0.925 0.776,1.1 133 1329 0.4036 0.927 0.777,1.11 132 1328
425.12 Other hypertrophic cardiomyopathy circulatory system Both 0.1652 0.892 0.76,1.05 163 1629 0.1722 0.894 0.761,1.05 163 1626
425.8 Other cardiomyopathy circulatory system Both 0.6194 1.06 0.832,1.36 60 600 0.6194 1.06 0.832,1.36 60 600
426 Cardiac conduction disorders circulatory system Both 0.2884 1.01 0.989,1.04 6910 69146 0.3981 1.02 0.976,1.06 2268 22720
426.2 Atrioventricular [AV] block circulatory system Both 0.5728 1.01 0.969,1.06 2114 21162 0.173 0.882 0.736,1.06 131 1314
426.21 First degree AV block circulatory system Both 0.2911 1.04 0.97,1.11 986 9867 0.2931 1.04 0.97,1.11 986 9850
426.23 Second degree AV block circulatory system Both 0.9376 1.0 0.911,1.11 452 4515 0.9354 1.0 0.911,1.11 449 4502
426.24 Atrioventricular block, complete circulatory system Both 0.3524 1.04 0.957,1.13 587 5868 0.3589 1.04 0.957,1.13 585 5855
426.25 Other heart block circulatory system Both 0.1629 0.879 0.734,1.05 131 1318 0.173 0.882 0.736,1.06 131 1314
426.3 Bundle branch block circulatory system Both 0.9226 1.0 0.967,1.04 3336 33359 0.5433 0.985 0.937,1.03 1741 17458
426.31 Right bundle branch block circulatory system Both 0.4721 1.02 0.967,1.08 1494 14933 0.5248 1.02 0.964,1.07 1489 14898
426.32 Left bundle branch block circulatory system Both 0.5 0.983 0.936,1.03 1750 17503 0.5433 0.985 0.937,1.03 1741 17458
426.4 Anomalous atrioventricular excitation circulatory system Both 0.4385 0.95 0.833,1.08 233 2328 0.4355 0.949 0.833,1.08 233 2322
426.8 Other cardiac conduction disorders circulatory system Both 0.5129 0.914 0.698,1.2 60 600 0.5333 0.918 0.7,1.2 60 599
426.9 Cardiac pacemaker/device in situ circulatory system Both 0.2056 1.03 0.986,1.07 2475 24774 0.3981 1.02 0.976,1.06 2268 22720
426.91 Cardiac pacemaker in situ circulatory system Both 0.4285 1.02 0.975,1.06 2274 22762 0.3981 1.02 0.976,1.06 2268 22720
427 Cardiac dysrhythmias circulatory system Both 0.8072 1.0 0.988,1.02 24207 206016 0.9528 1.0 0.968,1.03 3793 37951
427.1 Paroxysmal tachycardia, unspecified circulatory system Both 0.6427 1.01 0.973,1.05 3199 32017 0.2742 0.964 0.902,1.03 933 9351
427.11 Paroxysmal supraventricular tachycardia circulatory system Both 0.2234 1.03 0.984,1.07 2344 23474 0.2606 1.02 0.982,1.07 2333 23407
427.12 Paroxysmal ventricular tachycardia circulatory system Both 0.2818 0.964 0.903,1.03 936 9365 0.2742 0.964 0.902,1.03 933 9351
427.2 Atrial fibrillation and flutter circulatory system Both 0.3112 0.991 0.974,1.01 14628 133501 0.3451 0.992 0.975,1.01 14575 133147
427.3 Other specified cardiac dysrhythmias circulatory system Both 0.3724 0.984 0.949,1.02 3228 32281 0.3846 0.984 0.949,1.02 3217 32208
427.4 Cardiac arrest and ventricular fibrillation circulatory system Both 0.8954 0.996 0.939,1.06 1193 11915 0.4775 1.02 0.96,1.09 986 9870
427.41 Ventricular fibrillation and flutter circulatory system Both 0.1435 0.921 0.824,1.03 344 3437 0.1419 0.92 0.824,1.03 344 3433
427.42 Cardiac arrest circulatory system Both 0.4775 1.02 0.96,1.09 990 9890 0.4775 1.02 0.96,1.09 986 9870
427.5 Arrhythmia (cardiac) NOS circulatory system Both 0.1574 1.05 0.982,1.12 952 9541 0.1726 1.05 0.98,1.12 949 9514
427.6 Premature beats circulatory system Both 0.02692 1.11 1.01,1.21 535 5358 0.867 0.984 0.818,1.18 116 1164
427.61 Supraventricular premature beats circulatory system Both 0.869 0.985 0.819,1.18 117 1168 0.867 0.984 0.818,1.18 116 1164
427.7 Tachycardia NOS circulatory system Both 0.1656 1.03 0.987,1.08 2185 21865 0.1963 1.03 0.985,1.08 2161 21793
427.8 Sinoatrial node dysfunction (Bradycardia) circulatory system Both 0.811 0.988 0.891,1.09 402 4029 0.9057 0.994 0.896,1.1 399 4011
427.9 Palpitations circulatory system Both 0.9528 1.0 0.968,1.03 3811 38105 0.9528 1.0 0.968,1.03 3793 37951
428 Congestive heart failure; nonhypertensive circulatory system Both 0.26 1.02 0.988,1.04 5605 56018 0.139 1.02 0.992,1.06 4441 44442
428.1 Congestive heart failure (CHF) NOS circulatory system Both 0.5875 1.01 0.968,1.06 2111 21108 0.5395 1.01 0.97,1.06 2108 21071
428.2 Heart failure NOS circulatory system Both 0.1239 1.02 0.993,1.06 4455 44524 0.139 1.02 0.992,1.06 4441 44442
429 Ill-defined descriptions and complications of heart disease circulatory system Both 0.4188 1.03 0.956,1.11 716 7168 0.06607 1.14 0.991,1.32 196 1973
429.1 Heart transplant/surgery circulatory system Both 0.2884 1.15 0.89,1.48 64 639 0.2884 1.15 0.89,1.48 64 639
429.2 Abnormal function study of cardiovascular system circulatory system Both 0.7551 0.986 0.901,1.08 522 5211 0.7396 0.985 0.9,1.08 521 5199
429.3 Symptoms involving cardiovascular system circulatory system Both 0.06457 1.14 0.992,1.32 196 1978 0.06607 1.14 0.991,1.32 196 1973
430 Intracranial hemorrhage circulatory system Both 0.7261 1.01 0.962,1.06 1883 18825 0.8147 1.02 0.895,1.15 266 2662
430.1 Subarachnoid hemorrhage circulatory system Both 0.2891 1.04 0.968,1.12 836 8353 0.3055 1.04 0.966,1.12 831 8322
430.2 Intracerebral hemorrhage circulatory system Both 0.7211 1.01 0.941,1.09 765 7656 0.6637 1.02 0.943,1.1 764 7635
430.3 Subdural hemorrhage circulatory system Both 0.7943 1.02 0.897,1.15 267 2667 0.8147 1.02 0.895,1.15 266 2662
433 Cerebrovascular disease circulatory system Both 0.4592 1.01 0.986,1.03 8749 87456 0.7031 0.989 0.934,1.05 1272 12747
433.1 Occlusion and stenosis of precerebral arteries circulatory system Both 0.8356 1.01 0.948,1.07 1185 11825 0.7129 0.975 0.851,1.12 226 2263
433.12 Cerebral atherosclerosis circulatory system Both 0.7621 0.979 0.855,1.12 227 2267 0.7129 0.975 0.851,1.12 226 2263
433.2 Occlusion of cerebral arteries circulatory system Both 0.7178 0.994 0.963,1.03 4233 42320 0.9268 1.0 0.953,1.05 1670 16747
433.21 Cerebral artery occlusion, with cerebral infarction circulatory system Both 0.9863 1.0 0.952,1.05 1680 16794 0.9268 1.0 0.953,1.05 1670 16747
433.3 Cerebral ischemia circulatory system Both 0.2483 0.978 0.941,1.02 2895 28989 0.7362 1.01 0.964,1.05 2128 21325
433.31 Transient cerebral ischemia circulatory system Both 0.7295 1.01 0.964,1.05 2135 21379 0.7362 1.01 0.964,1.05 2128 21325
433.5 Cerebral aneurysm circulatory system Both 0.7345 1.02 0.916,1.13 394 3939 0.6442 1.03 0.922,1.14 390 3922
433.8 Late effects of cerebrovascular disease circulatory system Both 0.7228 0.99 0.935,1.05 1279 12783 0.7031 0.989 0.934,1.05 1272 12747
440 Atherosclerosis circulatory system Both 0.1875 1.04 0.982,1.1 1380 13822 0.3508 0.944 0.836,1.07 285 2863
440.1 Atherosclerosis of renal artery circulatory system Both 0.3381 1.1 0.907,1.33 113 1129 0.3334 1.1 0.907,1.33 112 1126
440.2 Atherosclerosis of the extremities circulatory system Both 0.01778 1.09 1.02,1.18 805 8070 0.01585 1.09 1.02,1.18 802 8055
440.9 Atherosclerosis of aorta circulatory system Both 0.3819 0.947 0.839,1.07 287 2867 0.3508 0.944 0.836,1.07 285 2863
441 Vascular insufficiency of intestine circulatory system Both 0.7244 0.985 0.907,1.07 614 6154 0.4416 0.953 0.842,1.08 277 2815
441.1 Acute vascular insufficiency of intestine circulatory system Both 0.4581 0.955 0.845,1.08 283 2827 0.4416 0.953 0.842,1.08 277 2815
442 Other aneurysm circulatory system Both 0.2388 1.03 0.981,1.08 1892 18959 0.5445 1.05 0.905,1.21 200 2018
442.1 Aortic aneurysm circulatory system Both 0.3565 1.03 0.972,1.08 1458 14625 0.8241 0.992 0.928,1.06 930 9330
442.11 Abdominal aortic aneurysm circulatory system Both 0.8204 0.992 0.928,1.06 931 9341 0.8241 0.992 0.928,1.06 930 9330
442.2 Aneurysm of iliac artery circulatory system Both 0.7396 1.04 0.842,1.27 102 1019 0.7396 1.04 0.843,1.27 102 1018
442.3 Aneurysm of artery of lower extremity circulatory system Both 0.8995 0.99 0.847,1.16 169 1696 0.9057 0.991 0.847,1.16 168 1693
442.4 Arterial dissection circulatory system Both 0.7063 1.05 0.809,1.37 54 549 0.7063 1.05 0.809,1.37 54 549
442.8 Aneurysm of other specified artery circulatory system Both 0.6053 1.04 0.9,1.2 203 2028 0.5445 1.05 0.905,1.21 200 2018
443 Peripheral vascular disease circulatory system Both 0.3698 1.02 0.982,1.05 3921 39273 0.2153 1.03 0.985,1.07 2567 25792
443.1 Raynaud's syndrome circulatory system Both 0.8241 0.993 0.935,1.05 1145 11438 0.8892 0.996 0.937,1.06 1136 11392
443.7 Peripheral angiopathy in diseases classified elsewhere circulatory system Both 0.3828 1.05 0.944,1.16 384 3878 0.3581 1.05 0.946,1.17 382 3874
443.8 Other specified peripheral vascular diseases circulatory system Both 0.4027 1.01 0.981,1.05 3686 36906 0.3917 1.01 0.981,1.05 3665 36803
443.9 Peripheral vascular disease, unspecified circulatory system Both 0.2056 1.03 0.986,1.07 2579 25846 0.2153 1.03 0.985,1.07 2567 25792
444 Arterial embolism and thrombosis circulatory system Both 0.3126 1.04 0.968,1.11 922 9251 0.3491 1.04 0.956,1.14 551 5546
444.1 Arterial embolism and thrombosis of lower extremity artery circulatory system Both 0.3319 1.04 0.957,1.14 554 5552 0.3491 1.04 0.956,1.14 551 5546
446 Polyarteritis nodosa and allied conditions circulatory system Both 0.4989 1.02 0.954,1.1 822 8226 0.2023 0.916 0.801,1.05 235 2391
446.4 Wegener's granulomatosis circulatory system Both 0.471 0.946 0.814,1.1 188 1878 0.4487 0.943 0.812,1.1 188 1871
446.5 Giant cell arteritis circulatory system Both 0.1403 1.08 0.975,1.2 388 3879 0.1585 1.08 0.971,1.2 384 3862
446.9 Arteritis NOS circulatory system Both 0.3141 0.934 0.818,1.07 239 2400 0.2023 0.916 0.801,1.05 235 2391
447 Other disorders of arteries and arterioles circulatory system Both 0.2158 1.04 0.98,1.1 1327 13316 0.05623 1.07 0.998,1.15 865 8691
447.1 Stricture of artery circulatory system Both 0.05623 1.07 0.998,1.15 868 8712 0.05623 1.07 0.998,1.15 865 8691
448 Disease of capillaries circulatory system Both 0.6871 1.04 0.87,1.24 142 1420 0.6714 1.04 0.871,1.24 140 1412
450 Noninfectious disorders of lymphatic channels circulatory system Both 0.7709 1.01 0.936,1.09 704 7034 0.5321 1.03 0.947,1.11 674 7014
451 Phlebitis and thrombophlebitis circulatory system Both 0.1045 1.03 0.994,1.06 3955 39683 0.07244 1.03 0.997,1.07 3621 36881
451.2 Phlebitis and thrombophlebitis of lower extremities circulatory system Both 0.05129 1.03 1.0,1.07 3683 36977 0.07244 1.03 0.997,1.07 3621 36881
452 Other venous embolism and thrombosis circulatory system Both 0.05012 1.09 1.0,1.19 564 5645 0.04266 1.09 1.0,1.19 548 5630
454 Varicose veins circulatory system Both 0.4055 1.01 0.989,1.03 11180 112047 0.5546 0.976 0.899,1.06 621 6307
454.1 Varicose veins of lower extremity circulatory system Both 0.3855 1.01 0.989,1.03 11503 115272 0.5546 0.976 0.899,1.06 621 6307
454.11 Varicose veins of lower extremity, symptomtic circulatory system Both 0.5152 0.973 0.897,1.06 624 6325 0.5546 0.976 0.899,1.06 621 6307
455 Hemorrhoids circulatory system Both 0.06457 1.01 0.999,1.03 23452 234585 0.06166 1.01 0.999,1.03 23360 233857
456 Chronic venous insufficiency [CVI] circulatory system Both 0.5768 0.958 0.826,1.11 184 1868 0.5794 0.959 0.826,1.11 184 1865
457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin circulatory system Both 0.01349 0.769 0.624,0.947 97 967 0.009772 0.758 0.615,0.935 96 964
458 Hypotension circulatory system Both 0.342 0.987 0.961,1.01 5769 57772 0.3784 0.984 0.951,1.02 3453 34907
458.1 Orthostatic hypotension circulatory system Both 0.537 1.02 0.963,1.08 1335 13376 0.6427 1.01 0.958,1.07 1323 13333
458.2 Iatrogenic hypotension circulatory system Both 0.3034 0.93 0.81,1.07 235 2348 0.5395 0.957 0.832,1.1 229 2342
458.9 Hypotension NOS circulatory system Both 0.3622 0.984 0.951,1.02 3494 35005 0.3784 0.984 0.951,1.02 3453 34907
459 Other disorders of circulatory system circulatory system Both 0.1148 1.01 0.997,1.03 16268 160790 0.06166 1.02 0.999,1.03 15962 158936
459.1 Hemorrhage NOS circulatory system Both 0.01479 0.804 0.674,0.958 142 1420 0.01514 0.804 0.674,0.959 141 1414
459.9 Circulatory disease NEC circulatory system Both 0.06607 1.02 0.999,1.03 16103 159422 0.06166 1.02 0.999,1.03 15962 158936
464 Acute sinusitis respiratory Both 0.6252 0.966 0.842,1.11 196 1957 0.6109 0.965 0.841,1.11 196 1950
465 Acute upper respiratory infections of multiple or unspecified sites respiratory Both 0.1233 1.03 0.991,1.08 2283 22827 0.1828 1.11 0.951,1.31 165 1643
465.2 Acute pharyngitis respiratory Both 0.1271 1.06 0.984,1.14 835 8348 0.2075 1.05 0.975,1.13 821 8308
465.4 Acute laryngitis and tracheitis respiratory Both 0.1854 1.11 0.95,1.3 165 1649 0.1828 1.11 0.951,1.31 165 1643
470 Septal Deviations/Turbinate Hypertrophy respiratory Both 0.3597 0.986 0.957,1.02 4654 46553 0.3811 0.987 0.957,1.02 4642 46435
471 Nasal polyps respiratory Both 0.9016 0.998 0.962,1.03 3297 32973 0.9099 0.998 0.962,1.03 3292 32919
472 Chronic pharyngitis and nasopharyngitis respiratory Both 0.2301 1.04 0.975,1.11 960 9594 0.246 1.04 0.973,1.11 955 9565
473 Diseases of the larynx and vocal cords respiratory Both 0.7447 1.01 0.967,1.05 2554 25548 0.863 0.994 0.934,1.06 1076 10760
473.1 Chronic laryngitis respiratory Both 0.5559 1.06 0.87,1.3 104 1038 0.5521 1.06 0.871,1.3 104 1037
473.3 Paralysis/spasm of vocal cords or larynx respiratory Both 0.6252 0.969 0.855,1.1 264 2647 0.6714 0.973 0.858,1.1 263 2641
473.4 Voice disturbance respiratory Both 0.9099 0.996 0.936,1.06 1080 10789 0.863 0.994 0.934,1.06 1076 10760
474 Acute and chronic tonsillitis respiratory Both 0.8222 1.01 0.958,1.06 1772 17710 0.867 0.995 0.935,1.06 1113 11173
474.1 Acute tonsillitis respiratory Both 0.4667 1.03 0.947,1.13 549 5486 0.4645 1.03 0.947,1.13 547 5471
474.2 Chronic tonsillitis and adenoiditis respiratory Both 0.8128 0.993 0.934,1.06 1122 11199 0.867 0.995 0.935,1.06 1113 11173
475 Chronic sinusitis respiratory Both 0.4355 0.984 0.945,1.02 2589 25882 0.4457 0.984 0.945,1.02 2576 25800
476 Allergic rhinitis respiratory Both 0.2979 0.967 0.908,1.03 1055 10563 0.241 0.963 0.903,1.03 1044 10542
477 Epistaxis or throat hemorrhage respiratory Both 0.8974 1.0 0.962,1.05 2447 24452 0.8395 1.0 0.963,1.05 2432 24383
478 Throat pain respiratory Both 0.3589 0.952 0.856,1.06 377 3789 0.3475 0.95 0.854,1.06 375 3774
479 Other upper respiratory disease respiratory Both 0.2588 0.982 0.95,1.01 4074 40737 0.2588 0.981 0.95,1.01 4058 40631
480 Pneumonia respiratory Both 0.6607 0.995 0.976,1.02 10336 103397 0.6745 1.02 0.944,1.09 787 7935
480.1 Bacterial pneumonia respiratory Both 0.984 1.0 0.975,1.03 6637 66410 0.2254 0.88 0.716,1.08 92 927
480.11 Pneumococcal pneumonia respiratory Both 0.7638 0.996 0.97,1.02 5883 58863 0.7621 0.996 0.969,1.02 5828 58694
480.12 Pseudomonal pneumonia respiratory Both 0.1968 0.874 0.711,1.07 93 929 0.2254 0.88 0.716,1.08 92 927
480.2 Viral pneumonia respiratory Both 0.6808 0.952 0.752,1.2 72 720 0.673 0.951 0.751,1.2 72 718
480.3 Pneumonia due to fungus (mycoses) respiratory Both 0.3664 0.911 0.745,1.11 99 989 0.3311 0.905 0.739,1.11 98 987
480.5 Bronchopneumonia and lung abscess respiratory Both 0.5546 1.02 0.95,1.1 794 7951 0.6745 1.02 0.944,1.09 787 7935
481 Influenza respiratory Both 0.09772 0.908 0.81,1.02 328 3278 0.06607 0.898 0.801,1.01 324 3272
483 Acute bronchitis and bronchiolitis respiratory Both 0.5082 1.05 0.908,1.22 193 1930 0.5408 1.05 0.904,1.21 191 1928
495 Asthma respiratory Both 0.1845 1.01 0.996,1.02 25689 250406 0.4508 1.05 0.921,1.2 248 2504
495.2 Asthma with exacerbation respiratory Both 0.4656 1.05 0.92,1.2 250 2510 0.4508 1.05 0.921,1.2 248 2504
496 Chronic airway obstruction respiratory Both 0.811 1.0 0.982,1.02 10424 101546 0.1694 0.967 0.923,1.01 1874 18784
496.1 Emphysema respiratory Both 0.2877 0.973 0.926,1.02 1743 17438 0.2421 0.971 0.924,1.02 1729 17404
496.2 Chronic bronchitis respiratory Both 0.4406 0.985 0.949,1.02 2947 29498 0.8974 0.997 0.959,1.04 2691 27005
496.21 Obstructive chronic bronchitis respiratory Both 0.984 1.0 0.961,1.04 2706 27081 0.8974 0.997 0.959,1.04 2691 27005
496.3 Bronchiectasis respiratory Both 0.1832 0.969 0.924,1.02 1885 18859 0.1694 0.967 0.923,1.01 1874 18784
497 Bronchitis respiratory Both 0.4624 1.03 0.949,1.12 626 6267 0.4932 1.03 0.947,1.12 622 6246
500 Lung disease due to external agents respiratory Both 0.414 0.959 0.867,1.06 412 4099 0.5929 0.964 0.844,1.1 243 2407
500.1 Extrinsic allergic alveolitis respiratory Both 0.865 0.981 0.782,1.23 79 784 0.865 0.981 0.782,1.23 79 784
500.2 Pneumoconiosis respiratory Both 0.5957 0.965 0.844,1.1 243 2409 0.5929 0.964 0.844,1.1 243 2407
501 Pneumonitis due to inhalation of food or vomitus respiratory Both 0.8166 1.01 0.932,1.09 656 6557 0.8872 1.01 0.929,1.09 650 6540
502 Postinflammatory pulmonary fibrosis respiratory Both 0.008128 0.912 0.852,0.976 917 9193 0.00537 0.907 0.848,0.972 911 9177
503 Pulmonary congestion and hypostasis respiratory Both 0.2541 1.05 0.963,1.15 508 5079 0.2831 1.05 0.96,1.15 502 5065
504 Other alveolar and parietoalveolar pneumonopathy respiratory Both 0.1432 0.92 0.823,1.03 328 3280 0.1074 0.912 0.815,1.02 326 3270
505 Other pulmonary inflamation or edema respiratory Both 0.3673 0.881 0.668,1.16 61 610 0.3673 0.881 0.668,1.16 61 610
506 Empyema and pneumothorax respiratory Both 0.4645 1.02 0.963,1.09 1133 11362 0.5272 1.02 0.96,1.08 1119 11331
507 Pleurisy; pleural effusion respiratory Both 0.4385 0.99 0.965,1.02 6419 64252 0.3428 0.988 0.962,1.01 6253 64082
508 Pulmonary collapse; interstitial and compensatory emphysema respiratory Both 0.07079 0.958 0.915,1.0 1996 19947 0.07943 0.959 0.916,1.0 1970 19893
509 Respiratory failure, insufficiency, arrest respiratory Both 0.6012 0.989 0.95,1.03 2599 26031 0.4093 0.957 0.861,1.06 385 3854
509.1 Respiratory failure respiratory Both 0.9397 1.0 0.957,1.05 2068 20708 0.9886 1.0 0.955,1.05 2051 20670
509.2 Respiratory insufficiency respiratory Both 0.7603 0.992 0.945,1.04 1806 18106 0.7534 0.992 0.945,1.04 1792 18071
509.5 Respiratory arrest respiratory Both 0.5546 0.951 0.805,1.12 143 1429 0.5212 0.947 0.8,1.12 142 1427
509.8 Dependence on respirator [Ventilator] or supplemental oxygen respiratory Both 0.389 0.955 0.859,1.06 386 3863 0.4093 0.957 0.861,1.06 385 3854
510 Other diseases of lung respiratory Both 0.1626 0.948 0.879,1.02 755 7554 0.1493 0.946 0.877,1.02 752 7528
512 Other symptoms of respiratory system respiratory Both 0.6823 0.995 0.974,1.02 9031 90349 0.743 0.989 0.924,1.06 903 9099
512.1 Wheezing respiratory Both 0.4753 0.952 0.832,1.09 220 2196 0.4786 0.952 0.832,1.09 219 2188
512.2 Painful respiration respiratory Both 0.879 1.01 0.879,1.16 207 2075 0.857 1.01 0.88,1.17 203 2071
512.7 Shortness of breath respiratory Both 0.778 0.996 0.97,1.02 5842 58498 0.7063 0.995 0.968,1.02 5783 58304
512.8 Cough respiratory Both 0.4111 0.984 0.947,1.02 2866 28642 0.3715 0.983 0.945,1.02 2844 28554
512.9 Other dyspnea respiratory Both 0.859 0.994 0.929,1.06 914 9124 0.743 0.989 0.924,1.06 903 9099
513 Respiratory abnormalities respiratory Both 0.7745 1.01 0.931,1.1 611 6112 0.08913 0.864 0.729,1.02 153 1537
513.3 Hypoventilation respiratory Both 0.2582 0.883 0.711,1.1 83 830 0.2541 0.882 0.71,1.09 83 829
513.4 Hyperventilation respiratory Both 0.1524 1.09 0.968,1.24 278 2778 0.1528 1.09 0.967,1.24 277 2772
513.8 Disorders of diaphragm respiratory Both 0.0871 0.863 0.729,1.02 153 1538 0.08913 0.864 0.729,1.02 153 1537
514 Abnormal findings examination of lungs respiratory Both 0.811 0.995 0.955,1.04 2465 24673 0.7447 0.993 0.953,1.04 2443 24591
516 Abnormal sputum respiratory Both 0.2992 1.02 0.979,1.07 2132 21335 0.2972 1.02 0.979,1.07 2066 20693
516.1 Hemoptysis respiratory Both 0.2812 1.03 0.98,1.07 2073 20745 0.2972 1.02 0.979,1.07 2066 20693
519 Other diseases of respiratory system, not elsewhere classified respiratory Both 0.1042 0.983 0.962,1.0 9366 93681 0.4295 1.05 0.931,1.18 300 3035
519.2 Respiratory complications respiratory Both 0.1012 1.1 0.981,1.24 327 3279 0.09772 1.1 0.982,1.24 322 3267
519.8 Other diseases of respiratory system, NEC respiratory Both 0.08128 0.981 0.96,1.0 8853 88522 0.0871 0.981 0.96,1.0 8770 88230
519.9 Symptoms involving respiratory system and other chest symptoms respiratory Both 0.3724 1.06 0.937,1.19 303 3049 0.4295 1.05 0.931,1.18 300 3035
520 Disorders of tooth development digestive Both 0.6209 1.01 0.967,1.06 2038 20354 0.3811 1.02 0.977,1.06 2354 23469
520.1 Hereditary disturbances in tooth structure digestive Both 0.3999 0.89 0.677,1.17 53 530 0.4159 0.893 0.679,1.17 53 528
520.2 Disturbances in tooth eruption digestive Both 0.4375 1.02 0.975,1.06 2356 23539 0.3811 1.02 0.977,1.06 2354 23469
521 Diseases of hard tissues of teeth digestive Both 0.3873 0.984 0.948,1.02 3016 30245 0.3412 0.982 0.946,1.02 3017 30233
521.1 Dental caries digestive Both 0.3491 0.982 0.947,1.02 3026 30353 0.3412 0.982 0.946,1.02 3017 30233
522 Diseases of pulp and periapical tissues digestive Both 0.865 0.996 0.949,1.05 1774 17750 0.861 1.01 0.947,1.07 1166 11698
522.5 Periapical abscess digestive Both 0.8851 1.0 0.947,1.07 1172 11731 0.861 1.01 0.947,1.07 1166 11698
523 Gingival and periodontal diseases digestive Both 0.6039 1.01 0.964,1.07 1681 16812 0.5483 0.974 0.892,1.06 557 5564
523.1 Gingivitis digestive Both 0.8954 1.01 0.832,1.23 113 1127 0.8872 1.01 0.833,1.24 113 1125
523.3 Periodontitis (acute or chronic) digestive Both 0.5821 1.02 0.958,1.08 1165 11650 0.5483 0.974 0.892,1.06 557 5564
523.31 Acute periodontitis digestive Both 0.7907 1.01 0.934,1.09 666 6667 0.7311 1.01 0.936,1.1 663 6653
523.32 Chronic periodontitis digestive Both 0.5888 0.976 0.895,1.07 560 5594 0.5483 0.974 0.892,1.06 557 5564
524 Dentofacial anomalies, including malocclusion digestive Both 0.07413 1.11 0.99,1.24 331 3307 0.2655 1.07 0.949,1.21 304 3044
524.3 Anomalies of tooth position/malocclusion digestive Both 0.2735 1.07 0.948,1.21 305 3046 0.2655 1.07 0.949,1.21 304 3044
525 Other diseases of the teeth and supporting structures digestive Both 0.955 1.0 0.962,1.04 2668 26728 0.5284 0.923 0.719,1.18 71 718
525.2 Atrophy of edentulous alveolar ridge digestive Both 0.492 0.917 0.715,1.17 72 720 0.5284 0.923 0.719,1.18 71 718
526 Diseases of the jaws digestive Both 0.191 1.05 0.978,1.12 928 9279 0.4457 1.05 0.921,1.21 232 2317
526.1 Cysts of the jaws digestive Both 0.8128 0.987 0.881,1.1 329 3289 0.8054 0.986 0.88,1.1 328 3284
526.3 Anomalies of jaw size/symmetry digestive Both 0.6839 0.945 0.721,1.24 61 610 0.5998 0.93 0.709,1.22 60 608
526.4 Temporomandibular joint disorders digestive Both 0.007943 1.2 1.05,1.36 240 2406 0.01413 1.18 1.03,1.35 233 2322
526.41 Temporomandibular joint disorder, unspecified digestive Both 0.01479 1.18 1.03,1.35 233 2336 0.01413 1.18 1.03,1.35 233 2322
526.5 Inflammatory conditions of jaw digestive Both 0.52 0.939 0.775,1.14 110 1098 0.4797 0.933 0.769,1.13 109 1095
526.9 Jaw disease NOS digestive Both 0.4365 1.05 0.922,1.21 233 2329 0.4457 1.05 0.921,1.21 232 2317
527 Diseases of the salivary glands digestive Both 0.6516 1.02 0.941,1.1 694 6943 0.278 0.902 0.748,1.09 119 1197
527.1 Hypertrophy of salivary gland digestive Both 0.3908 1.1 0.88,1.39 84 838 0.3811 1.11 0.882,1.39 84 835
527.2 Sialoadenitis digestive Both 0.4875 1.04 0.931,1.16 365 3656 0.5768 1.03 0.923,1.15 362 3637
527.7 Disturbance of salivary secretion digestive Both 0.2704 1.16 0.893,1.5 62 619 0.2636 1.16 0.894,1.5 62 616
527.8 Other specified diseases of the salivary glands digestive Both 0.2582 0.898 0.745,1.08 120 1200 0.278 0.902 0.748,1.09 119 1197
528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue digestive Both 0.1318 1.03 0.992,1.06 3873 38741 0.7031 1.02 0.91,1.15 313 3124
528.1 Stomatitis and mucositis digestive Both 0.743 1.02 0.924,1.12 468 4675 0.5834 0.94 0.752,1.17 83 839
528.11 Stomatitis and mucositis (ulcerative) digestive Both 0.4395 1.04 0.939,1.16 389 3884 0.4571 1.04 0.937,1.16 385 3862
528.12 Oral aphthae digestive Both 0.6699 0.953 0.763,1.19 84 840 0.5834 0.94 0.752,1.17 83 839
528.3 Cellulitis and abscess of oral soft tissues digestive Both 0.1968 1.1 0.951,1.28 179 1790 0.1914 1.1 0.952,1.28 179 1782
528.4 Cysts of oral soft tissues digestive Both 0.869 0.985 0.82,1.18 122 1219 0.6871 0.957 0.773,1.19 94 936
528.41 Cyst of the salivary gland digestive Both 0.695 0.958 0.774,1.19 94 940 0.6871 0.957 0.773,1.19 94 936
528.5 Diseases of lips digestive Both 0.2512 1.05 0.968,1.13 681 6813 0.2118 1.05 0.972,1.14 678 6789
528.6 Leukoplakia of oral mucosa digestive Both 0.05754 1.12 0.996,1.26 308 3079 0.05888 1.12 0.996,1.26 306 3067
528.7 Sialolithiasis digestive Both 0.6966 1.02 0.911,1.15 314 3138 0.7031 1.02 0.91,1.15 313 3124
529 Diseases and other conditions of the tongue digestive Both 0.826 0.993 0.937,1.05 1232 12312 0.9354 0.995 0.885,1.12 298 2979
529.1 Glossitis digestive Both 0.8831 0.991 0.881,1.11 299 2986 0.9354 0.995 0.885,1.12 298 2979
530 Diseases of esophagus digestive Both 0.743 1.0 0.991,1.01 33453 279172 0.5 0.985 0.942,1.03 2079 20790
530.1 Esophagitis, GERD and related diseases digestive Both 0.6457 1.0 0.991,1.01 31253 272429 0.05495 0.98 0.961,1.0 10402 104181
530.11 GERD digestive Both 0.6531 0.997 0.983,1.01 22633 225879 0.6383 0.997 0.983,1.01 22510 225056
530.12 Ulcer of esophagus digestive Both 0.415 1.01 0.983,1.04 5203 52068 0.335 1.01 0.986,1.04 5174 51943
530.14 Reflux esophagitis digestive Both 0.05129 0.98 0.961,1.0 10444 104493 0.05495 0.98 0.961,1.0 10402 104181
530.2 Esophageal bleeding (varices/hemorrhage) digestive Both 0.02951 0.946 0.899,0.995 1681 16808 0.03388 0.947 0.9,0.996 1671 16761
530.3 Stricture and stenosis of esophagus digestive Both 0.4477 1.02 0.971,1.07 1869 18684 0.4581 1.02 0.971,1.07 1859 18644
530.5 Disorders of esophageal motility digestive Both 0.8954 1.01 0.927,1.09 635 6365 0.9183 1.0 0.925,1.09 632 6341
530.6 Diverticulum of esophagus, acquired digestive Both 0.955 0.995 0.844,1.17 153 1527 0.9333 0.993 0.841,1.17 151 1525
530.7 Gastroesophageal laceration-hemorrhage syndrome digestive Both 0.3184 1.06 0.947,1.18 341 3416 0.3296 1.06 0.946,1.18 340 3413
530.9 Heartburn digestive Both 0.4842 0.984 0.941,1.03 2087 20881 0.5 0.985 0.942,1.03 2079 20790
531 Peptic ulcer (excl. esophageal) digestive Both 0.4775 1.01 0.985,1.03 7103 71066 0.5224 1.03 0.937,1.14 426 4258
531.1 Hemorrhage from gastrointestinal ulcer digestive Both 0.5768 1.02 0.944,1.11 637 6374 0.5902 1.02 0.943,1.11 633 6364
531.2 Gastric ulcer digestive Both 0.861 1.0 0.971,1.04 4091 40941 0.9333 1.0 0.97,1.03 4072 40805
531.3 Duodenal ulcer digestive Both 0.8453 1.0 0.967,1.04 2999 30005 0.9057 1.0 0.965,1.04 2986 29933
531.4 Peptic ulcer, site unspecified digestive Both 0.5495 1.03 0.935,1.13 427 4268 0.5224 1.03 0.937,1.14 426 4258
532 Dysphagia digestive Both 0.2188 1.02 0.991,1.04 6427 64329 0.2477 1.02 0.99,1.04 6396 64115
535 Gastritis and duodenitis digestive Both 0.2564 1.01 0.995,1.02 28078 261548 0.7998 0.976 0.81,1.18 120 1189
535.1 Acute gastritis digestive Both 0.5675 0.983 0.926,1.04 1183 11833 0.5781 0.983 0.927,1.04 1178 11797
535.2 Atrophic gastritis digestive Both 0.7464 0.983 0.884,1.09 370 3687 0.7464 0.983 0.884,1.09 370 3678
535.6 Duodenitis digestive Both 0.5012 0.992 0.969,1.02 7592 75928 0.526 0.992 0.969,1.02 7561 75720
535.8 Other specified gastritis digestive Both 0.1734 1.02 0.993,1.04 8071 80763 0.1941 1.02 0.992,1.04 8024 80467
535.9 Gastritis and duodenitis, NOS digestive Both 0.811 0.978 0.811,1.18 120 1191 0.7998 0.976 0.81,1.18 120 1189
536.8 Dyspepsia and other specified disorders of function of stomach digestive Both 0.1059 1.11 0.978,1.26 259 2576 0.09772 1.11 0.981,1.26 258 2565
537 Other disorders of stomach and duodenum digestive Both 0.3767 1.02 0.981,1.05 3391 33907 0.4436 1.01 0.979,1.05 3360 33790
540 Appendiceal conditions digestive Both 0.4613 1.01 0.977,1.05 3088 30890 0.6295 1.01 0.97,1.05 2592 25928
540.1 Appendicitis digestive Both 0.4487 1.01 0.977,1.05 2895 28963 0.6295 1.01 0.97,1.05 2592 25928
540.11 Acute appendicitis digestive Both 0.6516 1.01 0.969,1.05 2601 26019 0.6295 1.01 0.97,1.05 2592 25928
550 Abdominal hernia digestive Both 0.06918 0.991 0.981,1.0 45429 282640 0.2028 1.02 0.988,1.06 3375 34240
550.1 Inguinal hernia digestive Both 0.9572 1.0 0.984,1.02 15794 123247 0.9462 1.0 0.984,1.02 15787 123174
550.2 Diaphragmatic hernia digestive Both 0.00912 0.983 0.971,0.996 26494 238953 0.01047 0.984 0.971,0.996 26342 238098
550.3 Femoral hernia digestive Both 0.1875 1.06 0.974,1.14 651 6504 0.1694 1.06 0.976,1.15 645 6476
550.4 Umbilical hernia digestive Both 0.4797 0.988 0.955,1.02 3705 37072 0.414 0.986 0.953,1.02 3695 37019
550.5 Ventral hernia digestive Both 0.1476 1.03 0.991,1.06 3435 34338 0.2028 1.02 0.988,1.06 3375 34240
555 Inflammatory bowel disease and other gastroenteritis and colitis digestive Both 0.2541 1.02 0.987,1.05 4444 44442 0.3673 1.04 0.954,1.14 535 5370
555.1 Regional enteritis digestive Both 0.413 1.02 0.972,1.07 1734 17340 0.3846 1.02 0.973,1.07 1730 17293
555.2 Ulcerative colitis digestive Both 0.2188 1.02 0.987,1.06 3178 31786 0.3673 1.04 0.954,1.14 535 5370
555.21 Ulcerative colitis (chronic) digestive Both 0.4365 1.04 0.949,1.13 538 5382 0.3673 1.04 0.954,1.14 535 5370
556 Ulceration of the lower GI tract digestive Both 0.7745 1.01 0.948,1.07 1055 10592 0.5559 1.02 0.946,1.11 668 6693
556.1 Ulceration of intestine digestive Both 0.6194 1.02 0.942,1.1 670 6714 0.5559 1.02 0.946,1.11 668 6693
557 Intestinal malabsorption (non-celiac) digestive Both 0.9863 1.0 0.89,1.13 299 2987 0.8356 0.995 0.948,1.04 1820 18332
557.1 Celiac disease digestive Both 0.881 0.996 0.949,1.05 1837 18388 0.8356 0.995 0.948,1.04 1820 18332
558 Noninfectious gastroenteritis digestive Both 0.5821 1.0 0.988,1.02 15492 155105 0.561 1.0 0.988,1.02 15368 154673
559 Ileostomy status digestive Both 0.9954 1.0 0.951,1.05 1656 16541 0.984 1.0 0.95,1.05 1611 16498
560 Intestinal obstruction without mention of hernia digestive Both 0.3206 1.02 0.984,1.05 3936 39337 0.2754 1.02 0.984,1.06 3211 33451
560.1 Paralytic ileus digestive Both 0.1276 0.934 0.856,1.02 523 5231 0.271 0.951 0.871,1.04 508 5217
560.2 Impaction of intestine digestive Both 0.08318 1.12 0.986,1.27 268 2671 0.06761 1.13 0.991,1.28 266 2661
560.3 Peritoneal or intestinal adhesions digestive Both 0.3499 1.03 0.963,1.11 832 8317 0.3846 1.03 0.961,1.11 810 8295
560.4 Other intestinal obstruction digestive Both 0.3184 1.02 0.983,1.05 3358 33550 0.2754 1.02 0.984,1.06 3211 33451
561 Symptoms involving digestive system digestive Both 0.1919 0.989 0.973,1.01 15772 157686 0.4477 0.981 0.932,1.03 1653 16819
561.1 Diarrhea digestive Both 0.9462 0.997 0.908,1.09 466 4653 0.9333 0.996 0.907,1.09 463 4640
561.2 Flatulence digestive Both 0.3342 0.976 0.928,1.03 1687 16859 0.4477 0.981 0.932,1.03 1653 16819
562 Diverticulosis and diverticulitis digestive Both 0.0182 1.02 1.0,1.03 26714 211692 0.02754 1.01 1.0,1.03 26519 211095
562.1 Diverticulosis digestive Both 0.02089 1.02 1.0,1.03 26672 211642 0.02754 1.01 1.0,1.03 26519 211095
563 Constipation digestive Both 0.4571 1.01 0.988,1.03 10314 103140 0.4732 1.01 0.987,1.03 10155 102836
564 Functional digestive disorders digestive Both 0.8375 1.0 0.988,1.02 21639 209949 0.5546 1.01 0.988,1.02 15109 151297
564.1 Irritable Bowel Syndrome digestive Both 0.4406 0.989 0.962,1.02 5508 55117 0.4102 0.988 0.961,1.02 5458 54939
564.8 Abnormal findings on exam of gastrointestinal tract/ abdominal area digestive Both 0.9099 1.0 0.954,1.05 1645 16457 0.9016 0.997 0.948,1.05 1621 16416
564.9 Personal history of diseases of digestive system digestive Both 0.5284 1.01 0.989,1.02 15186 151648 0.5546 1.01 0.988,1.02 15109 151297
565 Anal and rectal conditions digestive Both 0.2489 1.01 0.993,1.03 14744 147535 0.5794 1.01 0.983,1.03 7318 73350
565.1 Anal and rectal polyp digestive Both 0.7161 1.0 0.981,1.03 7351 73533 0.5794 1.01 0.983,1.03 7318 73350
567 Peritonitis and retroperitoneal infections digestive Both 0.9616 1.0 0.937,1.07 929 9293 0.984 1.0 0.936,1.07 911 9273
568 Other disorders of peritoneum digestive Both 0.2704 1.02 0.984,1.06 3262 32602 0.3532 1.02 0.981,1.06 3031 30860
568.1 Peritoneal adhesions (postoperative) (postinfection) digestive Both 0.3228 1.02 0.982,1.06 3101 30987 0.3532 1.02 0.981,1.06 3031 30860
569 Other disorders of intestine digestive Both 0.4571 0.988 0.957,1.02 4192 41922 0.2404 0.945 0.86,1.04 470 4852
569.1 Toxic gastroenteritis and colitis digestive Both 0.6607 0.962 0.811,1.14 148 1479 0.7674 0.974 0.819,1.16 143 1474
569.2 Gastrointestinal complications digestive Both 0.2477 0.947 0.862,1.04 486 4868 0.2404 0.945 0.86,1.04 470 4852
571 Chronic liver disease and cirrhosis digestive Both 0.4699 1.01 0.977,1.05 2957 29628 0.3013 1.05 0.959,1.14 527 5273
571.5 Other chronic nonalcoholic liver disease digestive Both 0.561 1.01 0.966,1.07 1689 16917 0.7211 0.967 0.804,1.16 113 1137
571.51 Cirrhosis of liver without mention of alcohol digestive Both 0.7112 0.966 0.803,1.16 113 1139 0.7211 0.967 0.804,1.16 113 1137
571.6 Primary biliary cirrhosis digestive Both 0.1361 0.907 0.798,1.03 257 2568 0.1205 0.903 0.794,1.03 255 2558
571.8 Liver abscess and sequelae of chronic liver disease digestive Both 0.4613 1.03 0.96,1.09 976 9804 0.3013 1.05 0.959,1.14 527 5273
571.81 Portal hypertension digestive Both 0.3027 1.05 0.959,1.14 528 5285 0.3013 1.05 0.959,1.14 527 5273
572 Ascites (non malignant) digestive Both 0.02188 1.06 1.01,1.12 1544 15454 0.07413 1.05 0.995,1.11 1330 15409
573 Other disorders of liver digestive Both 0.5585 0.984 0.933,1.04 1496 14982 0.06166 0.872 0.755,1.01 206 2085
573.2 Liver replaced by transplant digestive Both 0.9441 1.01 0.823,1.23 96 960 0.9506 1.01 0.822,1.23 96 957
573.3 Hepatomegaly digestive Both 0.7161 0.978 0.869,1.1 297 2968 0.7568 0.981 0.872,1.11 296 2961
573.5 Jaundice (not of newborn) digestive Both 0.3631 1.03 0.963,1.11 896 8955 0.3475 1.03 0.964,1.11 891 8935
573.7 Abnormal results of function study of liver digestive Both 0.5546 1.01 0.976,1.05 3454 34597 0.5675 1.01 0.975,1.05 3429 34483
573.9 Abnormal serum enzyme levels digestive Both 0.06166 0.873 0.756,1.01 209 2089 0.06166 0.872 0.755,1.01 206 2085
574 Cholelithiasis and cholecystitis digestive Both 0.975 1.0 0.984,1.02 15607 156123 0.1629 1.03 0.989,1.07 2734 27416
574.1 Cholelithiasis digestive Both 0.3483 0.992 0.974,1.01 13549 135537 0.6095 0.993 0.966,1.02 5403 54042
574.11 Cholelithiasis with acute cholecystitis digestive Both 0.9354 0.998 0.946,1.05 1506 15072 0.9204 0.997 0.946,1.05 1497 14989
574.12 Cholelithiasis with other cholecystitis digestive Both 0.6281 0.993 0.966,1.02 5429 54289 0.6095 0.993 0.966,1.02 5403 54042
574.2 Calculus of bile duct digestive Both 0.05012 1.04 1.0,1.08 2620 26191 0.05495 1.04 0.999,1.08 2597 26072
574.3 Cholecystitis without cholelithiasis digestive Both 0.1377 1.03 0.991,1.07 2748 27523 0.1629 1.03 0.989,1.07 2734 27416
575 Other biliary tract disease digestive Both 0.3119 1.02 0.984,1.05 3867 38724 0.2518 0.939 0.843,1.05 342 3480
575.1 Cholangitis digestive Both 0.05012 1.1 1.0,1.21 495 4945 0.04898 1.1 1.0,1.21 489 4930
575.2 Obstruction of bile duct digestive Both 0.05623 1.07 0.998,1.16 774 7756 0.04266 1.08 1.0,1.16 767 7737
575.6 Cholesterolosis of gallbladder digestive Both 0.9397 1.0 0.913,1.1 458 4577 0.877 1.01 0.916,1.11 457 4552
575.7 Other disorders of gallbladder digestive Both 0.2649 1.03 0.977,1.09 1408 14107 0.2582 1.03 0.977,1.09 1402 14046
575.8 Other disorders of biliary tract digestive Both 0.8279 0.993 0.931,1.06 1036 10367 0.7568 0.99 0.928,1.06 1027 10320
575.9 Nonspecific abnormal findings on radiological and other examination of biliary tract digestive Both 0.2667 0.941 0.845,1.05 348 3488 0.2518 0.939 0.843,1.05 342 3480
577 Diseases of pancreas digestive Both 0.6561 0.991 0.952,1.03 2668 26677 0.7889 1.01 0.912,1.13 361 3635
577.1 Acute pancreatitis digestive Both 0.9162 0.998 0.952,1.04 1996 19962 0.859 0.996 0.951,1.04 1993 19876
577.2 Chronic pancreatitis digestive Both 0.929 0.996 0.91,1.09 515 5149 0.9141 0.995 0.909,1.09 514 5138
577.3 Cyst and pseudocyst of pancreas digestive Both 0.6792 1.02 0.92,1.14 365 3650 0.7889 1.01 0.912,1.13 361 3635
578 Gastrointestinal hemorrhage digestive Both 0.6637 1.0 0.989,1.02 20626 206278 0.826 1.0 0.975,1.03 5250 52643
578.1 Hematemesis digestive Both 0.5152 1.02 0.969,1.06 1958 19564 0.6982 1.01 0.963,1.06 1933 19515
578.2 Blood in stool digestive Both 0.4808 0.986 0.947,1.03 2626 26283 0.456 0.985 0.946,1.03 2613 26214
578.8 Hemorrhage of rectum and anus digestive Both 0.984 1.0 0.982,1.02 13073 130745 0.975 1.0 0.982,1.02 13004 130330
578.9 Hemorrhage of gastrointestinal tract digestive Both 0.8318 1.0 0.975,1.03 5275 52787 0.826 1.0 0.975,1.03 5250 52643
579 Other symptoms involving abdomen and pelvis digestive Both 0.1094 1.04 0.99,1.1 1548 15498 0.857 0.995 0.946,1.05 1646 16484
579.2 Splenomegaly digestive Both 0.6252 1.03 0.928,1.13 422 4246 0.597 1.03 0.929,1.14 420 4237
579.8 Nonspecific abnormal findings in stool contents digestive Both 0.867 0.996 0.946,1.05 1654 16540 0.857 0.995 0.946,1.05 1646 16484
580 Nephritis; nephrosis; renal sclerosis genitourinary Both 0.975 1.0 0.949,1.06 1531 15350 0.7551 0.98 0.862,1.11 252 2523
580.1 Glomerulonephritis genitourinary Both 0.7228 0.989 0.927,1.05 1052 10544 0.8433 0.993 0.925,1.07 864 8738
580.11 Proliferative glomerulonephritis genitourinary Both 0.08913 0.812 0.638,1.03 74 738 0.0912 0.812 0.637,1.03 73 737
580.12 Non-proliferative glomerulonephritis genitourinary Both 0.6442 1.04 0.878,1.23 135 1360 0.6516 1.04 0.877,1.23 135 1352
580.14 Chronic glomerulonephritis, NOS genitourinary Both 0.8147 0.992 0.924,1.06 876 8769 0.8433 0.993 0.925,1.07 864 8738
580.2 Nephrotic syndrome without mention of glomerulonephritis genitourinary Both 0.6486 1.02 0.93,1.12 468 4697 0.6457 1.02 0.931,1.12 468 4685
580.3 Nephritis and nephropathy without mention of glomerulonephritis genitourinary Both 0.597 0.966 0.848,1.1 246 2460 0.7551 0.98 0.862,1.11 252 2523
580.32 Nephritis and nephropathy with pathological lesion genitourinary Both 0.7534 0.98 0.862,1.11 253 2529 0.7551 0.98 0.862,1.11 252 2523
585 Renal failure genitourinary Both 0.415 1.01 0.986,1.04 6967 69751 0.8433 0.991 0.905,1.08 494 4942
585.1 Acute renal failure genitourinary Both 0.7145 1.01 0.976,1.04 4527 45305 0.7261 1.01 0.975,1.04 4459 45202
585.2 Renal failure NOS genitourinary Both 0.9141 0.997 0.945,1.05 1460 14625 0.9268 1.0 0.95,1.06 1433 14600
585.3 Chronic renal failure [CKD] genitourinary Both 0.9397 0.998 0.96,1.04 2644 26484 0.8433 0.991 0.905,1.08 494 4942
585.31 Renal dialysis genitourinary Both 0.8453 0.991 0.906,1.08 496 4955 0.8433 0.991 0.905,1.08 494 4942
586 Other disorders of the kidney and ureters genitourinary Both 0.1268 1.03 0.992,1.06 3355 33580 0.4667 1.03 0.958,1.1 879 9099
586.1 Anatomical abnormatilies of kidney and ureters genitourinary Both 0.7112 0.974 0.847,1.12 208 2089 0.826 0.983 0.846,1.14 177 1795
586.11 Small kidney genitourinary Both 0.7345 0.975 0.839,1.13 179 1799 0.826 0.983 0.846,1.14 177 1795
586.2 Cyst of kidney, acquired genitourinary Both 0.875 0.995 0.939,1.05 1257 12582 0.8831 0.996 0.939,1.06 1247 12559
586.3 Vascular disorders of kidney/hypertrophy genitourinary Both 0.2009 1.16 0.926,1.44 80 799 0.2032 1.15 0.925,1.44 80 798
586.4 Stricture/obstruction of ureter genitourinary Both 0.5129 1.02 0.956,1.09 910 9122 0.4667 1.03 0.958,1.1 879 9099
587 Kidney replaced by transpant genitourinary Both 0.3296 0.95 0.857,1.05 368 3683 0.3304 0.95 0.857,1.05 366 3678
588 Disorders resulting from impaired renal function genitourinary Both 0.04898 0.82 0.674,0.999 99 990 0.05129 0.82 0.672,1.0 97 984
589 Abnormal results of function study of kidney genitourinary Both 0.984 1.0 0.831,1.21 116 1158 0.9661 1.0 0.831,1.21 113 1154
590 Pyelonephritis genitourinary Both 0.975 0.999 0.944,1.06 1328 13285 0.9616 0.999 0.944,1.06 1317 13227
591 Urinary tract infection genitourinary Both 0.9616 1.0 0.982,1.02 12400 123937 0.8995 0.999 0.98,1.02 12236 123500
592 Cystitis and urethritis genitourinary Both 0.7603 0.994 0.958,1.03 2966 29661 0.4315 0.941 0.809,1.09 165 1655
592.1 Cystitis genitourinary Both 0.9333 1.0 0.964,1.04 2904 29035 0.6546 0.971 0.854,1.1 247 2474
592.11 Acute cystitis genitourinary Both 0.6577 1.04 0.875,1.24 138 1372 0.6501 1.04 0.876,1.24 138 1369
592.12 Chronic cystitis genitourinary Both 0.2223 0.958 0.895,1.03 889 8890 0.1811 0.954 0.891,1.02 882 8867
592.13 Chronic interstitial cystitis genitourinary Both 0.6966 0.975 0.857,1.11 249 2486 0.6546 0.971 0.854,1.1 247 2474
592.2 Urethritis and urethral syndrome genitourinary Both 0.4285 0.941 0.809,1.09 165 1662 0.4315 0.941 0.809,1.09 165 1655
593 Hematuria genitourinary Both 0.778 0.998 0.982,1.01 16068 160204 0.8128 0.998 0.982,1.01 15988 159776
594 Urinary calculus genitourinary Both 0.9441 0.999 0.974,1.03 6376 63761 0.1274 0.965 0.922,1.01 2046 20463
594.1 Calculus of kidney genitourinary Both 0.4887 1.01 0.977,1.05 3175 31757 0.4786 1.01 0.977,1.05 3169 31706
594.2 Calculus of lower urinary tract genitourinary Both 0.2535 0.958 0.889,1.03 776 7764 0.2547 0.958 0.889,1.03 776 7750
594.3 Calculus of ureter genitourinary Both 0.317 1.02 0.98,1.06 2401 24024 0.3793 1.02 0.977,1.06 2396 23987
594.8 Renal colic genitourinary Both 0.1042 0.963 0.92,1.01 2050 20500 0.1274 0.965 0.922,1.01 2046 20463
595 Hydronephrosis genitourinary Both 0.1452 1.04 0.988,1.08 1936 19395 0.09333 1.04 0.993,1.09 1847 19346
596 Other disorders of bladder genitourinary Both 0.06166 1.02 0.999,1.04 9771 97778 0.07413 1.05 0.995,1.1 1644 16517
596.1 Bladder neck obstruction genitourinary Both 0.118 1.04 0.991,1.09 1969 19690 0.118 1.04 0.991,1.09 1969 19685
596.5 Functional disorders of bladder genitourinary Both 0.06166 1.05 0.998,1.1 1658 16572 0.07413 1.05 0.995,1.1 1644 16517
597 Other disorders of urethra and urinary tract genitourinary Both 0.743 1.01 0.973,1.04 3913 39135 0.369 1.11 0.886,1.38 76 774
597.1 Urethral stricture (not specified as infectious) genitourinary Both 0.5768 1.01 0.975,1.05 3317 33137 0.6353 1.01 0.973,1.05 3303 33043
597.2 Urinary complications NEC genitourinary Both 0.4426 1.09 0.874,1.36 78 778 0.369 1.11 0.886,1.38 76 774
598 Abnormal findings on examination of urine genitourinary Both 0.7745 1.01 0.971,1.04 3528 35302 0.5781 1.03 0.92,1.16 299 3028
598.9 Other nonspecific findings on examination of urine genitourinary Both 0.5284 1.04 0.924,1.17 304 3035 0.5781 1.03 0.92,1.16 299 3028
599 Other symptoms/disorders or the urinary system genitourinary Both 0.2018 0.99 0.975,1.01 18428 184311 0.8872 0.997 0.951,1.04 1907 19117
599.1 Urinary obstruction genitourinary Both 0.5649 1.05 0.894,1.23 166 1670 0.4721 1.06 0.904,1.24 162 1667
599.2 Retention of urine genitourinary Both 0.9078 0.999 0.974,1.02 6718 67168 0.879 0.998 0.973,1.02 6676 67074
599.3 Dysuria genitourinary Both 0.5082 0.98 0.923,1.04 1196 11967 0.4966 0.979 0.922,1.04 1189 11932
599.4 Urinary incontinence genitourinary Both 0.04571 0.978 0.957,1.0 8748 87477 0.0389 0.977 0.956,0.999 8663 87023
599.5 Frequency of urination and polyuria genitourinary Both 0.6918 1.01 0.974,1.04 4018 40144 0.6516 1.01 0.975,1.04 3999 40045
599.6 Oliguria and anuria genitourinary Both 0.6039 1.05 0.862,1.29 105 1059 0.5236 1.07 0.872,1.31 104 1058
599.8 Other symptoms involving urinary system genitourinary Both 0.4932 1.09 0.848,1.41 62 620 0.507 1.09 0.845,1.41 62 619
599.9 Other abnormality of urination genitourinary Both 0.811 0.994 0.949,1.04 1913 19151 0.8872 0.997 0.951,1.04 1907 19117
600 Hyperplasia of prostate genitourinary Male 0.03236 1.02 1.0,1.04 11093 87892 0.03236 1.02 1.0,1.04 11093 87892
601 Inflammatory diseases of prostate genitourinary Male 0.7396 1.01 0.963,1.05 2081 20818 0.7852 0.984 0.874,1.11 303 3019
601.1 Prostatitis genitourinary Male 0.2911 1.03 0.976,1.08 1563 15644 0.1687 1.05 0.98,1.12 910 9089
601.11 Acute prostatitis genitourinary Male 0.6966 1.03 0.899,1.17 234 2358 0.6966 1.03 0.899,1.17 234 2358
601.12 Chronic prostatitis genitourinary Male 0.1687 1.05 0.98,1.12 910 9089 0.1687 1.05 0.98,1.12 910 9089
601.3 Orchitis and epididymitis genitourinary Male 0.3451 1.14 0.872,1.48 59 588 0.3451 1.14 0.872,1.48 59 588
601.4 Balanoposthitis genitourinary Male 0.2667 0.932 0.822,1.06 287 2864 0.2667 0.932 0.822,1.06 287 2864
601.8 Other inflammatory disorders of male genital organs genitourinary Male 0.7852 0.984 0.874,1.11 303 3019 0.7852 0.984 0.874,1.11 303 3019
602 Other disorders of prostate genitourinary Male 0.3573 1.03 0.971,1.09 1341 13408 0.3573 1.03 0.971,1.09 1341 13408
603 Other disorders of testis genitourinary Male 0.6237 1.01 0.967,1.06 2150 21512 0.5559 0.983 0.93,1.04 1339 13402
603.1 Hydrocele genitourinary Male 0.5559 0.983 0.93,1.04 1339 13402 0.5559 0.983 0.93,1.04 1339 13402
604 Disorders of penis genitourinary Male 0.1432 1.03 0.991,1.06 3280 32779 0.1183 1.03 0.992,1.07 2719 27172
604.1 Redundant prepuce and phimosis/BXO genitourinary Male 0.1183 1.03 0.992,1.07 2719 27172 0.1183 1.03 0.992,1.07 2719 27172
605 Erectile dysfunction [ED] genitourinary Male 0.7656 0.982 0.869,1.11 278 2800 0.7656 0.982 0.869,1.11 278 2800
608 Other disorders of male genital organs genitourinary Male 0.2399 1.02 0.985,1.06 2822 28236 0.2399 1.02 0.985,1.06 2822 28236
609 Male infertility and abnormal spermatozoa genitourinary Male 0.6237 1.03 0.903,1.19 214 2138 0.787 1.02 0.876,1.19 169 1698
609.1 Infertility, male genitourinary Male 0.6531 0.942 0.726,1.22 63 638 0.6531 0.942 0.726,1.22 63 638
609.2 Abnormal spermatozoa genitourinary Male 0.787 1.02 0.876,1.19 169 1698 0.787 1.02 0.876,1.19 169 1698
610 Benign mammary dysplasias genitourinary Female 0.3112 1.02 0.98,1.06 2482 24809 0.9727 1.0 0.926,1.08 690 6918
610.1 Cystic mastopathy genitourinary Female 0.4721 0.976 0.913,1.04 925 9250 0.5728 0.981 0.917,1.05 918 9194
610.2 Fibroadenosis of breast genitourinary Female 0.1738 1.09 0.965,1.22 306 3057 0.2004 1.08 0.96,1.22 302 3046
610.3 Fibrosclerosis of breast genitourinary Female 0.5248 1.04 0.924,1.17 302 3018 0.3589 1.06 0.939,1.19 299 3007
610.4 Benign neoplasm of breast genitourinary Female 0.2128 1.04 0.98,1.09 1388 13865 0.1795 1.04 0.983,1.1 1381 13778
610.8 Other specified benign mammary dysplasias genitourinary Female 0.9908 1.0 0.926,1.08 696 6954 0.9727 1.0 0.926,1.08 690 6918
611 Abnormal findings on mammogram or breast exam genitourinary Both 0.1578 1.04 0.986,1.09 1574 15731 0.0955 1.05 0.992,1.1 1515 15108
611.1 Abnormal mammogram genitourinary Both 0.7691 1.04 0.788,1.38 57 569 0.6855 1.06 0.799,1.41 56 569
611.3 Lump or mass in breast genitourinary Both 0.1096 1.04 0.99,1.1 1522 15213 0.0955 1.05 0.992,1.1 1515 15108
612 Breast conditions, congenital or relating to hormones genitourinary Both 0.7194 1.01 0.945,1.08 887 8871 0.9462 1.01 0.788,1.29 70 717
612.2 Hypertrophy of breast (Gynecomastia) genitourinary Both 0.673 1.02 0.947,1.09 849 8490 0.7328 1.01 0.944,1.09 845 8464
612.3 Congenital anomalies of breast genitourinary Both 0.9333 1.01 0.792,1.29 72 719 0.9462 1.01 0.788,1.29 70 717
613 Other nonmalignant breast conditions genitourinary Both 0.9036 1.0 0.954,1.06 1651 16519 0.5433 0.965 0.86,1.08 324 3264
613.1 Inflammatory disease of breast genitourinary Both 0.08128 1.07 0.992,1.16 720 7210 0.07413 1.07 0.993,1.16 715 7165
613.5 Mastodynia genitourinary Both 0.8995 0.985 0.773,1.25 77 768 0.877 0.981 0.77,1.25 76 766
613.7 Other signs and symptoms in breast genitourinary Both 0.2547 0.956 0.885,1.03 702 7013 0.2858 0.959 0.887,1.04 695 6972
613.8 Other specified disorders of breast genitourinary Both 0.5445 0.965 0.86,1.08 327 3278 0.5433 0.965 0.86,1.08 324 3264
613.9 Breast disorder NOS genitourinary Both 0.929 1.01 0.873,1.16 207 2069 ,
614 Inflammatory diseases of female pelvic organs genitourinary Female 0.03631 1.03 1.0,1.06 5711 57118 0.5998 1.03 0.915,1.17 267 2723
614.1 Pelvic peritoneal adhesions, female (postoperative) (postinfection) genitourinary Female 0.3828 1.02 0.978,1.06 2538 25363 0.5808 1.01 0.971,1.05 2436 25241
614.3 Pelvic inflammatory disease (PID) genitourinary Female 0.859 1.01 0.938,1.08 830 8308 0.166 0.925 0.828,1.03 336 3491
614.31 Acute inflammatory pelvic disease genitourinary Female 0.5236 0.915 0.696,1.2 61 608 0.5598 0.921 0.699,1.21 60 605
614.32 Chronic inflammatory pelvic disease genitourinary Female 0.5309 1.03 0.935,1.14 422 4221 0.8831 1.01 0.91,1.12 405 4201
614.33 Pelvic inflammatory disease, NOS genitourinary Female 0.2148 0.934 0.838,1.04 351 3510 0.166 0.925 0.828,1.03 336 3491
614.4 Inflammatory diseases of uterus, except cervix genitourinary Female 0.5585 1.04 0.917,1.18 277 2775 0.5188 1.04 0.919,1.18 273 2760
614.5 Inflammatory disease of cervix, vagina, and vulva genitourinary Female 0.04467 1.04 1.0,1.08 2601 26023 0.5998 1.03 0.915,1.17 267 2723
614.51 Cervicitis and endocervicitis genitourinary Female 0.008128 1.08 1.02,1.14 1318 13189 0.00912 1.08 1.02,1.14 1294 13111
614.52 Vaginitis and vulvovaginitis genitourinary Female 0.9616 1.0 0.908,1.11 428 4273 0.863 1.01 0.912,1.12 410 4250
614.53 Cyst or abscess of Bartholin's gland genitourinary Female 0.3475 1.04 0.962,1.12 755 7574 0.3365 1.04 0.963,1.12 752 7539
614.54 Abscess or ulceration of vulva genitourinary Female 0.7063 1.02 0.908,1.15 274 2737 0.5998 1.03 0.915,1.17 267 2723
615 Endometriosis genitourinary Female 0.00257 1.05 1.02,1.09 4029 40284 0.005888 1.05 1.01,1.08 3923 40099
617 Disorders secondary to childbirth, surgery, trauma genitourinary Female 0.6501 1.03 0.914,1.15 304 3037 0.5821 1.03 0.917,1.17 283 3014
618 Genital prolapse genitourinary Female 0.8375 0.998 0.979,1.02 11689 116878 0.6124 0.98 0.905,1.06 669 6748
618.1 Prolapse of vaginal walls genitourinary Female 0.879 1.0 0.978,1.03 7392 73940 0.9078 1.0 0.978,1.03 7333 73454
618.2 Uterine/Uterovaginal prolapse genitourinary Female 0.6053 0.993 0.965,1.02 5393 53918 0.52 0.991 0.963,1.02 5360 53575
618.5 Prolapse of vaginal vault after hysterectomy genitourinary Female 0.0389 0.909 0.83,0.995 512 5125 0.03981 0.908 0.829,0.996 505 5090
618.6 Vaginal enterocele, congenital or acquired genitourinary Female 0.6012 0.979 0.905,1.06 680 6794 0.6124 0.98 0.905,1.06 669 6748
619 Noninflammatory female genital disorders genitourinary Female 0.2223 1.01 0.992,1.04 8726 87297 0.7962 0.992 0.937,1.05 1290 13401
619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament genitourinary Female 0.3097 1.04 0.963,1.12 729 7284 0.2931 1.04 0.964,1.13 686 7246
619.2 Disorders of uterus, NEC genitourinary Female 0.2153 1.02 0.987,1.06 3324 33273 0.2742 1.02 0.984,1.06 3277 33083
619.3 Noninflammatory disorders of cervix genitourinary Female 0.9954 1.0 0.962,1.04 2860 28608 0.9462 0.999 0.961,1.04 2824 28467
619.4 Noninflammatory disorders of vagina genitourinary Female 0.3664 1.02 0.974,1.07 1768 17669 0.3296 1.03 0.975,1.08 1734 17575
619.5 Noninflammatory disorders of vulva and perineum genitourinary Female 0.9099 1.0 0.948,1.06 1350 13489 0.7962 0.992 0.937,1.05 1290 13401
620 Dysplasia of female genital organs genitourinary Female 0.6546 1.05 0.836,1.33 72 720 ,
621 Endometrial hyperplasia genitourinary Female 0.1493 1.05 0.984,1.11 1129 11294 0.1202 1.05 0.987,1.12 1116 11228
622 Polyp of female genital organs genitourinary Female 0.01622 1.02 1.0,1.05 10480 104803 0.01413 1.04 1.01,1.08 3415 34175
622.1 Polyp of corpus uteri genitourinary Female 0.08913 1.02 0.997,1.04 7857 78601 0.07762 1.02 0.998,1.05 7755 78151
622.2 Mucous polyp of cervix genitourinary Female 0.02291 1.04 1.01,1.08 3442 34387 0.01413 1.04 1.01,1.08 3415 34175
623 Hypertrophy of female genital organs genitourinary Female 0.7345 1.01 0.953,1.07 1268 12684 0.826 1.01 0.949,1.07 1251 12612
624 Symptoms involving female genital tract genitourinary Female 0.7925 1.01 0.939,1.09 797 7961 0.05012 0.973 0.948,1.0 5806 58283
624.1 Dystrophy of female genital tract genitourinary Female 0.4027 0.944 0.825,1.08 237 2365 0.3334 0.933 0.812,1.07 217 2355
624.2 Atrophy of female genital tract genitourinary Female 0.3041 1.05 0.955,1.16 440 4398 0.4355 1.04 0.942,1.15 427 4367
624.9 stress incontinence, female genitourinary Female 0.05129 0.974 0.948,1.0 5865 58634 0.05012 0.973 0.948,1.0 5806 58283
625 Pain and other symptoms associated with female genital organs genitourinary Female 0.07079 1.04 0.997,1.08 2876 28740 0.5272 1.02 0.96,1.08 1173 11840
625.1 Dyspareunia genitourinary Female 0.5272 1.02 0.96,1.08 1188 11891 0.5272 1.02 0.96,1.08 1173 11840
626 Disorders of menstruation and other abnormal bleeding from female genital tract genitourinary Female 0.006918 1.02 1.01,1.04 16168 115018 0.6124 1.01 0.959,1.07 1354 13563
626.1 Irregular menstrual cycle/bleeding genitourinary Female 0.01202 1.02 1.0,1.04 14110 109918 0.1076 1.03 0.994,1.06 3778 37843
626.11 Absent or infrequent menstruation genitourinary Female 0.6934 0.961 0.789,1.17 109 1099 0.6592 0.956 0.784,1.17 108 1093
626.12 Excessive or frequent menstruation genitourinary Female 9.12E-4 1.04 1.01,1.06 9727 91749 0.001047 1.04 1.01,1.06 9656 91339
626.13 Irregular menstrual cycle genitourinary Female 0.3556 1.02 0.976,1.07 1985 19829 0.3006 1.02 0.979,1.07 1972 19737
626.14 Irregular menstrual bleeding genitourinary Female 0.1014 1.03 0.995,1.06 3804 38021 0.1076 1.03 0.994,1.06 3778 37843
626.2 Dysmenorrhea genitourinary Female 0.8035 1.01 0.959,1.06 1778 17767 0.798 1.01 0.959,1.06 1769 17689
626.4 Premenstrual tension syndromes genitourinary Female 0.01778 0.825 0.704,0.967 159 1587 0.01698 0.824 0.703,0.966 159 1579
626.8 Infertility, female genitourinary Female 0.5321 1.02 0.963,1.08 1362 13613 0.6124 1.01 0.959,1.07 1354 13563
627 Menopausal and postmenopausal disorders genitourinary Female 0.3846 1.01 0.989,1.03 10392 103948 0.6081 1.03 0.916,1.16 308 3082
627.1 Postmenopausal bleeding genitourinary Female 0.597 1.01 0.984,1.03 9042 90439 0.6561 1.0 0.983,1.03 8929 89885
627.2 Symptomatic menopause genitourinary Female 0.9397 0.994 0.853,1.16 183 1826 0.9683 0.997 0.855,1.16 181 1819
627.3 Postmenopausal atrophic vaginitis genitourinary Female 0.4178 1.03 0.965,1.09 1111 11115 0.4645 1.02 0.962,1.09 1096 11046
627.4 Premenopausal menorrhagia genitourinary Female 0.7063 1.02 0.909,1.15 310 3097 0.6081 1.03 0.916,1.16 308 3082
628 Ovarian cyst genitourinary Female 1.0E-10 1.1 1.07,1.14 4747 47482 1.047E-9 1.1 1.07,1.13 4624 47274
634 Miscarriage; stillbirth pregnancy complications Female 0.4477 0.989 0.96,1.02 5218 36422 0.3707 1.05 0.942,1.17 330 3283
634.1 Missed abortion/Hydatidiform mole pregnancy complications Female 0.2301 0.964 0.908,1.02 1136 11300 0.3027 0.969 0.912,1.03 1128 11255
634.3 Ectopic pregnancy pregnancy complications Female 0.3908 1.05 0.94,1.17 331 3305 0.3707 1.05 0.942,1.17 330 3283
635 Hemorrhage during pregnancy; childbirth and postpartum pregnancy complications Female 0.3664 0.979 0.934,1.03 1974 17372 0.9311 1.0 0.946,1.06 1266 12260
635.2 Antepartum hemorrhage, abruptio placentae, and placenta previa pregnancy complications Female 0.4592 0.974 0.909,1.04 866 8614 0.4285 0.972 0.907,1.04 863 8582
635.3 Placenta previa and abruptio placenta pregnancy complications Female 0.8851 1.0 0.948,1.06 1270 12306 0.9311 1.0 0.946,1.06 1266 12260
636 Early or threatened labor; hemorrhage in early pregnancy pregnancy complications Female 0.7228 1.01 0.966,1.05 2347 19972 0.191 1.04 0.98,1.11 1080 10712
636.2 Early onset of delivery pregnancy complications Female 0.8337 1.01 0.93,1.09 617 6144 0.826 1.01 0.93,1.1 617 6117
636.3 Hemorrhage in early pregnancy pregnancy complications Female 0.191 1.04 0.98,1.11 1082 10766 0.191 1.04 0.98,1.11 1080 10712
638 Other high-risk pregnancy pregnancy complications Female 0.4634 0.911 0.709,1.17 70 700 0.5224 0.921 0.715,1.19 68 698
642 Hypertension complicating pregnancy, childbirth, and the puerperium pregnancy complications Female 0.6339 0.985 0.927,1.05 1110 11074 0.4887 0.96 0.855,1.08 305 3045
642.1 Preeclampsia and eclampsia pregnancy complications Female 0.514 0.962 0.857,1.08 307 3058 0.4887 0.96 0.855,1.08 305 3045
643 Excessive vomiting in pregnancy pregnancy complications Female 0.7834 0.98 0.85,1.13 215 2149 0.9977 1.0 0.842,1.19 152 1518
643.1 Hyperemesis gravidarum pregnancy complications Female 0.9247 1.01 0.85,1.2 153 1525 0.9977 1.0 0.842,1.19 152 1518
645 Late pregnancy and failed induction pregnancy complications Female 0.471 0.979 0.923,1.04 1250 12450 0.4256 0.976 0.921,1.04 1246 12404
646 Other complications of pregnancy NEC pregnancy complications Female 0.3266 1.02 0.978,1.07 2228 20847 0.2754 1.02 0.981,1.07 2219 20766
647 Infectious and parasitic complications affecting pregnancy pregnancy complications Female 0.9908 1.0 0.787,1.27 68 679 0.5445 1.04 0.917,1.18 272 2743
647.1 Infections of genitourinary tract during pregnancy pregnancy complications Female 0.5715 1.04 0.915,1.17 275 2748 0.5445 1.04 0.917,1.18 272 2743
649 Other conditions or status of the mother complicating pregnancy, childbirth, or the puerperium pregnancy complications Female 0.8054 1.02 0.848,1.24 113 1129 0.9204 1.01 0.869,1.17 193 1912
649.1 Diabetes or abnormal glucose tolerance complicating pregnancy pregnancy complications Female 0.9183 1.01 0.87,1.17 193 1922 0.9204 1.01 0.869,1.17 193 1912
650 Normal delivery pregnancy complications Female 0.9099 0.997 0.952,1.05 1922 18973 0.9268 0.998 0.952,1.05 1919 18898
651 Multiple gestation pregnancy complications Female 0.2938 0.943 0.846,1.05 346 3454 0.2679 0.94 0.843,1.05 345 3446
652 Malposition and malpresentation of fetus or obstruction pregnancy complications Female 0.5272 1.02 0.967,1.07 1716 16521 0.5284 1.02 0.967,1.07 1710 16462
653 Problems associated with amniotic cavity and membranes pregnancy complications Female 0.8185 0.994 0.94,1.05 1401 13649 0.7962 0.993 0.94,1.05 1398 13601
654 Other and unspecified complications of birth; puerperium affecting management of mother pregnancy complications Female 0.5702 1.07 0.847,1.35 74 739 0.5546 1.07 0.849,1.36 74 734
655 Known or suspected fetal abnormality affecting management of mother pregnancy complications Female 0.1648 1.02 0.991,1.06 4306 29454 0.1618 1.02 0.991,1.06 4298 29329
656 Other perinatal conditions of fetus or newborn pregnancy complications Both 0.5521 0.942 0.772,1.15 109 1080 0.5508 0.941 0.772,1.15 109 1077
661 Fetal distress and abnormal forces of labor pregnancy complications Female 0.2371 1.03 0.983,1.07 2265 18397 0.2761 1.02 0.981,1.07 2259 18327
663 Umbilical cord complications during labor and delivery pregnancy complications Female 0.9247 1.0 0.919,1.1 532 5316 0.9795 0.999 0.913,1.09 529 5292
665 Obstetrical/birth trauma pregnancy complications Female 0.2213 1.02 0.989,1.05 5313 29472 0.2388 1.02 0.988,1.05 5298 29352
669 Complications of labor and delivery NEC pregnancy complications Female 0.3148 1.02 0.98,1.06 2552 21174 0.2944 1.02 0.981,1.07 2545 21091
671 Venous/cerebrovascular complications embolism in pregnancy and the puerperium pregnancy complications Female 0.865 1.01 0.867,1.18 164 1628 0.875 1.01 0.866,1.18 164 1622
674 Other complications of the puerperium NEC pregnancy complications Female 0.3999 1.06 0.93,1.2 262 2605 0.3945 1.06 0.93,1.2 262 2590
676 Other disorders of the breast associated with childbirth and disorders of lactation pregnancy complications Female 0.0195 0.73 0.56,0.951 63 624 0.01995 0.731 0.561,0.952 63 623
679 Complications of in utero procedures dermatologic Female 0.875 1.02 0.779,1.34 53 530 0.863 1.02 0.78,1.34 53 528
681 Superficial cellulitis and abscess dermatologic Both 0.9661 0.999 0.975,1.02 7200 72225 0.3076 1.05 0.96,1.14 579 5966
681.1 Cellulitis and abscess of fingers/toes dermatologic Both 0.0955 1.08 0.987,1.18 563 5647 0.113 1.07 0.983,1.17 559 5634
681.2 Cellulitis and abscess of face/neck dermatologic Both 0.7063 0.983 0.897,1.08 520 5208 0.6668 0.98 0.895,1.07 516 5195
681.3 Cellulitis and abscess of arm/hand dermatologic Both 0.6577 0.994 0.966,1.02 5481 55014 0.6266 0.993 0.966,1.02 5451 54878
681.5 Cellulitis and abscess of leg, except foot dermatologic Both 0.6998 0.995 0.967,1.02 5487 55074 0.6699 0.994 0.967,1.02 5457 54938
681.6 Cellulitis and abscess of foot, toe dermatologic Both 0.6745 0.994 0.967,1.02 5444 54643 0.6457 0.993 0.966,1.02 5414 54509
681.7 Cellulitis and abscess of trunk dermatologic Both 0.2661 1.05 0.964,1.14 597 5987 0.3076 1.05 0.96,1.14 579 5966
686 Other local infections of skin and subcutaneous tissue dermatologic Both 0.08318 1.05 0.993,1.11 1337 13427 0.2582 1.07 0.954,1.19 360 3601
686.1 Carbuncle and furuncle dermatologic Both 0.871 0.996 0.955,1.04 2284 22925 0.811 0.995 0.953,1.04 2277 22852
686.3 Pilonidal cyst dermatologic Both 0.8166 1.01 0.927,1.1 583 5837 0.7603 1.01 0.93,1.1 582 5821
686.4 Pyogenic granuloma dermatologic Both 0.2624 1.07 0.954,1.19 362 3615 0.2582 1.07 0.954,1.19 360 3601
687 Symptoms affecting skin dermatologic Both 0.7621 1.01 0.927,1.11 548 5508 0.2099 0.976 0.939,1.01 2871 28778
687.1 Rash and other nonspecific skin eruption dermatologic Both 0.6501 1.01 0.967,1.06 2146 21470 0.857 1.0 0.96,1.05 2118 21392
687.2 Localized superficial swelling, mass, or lump dermatologic Both 0.8492 1.01 0.896,1.14 283 2839 0.8892 1.01 0.893,1.14 281 2825
687.3 Changes in skin texture dermatologic Both 0.6471 0.954 0.781,1.17 106 1070 0.6427 0.954 0.78,1.17 106 1067
687.4 Disturbance of skin sensation dermatologic Both 0.2065 0.976 0.939,1.01 2884 28859 0.2099 0.976 0.939,1.01 2871 28778
689 Disorder of skin and subcutaneous tissue NOS dermatologic Both 0.7145 0.995 0.968,1.02 5747 57521 0.7328 0.995 0.969,1.02 5716 57297
690 Erythematosquamous dermatosis dermatologic Both 0.984 1.0 0.794,1.27 71 710 0.9908 1.0 0.765,1.31 53 530
690.1 Seborrheic dermatitis dermatologic Both 0.9908 1.0 0.765,1.31 53 530 0.9908 1.0 0.765,1.31 53 530
691 Congenital anomalies of skin dermatologic Both 0.3864 0.922 0.768,1.11 120 1199 0.3784 0.921 0.767,1.11 120 1198
694 Dyschromia and Vitiligo dermatologic Both 0.7447 0.989 0.925,1.06 986 9854 0.9016 1.01 0.837,1.22 115 1166
694.1 Vitiligo dermatologic Both 0.9572 0.993 0.754,1.31 60 599 0.912 1.02 0.77,1.34 59 599
694.2 Other dyschromia dermatologic Both 0.7482 0.988 0.917,1.06 782 7821 0.7311 0.987 0.916,1.06 780 7782
694.3 Vascular disorders of skin dermatologic Both 0.8974 1.01 0.839,1.22 117 1170 0.9016 1.01 0.837,1.22 115 1166
695 Erythematous conditions dermatologic Both 0.3013 1.02 0.98,1.07 2379 23813 0.5572 1.03 0.935,1.13 457 4658
695.1 Toxic erythema dermatologic Both 0.4797 0.933 0.768,1.13 109 1090 0.52 0.938 0.773,1.14 108 1085
695.2 Bullous dermatoses dermatologic Both 0.5433 0.948 0.798,1.13 137 1365 0.2051 0.862 0.684,1.09 72 727
695.21 Dermatitis herpetiformis dermatologic Both 0.6855 1.06 0.801,1.4 57 569 0.673 1.06 0.803,1.4 57 567
695.22 Pemphigus and pemphigoid dermatologic Both 0.2624 0.877 0.697,1.1 73 727 0.2051 0.862 0.684,1.09 72 727
695.3 Rosacea dermatologic Both 0.1679 1.09 0.966,1.22 309 3097 0.171 1.09 0.965,1.22 308 3083
695.4 Lupus (localized and systemic) dermatologic Both 0.8072 1.01 0.913,1.12 411 4114 0.9908 1.0 0.891,1.12 338 3389
695.41 Cutaneous lupus erythematosus dermatologic Both 0.5675 0.95 0.796,1.13 130 1295 0.5888 0.952 0.797,1.14 130 1288
695.42 Systemic lupus erythematosus dermatologic Both 0.9268 0.995 0.886,1.12 340 3407 0.9908 1.0 0.891,1.12 338 3389
695.7 Prurigo and Lichen dermatologic Both 0.3963 1.03 0.959,1.11 775 7760 0.3681 1.03 0.961,1.11 765 7721
695.8 Other specified erythematous conditions dermatologic Both 0.2183 0.921 0.808,1.05 236 2359 0.1279 0.833 0.658,1.05 76 758
695.81 Erythema nodosum dermatologic Both 0.1324 0.835 0.66,1.06 76 760 0.1279 0.833 0.658,1.05 76 758
695.9 Unspecified erythematous condition dermatologic Both 0.3846 1.04 0.948,1.15 467 4672 0.5572 1.03 0.935,1.13 457 4658
696 Psoriasis and related disorders dermatologic Both 0.5093 0.986 0.944,1.03 2252 22509 0.3141 0.961 0.889,1.04 706 7027
696.4 Psoriasis dermatologic Both 0.4699 0.984 0.942,1.03 2198 21969 0.3141 0.961 0.889,1.04 706 7027
696.41 Psoriasis vulgaris dermatologic Both 0.875 0.996 0.947,1.05 1680 16796 0.9462 0.998 0.949,1.05 1673 16748
696.42 Psoriatic arthropathy dermatologic Both 0.3027 0.96 0.889,1.04 706 7052 0.3141 0.961 0.889,1.04 706 7027
697 Sarcoidosis dermatologic Both 0.8204 1.01 0.924,1.1 539 5373 0.8933 1.01 0.92,1.1 534 5353
698 Pruritus and related conditions dermatologic Both 0.9162 0.996 0.926,1.07 782 7814 0.9506 0.998 0.927,1.07 773 7793
700 Corns and callosities dermatologic Both 0.5508 1.04 0.92,1.17 291 2904 0.514 1.04 0.923,1.17 288 2885
701 Other hypertrophic and atrophic conditions of skin dermatologic Both 0.2704 0.983 0.954,1.01 4663 46650 0.6808 1.04 0.854,1.27 101 1017
701.1 Keratoderma, acquired dermatologic Both 0.1991 1.15 0.928,1.43 87 870 0.1622 1.17 0.939,1.45 86 869
701.2 Scar conditions and fibrosis of skin dermatologic Both 0.9506 1.0 0.959,1.05 2348 23478 0.9057 1.0 0.961,1.05 2333 23376
701.3 Circumscribed scleroderma dermatologic Both 0.271 1.16 0.89,1.51 61 610 0.2432 1.17 0.898,1.53 60 607
701.4 Keloid scar dermatologic Both 0.5164 0.955 0.831,1.1 216 2159 0.5358 0.957 0.833,1.1 216 2150
701.5 Abnormal granulation tissue dermatologic Both 0.5649 1.03 0.934,1.13 455 4568 0.5395 1.03 0.935,1.14 452 4547
701.6 Acquired acanthosis nigricans dermatologic Both 0.6339 1.05 0.86,1.28 102 1019 0.6808 1.04 0.854,1.27 101 1017
702 Degenerative skin conditions and other dermatoses dermatologic Both 0.3273 0.986 0.959,1.01 5459 54587 0.09333 0.969 0.933,1.01 3061 30653
702.1 Actinic keratosis dermatologic Both 0.5623 1.01 0.972,1.05 2585 25842 0.5458 1.01 0.972,1.05 2550 25737
702.2 Seborrheic keratosis dermatologic Both 0.0871 0.968 0.933,1.0 3078 30772 0.09333 0.969 0.933,1.01 3061 30653
703 Diseases of nail, NOS dermatologic Both 0.2972 0.944 0.847,1.05 354 3539 0.9705 0.999 0.935,1.07 960 9626
703.1 Ingrowing nail dermatologic Both 0.9057 0.996 0.933,1.06 966 9660 0.9705 0.999 0.935,1.07 960 9626
704 Diseases of hair and hair follicles dermatologic Both 0.9931 1.0 0.972,1.03 5267 52727 0.8356 0.975 0.769,1.24 76 757
704.1 Alopecia dermatologic Both 0.6531 0.96 0.802,1.15 125 1269 0.8356 0.981 0.819,1.17 123 1263
704.8 Other specified diseases of hair and hair follicles dermatologic Both 0.8395 0.976 0.77,1.24 76 759 0.8356 0.975 0.769,1.24 76 757
705 Disorders of sweat glands dermatologic Both 0.05012 0.873 0.761,1.0 228 2287 0.9441 0.997 0.916,1.09 588 5905
705.3 Hidradenitis dermatologic Both 0.2032 0.906 0.778,1.05 186 1868 0.2541 0.915 0.786,1.07 185 1860
705.8 Hyperhidrosis dermatologic Both 0.8851 0.994 0.913,1.08 591 5919 0.9441 0.997 0.916,1.09 588 5905
706 Diseases of sebaceous glands dermatologic Both 0.6683 0.995 0.973,1.02 8317 83195 0.6653 0.995 0.973,1.02 8752 87572
706.1 Acne dermatologic Both 0.7161 0.959 0.766,1.2 78 779 0.7194 0.96 0.766,1.2 78 776
706.2 Sebaceous cyst dermatologic Both 0.7063 0.996 0.974,1.02 8787 87882 0.6653 0.995 0.973,1.02 8752 87572
707 Chronic ulcer of skin dermatologic Both 0.6808 1.01 0.964,1.06 1953 19654 0.8147 0.992 0.927,1.06 901 9065
707.1 Decubitus ulcer dermatologic Both 0.7586 0.989 0.925,1.06 909 9097 0.8147 0.992 0.927,1.06 901 9065
709 Diffuse diseases of connective tissue dermatologic Both 0.537 0.989 0.955,1.02 3432 34317 0.3565 0.982 0.944,1.02 2702 27034
709.2 Sicca syndrome dermatologic Both 0.9311 0.996 0.909,1.09 508 5073 0.798 0.988 0.901,1.08 503 5045
709.3 Systemic sclerosis dermatologic Both 0.2265 1.1 0.941,1.29 176 1753 0.2254 1.1 0.942,1.29 176 1745
709.6 Other specified diffuse diseases of connective tissue dermatologic Both 0.5093 1.09 0.844,1.41 65 649 0.5715 1.08 0.833,1.39 64 647
709.7 Unspecified diffuse connective tissue disease dermatologic Both 0.3459 0.981 0.944,1.02 2714 27144 0.3565 0.982 0.944,1.02 2702 27034
939 Atopic/contact dermatitis due to other or unspecified dermatologic Both 0.6209 1.01 0.967,1.06 2094 20961 0.6471 1.01 0.966,1.06 2077 20896
710 Osteomyelitis, periostitis, and other infections involving bone musculoskeletal Both 0.177 1.06 0.974,1.15 602 6034 0.05623 1.11 0.997,1.23 398 3986
710.1 Osteomyelitis musculoskeletal Both 0.1191 1.07 0.982,1.17 556 5574 0.05623 1.11 0.997,1.23 398 3986
710.12 Chronic osteomyelitis musculoskeletal Both 0.3357 1.07 0.928,1.24 194 1947 0.3251 1.08 0.93,1.25 194 1943
710.19 Unspecified osteomyelitis musculoskeletal Both 0.0537 1.11 0.998,1.23 398 3997 0.05623 1.11 0.997,1.23 398 3986
711 Arthropathy associated with infections musculoskeletal Both 0.4355 1.04 0.941,1.15 421 4225 0.8147 0.987 0.881,1.11 326 3291
711.1 Pyogenic arthritis musculoskeletal Both 0.7816 0.984 0.879,1.1 328 3296 0.8147 0.987 0.881,1.11 326 3291
712 Infective connective tissue disorders musculoskeletal Both 0.02754 0.777 0.621,0.973 81 810 0.03162 0.781 0.624,0.979 80 809
713 Arthropathy associated with other disorders classified elsewhere musculoskeletal Both 0.9397 0.994 0.842,1.17 148 1499 0.6776 1.05 0.825,1.34 65 668
713.5 Arthropathy associated with neurological disorders musculoskeletal Both 0.6839 1.05 0.825,1.34 65 669 0.6776 1.05 0.825,1.34 65 668
714 Rheumatoid arthritis and other inflammatory polyarthropathies musculoskeletal Both 0.9705 1.0 0.971,1.03 4832 48320 0.8017 1.0 0.973,1.04 4337 43505
714.1 Rheumatoid arthritis musculoskeletal Both 0.8892 1.0 0.972,1.03 4372 43714 0.8017 1.0 0.973,1.04 4337 43505
715 Other inflammatory spondylopathies musculoskeletal Both 0.1432 1.04 0.987,1.09 1659 16588 8.913E-4 1.15 1.06,1.25 617 6163
715.1 Sacroiliitis NEC musculoskeletal Both 0.7311 1.04 0.849,1.26 113 1129 0.7063 1.04 0.852,1.27 113 1122
715.2 Ankylosing spondylitis musculoskeletal Both 9.333E-4 1.15 1.06,1.25 618 6177 8.913E-4 1.15 1.06,1.25 617 6163
716 Other arthropathies musculoskeletal Both 0.8831 0.999 0.988,1.01 37478 265375 0.877 0.999 0.988,1.01 35757 261420
716.1 Unspecified polyarthropathy or polyarthritis musculoskeletal Both 0.861 0.997 0.963,1.03 3505 35090 0.7925 0.995 0.961,1.03 3487 34930
716.2 Unspecified monoarthritis musculoskeletal Both 0.8492 0.998 0.982,1.02 15522 155339 0.8892 0.999 0.982,1.02 15475 154827
716.9 Arthropathy NOS musculoskeletal Both 0.9141 0.999 0.988,1.01 35944 262308 0.877 0.999 0.988,1.01 35757 261420
717 Polymyalgia Rheumatica musculoskeletal Both 0.3499 1.03 0.969,1.09 1145 11480 0.3639 1.03 0.968,1.09 1133 11425
720 Spinal stenosis musculoskeletal Both 0.03162 0.964 0.932,0.997 3705 37091 0.03236 0.964 0.932,0.997 3690 36943
721 Spondylosis and allied disorders musculoskeletal Both 0.1517 0.983 0.961,1.01 7832 78318 0.00537 0.855 0.766,0.955 350 3504
721.1 Spondylosis without myelopathy musculoskeletal Both 0.4887 0.99 0.962,1.02 5045 50451 0.4064 0.988 0.959,1.02 5010 50255
721.2 Spondylosis with myelopathy musculoskeletal Both 0.2944 1.09 0.931,1.26 189 1899 0.3055 1.08 0.929,1.26 188 1896
721.8 Other allied disorders of spine musculoskeletal Both 0.004677 0.854 0.765,0.953 352 3519 0.00537 0.855 0.766,0.955 350 3504
722 Intervertebral disc disorders musculoskeletal Both 0.4074 0.991 0.97,1.01 8978 89848 0.9705 1.0 0.97,1.03 4391 43976
722.1 Displacement of intervertebral disc musculoskeletal Both 0.6745 0.981 0.895,1.07 512 5116 0.6546 0.979 0.894,1.07 510 5101
722.6 Degeneration of intervertebral disc musculoskeletal Both 0.7413 0.994 0.956,1.03 2831 28328 0.7464 0.994 0.956,1.03 2820 28204
722.8 Postlaminectomy syndrome musculoskeletal Both 0.04467 0.783 0.617,0.994 67 669 0.04571 0.784 0.618,0.995 67 662
722.9 Other and unspecified disc disorder musculoskeletal Both 0.9441 0.999 0.968,1.03 4407 44127 0.9705 1.0 0.97,1.03 4391 43976
723 Other disorders of cervical region musculoskeletal Both 0.9954 1.0 0.915,1.09 517 5173 0.3499 0.912 0.753,1.11 107 1065
723.1 Torticollis musculoskeletal Both 0.3436 0.911 0.752,1.1 107 1068 0.3499 0.912 0.753,1.11 107 1065
724 Other and unspecified disorders of back musculoskeletal Both 0.3184 0.977 0.934,1.02 2052 20514 0.3508 0.976 0.928,1.03 1608 16088
724.1 Disorders of sacrum musculoskeletal Both 0.7998 0.987 0.891,1.09 403 4024 0.743 0.983 0.887,1.09 400 4002
724.2 Disorders of coccyx musculoskeletal Both 0.7816 0.986 0.891,1.09 406 4054 0.7328 0.982 0.888,1.09 403 4031
724.8 Other symptoms referable to back musculoskeletal Both 0.9247 1.01 0.79,1.3 63 630 0.9705 0.995 0.775,1.28 62 629
724.9 Other unspecified back disorders musculoskeletal Both 0.3281 0.975 0.927,1.03 1614 16139 0.3508 0.976 0.928,1.03 1608 16088
726 Peripheral enthesopathies and allied syndromes musculoskeletal Both 0.0263 1.02 1.0,1.04 14663 146691 0.8166 1.01 0.94,1.08 851 8557
726.1 Enthesopathy musculoskeletal Both 0.06166 1.02 0.999,1.04 9589 95900 0.06166 1.02 0.999,1.04 9557 95565
726.2 Synoviopathy musculoskeletal Both 0.08913 1.1 0.986,1.23 334 3336 0.09333 1.1 0.984,1.23 333 3318
726.3 Bursitis musculoskeletal Both 0.8375 1.01 0.939,1.08 854 8573 0.8166 1.01 0.94,1.08 851 8557
727 Other disorders of synovium, tendon, and bursa musculoskeletal Both 0.826 0.997 0.974,1.02 7331 73332 0.3475 1.08 0.916,1.28 143 1427
727.1 Synovitis and tenosynovitis musculoskeletal Both 0.7816 1.01 0.967,1.05 2737 27406 0.7534 1.01 0.967,1.05 2727 27296
727.2 Bursitis disorders musculoskeletal Both 0.6871 0.96 0.786,1.17 103 1029 0.6745 0.958 0.785,1.17 103 1022
727.4 Ganglion and cyst of synovium, tendon, and bursa musculoskeletal Both 0.7079 0.993 0.957,1.03 3109 31085 0.6823 0.992 0.956,1.03 3090 30947
727.5 Rupture of synovium musculoskeletal Both 0.3631 1.04 0.955,1.13 586 5854 0.3715 1.04 0.955,1.13 583 5838
727.6 Rupture of tendon, nontraumatic musculoskeletal Both 0.2535 0.938 0.841,1.05 353 3527 0.2541 0.938 0.841,1.05 353 3508
727.7 Contracture of tendon (sheath) musculoskeletal Both 0.3467 1.08 0.916,1.28 143 1429 0.3475 1.08 0.916,1.28 143 1427
728 Disorders of muscle, ligament, and fascia musculoskeletal Both 0.06918 0.969 0.937,1.0 3677 36788 0.2427 0.979 0.946,1.01 3471 34724
728.2 Laxity of ligament or hypermobility syndrome musculoskeletal Both 0.3793 1.05 0.946,1.16 412 4115 0.3656 1.05 0.947,1.16 411 4101
728.7 Fasciitis musculoskeletal Both 0.2123 0.979 0.947,1.01 3803 38045 0.2427 0.979 0.946,1.01 3471 34724
728.71 Contracture of palmar fascia [Dupuytren's disease] musculoskeletal Both 0.2477 0.98 0.946,1.01 3477 34788 0.2427 0.979 0.946,1.01 3471 34724
729 Other disorders of soft tissues musculoskeletal Both 0.1614 1.02 0.992,1.05 6014 60309 0.2018 0.874 0.711,1.07 101 1008
729.1 Rheumatism, unspecified and fibrositis musculoskeletal Both 0.912 1.0 0.941,1.07 1005 10063 0.861 1.01 0.943,1.07 996 10006
729.3 Panniculitis musculoskeletal Both 0.2037 0.875 0.712,1.08 101 1009 0.2018 0.874 0.711,1.07 101 1008
731 Osteitis deformans and osteopathies associated with other disorders classified elsewhere musculoskeletal Both 0.867 1.01 0.895,1.14 276 2758 0.7762 0.982 0.863,1.12 253 2594
731.1 Osteitis deformans [Paget's disease of bone] musculoskeletal Both 0.9333 1.01 0.886,1.14 261 2609 0.7762 0.982 0.863,1.12 253 2594
732 Osteochondropathies musculoskeletal Both 0.1167 0.927 0.843,1.02 467 4679 0.471 1.1 0.845,1.44 57 569
732.1 Juvenile osteochondrosis musculoskeletal Both 0.3155 0.929 0.804,1.07 207 2068 0.354 0.934 0.809,1.08 206 2058
732.7 Osteochondritis dissecans musculoskeletal Both 0.4786 1.1 0.844,1.44 57 570 0.471 1.1 0.845,1.44 57 569
733 Other disorders of bone and cartilage musculoskeletal Both 0.1259 0.963 0.917,1.01 1777 17814 0.9397 1.01 0.834,1.22 121 1203
733.2 Cyst of bone musculoskeletal Both 0.07244 0.901 0.803,1.01 311 3115 0.07762 0.902 0.805,1.01 311 3101
733.4 Aseptic necrosis of bone musculoskeletal Both 0.9661 1.0 0.917,1.09 540 5393 0.877 1.01 0.921,1.1 538 5378
733.6 Costochondritis musculoskeletal Both 0.1923 1.13 0.941,1.35 128 1276 0.1849 1.13 0.943,1.36 128 1272
733.8 Malunion and nonunion of fracture musculoskeletal Both 0.7278 1.01 0.953,1.07 1231 12313 0.6166 1.02 0.957,1.08 1223 12276
733.9 Chondromalacia musculoskeletal Both 0.9484 1.01 0.833,1.21 121 1206 0.9397 1.01 0.834,1.22 121 1203
735 Acquired foot deformities musculoskeletal Both 0.8433 0.998 0.977,1.02 9603 96090 0.6295 0.994 0.969,1.02 6604 66049
735.1 Flat foot musculoskeletal Both 0.873 0.988 0.85,1.15 189 1910 0.8395 0.985 0.847,1.14 188 1899
735.2 Acquired toe deformities musculoskeletal Both 0.9311 1.0 0.973,1.03 5070 50712 0.9268 0.998 0.947,1.05 1547 15448
735.21 Hammer toe (acquired) musculoskeletal Both 0.6918 0.991 0.945,1.04 1929 19324 0.6982 0.991 0.945,1.04 1916 19213
735.23 Hallux rigidus musculoskeletal Both 0.875 0.996 0.945,1.05 1555 15527 0.9268 0.998 0.947,1.05 1547 15448
735.3 Hallux valgus (Bunion) musculoskeletal Both 0.5358 0.992 0.967,1.02 6643 66463 0.6295 0.994 0.969,1.02 6604 66049
736 Other acquired deformities of limbs musculoskeletal Both 0.07943 0.956 0.908,1.01 1627 16282 0.5408 0.959 0.839,1.1 247 2468
736.2 Acquired deformities of finger musculoskeletal Both 0.5224 0.957 0.838,1.09 248 2476 0.5408 0.959 0.839,1.1 247 2468
737 Curvature of spine musculoskeletal Both 0.4207 0.975 0.918,1.04 1128 11300 0.3681 0.971 0.912,1.03 1055 10567
737.3 Kyphoscoliosis and scoliosis musculoskeletal Both 0.3027 0.967 0.908,1.03 1061 10632 0.3681 0.971 0.912,1.03 1055 10567
738 Other acquired musculoskeletal deformity musculoskeletal Both 0.7261 1.01 0.962,1.06 1904 19058 0.9183 0.997 0.946,1.05 1504 15072
738.4 Acquired spondylolisthesis musculoskeletal Both 0.9441 0.998 0.947,1.05 1513 15147 0.9183 0.997 0.946,1.05 1504 15072
739 Contracture of joint musculoskeletal Both 0.07586 0.92 0.839,1.01 488 4884 0.07943 0.92 0.839,1.01 483 4869
740 Osteoarthrosis musculoskeletal Both 0.863 1.0 0.989,1.01 27707 231603 0.9441 1.0 0.982,1.02 12185 122272
740.1 Osteoarthritis; localized musculoskeletal Both 0.7603 1.0 0.987,1.02 17412 169419 0.02455 1.13 1.02,1.26 346 3463
740.11 Osteoarthrosis, localized, primary musculoskeletal Both 0.3981 1.01 0.988,1.03 8974 89750 0.3581 1.01 0.989,1.03 8941 89391
740.12 Osteoarthrosis, localized, secondary musculoskeletal Both 0.02512 1.13 1.02,1.26 348 3474 0.02455 1.13 1.02,1.26 346 3463
740.2 Osteoarthrosis, generalized musculoskeletal Both 0.2884 1.05 0.962,1.14 598 5969 0.2767 1.05 0.963,1.14 592 5944
740.9 Osteoarthrosis NOS musculoskeletal Both 0.8831 1.0 0.983,1.02 12270 122792 0.9441 1.0 0.982,1.02 12185 122272
741 Symptoms and disorders of the joints musculoskeletal Both 0.3083 1.02 0.984,1.05 3563 35648 0.1104 1.25 0.95,1.65 54 532
741.1 Ankylosis of joint musculoskeletal Both 0.8511 0.981 0.8,1.2 102 1019 0.857 0.981 0.8,1.2 102 1017
741.2 Stiffness of joint musculoskeletal Both 0.4246 0.967 0.89,1.05 614 6146 0.375 0.963 0.887,1.05 612 6119
741.3 Difficulty in walking musculoskeletal Both 0.8337 1.02 0.864,1.2 154 1540 0.9419 1.01 0.854,1.19 153 1533
741.4 Joint effusions musculoskeletal Both 0.3899 1.02 0.97,1.08 1418 14197 0.4074 1.02 0.969,1.08 1414 14153
741.5 Hemarthrosis musculoskeletal Both 0.4207 1.08 0.891,1.32 110 1100 0.413 1.08 0.893,1.32 110 1098
741.6 Villonodular synovitis musculoskeletal Both 0.1112 1.25 0.949,1.65 54 535 0.1104 1.25 0.95,1.65 54 532
742 Derangement of joint, non-traumatic musculoskeletal Both 0.2183 0.976 0.939,1.01 2843 28441 0.2483 0.973 0.93,1.02 1990 19863
742.1 Loose body in joint musculoskeletal Both 0.4385 0.956 0.854,1.07 333 3337 0.4446 0.957 0.854,1.07 333 3329
742.2 Pathological, developmental or recurrent dislocation musculoskeletal Both 0.561 1.06 0.862,1.32 95 960 0.5689 1.06 0.861,1.31 95 955
742.8 Articular cartilage disorder musculoskeletal Both 0.8511 1.01 0.92,1.11 500 4996 0.8453 1.01 0.92,1.11 498 4980
742.9 Other derangement of joint musculoskeletal Both 0.2523 0.974 0.93,1.02 1993 19926 0.2483 0.973 0.93,1.02 1990 19863
743 Osteoporosis, osteopenia and pathological fracture musculoskeletal Both 0.6281 0.994 0.971,1.02 7563 75729 0.8318 1.01 0.937,1.08 812 8107
743.1 Osteoporosis musculoskeletal Both 0.4325 0.99 0.965,1.02 6400 64107 0.5875 0.976 0.895,1.06 523 5264
743.11 Osteoporosis NOS musculoskeletal Both 0.413 0.989 0.962,1.02 5549 55604 0.4909 0.99 0.963,1.02 5494 55231
743.13 Other specified osteoporosis musculoskeletal Both 0.5781 0.976 0.895,1.06 529 5283 0.5875 0.976 0.895,1.06 523 5264
743.2 Pathologic fracture musculoskeletal Both 0.9419 1.0 0.919,1.1 516 5179 0.865 1.01 0.922,1.1 508 5155
743.9 Osteopenia or other disorder of bone and cartilage musculoskeletal Both 0.8054 1.01 0.938,1.09 815 8144 0.8318 1.01 0.937,1.08 812 8107
745 Pain in joint musculoskeletal Both 0.861 1.0 0.979,1.03 7975 79789 0.8204 1.0 0.98,1.03 7941 79486
747 Cardiac and circulatory congenital anomalies congenital anomalies Both 0.4732 1.01 0.976,1.05 2802 28058 0.8035 1.02 0.869,1.2 164 1677
747.1 Cardiac congenital anomalies congenital anomalies Both 0.5768 1.01 0.972,1.05 2628 26323 0.9376 1.0 0.954,1.05 1810 18150
747.11 Cardiac shunt/ heart septal defect congenital anomalies Both 0.1945 1.06 0.972,1.15 584 5838 0.177 1.06 0.974,1.16 583 5815
747.12 Valvular heart disease/ heart chambers congenital anomalies Both 0.7925 0.982 0.859,1.12 235 2358 0.8054 0.983 0.86,1.12 234 2352
747.13 Congenital anomalies of great vessels congenital anomalies Both 0.9594 1.0 0.954,1.05 1816 18200 0.9376 1.0 0.954,1.05 1810 18150
747.2 Congenital anomalies of peripheral vascular system congenital anomalies Both 0.7482 1.03 0.875,1.2 167 1680 0.8035 1.02 0.869,1.2 164 1677
748 Anomalies of respiratory system, congenital congenital anomalies Both 0.2296 1.2 0.892,1.61 51 510 0.2239 1.2 0.894,1.61 51 507
749 Congenital anomalies of face and neck congenital anomalies Both 0.3184 0.942 0.838,1.06 303 3029 0.3412 0.945 0.84,1.06 303 3015
750 Digestive congenital anomalies congenital anomalies Both 0.02138 1.1 1.01,1.19 686 6870 0.1486 1.15 0.953,1.38 116 1172
750.1 Upper gastrointestinal congenital anomalies congenital anomalies Both 0.3055 1.06 0.947,1.19 327 3263 0.4519 1.06 0.912,1.23 189 1906
750.13 Congenital anomalies of mouth/tongue congenital anomalies Both 0.3243 1.08 0.929,1.25 191 1909 0.4519 1.06 0.912,1.23 189 1906
750.2 Lower gastrointestinal congenital anomalies congenital anomalies Both 0.02754 1.13 1.01,1.26 356 3574 0.1486 1.15 0.953,1.38 116 1172
750.21 Congenital anomalies of intestine congenital anomalies Both 0.1038 1.12 0.977,1.28 225 2256 0.1262 1.11 0.971,1.27 223 2248
750.22 Congenital anomaly of gallbladder, bile ducts, liver, pancreas congenital anomalies Both 0.1531 1.14 0.951,1.37 117 1179 0.1486 1.15 0.953,1.38 116 1172
751 Genitourinary congenital anomalies congenital anomalies Both 0.8147 0.994 0.943,1.05 1527 15286 0.7852 1.02 0.908,1.14 332 3339
751.1 Congenital anomalies of genital organs congenital anomalies Both 0.6339 1.02 0.943,1.1 694 6932 0.5689 1.04 0.91,1.19 222 2217
751.11 Congenital anomalies of female genital organs congenital anomalies Female 0.5093 1.03 0.939,1.14 455 4546 0.4688 1.04 0.941,1.14 452 4525
751.12 Congenital anomalies of male genital organs congenital anomalies Male 0.5689 1.04 0.91,1.19 222 2217 0.5689 1.04 0.91,1.19 222 2217
751.2 Congenital anomalies of urinary system congenital anomalies Both 0.7063 0.986 0.919,1.06 836 8385 0.7852 1.02 0.908,1.14 332 3339
751.21 Cystic kidney disease congenital anomalies Both 0.4966 0.966 0.874,1.07 424 4246 0.514 0.967 0.875,1.07 421 4233
751.22 Other specified congenital anomalies of kidney congenital anomalies Both 0.743 1.02 0.911,1.14 333 3346 0.7852 1.02 0.908,1.14 332 3339
752 Nervous system congenital anomalies congenital anomalies Both 0.6026 0.969 0.861,1.09 328 3307 0.9705 0.995 0.787,1.26 78 777
752.1 Neural tube defects congenital anomalies Both 0.7295 0.977 0.856,1.12 253 2557 0.9141 1.01 0.872,1.16 207 2098
752.11 Spina bifida congenital anomalies Both 0.8995 1.01 0.874,1.17 208 2108 0.9141 1.01 0.872,1.16 207 2098
752.2 Other specified congenital anomalies of nervous system congenital anomalies Both 0.9419 0.991 0.783,1.25 78 780 0.9705 0.995 0.787,1.26 78 777
753 Congenital anomalies of the eye congenital anomalies Both 0.4677 0.937 0.787,1.12 127 1270 0.631 1.06 0.846,1.32 76 759
753.1 Congenital cataract and lens anomalies congenital anomalies Both 0.6353 1.06 0.846,1.32 76 760 0.631 1.06 0.846,1.32 76 759
754 Congenital musculoskeletal deformities of spine congenital anomalies Both 0.4624 1.08 0.884,1.31 109 1099 0.4887 1.07 0.88,1.31 108 1096
755 Congenital anomalies of limbs congenital anomalies Both 0.6792 1.02 0.924,1.13 425 4276 0.6368 1.05 0.861,1.28 106 1064
755.1 Congenital deformities of feet congenital anomalies Both 0.3373 0.932 0.806,1.08 208 2086 0.3258 0.93 0.804,1.07 207 2078
755.6 Other congenital anomalies of lower limb, including pelvic girdle congenital anomalies Both 0.5236 1.05 0.896,1.24 160 1620 0.6368 1.05 0.861,1.28 106 1064
755.61 Congenital hip dysplasia and deformity congenital anomalies Both 0.6109 1.05 0.865,1.28 106 1070 0.6368 1.05 0.861,1.28 106 1064
756 Other congenital musculoskeletal anomalies congenital anomalies Both 0.2193 0.948 0.872,1.03 587 5872 0.08913 0.918 0.832,1.01 432 4339
756.3 Congenital anomalies of muscle, tendon, fascia, and connective tissue congenital anomalies Both 0.673 1.05 0.837,1.32 81 810 0.6745 1.05 0.836,1.32 81 807
756.5 Congenital osteodystrophies congenital anomalies Both 0.1026 0.921 0.835,1.02 435 4356 0.08913 0.918 0.832,1.01 432 4339
758 Chromosomal anomalies and genetic disorders congenital anomalies Both 0.05012 1.18 1.0,1.38 148 1708 0.03162 1.31 1.02,1.68 60 825
758.1 Chromosomal anomalies congenital anomalies Both 0.0309 1.31 1.02,1.68 60 830 0.03162 1.31 1.02,1.68 60 825
759 Other and unspecified congenital anomalies congenital anomalies Both 0.335 1.07 0.929,1.24 216 2159 0.4581 1.08 0.875,1.35 96 955
759.1 Anomalies of endocrine glands, congenital congenital anomalies Both 0.4764 1.08 0.872,1.34 96 959 0.4581 1.08 0.875,1.35 96 955
760 Back pain symptoms Both 0.9661 1.0 0.981,1.02 11126 111353 0.869 1.0 0.982,1.02 11067 110933
761 Cervicalgia symptoms Both 0.929 1.0 0.955,1.05 1791 17901 0.8337 1.01 0.958,1.06 1779 17834
764 Sciatica symptoms Both 0.984 1.0 0.959,1.04 2372 23732 0.9638 0.999 0.958,1.04 2365 23646
766 Neuralgia, neuritis, and radiculitis NOS symptoms Both 0.3396 0.971 0.915,1.03 1172 11738 0.3412 0.971 0.915,1.03 1168 11685
770 Myalgia and myositis unspecified symptoms Both 0.1945 0.947 0.873,1.03 631 6311 0.1521 0.942 0.868,1.02 628 6295
771 Musculoskeletal symptoms referable to limbs symptoms Both 0.4365 1.03 0.959,1.1 870 8687 0.1738 1.02 0.991,1.05 4576 46170
771.1 Swelling of limb symptoms Both 0.1503 1.02 0.992,1.05 4617 46330 0.1738 1.02 0.991,1.05 4576 46170
772 Symptoms of the muscles symptoms Both 0.1954 1.05 0.973,1.14 659 6581 0.2084 1.05 0.972,1.14 654 6558
773 Pain in limb symptoms Both 0.7691 1.0 0.978,1.03 6209 62203 0.7709 1.0 0.978,1.03 6177 61969
780 Hypothermia/Chills symptoms Both 0.8318 1.02 0.87,1.19 171 1719 0.8166 1.02 0.872,1.19 171 1714
781 Symptoms involving nervous and musculoskeletal systems symptoms Both 0.7962 1.01 0.96,1.05 1870 18715 0.8147 1.01 0.959,1.05 1862 18658
782.3 Edema symptoms Both 0.1603 1.04 0.986,1.09 1642 16450 0.138 1.04 0.988,1.09 1614 16395
782.6 Pallor and flushing symptoms Both 0.2767 1.09 0.934,1.27 175 1748 0.2754 1.09 0.934,1.27 174 1743
783 Fever of unknown origin symptoms Both 0.227 1.02 0.988,1.05 3911 39105 0.2786 1.02 0.985,1.05 3826 38989
785 Abdominal pain symptoms Both 0.6653 1.0 0.992,1.01 40080 301686 0.6501 1.0 0.992,1.01 39766 300783
788 Syncope and collapse symptoms Both 0.4375 1.01 0.987,1.03 9069 90813 0.4188 1.01 0.987,1.03 9025 90554
789 Nausea and vomiting symptoms Both 0.9311 0.999 0.98,1.02 11577 115807 0.9441 1.0 0.982,1.02 11364 115403
790 Nonspecific findings on examination of blood symptoms Both 0.9795 0.998 0.846,1.18 150 1500 0.2061 1.02 0.991,1.04 6309 63539
790.1 Elevated sedimentation rate symptoms Both 0.5702 1.07 0.855,1.33 84 840 0.5433 1.07 0.858,1.34 84 835
790.6 Other abnormal blood chemistry symptoms Both 0.1897 1.02 0.992,1.04 6357 63635 0.2061 1.02 0.991,1.04 6309 63539
791 Gangrene symptoms Both 0.7015 0.983 0.901,1.07 549 5501 0.7447 0.985 0.903,1.08 545 5487
792 Abnormal Papanicolaou smear of cervix and cervical HPV symptoms Female 0.2377 1.14 0.917,1.42 98 966 0.1698 1.17 0.936,1.45 95 966
793 Nonspecific abnormal findings on radiological and other examination of musculoskeletal system symptoms Both 0.5559 0.949 0.798,1.13 134 1340 0.05888 0.919 0.842,1.0 560 5624
793.2 Nonspecific abnormal findings on radiological and other examination of other intrathoracic organs (echocardiogram, etc) symptoms Both 0.07244 0.923 0.846,1.01 565 5647 0.05888 0.919 0.842,1.0 560 5624
794 Abnormal results of other function studies (bladder, pancreas, placenta, spleen, etc) symptoms Both 0.2014 1.13 0.936,1.37 120 1198 0.1959 1.13 0.937,1.37 119 1191
797 Shock symptoms Both 0.7852 0.977 0.828,1.15 156 1559 0.2495 0.889 0.729,1.09 102 1019
797.1 Cardiogenic shock symptoms Both 0.2506 0.89 0.729,1.09 102 1020 0.2495 0.889 0.729,1.09 102 1019
798 Malaise and fatigue symptoms Both 0.4217 1.01 0.979,1.05 3408 34103 0.8375 1.01 0.927,1.1 588 5885
798.1 Chronic fatigue syndrome symptoms Both 0.7889 1.01 0.93,1.1 591 5913 0.8375 1.01 0.927,1.1 588 5885
800 Fracture of lower limb injuries & poisonings Both 0.4603 0.991 0.967,1.02 7035 70329 0.7516 0.988 0.917,1.06 766 7632
800.1 Fracture of neck of femur injuries & poisonings Both 0.5321 0.985 0.938,1.03 1815 18152 0.5236 0.984 0.938,1.03 1798 18070
800.2 Fracture of unspecified part of femur injuries & poisonings Both 0.4074 0.938 0.807,1.09 170 1693 0.4276 0.941 0.809,1.09 169 1686
800.3 Fracture of tibia and fibula injuries & poisonings Both 0.5834 0.988 0.945,1.03 2158 21577 0.6067 0.988 0.946,1.03 2146 21523
800.4 Fracture of patella injuries & poisonings Both 0.743 0.988 0.916,1.06 766 7661 0.7516 0.988 0.917,1.06 766 7632
801 Fracture of ankle and foot injuries & poisonings Both 0.7709 0.994 0.951,1.04 2205 22041 0.4645 0.982 0.936,1.03 1825 18283
801.1 Fracture of foot injuries & poisonings Both 0.4932 0.983 0.937,1.03 1835 18346 0.4645 0.982 0.936,1.03 1825 18283
802 Fracture of pelvis injuries & poisonings Both 0.2244 0.954 0.884,1.03 718 7185 0.2239 0.954 0.884,1.03 715 7164
803 Fracture of upper limb injuries & poisonings Both 0.9954 1.0 0.978,1.02 8288 82880 0.8551 0.995 0.944,1.05 1512 15168
803.1 Fracture of humerus injuries & poisonings Both 0.9931 1.0 0.952,1.05 1691 16883 0.9572 1.0 0.953,1.05 1685 16802
803.2 Fracture of radius and ulna injuries & poisonings Both 0.7998 0.996 0.968,1.03 5215 52171 0.8933 0.998 0.97,1.03 5188 51898
803.3 Fracture of clavicle or scapula injuries & poisonings Both 0.8913 0.996 0.945,1.05 1518 15186 0.8551 0.995 0.944,1.05 1512 15168
804 Fracture of hand or wrist injuries & poisonings Both 0.7852 0.995 0.96,1.03 3339 33384 0.8453 0.996 0.962,1.03 3328 33295
805 Fracture of vertebral column without mention of spinal cord injury injuries & poisonings Both 0.7447 0.991 0.938,1.05 1358 13565 0.7762 0.992 0.939,1.05 1352 13524
807 Fracture of ribs injuries & poisonings Both 0.9931 1.0 0.929,1.08 776 7752 0.9817 1.0 0.929,1.08 772 7730
809 Fracture of unspecified bones injuries & poisonings Both 0.7499 1.01 0.954,1.07 1300 12998 0.7762 1.01 0.953,1.07 1295 12958
817 Concussion injuries & poisonings Both 0.826 1.01 0.893,1.15 243 2428 0.8054 1.02 0.894,1.15 243 2420
818 Intracranial hemorrhage (injury) injuries & poisonings Both 0.5483 0.973 0.89,1.06 522 5213 0.5957 0.976 0.893,1.07 519 5206
819 Skull and face fracture and other intercranial injury injuries & poisonings Both 0.6194 1.01 0.972,1.05 2957 29596 0.6368 1.01 0.972,1.05 2947 29545
823 Torus fracture injuries & poisonings Both 0.8356 0.995 0.946,1.05 1673 16710 0.8954 0.997 0.948,1.05 1663 16662
830 Dislocation injuries & poisonings Both 0.02399 0.95 0.908,0.993 2088 20872 0.01995 0.948 0.906,0.992 2081 20831
835 Internal derangement of knee injuries & poisonings Both 0.5728 0.995 0.979,1.01 15221 152247 0.6039 0.996 0.979,1.01 15185 151825
836 Traumatic arthropathy injuries & poisonings Both 0.3006 1.05 0.959,1.15 526 5267 0.3597 1.04 0.954,1.14 525 5260
840 Sprains and strains injuries & poisonings Both 0.514 1.03 0.938,1.14 470 4697 0.5105 1.03 0.938,1.14 469 4684
850 Hemorrhage or hematoma complicating a procedure injuries & poisonings Both 0.1167 1.02 0.994,1.05 5259 52626 0.1429 1.02 0.993,1.05 5196 52463
851 Complications of transplants and reattached limbs injuries & poisonings Both 0.9183 1.01 0.855,1.19 157 1567 0.8017 1.02 0.865,1.21 156 1559
853 Complication of colostomy or enterostomy injuries & poisonings Both 0.2 1.06 0.969,1.16 501 5010 0.1714 1.07 0.973,1.17 480 5001
854 Complications of cardiac/vascular device, implant, and graft injuries & poisonings Both 0.01023 1.06 1.02,1.12 1826 18238 0.01023 1.06 1.01,1.12 1814 18201
857 Mechanical complication of unspecified genitourinary device, implant, and graft injuries & poisonings Both 0.8375 1.01 0.95,1.07 1241 12418 0.7145 1.01 0.954,1.07 1230 12379
858 Complication of internal orthopedic device injuries & poisonings Both 0.8913 0.997 0.962,1.03 3158 31607 0.865 0.997 0.961,1.03 3141 31484
859 Complication due to other implant and internal device injuries & poisonings Both 0.8892 0.997 0.962,1.03 3259 32599 0.9572 0.999 0.963,1.04 3235 32498
870 Open wounds of head; neck; and trunk injuries & poisonings Both 0.5023 1.01 0.977,1.05 3502 35062 0.08913 0.805 0.627,1.03 68 678
870.1 Open wound or laceration of eye or eyelid injuries & poisonings Both 0.8166 0.985 0.867,1.12 272 2713 0.8204 0.985 0.867,1.12 272 2710
870.2 Open wound of ear injuries & poisonings Both 0.8872 1.01 0.875,1.17 196 1949 0.8831 1.01 0.875,1.17 196 1946
870.3 Other open wound of head and face injuries & poisonings Both 0.6918 1.01 0.97,1.05 2904 29085 0.6457 1.01 0.971,1.05 2897 29014
870.4 Open wound of nose and sinus injuries & poisonings Both 0.05129 1.14 0.999,1.31 220 2199 0.0537 1.14 0.998,1.31 219 2193
870.6 Open wound of neck injuries & poisonings Both 0.08913 0.805 0.627,1.03 68 678 0.08913 0.805 0.627,1.03 68 678
871 Open wounds of extremities injuries & poisonings Both 0.7586 1.01 0.973,1.04 4063 40648 0.2911 1.09 0.932,1.26 178 1781
871.1 Open wound of hand except finger(s) injuries & poisonings Both 0.7447 0.953 0.714,1.27 53 530 0.7447 0.953 0.714,1.27 53 530
871.2 Open wound of finger(s) injuries & poisonings Both 0.5998 1.06 0.858,1.3 91 900 0.5821 1.06 0.86,1.31 90 898
871.3 Open wound of foot except toe(s) alone injuries & poisonings Both 0.2938 1.08 0.932,1.26 178 1785 0.2911 1.09 0.932,1.26 178 1781
872 Traumatic amputation injuries & poisonings Both 0.228 0.944 0.859,1.04 475 4742 0.2265 0.943 0.858,1.04 475 4738
873 Broken tooth injuries & poisonings Both 0.5649 1.04 0.909,1.19 229 2289 0.5702 1.04 0.908,1.19 228 2284
874 Complication of amputation stump injuries & poisonings Both 0.826 1.02 0.872,1.19 169 1710 0.8414 1.02 0.871,1.19 169 1705
905 Late effects of musculoskeletal and connective tissue injuries injuries & poisonings Both 0.2773 0.915 0.779,1.07 157 1567 0.2767 0.914 0.778,1.07 157 1562
907 Injuries to the nervous system injuries & poisonings Both 0.6561 1.01 0.957,1.07 1314 13140 0.6152 1.01 0.959,1.07 1310 13105
915 Superficial injury without mention of infection injuries & poisonings Both 0.5559 1.01 0.978,1.04 4260 42663 0.4732 1.01 0.98,1.04 4238 42543
916 Contusion injuries & poisonings Both 0.8395 0.994 0.942,1.05 1450 14506 0.873 0.996 0.943,1.05 1445 14472
930 Allergic reaction to food injuries & poisonings Both 0.798 0.98 0.841,1.14 179 1807 0.8128 0.982 0.842,1.14 178 1797
938 Dermatitis due to solar radiation injuries & poisonings Both 0.3981 0.956 0.862,1.06 389 3899 0.8433 0.987 0.868,1.12 252 2518
938.2 Chronic dermatitis due to solar radiation injuries & poisonings Both 0.8375 0.987 0.867,1.12 252 2530 0.8433 0.987 0.868,1.12 252 2518
941 Adverse reaction to serum or vaccine injuries & poisonings Both 0.03715 1.16 1.01,1.33 225 2249 0.04266 1.15 1.0,1.32 221 2241
942 Infusion and transfusion reaction injuries & poisonings Both 0.01175 0.774 0.634,0.945 104 1038 0.006166 0.753 0.614,0.922 100 1033
946 Anaphylactic shock NOS injuries & poisonings Both 0.7798 0.988 0.905,1.08 550 5509 0.8222 0.99 0.908,1.08 548 5488
947 Urticaria injuries & poisonings Both 0.2328 0.936 0.84,1.04 371 3707 0.1972 0.931 0.835,1.04 369 3694
949 Allergies, other injuries & poisonings Both 0.3784 1.05 0.946,1.16 397 3989 0.4246 1.04 0.941,1.15 393 3978
952 Spinal cord injury without evidence of spinal bone injury injuries & poisonings Both 0.2897 1.06 0.955,1.17 423 4224 0.2825 1.06 0.955,1.17 421 4211
957 Injury to other and unspecified nerves injuries & poisonings Both 0.1963 0.922 0.814,1.04 269 2698 0.235 0.928 0.82,1.05 268 2685
958 Certain early complications of trauma or procedure injuries & poisonings Both 0.9016 1.01 0.917,1.1 491 4926 0.6855 0.954 0.76,1.2 73 738
958.1 Postoperative shock injuries & poisonings Both 0.5333 1.09 0.826,1.45 55 555 0.4613 1.11 0.836,1.48 52 554
958.2 Traumatic and surgical subcutaneous emphysema injuries & poisonings Both 0.6397 0.947 0.756,1.19 74 740 0.6855 0.954 0.76,1.2 73 738
960 Poisoning by antibiotics injuries & poisonings Both 0.4539 1.01 0.991,1.02 18100 181147 0.7228 1.0 0.987,1.02 15713 158012
960.2 Allergy/adverse effect of penicillin injuries & poisonings Both 0.6427 1.0 0.988,1.02 15846 158623 0.7228 1.0 0.987,1.02 15713 158012
961 Poisoning by other anti-infectives injuries & poisonings Both 0.787 0.986 0.891,1.09 420 4195 0.1222 1.06 0.985,1.14 861 8664
961.1 Poisoning/allergy of sulfonamides injuries & poisonings Both 0.134 1.06 0.983,1.13 869 8703 0.1222 1.06 0.985,1.14 861 8664
962 Poisoning by hormones and synthetic substitutes injuries & poisonings Both 0.9183 0.994 0.894,1.11 371 3707 0.865 1.01 0.907,1.12 360 3626
962.3 Hormones and synthetic substitutes causing adverse effects in therapeutic use injuries & poisonings Both 0.811 1.01 0.911,1.13 364 3638 0.865 1.01 0.907,1.12 360 3626
963 Poisoning by primarily systemic agents injuries & poisonings Both 0.6561 1.03 0.898,1.19 223 2228 0.7328 1.02 0.89,1.18 215 2218
964 Poisoning by agents primarily affecting blood constituents injuries & poisonings Both 0.4064 1.05 0.932,1.19 282 2830 0.561 1.04 0.916,1.17 273 2763
964.1 Anticoagulants causing adverse effects injuries & poisonings Both 0.4989 1.04 0.922,1.18 276 2770 0.561 1.04 0.916,1.17 273 2763
965 Poisoning by analgesics, antipyretics, and antirheumatics injuries & poisonings Both 0.156 1.02 0.993,1.05 6082 60875 0.2938 0.948 0.859,1.05 403 4035
965.1 Opiates and related narcotics causing adverse effects in therapeutic use injuries & poisonings Both 0.5741 1.02 0.958,1.08 1144 11447 0.6353 1.01 0.955,1.08 1125 11397
965.2 Antirheumatics causing adverse effects in therapeutic use injuries & poisonings Both 0.1368 1.07 0.978,1.18 476 4767 0.1276 1.08 0.979,1.18 475 4751
965.3 Salicylates causing adverse effects in therapeutic use injuries & poisonings Both 0.2844 0.947 0.858,1.05 403 4045 0.2938 0.948 0.859,1.05 403 4035
966 Poisoning by anticonvulsants and anti-Parkinsonism drugs injuries & poisonings Both 0.9528 0.997 0.912,1.09 512 5123 0.9376 0.996 0.911,1.09 510 5099
967 Adverse effects of sedatives or other central nervous system depressants and anesthetics injuries & poisonings Both 0.02951 0.911 0.838,0.991 583 5843 0.02951 0.911 0.837,0.991 575 5817
969 Poisoning by psychotropic agents injuries & poisonings Both 0.4315 1.02 0.973,1.07 1950 19519 0.4188 1.02 0.973,1.07 1939 19457
971 Poisoning by drugs primarily affecting the autonomic nervous system injuries & poisonings Both 0.4753 0.949 0.822,1.1 190 1908 0.4457 0.945 0.818,1.09 188 1904
972 Poisoning by agents primarily affecting the cardiovascular system injuries & poisonings Both 0.5333 1.04 0.92,1.18 271 2717 0.9954 1.0 0.806,1.24 84 846
972.6 Antihypertensive agents causing adverse effects injuries & poisonings Both 0.9886 0.999 0.804,1.24 84 849 0.9954 1.0 0.806,1.24 84 846
973 Poisoning by agents primarily affecting the gastrointestinal system injuries & poisonings Both 0.6383 1.05 0.861,1.28 108 1080 0.6339 1.05 0.862,1.28 108 1074
974 Poisoning by water, mineral, and uric acid metabolism drugs injuries & poisonings Both 0.01995 1.27 1.04,1.55 101 1018 0.01738 1.28 1.04,1.56 101 1012
975 Poisoning by agents primarily acting on the smooth and skeletal muscles and respiratory system injuries & poisonings Both 0.4887 0.917 0.718,1.17 64 640 0.4887 0.917 0.718,1.17 64 640
976 Poisoning by agents primarily affecting skin & mucous membrane, ophthalmological, otorhinolaryngological, & dental drugs injuries & poisonings Both 0.4842 0.912 0.703,1.18 58 580 0.5082 0.916 0.706,1.19 58 578
977 Personal history of allergy to medicinal agents injuries & poisonings Both 0.4365 1.05 0.924,1.2 234 2337 0.4365 1.05 0.923,1.21 226 2332
979 Adverse drug events and drug allergies injuries & poisonings Both 0.08913 1.07 0.99,1.16 698 6966 0.08511 1.07 0.99,1.16 687 6944
981 Toxic effect of (non-ethyl) alcohol and petroleum and other solvents injuries & poisonings Both 0.8933 0.99 0.855,1.15 200 1999 0.9057 0.991 0.856,1.15 200 1992
986 Toxic effect of carbon monoxide injuries & poisonings Both 0.4046 0.897 0.693,1.16 62 620 0.4046 0.897 0.693,1.16 62 620
987 Toxic effect of other gases, fumes, or vapors injuries & poisonings Both 0.4305 1.08 0.89,1.32 105 1049 0.4355 1.08 0.888,1.32 104 1047
988 Toxic effect of noxious substances eaten as food injuries & poisonings Both 0.5508 1.06 0.875,1.28 111 1128 0.5284 1.06 0.878,1.29 111 1123
989 Toxic effect of other substances, chiefly nonmedicinal as to source injuries & poisonings Both 0.1297 1.19 0.951,1.48 89 890 0.1236 1.19 0.954,1.48 89 887
990 Effects radiation NOS injuries & poisonings Both 0.3236 0.982 0.946,1.02 3113 31140 0.3162 0.981 0.945,1.02 3045 31026
994 Sepsis and SIRS injuries & poisonings Both 0.3404 1.02 0.981,1.06 3028 30268 0.2972 1.02 0.983,1.06 2958 30182
994.2 Sepsis injuries & poisonings Both 0.3404 1.02 0.981,1.06 3028 30268 0.2972 1.02 0.983,1.06 2958 30182
1000 Burns injuries & poisonings Both 0.1374 1.07 0.979,1.16 578 5796 0.1247 1.07 0.981,1.17 576 5786
1001 Foreign body injury injuries & poisonings Both 0.2366 1.04 0.977,1.1 1199 12007 0.2178 1.04 0.978,1.1 1195 11969
1002 Symptoms concerning nutrition, metabolism, and development injuries & poisonings Both 0.3258 0.986 0.959,1.01 5480 54819 0.2958 0.985 0.958,1.01 5446 54604
1004 Other signs and symptoms involving emotional state injuries & poisonings Both 0.1148 0.909 0.807,1.02 300 2997 0.08913 0.901 0.8,1.02 295 2982
1005 Other symptoms injuries & poisonings Both 0.2178 0.966 0.915,1.02 1444 14422 0.2965 0.971 0.919,1.03 1422 14383
1006 Crushing injury injuries & poisonings Both 0.3565 0.941 0.827,1.07 256 2558 0.3573 0.941 0.827,1.07 256 2556
1007 Injury to blood vessels injuries & poisonings Both 0.4853 1.05 0.922,1.19 256 2559 0.5012 1.04 0.92,1.18 256 2550
1008 Crushing or internal injury to organs injuries & poisonings Both 0.8337 1.01 0.945,1.07 1013 10132 0.7362 1.01 0.948,1.08 1006 10122
1009 Injury, NOS injuries & poisonings Both 0.7362 1.0 0.982,1.03 8482 84911 0.7551 1.0 0.981,1.03 8454 84699
1010 Other tests injuries & poisonings Both 0.618 0.993 0.967,1.02 5945 59512 0.6531 0.994 0.968,1.02 5891 59290
1011 Complications of surgical and medical procedures injuries & poisonings Both 0.8072 1.0 0.981,1.02 9152 91588 0.6934 1.0 0.983,1.03 9072 91278
1012 Late effect injuries & poisonings Both 0.8318 0.978 0.799,1.2 105 1057 0.8279 0.978 0.798,1.2 105 1053
1013 Asphyxia and hypoxemia injuries & poisonings Both 0.6152 1.03 0.92,1.15 316 3168 0.7709 1.02 0.908,1.14 313 3162
1014 Effects of heat, cold and air pressure injuries & poisonings Both 0.2138 0.847 0.653,1.1 66 659 0.2168 0.848 0.654,1.1 66 658
1015 Effects of other external causes injuries & poisonings Both 0.9141 1.0 0.971,1.03 4226 42294 0.8872 1.0 0.971,1.03 4155 42145
1019 Other ill-defined and unknown causes of morbidity and mortality injuries & poisonings Both 0.4989 1.01 0.989,1.02 15895 159019 0.5675 1.0 0.989,1.02 15777 158468
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LEGENDS

Figure 1: PheWAS results
P-values correspond to associations between the polygenic risk score (PRS) and the electronic health record-derived phenotype obtained using Firth’s logistic regression and also adjusting for age, gender, genotyping array, and the first four genotype principal components.
Upward (downward)-pointing triangles indicate a positive (negative) association.
Additional details are available by hovering the cursor over a particular triangle and by clicking the triangle. The horizontal dashed line indicates phenome-wide significance. Results are color-coded by disease category.

Figure 2: Exclusion PheWAS results
Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.
This figure provides the beta estimate for the adjusted association between the PRS and the selected phenotype from Firth-corrected logistic regression. The corresponding confidence intervals are also shown. Results are presented for models using either a continuous or a categorical version of the PRS.
Q1 through Q4 represent the four quartiles of the PRS.

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