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UKB PRS for Breast cancer [female](174.1) based on Michailidou K et al. 2018
GWAS reference: 29059683 GWAS source: Michailidou K et al. 2018 PRS method: P_5e-08
PRSweb LD reference: MGI GWAS phenotype: Breast cancer [female], Overall PRSweb date: 2020-06-20
GWAS ID: Onco_iCOGS_Overall_BRCA GWAS URL: http://bcac.ccge.medschl.cam.ac.uk/bcacdata/oncoarray/oncoarray-and-combined-summary-result/gwas-summary-results-breast-cancer-risk-2017 Genome build: GRCh37/hg19
PRS tuning parameter: P<=5e-08 PRS evaluation in: UKB
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CSV EXCEL
PRS PheWAS Summary Statistics Exclusion PRS PheWAS Summary Statistics
PheWAS
Code		 Description Category Sex P value Odds
Ratio 		95% CI # Cases # Controls P value Odds
Ratio		 95% CI # Cases # Controls
008 Intestinal infection infectious diseases Both 0.2254 1.01 0.992,1.04 8842 88430 0.1175 1.05 0.987,1.12 993 9977
008.5 Bacterial enteritis infectious diseases Both 0.7464 1.01 0.968,1.05 2718 27172 0.7129 1.02 0.935,1.1 601 6297
008.52 Intestinal infection due to C. difficile infectious diseases Both 0.3516 1.04 0.959,1.12 653 6533 0.7129 1.02 0.935,1.1 601 6297
008.6 Viral Enteritis infectious diseases Both 0.4592 1.03 0.957,1.1 862 8622 0.857 1.01 0.936,1.08 811 8331
008.7 Intestinal infection due to protozoa infectious diseases Both 0.2761 1.16 0.889,1.51 55 550 0.2455 1.17 0.896,1.54 54 542
010 Tuberculosis infectious diseases Both 0.05781 1.17 0.995,1.37 166 1659 0.1832 0.982 0.955,1.01 5636 57417
038 Septicemia infectious diseases Both 0.1239 1.03 0.993,1.06 4175 41776 0.2099 0.942 0.857,1.03 469 4877
038.1 Gram negative septicemia infectious diseases Both 0.6546 1.02 0.947,1.09 850 8501 0.9772 1.0 0.931,1.08 806 8283
038.2 Gram positive septicemia infectious diseases Both 0.2455 0.947 0.864,1.04 494 4978 0.2099 0.942 0.857,1.03 469 4877
041 Bacterial infection NOS infectious diseases Both 0.241 1.01 0.993,1.03 12017 120377 0.1549 0.971 0.932,1.01 2565 26190
041.1 Staphylococcus infections infectious diseases Both 0.3319 1.02 0.982,1.06 3128 31348 0.9572 1.0 0.963,1.04 2860 30495
041.2 Streptococcus infection infectious diseases Both 0.3133 1.03 0.976,1.08 1641 16433 0.5188 1.02 0.966,1.07 1576 16002
041.4 E. coli infectious diseases Both 0.2065 0.975 0.937,1.01 2730 27319 0.1549 0.971 0.932,1.01 2565 26190
053 Herpes zoster infectious diseases Both 0.507 1.04 0.934,1.15 411 4137 0.673 1.05 0.84,1.31 91 914
053.1 Herpes zoster with nervous system complications infectious diseases Both 0.6237 1.06 0.85,1.31 95 949 0.673 1.05 0.84,1.31 91 914
054 Herpes simplex infectious diseases Both 0.9376 0.994 0.863,1.14 211 2107 0.8299 0.984 0.85,1.14 195 2043
070 Viral hepatitis infectious diseases Both 0.4656 0.969 0.891,1.05 590 5916 0.6902 0.98 0.886,1.08 411 4155
070.1 Viral hepatitis A infectious diseases Both 0.4074 1.1 0.875,1.39 69 690 0.4355 1.1 0.866,1.4 64 665
070.2 Viral hepatitis B infectious diseases Both 0.1426 0.875 0.733,1.05 132 1330 0.1762 0.884 0.74,1.06 129 1306
070.3 Viral hepatitis C infectious diseases Both 0.9528 1.0 0.883,1.14 255 2568 0.7413 1.02 0.898,1.16 252 2515
070.4 Chronic hepatitis infectious diseases Both 0.1919 1.09 0.96,1.23 276 2767 0.1114 1.11 0.977,1.26 263 2639
070.9 Hepatitis NOS infectious diseases Both 0.6839 0.98 0.888,1.08 428 4287 0.6902 0.98 0.886,1.08 411 4155
071 Human immunodeficiency virus [HIV] disease infectious diseases Both 0.2042 1.12 0.941,1.33 147 1467 0.1387 1.16 0.954,1.41 117 1168
071.1 HIV infection, symptomatic infectious diseases Both 0.1387 1.16 0.953,1.41 117 1168 0.1387 1.16 0.954,1.41 117 1168
078 Viral warts & HPV infectious diseases Both 0.7228 0.988 0.927,1.05 1004 10036 0.5848 0.982 0.919,1.05 964 9684
079 Viral infection infectious diseases Both 0.1256 1.03 0.992,1.07 2769 27694 0.4529 0.907 0.702,1.17 62 621
079.1 Varicella infection infectious diseases Both 0.4634 0.91 0.707,1.17 64 640 0.4529 0.907 0.702,1.17 62 621
080 Postoperative infection infectious diseases Both 0.139 1.02 0.993,1.06 4473 44775 0.4898 0.989 0.957,1.02 4013 43412
081 Infection/inflammation of internal prosthetic device; implant; and graft infectious diseases Both 0.6124 1.01 0.97,1.05 2477 24765 0.5224 0.986 0.944,1.03 2238 24034
090 Sexually transmitted infections (not HIV or hepatitis) infectious diseases Both 0.798 0.97 0.771,1.22 71 709 0.6998 0.955 0.755,1.21 67 692
110 Dermatophytosis / Dermatomycosis infectious diseases Both 0.4753 0.956 0.846,1.08 279 2810 0.6026 0.955 0.804,1.13 139 1386
110.1 Dermatophytosis infectious diseases Both 0.4943 0.958 0.846,1.08 273 2750 0.6026 0.955 0.804,1.13 139 1386
110.11 Dermatophytosis of nail infectious diseases Both 0.1099 0.822 0.646,1.05 74 756 0.07889 0.804 0.631,1.03 73 736
110.12 Althete's foot infectious diseases Both 0.6442 0.96 0.809,1.14 141 1410 0.6026 0.955 0.804,1.13 139 1386
112 Candidiasis infectious diseases Both 0.3819 0.98 0.938,1.02 2126 21275 0.04266 0.953 0.91,0.998 1944 20482
117 Mycoses infectious diseases Both 0.6966 1.02 0.907,1.16 272 2719 0.375 0.931 0.794,1.09 155 1600
117.4 Aspergillosis infectious diseases Both 0.3357 0.927 0.795,1.08 165 1650 0.375 0.931 0.794,1.09 155 1600
130 Spirochetal infection infectious diseases Both 0.3214 1.13 0.891,1.42 80 800 0.4055 1.11 0.872,1.4 78 787
133 Arthropod-borne diseases infectious diseases Both 0.4416 0.908 0.71,1.16 69 689 0.5572 0.928 0.724,1.19 69 667
134 Helminthiases infectious diseases Both 0.1148 1.16 0.965,1.39 127 1267 0.3631 1.1 0.896,1.35 101 1019
134.1 Intestinal helminthiases infectious diseases Both 0.2624 1.12 0.918,1.37 106 1058 0.3631 1.1 0.896,1.35 101 1019
136 Other infectious and parasitic diseases infectious diseases Both 0.01059 1.21 1.04,1.4 205 2050 0.03581 1.17 1.01,1.36 197 1983
145 Cancer of mouth neoplasms Both 0.5689 0.976 0.9,1.06 642 6415 0.03013 1.35 1.03,1.77 51 531
145.2 Cancer of tongue neoplasms Both 0.2661 0.936 0.832,1.05 310 3096 0.2028 0.925 0.821,1.04 299 3043
145.3 Cancer of major salivary glands neoplasms Both 0.5236 0.937 0.768,1.14 105 1049 0.5808 0.944 0.771,1.16 100 1016
145.5 Cancer of the mouth floor neoplasms Both 0.02742 1.35 1.03,1.76 54 539 0.03013 1.35 1.03,1.77 51 531
149 Cancer of larynx, pharynx, nasal cavities neoplasms Both 0.2377 0.952 0.878,1.03 635 6342 0.5702 0.923 0.701,1.22 51 549
149.1 Cancer of oropharynx neoplasms Both 0.4227 0.948 0.833,1.08 252 2517 0.3475 0.939 0.824,1.07 246 2476
149.4 Cancer of larynx neoplasms Both 0.6295 0.97 0.856,1.1 265 2640 0.6223 0.969 0.855,1.1 263 2610
149.9 Cancer of of nasal cavities neoplasms Both 0.2754 0.864 0.664,1.12 57 570 0.5702 0.923 0.701,1.22 51 549
150 Cancer of esophagus neoplasms Both 0.6561 1.02 0.945,1.09 762 7630 0.8414 0.992 0.92,1.07 731 7507
151 Cancer of stomach neoplasms Both 0.3289 1.04 0.958,1.14 569 5696 0.399 1.04 0.952,1.13 546 5582
153 Colorectal cancer neoplasms Both 0.6998 1.01 0.976,1.04 4580 45799 0.8147 0.995 0.951,1.04 2082 21023
153.2 Colon cancer neoplasms Both 0.6152 1.01 0.973,1.05 3105 31046 0.7925 1.01 0.968,1.04 2968 30114
153.3 Malignant neoplasm of rectum, rectosigmoid junction, and anus neoplasms Both 0.7638 0.993 0.95,1.04 2164 21640 0.8147 0.995 0.951,1.04 2082 21023
155 Cancer of liver and intrahepatic bile duct neoplasms Both 0.5047 0.966 0.873,1.07 400 4008 0.955 1.0 0.856,1.18 155 1545
155.1 Malignant neoplasm of liver, primary neoplasms Both 0.9376 0.994 0.848,1.16 158 1580 0.955 1.0 0.856,1.18 155 1545
157 Pancreatic cancer neoplasms Both 0.6823 0.983 0.907,1.07 659 6582 0.673 0.982 0.905,1.07 634 6387
158 Neoplasm of unspecified nature of digestive system neoplasms Both 0.01112 1.08 1.02,1.16 1063 10635 0.04732 1.07 1.0,1.14 1014 10297
159 Malignant neoplasm of other and ill-defined sites within the digestive organs and peritoneum neoplasms Both 0.02421 1.03 1.0,1.06 5567 55694 0.5297 1.05 0.903,1.22 183 1825
159.2 Malignant neoplasm of small intestine, including duodenum neoplasms Both 0.05572 1.15 0.997,1.33 190 1900 0.113 1.13 0.972,1.31 181 1851
159.3 Malignant neoplasm of gallbladder and extrahepatic bile ducts neoplasms Both 0.2972 1.08 0.936,1.24 205 2048 0.3034 1.08 0.933,1.25 196 1964
159.4 Malignant neoplasm of retroperitoneum and peritoneum neoplasms Both 0.7096 1.03 0.888,1.19 193 1925 0.5297 1.05 0.903,1.22 183 1825
164 Cancer of intrathoracic organs neoplasms Both 0.9954 0.999 0.759,1.31 60 600 0.7015 0.945 0.708,1.26 53 582
165 Cancer within the respiratory system neoplasms Both 0.7925 0.995 0.957,1.03 2824 28235 0.4656 0.983 0.94,1.03 2065 21597
165.1 Cancer of bronchus; lung neoplasms Both 0.929 1.0 0.959,1.05 2230 22307 0.4656 0.983 0.94,1.03 2065 21597
170 Cancer of bone and connective tissue neoplasms Both 0.9419 1.0 0.91,1.11 437 4364 0.7261 1.02 0.908,1.15 301 3194
170.1 Bone cancer neoplasms Both 0.859 1.02 0.853,1.21 131 1309 0.5082 1.06 0.887,1.27 121 1271
170.2 Cancer of connective tissue neoplasms Both 0.5433 1.04 0.925,1.16 331 3303 0.7261 1.02 0.908,1.15 301 3194
172 Skin cancer neoplasms Both 0.07499 0.984 0.967,1.0 13495 134987 0.236 0.951 0.876,1.03 634 6438
172.1 Melanomas of skin, dx or hx neoplasms Both 0.1096 1.03 0.993,1.07 2681 26792 0.07396 1.04 0.996,1.08 2599 26116
172.11 Melanomas of skin neoplasms Both 0.07586 1.04 0.996,1.08 2713 27112 0.07396 1.04 0.996,1.08 2599 26116
172.2 Other non-epithelial cancer of skin neoplasms Both 0.009638 0.974 0.955,0.994 11000 110056 0.003048 0.97 0.951,0.99 10529 106496
172.3 Carcinoma in situ of skin neoplasms Both 0.4989 0.973 0.898,1.05 666 6656 0.236 0.951 0.876,1.03 634 6438
173 Neoplasm of uncertain behavior of skin neoplasms Both 0.3802 1.07 0.921,1.24 181 1818 0.5715 1.04 0.897,1.22 173 1759
174 Breast cancer neoplasms Both 0.0 1.58 1.55,1.61 12686 126597 ,
174.1 Breast cancer [female] neoplasms Female 0.0 1.59 1.56,1.62 12476 124506 ,
174.11 Malignant neoplasm of female breast neoplasms Female 0.0 1.6 1.57,1.63 11757 117502 ,
174.3 Neoplasm of uncertain behavior of breast neoplasms Both 6.442E-4 1.38 1.15,1.67 115 1148 ,
175 Acquired absence of breast neoplasms Female 1.995E-112 1.62 1.55,1.69 2400 24010 3.741E-4 1.53 1.21,1.94 63 24010
180 Cervical cancer and dysplasia neoplasms Female 0.8511 1.0 0.961,1.05 2174 21747 0.1033 0.962 0.919,1.01 1960 20784
180.1 Cervical cancer neoplasms Female 0.05929 1.13 0.995,1.28 272 2720 0.09772 1.11 0.98,1.27 251 2720
180.3 Cervical intraepithelial neoplasia [CIN] [Cervical dysplasia] neoplasms Female 0.7096 0.991 0.948,1.04 2078 20784 0.1033 0.962 0.919,1.01 1960 20784
182 Malignant neoplasm of uterus neoplasms Female 0.003258 1.09 1.03,1.15 1282 12836 0.3373 1.03 0.969,1.1 1123 12836
184 Cancer of other female genital organs neoplasms Female 0.04083 1.06 1.0,1.12 1378 13772 0.5984 0.968 0.857,1.09 286 3049
184.1 Malignant neoplasm of ovary and other uterine adnexa neoplasms Female 0.01355 1.09 1.02,1.16 967 9667 0.1919 1.05 0.977,1.12 842 9387
184.11 Malignant neoplasm of ovary neoplasms Female 0.02661 1.08 1.01,1.15 939 9387 0.1919 1.05 0.977,1.12 842 9387
184.2 Cancer of other female genital organs (excluding uterus and ovary) neoplasms Female 0.8453 1.01 0.899,1.14 305 3049 0.5984 0.968 0.857,1.09 286 3049
185 Cancer of prostate neoplasms Male 0.9638 1.0 0.974,1.03 5974 58812 0.9419 0.999 0.973,1.03 5954 58768
187 Cancer of other male genital organs neoplasms Male 0.01205 1.13 1.03,1.25 449 4485 0.2 1.13 0.936,1.37 109 1098
187.1 Malignant neoplasm of unspecified male genital organ neoplasms Male 0.6823 0.95 0.742,1.22 70 700 0.6808 0.95 0.743,1.21 70 699
187.2 Malignant neoplasm of testis neoplasms Male 0.03846 1.14 1.01,1.29 287 2868 0.03846 1.14 1.01,1.29 287 2868
187.8 Neoplasm of uncertain behavior of male genital organs neoplasms Male 0.191 1.14 0.939,1.37 110 1098 0.2 1.13 0.936,1.37 109 1098
189 Cancer of urinary organs (incl. kidney and bladder) neoplasms Both 0.1315 0.976 0.945,1.01 4160 41604 0.07816 0.857 0.722,1.02 140 1419
189.1 Cancer of kidney and renal pelvis neoplasms Both 0.6934 1.01 0.951,1.08 1073 10723 0.09795 1.23 0.963,1.57 63 646
189.11 Malignant neoplasm of kidney, except pelvis neoplasms Both 0.9141 0.996 0.935,1.06 1033 10324 0.8241 0.993 0.93,1.06 996 10080
189.12 Malignant neoplasm of renal pelvis neoplasms Both 0.1081 1.22 0.957,1.55 66 660 0.09795 1.23 0.963,1.57 63 646
189.2 Cancer of bladder neoplasms Both 0.004498 0.941 0.902,0.981 2409 24113 0.003656 0.935 0.894,0.978 2076 21095
189.21 Malignant neoplasm of bladder neoplasms Both 0.006653 0.94 0.899,0.983 2142 21447 0.003656 0.935 0.894,0.978 2076 21095
189.4 Malignant neoplasm of other urinary organs neoplasms Both 0.0542 0.846 0.714,1.0 144 1439 0.07816 0.857 0.722,1.02 140 1419
190 Cancer of eye neoplasms Both 0.5164 1.05 0.904,1.22 176 1758 0.6887 1.03 0.884,1.21 169 1707
191 Manlignant and unknown neoplasms of brain and nervous system neoplasms Both 0.984 1.0 0.925,1.08 689 6879 0.7464 0.985 0.899,1.08 504 5095
191.1 Cancer of brain and nervous system neoplasms Both 0.5848 0.976 0.896,1.06 566 5650 0.7464 0.985 0.899,1.08 504 5095
191.11 Cancer of brain neoplasms Both 0.9977 1.0 0.914,1.09 525 5240 0.7464 0.985 0.899,1.08 504 5095
193 Thyroid cancer neoplasms Both 0.2158 0.932 0.834,1.04 346 3466 0.08851 0.904 0.805,1.02 318 3327
194 Cancer of other endocrine glands neoplasms Both 0.2636 0.886 0.717,1.1 95 949 0.1368 0.846 0.679,1.05 88 921
195 Cancer, suspected or other neoplasms Both 1.0E-4 1.03 1.02,1.05 16967 165463 0.9727 1.0 0.983,1.02 14863 156272
195.1 Malignant neoplasm, other neoplasms Both 6.982E-4 1.03 1.01,1.04 16267 159497 0.9727 1.0 0.983,1.02 14863 156272
197 Chemotherapy neoplasms Both 2.344E-15 1.06 1.04,1.07 21433 213213 0.1489 0.989 0.974,1.0 17657 207907
198 Secondary malignant neoplasm neoplasms Both 5.495E-25 1.12 1.09,1.14 9552 95503 0.7834 0.978 0.832,1.15 149 1849
198.1 Secondary malignancy of lymph nodes neoplasms Both 7.762E-27 1.16 1.13,1.2 5368 53670 0.01107 0.954 0.919,0.989 3078 52189
198.2 Secondary malignancy of respiratory organs neoplasms Both 0.006855 1.06 1.02,1.11 2267 22670 0.2254 0.971 0.925,1.02 1777 22192
198.3 Secondary malignant neoplasm of digestive systems neoplasms Both 0.2612 1.03 0.978,1.08 1549 15496 0.6966 0.989 0.936,1.05 1354 15054
198.4 Secondary malignant neoplasm of liver neoplasms Both 3.664E-5 1.09 1.04,1.13 2665 26648 0.8954 1.0 0.96,1.05 2186 26106
198.5 Secondary malignancy of brain/spine neoplasms Both 0.001422 1.12 1.05,1.2 848 8473 0.8091 0.99 0.913,1.07 641 8296
198.6 Secondary malignancy of bone neoplasms Both 1.282E-7 1.13 1.08,1.18 2161 21600 0.389 0.977 0.928,1.03 1547 21152
198.7 Secondary malignant neoplasm of skin neoplasms Both 0.1905 1.1 0.953,1.27 188 1890 0.7834 0.978 0.832,1.15 149 1849
199 Neoplasm of uncertain behavior neoplasms Both 0.5662 1.02 0.963,1.07 1432 14313 0.8017 0.973 0.786,1.2 89 926
199.4 Neurofibromatosis neoplasms Both 0.875 0.983 0.798,1.21 95 950 0.8017 0.973 0.786,1.2 89 926
200 Myeloproliferative disease neoplasms Both 0.1503 1.05 0.983,1.12 991 9911 0.4624 0.962 0.867,1.07 376 3804
200.1 Polycythemia vera neoplasms Both 0.5943 0.973 0.878,1.08 387 3867 0.4624 0.962 0.867,1.07 376 3804
201 Hodgkin's disease neoplasms Both 0.2723 1.07 0.946,1.22 259 2598 0.3532 1.06 0.935,1.21 250 2530
202 Cancer of other lymphoid, histiocytic tissue neoplasms Both 0.6902 1.01 0.966,1.05 2264 22709 0.4457 1.03 0.949,1.13 566 5631
202.2 Non-Hodgkins lymphoma neoplasms Both 0.984 1.0 0.953,1.05 1802 18073 0.4457 1.03 0.949,1.13 566 5631
202.21 Nodular lymphoma neoplasms Both 0.9078 0.994 0.892,1.11 363 3647 0.7998 0.986 0.884,1.1 354 3530
202.24 Large cell lymphoma neoplasms Both 0.4508 1.03 0.949,1.13 581 5824 0.4457 1.03 0.949,1.13 566 5631
204 Leukemia neoplasms Both 0.1811 0.966 0.919,1.02 1660 16630 0.9078 1.01 0.919,1.1 539 5406
204.1 Lymphoid leukemia neoplasms Both 0.1194 0.934 0.858,1.02 577 5784 0.2275 0.945 0.862,1.04 489 4957
204.11 Lymphoid leukemia, acute neoplasms Both 0.6592 0.938 0.705,1.25 56 560 0.8128 0.965 0.72,1.29 52 549
204.12 Lymphoid leukemia, chronic neoplasms Both 0.1403 0.934 0.853,1.02 507 5084 0.2275 0.945 0.862,1.04 489 4957
204.2 Myeloid leukemia neoplasms Both 0.1698 0.935 0.849,1.03 462 4617 0.9419 1.01 0.846,1.2 139 1394
204.21 Myeloid leukemia, acute neoplasms Both 0.08531 0.904 0.805,1.01 329 3287 0.1005 0.906 0.806,1.02 316 3196
204.22 Myeloid leukemia, chronic neoplasms Both 0.9886 1.0 0.843,1.19 144 1440 0.9419 1.01 0.846,1.2 139 1394
204.4 Multiple myeloma neoplasms Both 0.865 1.01 0.923,1.1 555 5560 0.9078 1.01 0.919,1.1 539 5406
208 Benign neoplasm of colon neoplasms Both 0.455 0.994 0.98,1.01 19856 191891 0.3236 0.993 0.978,1.01 19228 186240
210 Benign neoplasm of lip, oral cavity, and pharynx neoplasms Both 0.6427 1.02 0.951,1.08 978 9781 0.863 1.01 0.941,1.08 936 9450
211 Benign neoplasm of other parts of digestive system neoplasms Both 0.4375 1.01 0.983,1.04 5243 52452 0.4446 1.01 0.982,1.04 5006 50361
212 Benign neoplasm of respiratory and intrathoracic organs neoplasms Both 0.3926 1.05 0.939,1.17 347 3466 0.4315 1.05 0.935,1.17 338 3385
213 Benign neoplasm of bone and articular cartilage neoplasms Both 0.3908 1.05 0.937,1.18 318 3187 0.3926 1.05 0.936,1.18 300 3096
214 Lipoma neoplasms Both 0.5534 1.01 0.982,1.03 6231 62346 0.2518 1.02 0.987,1.05 4386 44453
214.1 Lipoma of skin and subcutaneous tissue neoplasms Both 0.2844 1.02 0.986,1.05 4585 45872 0.2518 1.02 0.987,1.05 4386 44453
215 Other benign neoplasm of connective and other soft tissue neoplasms Both 0.3899 0.973 0.915,1.04 1107 11061 0.227 0.961 0.902,1.02 1046 10650
216 Benign neoplasm of skin neoplasms Both 0.4295 1.01 0.986,1.03 7664 76660 0.6039 1.01 0.983,1.03 7309 73983
217 Vascular hamartomas and non-neoplastic nevi neoplasms Both 0.2153 1.05 0.971,1.14 632 6313 0.09419 1.08 0.988,1.17 566 5742
217.1 Nevus, non-neoplastic neoplasms Both 0.1081 1.07 0.985,1.16 595 5943 0.09419 1.08 0.988,1.17 566 5742
218 Benign neoplasm of uterus neoplasms Female 0.0455 1.02 1.0,1.04 10023 100200 0.3467 0.947 0.847,1.06 327 3355
218.1 Uterine leiomyoma neoplasms Female 0.01795 1.02 1.0,1.05 10241 102376 0.09772 1.02 0.997,1.04 9500 96859
218.2 Other benign neoplasm of uterus neoplasms Female 0.5649 0.969 0.87,1.08 355 3548 0.3467 0.947 0.847,1.06 327 3355
220 Benign neoplasm of ovary neoplasms Female 0.8511 0.995 0.942,1.05 1445 14483 0.2535 0.968 0.915,1.02 1338 14483
221 Benign neoplasm of other female genital organs neoplasms Female 0.4295 0.946 0.823,1.09 220 2196 0.1161 0.89 0.77,1.03 198 2196
222 Benign neoplasm of male genital organs neoplasms Male 0.1035 1.14 0.973,1.34 160 1600 0.1309 1.13 0.964,1.33 159 1600
223 Benign neoplasm of kidney and other urinary organs neoplasms Both 0.4395 0.941 0.806,1.1 173 1729 0.6368 0.963 0.822,1.13 166 1683
224 Benign neoplasm of eye neoplasms Both 0.389 1.08 0.906,1.29 129 1299 0.6577 1.06 0.832,1.34 65 656
224.1 Benign neoplasm of eye, uveal neoplasms Both 0.6223 1.06 0.84,1.34 67 680 0.6577 1.06 0.832,1.34 65 656
225 Benign neoplasm of brain and other parts of nervous system neoplasms Both 0.5649 1.02 0.951,1.1 816 8155 0.2661 0.856 0.651,1.13 56 563
225.1 Benign neoplasm of brain, cranial nerves, meninges neoplasms Both 0.3999 1.03 0.959,1.11 775 7756 0.3656 1.04 0.96,1.12 739 7446
225.2 Benign neoplasm of spinal cord, meninges neoplasms Both 0.4036 0.893 0.685,1.16 59 589 0.2661 0.856 0.651,1.13 56 563
226 Benign neoplasm of thyroid glands neoplasms Both 0.4966 1.04 0.923,1.18 266 2664 0.6166 1.03 0.909,1.17 249 2522
227 Benign neoplasm of other endocrine glands and related structures neoplasms Both 0.4256 0.972 0.907,1.04 861 8635 0.6194 1.03 0.915,1.16 301 3042
227.1 Benign neoplasm of adrenal gland neoplasms Both 0.2999 0.924 0.795,1.07 186 1857 0.2799 0.919 0.788,1.07 179 1810
227.2 Benign neoplasm of parathyroid gland neoplasms Both 0.1991 0.934 0.841,1.04 371 3709 0.1871 0.929 0.833,1.04 343 3542
227.3 Benign neoplasm of pituitary gland and craniopharyngeal duct (pouch) neoplasms Both 0.5272 1.04 0.924,1.17 309 3114 0.6194 1.03 0.915,1.16 301 3042
228 Hemangioma and lymphangioma, any site neoplasms Both 0.3767 1.02 0.972,1.08 1596 15966 0.3342 1.03 0.974,1.08 1537 15454
229 Benign neoplasm of unspecified sites neoplasms Both 0.9954 1.0 0.959,1.04 2397 23955 0.7998 0.994 0.952,1.04 2266 22955
860 Bone marrow or stem cell transplant neoplasms Both 0.3589 1.13 0.874,1.45 68 680 0.3062 1.14 0.885,1.48 66 661
240 Simple and unspecified goiter endocrine/metabolic Both 0.2042 1.05 0.972,1.14 600 6016 0.4786 1.03 0.947,1.12 554 5720
241 Nontoxic nodular goiter endocrine/metabolic Both 0.2094 0.962 0.905,1.02 1107 11092 0.2735 0.956 0.882,1.04 630 6447
241.1 Nontoxic uninodular goiter endocrine/metabolic Both 0.4169 0.963 0.878,1.06 471 4706 0.3926 0.959 0.872,1.06 442 4497
241.2 Nontoxic multinodular goiter endocrine/metabolic Both 0.2884 0.959 0.888,1.04 676 6784 0.2735 0.956 0.882,1.04 630 6447
242 Thyrotoxicosis with or without goiter endocrine/metabolic Both 0.08531 0.959 0.914,1.01 1854 18531 0.3013 0.911 0.762,1.09 129 1312
242.1 Graves' disease endocrine/metabolic Both 0.2812 0.948 0.861,1.04 456 4553 0.1618 0.931 0.842,1.03 424 4357
242.2 Toxic multinodular goiter endocrine/metabolic Both 0.2704 1.13 0.912,1.39 91 910 0.5012 1.08 0.865,1.35 83 865
242.3 Exophthalmos endocrine/metabolic Both 0.2421 0.903 0.76,1.07 138 1379 0.3013 0.911 0.762,1.09 129 1312
244 Hypothyroidism endocrine/metabolic Both 0.8414 1.0 0.985,1.02 14590 145053 0.4198 0.993 0.975,1.01 12915 131813
244.1 Secondary hypothyroidism endocrine/metabolic Both 0.929 1.0 0.943,1.07 1108 11079 0.1432 0.953 0.893,1.02 987 10500
244.2 Acquired hypothyroidism endocrine/metabolic Both 0.06194 0.832 0.685,1.01 101 1010 0.06808 0.833 0.685,1.01 98 953
244.4 Hypothyroidism NOS endocrine/metabolic Both 0.7925 1.0 0.985,1.02 13918 138926 0.4198 0.993 0.975,1.01 12915 131813
245 Thyroiditis endocrine/metabolic Both 0.263 0.934 0.828,1.05 288 2877 0.8974 1.01 0.876,1.16 202 1962
245.2 Chronic thyroiditis endocrine/metabolic Both 0.9247 1.01 0.878,1.15 218 2177 0.8974 1.01 0.876,1.16 202 1962
245.21 Chronic lymphocytic thyroiditis endocrine/metabolic Both 0.6966 1.03 0.895,1.18 210 2097 0.8974 1.01 0.876,1.16 202 1962
246 Other disorders of thyroid endocrine/metabolic Both 0.3936 0.957 0.864,1.06 397 3975 0.4753 0.962 0.866,1.07 365 3773
250 Diabetes mellitus endocrine/metabolic Both 0.227 1.01 0.994,1.02 19787 186006 0.6902 1.01 0.956,1.07 1298 13037
250.1 Type 1 diabetes endocrine/metabolic Both 0.7551 1.01 0.968,1.05 2758 27621 0.7568 1.03 0.87,1.21 153 1581
250.11 Type 1 diabetes with ketoacidosis endocrine/metabolic Both 0.5058 0.956 0.838,1.09 239 2389 0.3459 0.937 0.819,1.07 228 2327
250.12 Type 1 diabetes with renal manifestations endocrine/metabolic Both 0.8222 1.03 0.815,1.29 76 770 0.9863 0.998 0.787,1.27 72 756
250.13 Type 1 diabetes with ophthalmic manifestations endocrine/metabolic Both 0.3327 1.05 0.953,1.15 473 4744 0.4266 1.04 0.944,1.14 455 4628
250.14 Type 1 diabetes with neurological manifestations endocrine/metabolic Both 0.6266 1.04 0.886,1.22 160 1610 0.7568 1.03 0.87,1.21 153 1581
250.2 Type 2 diabetes endocrine/metabolic Both 0.1803 1.01 0.995,1.03 17831 170202 0.9817 0.999 0.911,1.1 490 4956
250.21 Type 2 diabetes with ketoacidosis endocrine/metabolic Both 0.03069 0.797 0.649,0.979 104 1050 0.006982 0.748 0.605,0.924 99 1025
250.22 Type 2 diabetes with renal manifestations endocrine/metabolic Both 0.3882 0.939 0.813,1.08 200 2018 0.3864 0.938 0.813,1.08 198 1974
250.23 Type 2 diabetes with ophthalmic manifestations endocrine/metabolic Both 0.5998 0.983 0.921,1.05 986 9907 0.618 0.984 0.921,1.05 967 9690
250.24 Type 2 diabetes with neurological manifestations endocrine/metabolic Both 0.7396 1.02 0.927,1.11 503 5066 0.9817 0.999 0.911,1.1 490 4956
250.4 Abnormal glucose endocrine/metabolic Both 0.8222 1.01 0.932,1.09 680 6827 0.9354 1.0 0.905,1.11 399 4066
250.41 Impaired fasting glucose endocrine/metabolic Both 0.6295 0.97 0.855,1.1 265 2659 0.4977 0.957 0.842,1.09 257 2600
250.42 Other abnormal glucose endocrine/metabolic Both 0.3639 1.05 0.947,1.16 416 4178 0.9354 1.0 0.905,1.11 399 4066
250.5 Glycosuria or Acetonuria endocrine/metabolic Both 0.2178 1.12 0.938,1.33 131 1308 0.2512 1.11 0.93,1.32 128 1271
250.6 Polyneuropathy in diabetes endocrine/metabolic Both 0.867 1.01 0.904,1.13 349 3495 0.9462 0.996 0.891,1.11 342 3436
250.7 Diabetic retinopathy endocrine/metabolic Both 0.6486 1.01 0.958,1.07 1329 13335 0.6902 1.01 0.956,1.07 1298 13037
251.1 Hypoglycemia endocrine/metabolic Both 0.7925 0.991 0.927,1.06 932 9370 0.8375 0.993 0.928,1.06 907 9125
252 Disorders of parathyroid gland endocrine/metabolic Both 0.7031 0.987 0.922,1.06 873 8719 0.9419 0.994 0.834,1.18 134 1361
252.1 Hyperparathyroidism endocrine/metabolic Both 0.3443 0.966 0.899,1.04 781 7802 0.4875 0.974 0.904,1.05 727 7455
252.2 Hypoparathyroidism endocrine/metabolic Both 0.9204 1.01 0.853,1.19 142 1418 0.9419 0.994 0.834,1.18 134 1361
253 Disorders of the pituitary gland and its hypothalamic control endocrine/metabolic Both 0.8531 1.01 0.931,1.09 681 6821 0.9376 1.01 0.851,1.19 151 1519
253.1 Pituitary hyperfunction endocrine/metabolic Both 0.5395 1.05 0.901,1.22 187 1867 0.2917 1.12 0.904,1.4 90 908
253.11 Acromegaly and gigantism endocrine/metabolic Both 0.3819 1.1 0.89,1.35 95 949 0.2917 1.12 0.904,1.4 90 908
253.2 Pituitary hypofunction endocrine/metabolic Both 0.561 1.04 0.916,1.17 260 2618 0.4989 1.04 0.921,1.18 255 2563
253.3 Diabetes insipidus endocrine/metabolic Both 0.3266 0.896 0.719,1.12 92 919 0.2588 0.878 0.701,1.1 88 887
253.7 Other disorders of neurohypophysis endocrine/metabolic Both 0.859 0.985 0.836,1.16 158 1578 0.9376 1.01 0.851,1.19 151 1519
255 Disorders of adrenal glands endocrine/metabolic Both 0.3459 0.962 0.887,1.04 638 6374 0.1549 0.922 0.825,1.03 350 3469
255.1 Adrenal hyperfunction endocrine/metabolic Both 0.4345 1.06 0.916,1.23 180 1797 0.3698 1.11 0.882,1.4 74 742
255.11 Cushing's syndrome endocrine/metabolic Both 0.9484 0.994 0.819,1.21 103 1029 0.9795 1.0 0.821,1.22 98 980
255.12 Hyperaldosteronism endocrine/metabolic Both 0.2904 1.13 0.901,1.42 76 759 0.3698 1.11 0.882,1.4 74 742
255.2 Adrenal hypofunction endocrine/metabolic Both 0.09268 0.91 0.815,1.02 362 3617 0.1549 0.922 0.825,1.03 350 3469
255.21 Glucocorticoid deficiency endocrine/metabolic Both 0.1324 0.919 0.824,1.03 361 3607 0.1549 0.922 0.825,1.03 350 3469
256 Ovarian dysfunction endocrine/metabolic Female 0.2851 1.07 0.942,1.23 240 2397 0.1854 1.1 0.955,1.27 201 2023
256.4 Polycystic ovaries endocrine/metabolic Female 0.166 1.1 0.96,1.27 209 2088 0.1854 1.1 0.955,1.27 201 2023
257 Testicular dysfunction endocrine/metabolic Male 0.3556 1.08 0.918,1.27 160 1619 0.4266 1.07 0.906,1.26 151 1538
257.1 Testicular hypofunction endocrine/metabolic Male 0.4487 1.07 0.903,1.26 152 1539 0.4266 1.07 0.906,1.26 151 1538
258 Iatrogenic endocrine disorders endocrine/metabolic Both 0.9977 1.0 0.813,1.23 102 1020 0.9333 1.01 0.82,1.24 101 984
259 Other endocrine disorders endocrine/metabolic Both 0.6109 0.958 0.81,1.13 149 1498 0.5728 0.951 0.8,1.13 139 1442
260 Protein-calorie malnutrition endocrine/metabolic Both 0.1007 1.13 0.977,1.3 202 2018 0.8872 0.995 0.925,1.07 800 8034
260.1 Cachexia endocrine/metabolic Both 0.4426 1.11 0.846,1.47 51 510 ,
260.6 Anorexia endocrine/metabolic Both 0.9977 1.0 0.931,1.07 830 8317 0.8872 0.995 0.925,1.07 800 8034
261 Vitamin deficiency endocrine/metabolic Both 0.7362 1.01 0.952,1.07 1199 11974 0.6637 1.05 0.833,1.33 72 728
261.2 Vitamin B-complex deficiencies endocrine/metabolic Both 1.0 1.0 0.928,1.08 755 7541 0.9638 0.998 0.925,1.08 728 7267
261.4 Vitamin D deficiency endocrine/metabolic Both 0.863 1.01 0.917,1.11 447 4462 0.6637 1.05 0.833,1.33 72 728
261.41 Rickets or osteomalacia endocrine/metabolic Both 0.7211 1.04 0.83,1.31 77 769 0.6637 1.05 0.833,1.33 72 728
262 Mineral deficiency NEC endocrine/metabolic Both 0.6266 0.968 0.847,1.1 241 2407 0.7362 0.977 0.851,1.12 224 2303
269 Proteinuria endocrine/metabolic Both 0.2183 0.932 0.834,1.04 338 3378 0.2541 0.936 0.836,1.05 330 3297
270 Disorders of protein plasma/amino-acid transport and metabolism endocrine/metabolic Both 0.8954 0.992 0.883,1.12 303 3028 0.7674 1.04 0.813,1.32 67 667
270.3 Disorders of plasma protein metabolism endocrine/metabolic Both 0.6918 1.03 0.903,1.17 261 2608 0.7674 1.04 0.813,1.32 67 667
270.32 Paraproteinemia endocrine/metabolic Both 0.4571 1.06 0.912,1.23 191 1910 0.3767 1.07 0.92,1.24 184 1844
270.33 Amyloidosis endocrine/metabolic Both 0.456 0.928 0.762,1.13 113 1129 0.2339 0.884 0.721,1.08 107 1093
270.35 Macroglobulinemia endocrine/metabolic Both 0.912 1.01 0.797,1.29 69 689 0.7674 1.04 0.813,1.32 67 667
271 Disorders of carbohydrate transport and metabolism endocrine/metabolic Both 0.4111 1.07 0.911,1.26 160 1600 0.3076 1.1 0.918,1.31 132 1339
271.3 Intestinal disaccharidase deficiencies and disaccharide malabsorption endocrine/metabolic Both 0.1592 1.13 0.952,1.35 139 1391 0.3076 1.1 0.918,1.31 132 1339
272 Disorders of lipoid metabolism endocrine/metabolic Both 0.8492 1.0 0.99,1.01 34835 235433 0.8241 0.984 0.853,1.14 207 2042
272.1 Hyperlipidemia endocrine/metabolic Both 0.8511 1.0 0.99,1.01 34764 235203 0.859 0.986 0.84,1.16 163 1597
272.11 Hypercholesterolemia endocrine/metabolic Both 0.8831 1.0 0.989,1.01 32324 228083 0.5598 0.996 0.985,1.01 31216 220787
272.12 Hyperglyceridemia endocrine/metabolic Both 0.3069 1.14 0.883,1.48 58 580 0.2415 1.17 0.9,1.52 58 570
272.13 Mixed hyperlipidemia endocrine/metabolic Both 0.9016 0.99 0.844,1.16 164 1637 0.859 0.986 0.84,1.16 163 1597
272.9 Unspecified disorder of lipoid metabolism endocrine/metabolic Both 0.5794 0.961 0.834,1.11 211 2109 0.8241 0.984 0.853,1.14 207 2042
274 Gout and other crystal arthropathies endocrine/metabolic Both 0.1009 0.972 0.94,1.01 3724 37231 0.975 0.999 0.915,1.09 543 5425
274.1 Gout endocrine/metabolic Both 0.08831 0.969 0.934,1.0 3171 31705 0.4036 0.918 0.752,1.12 110 1110
274.11 Gouty arthropathy endocrine/metabolic Both 0.4603 0.928 0.761,1.13 112 1119 0.4036 0.918 0.752,1.12 110 1110
274.2 Crystal arthropathies endocrine/metabolic Both 0.867 1.01 0.927,1.09 613 6124 0.975 0.999 0.915,1.09 543 5425
274.21 Chondrocalcinosis endocrine/metabolic Both 0.9354 1.0 0.92,1.09 558 5576 0.975 0.999 0.915,1.09 543 5425
275 Disorders of mineral metabolism endocrine/metabolic Both 0.1738 1.03 0.986,1.08 2107 21070 0.5395 1.03 0.946,1.11 641 6412
275.3 Disorders of magnesium metabolism endocrine/metabolic Both 0.5212 1.04 0.932,1.15 375 3745 0.984 1.0 0.898,1.12 350 3620
275.5 Disorders of calcium/phosphorus metabolism endocrine/metabolic Both 0.4864 1.02 0.963,1.08 1202 12019 0.0798 0.867 0.74,1.02 164 1688
275.53 Disorders of phosphorus metabolism endocrine/metabolic Both 0.06966 0.865 0.739,1.01 171 1717 0.0798 0.867 0.74,1.02 164 1688
276 Disorders of fluid, electrolyte, and acid-base balance endocrine/metabolic Both 0.2421 1.01 0.99,1.04 7284 72932 0.8299 1.02 0.849,1.23 124 1234
276.1 Electrolyte imbalance endocrine/metabolic Both 0.7586 1.01 0.973,1.04 4086 40930 0.8147 1.01 0.952,1.07 1338 13705
276.11 Hyperosmolality and/or hypernatremia endocrine/metabolic Both 0.5754 1.04 0.91,1.18 239 2409 0.6266 1.03 0.905,1.18 233 2344
276.12 Hyposmolality and/or hyponatremia endocrine/metabolic Both 0.877 0.996 0.95,1.05 1818 18200 0.6324 0.988 0.94,1.04 1712 17550
276.13 Hyperpotassemia endocrine/metabolic Both 0.7345 0.989 0.926,1.06 969 9728 0.5383 0.979 0.916,1.05 923 9507
276.14 Hypopotassemia endocrine/metabolic Both 0.5383 1.02 0.963,1.07 1424 14235 0.8147 1.01 0.952,1.07 1338 13705
276.4 Acid-base balance disorder endocrine/metabolic Both 0.5768 1.02 0.958,1.08 1161 11629 0.879 1.02 0.836,1.23 109 1093
276.41 Acidosis endocrine/metabolic Both 0.6577 1.01 0.953,1.08 1056 10577 0.8872 0.995 0.933,1.06 1008 10309
276.42 Alkalosis endocrine/metabolic Both 0.869 1.02 0.84,1.23 113 1129 0.879 1.02 0.836,1.23 109 1093
276.5 Hypovolemia endocrine/metabolic Both 0.2594 1.02 0.984,1.06 2827 28265 0.879 0.997 0.958,1.04 2627 27375
276.6 Fluid overload endocrine/metabolic Both 0.6012 1.03 0.933,1.13 451 4535 0.7727 1.01 0.921,1.12 433 4415
276.8 Polydipsia endocrine/metabolic Both 0.7568 1.03 0.858,1.23 128 1278 0.8299 1.02 0.849,1.23 124 1234
277 Other disorders of metabolism endocrine/metabolic Both 0.7112 1.01 0.946,1.08 899 8977 0.3548 1.14 0.862,1.51 51 509
277.4 Disorders of bilirubin excretion endocrine/metabolic Both 0.9268 0.995 0.892,1.11 362 3613 0.8375 0.989 0.885,1.1 350 3555
277.5 Other disorders of lipoid metabolism endocrine/metabolic Both 0.3034 1.07 0.938,1.23 230 2298 0.3548 1.14 0.862,1.51 51 509
277.51 Lipoprotein disorders endocrine/metabolic Both 0.317 1.15 0.872,1.53 52 520 0.3548 1.14 0.862,1.51 51 509
278 Overweight, obesity and other hyperalimentation endocrine/metabolic Both 0.8241 0.998 0.978,1.02 10804 108289 0.2618 0.864 0.669,1.12 65 634
278.1 Obesity endocrine/metabolic Both 0.826 0.998 0.978,1.02 10642 106670 0.3396 0.99 0.97,1.01 10127 103273
278.3 Localized adiposity endocrine/metabolic Both 0.9908 0.999 0.8,1.25 84 838 0.9247 1.01 0.8,1.28 75 804
278.4 Abnormal weight gain endocrine/metabolic Both 0.3041 0.875 0.678,1.13 66 660 0.2618 0.864 0.669,1.12 65 634
279 Disorders involving the immune mechanism endocrine/metabolic Both 0.125 0.904 0.794,1.03 250 2510 0.4808 0.955 0.841,1.08 244 2455
279.1 Immunity deficiency endocrine/metabolic Both 0.005395 0.815 0.706,0.941 209 2100 0.005508 0.776 0.649,0.928 134 1331
279.11 Deficiency of humoral immunity endocrine/metabolic Both 0.008831 0.79 0.662,0.942 138 1390 0.005508 0.776 0.649,0.928 134 1331
279.7 Other immunological findings endocrine/metabolic Both 0.6039 0.967 0.852,1.1 248 2478 0.4808 0.955 0.841,1.08 244 2455
275.1 Disorders of iron metabolism hematopoietic Both 0.5929 1.02 0.943,1.11 653 6535 0.5395 1.03 0.946,1.11 641 6412
280 Iron deficiency anemias hematopoietic Both 0.6223 1.01 0.983,1.03 7610 76168 0.09247 0.918 0.832,1.01 427 4366
280.1 Iron deficiency anemias, unspecified or not due to blood loss hematopoietic Both 0.4656 1.01 0.985,1.03 7311 73153 0.5164 1.01 0.984,1.03 7021 70520
280.2 Iron deficiency anemia secondary to blood loss (chronic) hematopoietic Both 0.05321 0.909 0.825,1.0 452 4541 0.09247 0.918 0.832,1.01 427 4366
281 Other deficiency anemia hematopoietic Both 0.05058 0.94 0.884,1.0 1112 11126 0.7889 1.04 0.791,1.36 51 525
281.1 Megaloblastic anemia hematopoietic Both 0.03236 0.933 0.876,0.994 1066 10669 0.867 1.01 0.868,1.18 178 1775
281.11 Pernicious anemia hematopoietic Both 0.0195 0.914 0.848,0.986 750 7514 0.02735 0.917 0.849,0.99 711 7206
281.12 Other vitamin B12 deficiency anemia hematopoietic Both 0.4539 0.942 0.806,1.1 177 1769 0.6012 0.959 0.818,1.12 170 1710
281.13 Folate-deficiency anemia hematopoietic Both 0.929 1.01 0.864,1.17 183 1836 0.867 1.01 0.868,1.18 178 1775
281.9 Deficiency anemias hematopoietic Both 0.5572 1.08 0.829,1.41 54 538 0.7889 1.04 0.791,1.36 51 525
282 Hereditary hemolytic anemias hematopoietic Both 0.8035 1.02 0.865,1.21 150 1499 0.2143 0.869 0.696,1.08 82 823
282.8 Other hemoglobinopathies hematopoietic Both 0.9594 1.01 0.764,1.33 56 560 ,
282.9 Other hereditary hemolytic anemias hematopoietic Both 0.3589 0.903 0.725,1.12 85 849 0.2143 0.869 0.696,1.08 82 823
283 Acquired hemolytic anemias hematopoietic Both 0.9397 0.993 0.832,1.19 135 1377 0.3327 0.904 0.737,1.11 100 1031
283.1 Autoimmune hemolytic anemias hematopoietic Both 0.3357 0.905 0.739,1.11 103 1059 0.3327 0.904 0.737,1.11 100 1031
284 Aplastic anemia hematopoietic Both 0.123 1.08 0.979,1.19 435 4357 0.2051 1.07 0.965,1.18 411 4245
285 Other anemias hematopoietic Both 0.1256 1.01 0.996,1.03 12104 121094 0.863 1.01 0.901,1.13 333 4002
285.1 Acute posthemorrhagic anemia hematopoietic Both 0.4207 0.951 0.841,1.07 271 2707 0.1531 0.911 0.801,1.04 247 2611
285.2 Anemia of chronic disease hematopoietic Both 0.134 1.06 0.982,1.15 697 6980 0.863 1.01 0.901,1.13 333 4002
285.22 Anemia in neoplastic disease hematopoietic Both 0.06457 1.1 0.994,1.22 414 4147 0.863 1.01 0.901,1.13 333 4002
286 Coagulation defects hematopoietic Both 0.778 0.99 0.926,1.06 921 9218 0.2443 0.939 0.845,1.04 360 3754
286.1 Congenital coagulation defects hematopoietic Both 0.2286 1.06 0.964,1.17 459 4594 0.7551 1.04 0.797,1.37 59 617
286.11 Von willebrand's disease hematopoietic Both 0.7482 0.966 0.784,1.19 96 959 0.7499 0.965 0.776,1.2 88 927
286.12 Congenital deficiency of other clotting factors (including factor VII) hematopoietic Both 0.3327 1.06 0.942,1.19 294 2944 0.507 1.04 0.923,1.18 280 2851
286.13 Congenital factor VIII disorder hematopoietic Both 0.7516 1.04 0.803,1.35 63 630 0.7551 1.04 0.797,1.37 59 617
286.5 Hemorrhagic disorder due to intrinsic circulating anticoagulants hematopoietic Both 0.9247 0.989 0.795,1.23 86 860 0.929 1.01 0.81,1.26 85 843
286.7 Other and unspecified coagulation defects hematopoietic Both 0.3864 0.956 0.863,1.06 386 3867 0.2443 0.939 0.845,1.04 360 3754
287 Purpura and other hemorrhagic conditions hematopoietic Both 0.9226 0.997 0.948,1.05 1652 16532 0.7464 0.961 0.755,1.22 71 736
287.1 Spontaneous ecchymoses hematopoietic Both 0.6081 1.05 0.872,1.26 129 1290 0.4529 1.07 0.891,1.3 125 1247
287.2 Allergic purpura hematopoietic Both 0.5848 0.923 0.692,1.23 51 510 ,
287.3 Thrombocytopenia hematopoietic Both 0.8166 0.994 0.943,1.05 1553 15543 0.7464 0.961 0.755,1.22 71 736
287.31 Primary thrombocytopenia hematopoietic Both 0.335 0.951 0.859,1.05 419 4195 0.2723 0.944 0.851,1.05 401 4058
287.32 Secondary thrombocytopenia hematopoietic Both 0.9183 1.01 0.801,1.28 75 749 0.7464 0.961 0.755,1.22 71 736
288 Diseases of white blood cells hematopoietic Both 1.567E-8 1.1 1.06,1.14 3765 37672 0.877 1.02 0.797,1.3 68 692
288.1 Decreased white blood cell count hematopoietic Both 8.59E-10 1.12 1.08,1.16 3168 31704 0.7691 1.01 0.964,1.05 2259 30604
288.11 Neutropenia hematopoietic Both 1.343E-9 1.12 1.08,1.16 3176 31784 0.7691 1.01 0.964,1.05 2259 30604
288.3 Eosinophilia hematopoietic Both 0.6486 1.06 0.831,1.35 71 709 0.877 1.02 0.797,1.3 68 692
289 Other diseases of blood and blood-forming organs hematopoietic Both 0.1503 1.05 0.982,1.13 862 8625 0.1233 0.848 0.687,1.05 87 878
289.3 Personal history of diseases of blood and blood-forming organs hematopoietic Both 0.06699 1.12 0.992,1.26 290 2897 0.06095 1.12 0.995,1.27 275 2799
289.4 Lymphadenitis hematopoietic Both 0.3614 1.02 0.979,1.06 2602 26061 0.7568 0.993 0.952,1.04 2365 25341
289.5 Diseases of spleen hematopoietic Both 0.1968 1.06 0.97,1.16 516 5153 0.3811 1.04 0.951,1.14 491 4991
289.8 Polycythemia, secondary hematopoietic Both 0.6237 0.971 0.863,1.09 292 2917 0.5534 0.965 0.857,1.09 286 2877
289.9 Abnormality of red blood cells hematopoietic Both 0.1225 0.849 0.69,1.05 90 900 0.1233 0.848 0.687,1.05 87 878
290 Delirium dementia and amnestic and other cognitive disorders mental disorders Both 0.399 0.98 0.935,1.03 1929 19281 0.6902 1.05 0.826,1.34 69 700
290.1 Dementias mental disorders Both 0.1303 0.951 0.892,1.01 1004 10032 0.1107 1.12 0.974,1.29 198 1958
290.11 Alzheimer's disease mental disorders Both 0.4477 0.962 0.871,1.06 431 4307 0.52 0.967 0.873,1.07 402 4115
290.16 Vascular dementia mental disorders Both 0.1413 1.11 0.965,1.28 201 2008 0.1107 1.12 0.974,1.29 198 1958
290.2 Delirium due to conditions classified elsewhere mental disorders Both 0.8091 1.01 0.932,1.09 650 6501 0.8356 0.991 0.913,1.08 622 6316
290.3 Other persistent mental disorders due to conditions classified elsewhere mental disorders Both 0.7096 1.05 0.823,1.33 70 709 0.6902 1.05 0.826,1.34 69 700
291 Other specified nonpsychotic and/or transient mental disorders mental disorders Both 0.9099 0.996 0.928,1.07 836 8385 0.7998 0.987 0.893,1.09 416 4258
291.1 Transient mental disorders due to conditions classified elsewhere mental disorders Both 0.5297 1.06 0.886,1.27 132 1320 0.7447 1.03 0.86,1.24 128 1283
291.4 Specific nonpsychotic mental disorders due to brain damage mental disorders Both 0.6039 0.968 0.857,1.09 286 2867 0.6324 0.97 0.857,1.1 280 2780
291.8 Alteration of consciousness mental disorders Both 0.9817 0.999 0.906,1.1 436 4376 0.7998 0.987 0.893,1.09 416 4258
292 Neurological disorders mental disorders Both 0.8337 1.0 0.973,1.03 4621 46260 0.3334 1.06 0.941,1.2 297 2975
292.1 Aphasia/speech disturbance mental disorders Both 0.4335 0.979 0.929,1.03 1504 15074 0.1667 0.963 0.912,1.02 1436 14647
292.2 Mild cognitive impairment mental disorders Both 0.7112 1.03 0.885,1.2 190 1907 0.7362 1.03 0.882,1.2 186 1857
292.3 Memory loss mental disorders Both 0.2636 1.05 0.967,1.13 696 6978 0.2427 1.05 0.969,1.13 672 6772
292.4 Altered mental status mental disorders Both 0.3069 0.977 0.935,1.02 2181 21827 0.07656 0.96 0.918,1.0 2077 21189
292.6 Hallucinations mental disorders Both 0.3819 1.05 0.937,1.19 307 3073 0.3334 1.06 0.941,1.2 297 2975
293 Symptoms involving head and neck mental disorders Both 0.3622 0.979 0.936,1.02 2078 20779 0.3258 0.966 0.9,1.04 853 8740
293.1 Swelling, mass, or lump in head and neck [Space-occupying lesion, intracranial NOS] mental disorders Both 0.8279 0.992 0.927,1.06 901 9010 0.3258 0.966 0.9,1.04 853 8740
295 Schizophrenia and other psychotic disorders mental disorders Both 0.4943 1.02 0.956,1.1 841 8446 0.8204 0.982 0.841,1.15 167 1664
295.1 Schizophrenia mental disorders Both 0.3206 1.04 0.959,1.14 574 5766 0.3648 1.04 0.955,1.13 556 5660
295.2 Paranoid disorders mental disorders Both 0.4169 1.06 0.917,1.23 178 1780 0.3784 1.07 0.921,1.24 169 1732
295.3 Psychosis mental disorders Both 0.8433 0.985 0.845,1.15 169 1710 0.8204 0.982 0.841,1.15 167 1664
296 Mood disorders mental disorders Both 0.8356 0.998 0.98,1.02 12372 123822 0.5572 1.03 0.926,1.15 349 3472
296.1 Bipolar mental disorders Both 0.5821 0.982 0.922,1.05 1059 10599 0.3516 0.97 0.909,1.03 1015 10309
296.2 Depression mental disorders Both 0.8375 0.998 0.979,1.02 11737 117469 0.5572 1.03 0.926,1.15 349 3472
296.22 Major depressive disorder mental disorders Both 0.3908 1.05 0.942,1.17 361 3604 0.5572 1.03 0.926,1.15 349 3472
297.2 Suicide or self-inflicted injury mental disorders Both 0.507 1.04 0.926,1.17 311 3070 0.7534 1.02 0.905,1.15 299 2966
300 Anxiety disorders mental disorders Both 0.6918 0.995 0.97,1.02 6844 68484 0.3926 0.92 0.76,1.11 113 1101
300.1 Anxiety disorder mental disorders Both 0.869 1.0 0.977,1.03 6324 63282 0.07379 0.918 0.837,1.01 464 4821
300.11 Generalized anxiety disorder mental disorders Both 0.5875 0.954 0.805,1.13 149 1499 0.4446 0.935 0.786,1.11 143 1453
300.12 Agorophobia, social phobia, and panic disorder mental disorders Both 0.1995 1.05 0.974,1.14 707 7065 0.3381 1.04 0.961,1.12 669 6839
300.13 Phobia mental disorders Both 0.2323 0.947 0.865,1.04 501 5013 0.07379 0.918 0.837,1.01 464 4821
300.3 Obsessive-compulsive disorders mental disorders Both 0.1191 0.869 0.728,1.04 140 1407 0.1718 0.884 0.74,1.06 139 1371
300.4 Dysthymic disorder mental disorders Both 0.4436 0.897 0.678,1.19 53 530 ,
300.8 Acute reaction to stress mental disorders Both 0.6792 1.04 0.863,1.25 124 1238 0.4966 1.07 0.883,1.29 119 1210
300.9 Posttraumatic stress disorder mental disorders Both 0.3855 0.919 0.759,1.11 113 1129 0.3926 0.92 0.76,1.11 113 1101
301 Personality disorders mental disorders Both 0.4721 0.959 0.857,1.07 334 3338 0.1841 0.878 0.726,1.06 113 1147
301.2 Antisocial/borderline personality disorder mental disorders Both 0.2198 0.89 0.738,1.07 119 1186 0.1841 0.878 0.726,1.06 113 1147
302 Sexual and gender identity disorders mental disorders Both 0.6266 0.97 0.857,1.1 283 2845 0.6501 0.972 0.859,1.1 283 2836
303 Psychogenic and somatoform disorders mental disorders Both 0.4498 0.965 0.878,1.06 467 4679 0.01972 0.802 0.666,0.965 119 1183
303.3 Psychogenic disorder mental disorders Both 0.7603 0.983 0.882,1.1 350 3510 0.9226 0.994 0.89,1.11 336 3398
303.4 Somatoform disorder mental disorders Both 0.02576 0.814 0.679,0.975 123 1229 0.01972 0.802 0.666,0.965 119 1183
304 Adjustment reaction mental disorders Both 0.5164 0.961 0.853,1.08 293 2936 0.4256 0.952 0.843,1.07 279 2852
305.2 Eating disorder mental disorders Both 0.826 0.976 0.785,1.21 90 900 0.6457 0.949 0.76,1.19 87 874
306 Other mental disorder mental disorders Both 0.9311 1.0 0.988,1.01 28056 230087 0.08851 1.1 0.985,1.24 305 3053
306.9 Tension headache mental disorders Both 0.1143 1.09 0.979,1.22 315 3148 0.08851 1.1 0.985,1.24 305 3053
313 Pervasive developmental disorders mental disorders Both 0.6934 0.956 0.763,1.2 76 770 0.861 0.976 0.742,1.28 51 535
313.3 Autism mental disorders Both 0.877 0.979 0.748,1.28 53 539 0.861 0.976 0.742,1.28 51 535
315 Develomental delays and disorders mental disorders Both 5.808E-4 0.825 0.739,0.92 351 3517 0.02455 0.778 0.626,0.968 87 864
315.1 Learning disorder mental disorders Both 0.8356 1.02 0.866,1.19 161 1610 0.6383 1.04 0.885,1.22 159 1580
315.2 Speech and language disorder mental disorders Both 0.02564 0.78 0.627,0.97 88 880 0.02455 0.778 0.626,0.968 87 864
316 Substance addiction and disorders mental disorders Both 0.4083 1.01 0.984,1.04 5313 53131 0.5902 1.01 0.98,1.04 5205 52399
316.1 Polyneuropathy due to drugs mental disorders Both 0.6209 1.07 0.821,1.39 60 599 ,
317 Alcohol-related disorders mental disorders Both 0.9931 1.0 0.982,1.02 12696 126892 0.3516 1.03 0.963,1.11 822 8297
317.1 Alcoholism mental disorders Both 0.8035 1.0 0.981,1.02 8890 88923 0.3516 1.03 0.963,1.11 822 8297
317.11 Alcoholic liver damage mental disorders Both 0.2198 1.05 0.974,1.12 838 8392 0.3516 1.03 0.963,1.11 822 8297
318 Tobacco use disorder mental disorders Both 0.4315 1.01 0.991,1.02 19359 185465 0.9817 1.0 0.985,1.02 18601 181065
320 Meningitis neurological Both 0.7015 1.02 0.925,1.12 444 4447 0.9572 1.0 0.908,1.11 432 4318
323 Encephalitis neurological Both 0.317 0.944 0.844,1.06 342 3422 0.006823 0.711 0.556,0.91 70 714
323.2 Acute (transverse) myelitis neurological Both 0.01368 0.738 0.579,0.939 74 739 0.006823 0.711 0.556,0.91 70 714
324 Other CNS infection and poliomyelitis neurological Both 0.9183 0.994 0.883,1.12 292 2916 0.7534 1.02 0.904,1.15 281 2812
327 Sleep disorders neurological Both 0.4365 0.976 0.919,1.04 1164 11659 0.6152 1.04 0.88,1.24 133 1347
327.3 Sleep apnea neurological Both 0.3698 0.986 0.956,1.02 4428 44318 0.3631 0.986 0.956,1.02 4346 43580
327.4 Insomnia neurological Both 0.4909 1.06 0.904,1.23 163 1660 0.6152 1.04 0.88,1.24 133 1347
327.41 Organic or persistent insomnia neurological Both 0.5534 1.05 0.889,1.25 136 1390 0.6152 1.04 0.88,1.24 133 1347
331 Other cerebral degenerations neurological Both 0.2213 1.04 0.978,1.1 1142 11416 0.09333 1.09 0.986,1.21 415 4183
331.1 Hydrocephalus neurological Both 0.6823 1.02 0.93,1.12 502 5014 0.7603 1.01 0.923,1.12 471 4812
331.9 Cerebral degeneration, unspecified neurological Both 0.09484 1.09 0.986,1.2 430 4298 0.09333 1.09 0.986,1.21 415 4183
332 Parkinson's disease neurological Both 0.5483 0.981 0.923,1.04 1126 11254 0.4875 0.978 0.919,1.04 1088 10941
333 Extrapyramidal disease and abnormal movement disorders neurological Both 0.5082 0.977 0.913,1.05 894 8954 0.3221 1.07 0.938,1.22 243 2417
333.1 Essential tremor neurological Both 0.8222 1.02 0.885,1.17 216 2157 0.9616 0.997 0.866,1.15 209 2069
333.2 Myoclonus neurological Both 0.3097 0.9 0.734,1.1 96 958 0.3741 0.911 0.742,1.12 95 936
333.4 Torsion dystonia neurological Both 0.5284 1.04 0.918,1.18 253 2528 0.3221 1.07 0.938,1.22 243 2417
334 Degenerative disease of the spinal cord neurological Both 0.2323 1.03 0.981,1.08 1812 18130 0.743 0.978 0.859,1.11 236 2370
334.1 Spinocerebellar disease neurological Both 0.5902 1.05 0.874,1.27 117 1169 0.9183 0.99 0.817,1.2 110 1137
334.2 Anterior horn cell disease neurological Both 0.9016 0.992 0.873,1.13 245 2446 0.743 0.978 0.859,1.11 236 2370
335 Multiple sclerosis neurological Both 0.9506 0.998 0.944,1.06 1340 13385 0.9638 1.0 0.945,1.06 1274 12847
337 Disorders of the autonomic nervous system neurological Both 0.3404 1.06 0.937,1.21 266 2668 0.975 1.0 0.788,1.28 70 700
337.1 Peripheral autonomic neuropathy neurological Both 0.8933 1.02 0.8,1.29 72 719 0.975 1.0 0.788,1.28 70 700
338 Pain neurological Both 0.3733 1.03 0.96,1.11 768 7692 0.7709 1.02 0.912,1.13 362 3666
338.1 Acute pain neurological Both 0.3945 1.05 0.943,1.16 394 3937 0.5164 1.04 0.931,1.15 362 3815
338.2 Chronic pain neurological Both 0.8204 1.01 0.911,1.12 380 3817 0.7709 1.02 0.912,1.13 362 3666
339 Other headache syndromes neurological Both 0.5754 0.993 0.971,1.02 7819 78241 0.492 0.992 0.968,1.02 7463 75424
340 Migraine neurological Both 0.3648 1.02 0.98,1.06 2860 28602 0.1349 1.11 0.967,1.28 202 2041
340.1 Migrain with aura neurological Both 0.105 1.12 0.976,1.29 212 2117 0.1349 1.11 0.967,1.28 202 2041
341 Other demyelinating diseases of central nervous system neurological Both 0.5023 0.956 0.839,1.09 252 2535 0.4519 0.95 0.832,1.09 244 2464
342 Hemiplegia neurological Both 0.05 0.948 0.899,1.0 1494 14947 0.03631 0.944 0.895,0.996 1446 14540
343 Infantile cerebral palsy neurological Both 0.2148 1.11 0.941,1.31 145 1450 0.2249 1.11 0.939,1.31 143 1415
344 Other paralytic syndromes neurological Both 0.09594 0.935 0.863,1.01 658 6593 0.06237 0.926 0.854,1.0 632 6437
345 Epilepsy, recurrent seizures, convulsions neurological Both 0.399 0.988 0.959,1.02 5023 50270 0.631 0.989 0.947,1.03 2142 21744
345.1 Epilepsy neurological Both 0.1517 0.95 0.885,1.02 866 8661 0.06223 0.887 0.783,1.01 267 2686
345.11 Generalized convulsive epilepsy neurological Both 0.8954 1.01 0.912,1.11 439 4385 0.6871 1.02 0.924,1.13 428 4271
345.12 Partial epilepsy neurological Both 0.03864 0.878 0.777,0.993 277 2776 0.06223 0.887 0.783,1.01 267 2686
345.3 Convulsions neurological Both 0.6209 0.989 0.947,1.03 2235 22339 0.631 0.989 0.947,1.03 2142 21744
346.1 Nonspecific abnormal findings on radiological and other examination of skull and head neurological Both 0.1422 1.14 0.958,1.34 144 1438 0.2553 1.11 0.928,1.32 131 1398
348 Other conditions of brain neurological Both 0.3589 1.03 0.962,1.11 778 7808 0.3917 0.955 0.859,1.06 372 3792
348.2 Cerebral edema and compression of brain neurological Both 0.5834 1.04 0.915,1.17 268 2678 0.8241 1.01 0.893,1.15 251 2586
348.4 Cerebral cysts neurological Both 0.1306 0.873 0.733,1.04 133 1350 0.09141 0.857 0.716,1.03 128 1308
348.7 Coma neurological Both 0.3048 0.945 0.847,1.05 358 3596 0.2582 0.938 0.84,1.05 345 3492
348.8 Encephalopathy, not elsewhere classified neurological Both 0.4634 1.05 0.922,1.19 249 2504 0.3606 1.06 0.932,1.21 239 2449
348.9 Other conditions of brain, NOS neurological Both 0.6918 0.979 0.883,1.09 390 3899 0.3917 0.955 0.859,1.06 372 3792
349 Other and unspecified disorders of the nervous system neurological Both 0.6561 1.03 0.918,1.14 342 3414 0.6792 1.02 0.915,1.15 325 3287
350 Abnormal movement neurological Both 0.1679 0.972 0.934,1.01 2671 26722 0.9977 1.0 0.768,1.3 54 522
350.1 Abnormal involuntary movements neurological Both 0.001986 0.897 0.837,0.961 887 8852 6.561E-4 0.884 0.823,0.949 845 8588
350.2 Abnormality of gait neurological Both 0.8933 1.0 0.953,1.06 1596 15969 0.6501 0.988 0.937,1.04 1502 15466
350.3 Lack of coordination neurological Both 0.3491 0.95 0.853,1.06 363 3638 0.309 0.945 0.847,1.05 353 3531
350.6 Disturbances of sensation of smell and taste neurological Both 0.9397 0.99 0.759,1.29 54 540 0.9977 1.0 0.768,1.3 54 522
351 Other peripheral nerve disorders neurological Both 0.2239 1.01 0.993,1.03 12420 124321 0.2805 1.01 0.992,1.03 11866 119214
352 Disorders of other cranial nerves neurological Both 0.975 0.999 0.946,1.06 1370 13706 0.9727 0.999 0.931,1.07 846 8492
352.1 Trigeminal nerve disorders [CN5] neurological Both 0.863 0.992 0.903,1.09 463 4638 0.5821 0.973 0.884,1.07 445 4471
352.2 Facial nerve disorders [CN7] neurological Both 0.9397 0.997 0.931,1.07 880 8795 0.9727 0.999 0.931,1.07 846 8492
353 Nerve root and plexus disorders neurological Both 0.8299 0.993 0.935,1.06 1131 11319 0.8356 0.972 0.743,1.27 56 546
353.1 Nerve plexus lesions neurological Both 0.6622 0.959 0.793,1.16 114 1138 0.5998 0.948 0.778,1.16 106 1098
353.2 Nerve root lesions neurological Both 0.778 0.962 0.736,1.26 57 570 0.8356 0.972 0.743,1.27 56 546
356 Hereditary and idiopathic peripheral neuropathy neurological Both 0.1726 0.886 0.745,1.05 152 1520 0.195 0.89 0.747,1.06 149 1489
357 Inflammatory and toxic neuropathy neurological Both 0.798 1.01 0.953,1.06 1361 13648 0.9908 1.0 0.945,1.06 1282 13335
358 Myoneural disorders neurological Both 0.8147 0.984 0.856,1.13 211 2109 0.1892 0.904 0.778,1.05 183 1863
358.1 Myasthenia gravis neurological Both 0.3945 0.939 0.811,1.09 192 1919 0.1892 0.904 0.778,1.05 183 1863
359 Muscular dystrophies and other myopathies neurological Both 0.3648 1.04 0.95,1.15 465 4646 0.9162 1.01 0.9,1.12 337 3474
359.1 Muscular dystrophies neurological Both 0.6237 1.05 0.871,1.26 122 1219 0.5272 1.06 0.881,1.28 119 1185
359.2 Myopathy neurological Both 0.6412 1.03 0.921,1.14 360 3597 0.9162 1.01 0.9,1.12 337 3474
360 Disorders of the globe sense organs Both 0.3981 1.05 0.939,1.17 337 3367 0.5534 1.04 0.913,1.19 241 2416
360.2 Progressive myopia sense organs Both 0.5534 1.04 0.914,1.18 251 2508 0.5534 1.04 0.913,1.19 241 2416
361 Retinal detachments and defects sense organs Both 0.5093 1.01 0.976,1.05 3246 32453 0.2951 0.879 0.691,1.12 67 660
361.1 Retinal detachment with retinal defect sense organs Both 0.04266 1.06 1.0,1.12 1389 13884 0.04246 1.06 1.0,1.12 1355 13554
361.2 Retinoschisis and retinal cysts sense organs Both 0.2317 0.864 0.679,1.1 68 680 0.2951 0.879 0.691,1.12 67 660
362 Other retinal disorders sense organs Both 0.2193 1.02 0.988,1.06 3836 38370 0.414 0.923 0.763,1.12 116 1123
362.2 Degeneration of macula and posterior pole of retina sense organs Both 0.07447 1.04 0.996,1.09 2182 21813 0.271 1.03 0.981,1.07 2054 20788
362.29 Macular degeneration (senile) of retina NOS sense organs Both 0.07852 1.04 0.996,1.09 2179 21783 0.271 1.03 0.981,1.07 2054 20788
362.3 Other nondiabetic retinopathy sense organs Both 0.7145 0.97 0.825,1.14 161 1609 0.5821 1.06 0.86,1.31 96 957
362.31 Separation of retinal layers sense organs Both 0.4831 1.08 0.877,1.32 99 990 0.5821 1.06 0.86,1.31 96 957
362.4 Retinal vascular changes and abnomalities sense organs Both 0.7345 1.01 0.944,1.09 848 8477 0.9397 0.997 0.929,1.07 814 8244
362.6 Peripheral retinal degenerations sense organs Both 0.1841 1.11 0.953,1.29 182 1827 0.2924 1.09 0.932,1.26 174 1782
362.7 Hereditary retinal dystrophies sense organs Both 0.2173 0.866 0.689,1.09 82 812 0.1538 0.845 0.671,1.07 80 787
362.8 Retinal hemorrhage/ischemia sense organs Both 0.3597 0.914 0.754,1.11 116 1159 0.414 0.923 0.763,1.12 116 1123
363 Chorioretinal inflammations, scars, and other disorders of choroid sense organs Both 0.0278 1.19 1.02,1.4 170 1699 0.4227 1.11 0.863,1.42 67 673
363.3 Chorioretinal scars sense organs Both 0.4074 1.11 0.868,1.42 69 690 0.4227 1.11 0.863,1.42 67 673
364 Corneal opacity and other disorders of cornea sense organs Both 0.4477 1.03 0.952,1.12 647 6485 0.1807 1.15 0.936,1.42 97 967
364.1 Corneal opacity sense organs Both 0.5559 0.938 0.756,1.16 90 910 0.859 0.981 0.79,1.22 87 886
364.2 Corneal edema sense organs Both 0.9484 0.993 0.795,1.24 79 800 0.912 0.987 0.788,1.24 76 771
364.4 Corneal degenerations sense organs Both 0.4121 1.06 0.92,1.22 201 2017 0.9795 1.0 0.801,1.26 86 856
364.41 Keratoconus sense organs Both 0.9908 0.999 0.798,1.25 86 869 0.9795 1.0 0.801,1.26 86 856
364.5 Corneal dystrophy sense organs Both 0.9311 0.994 0.863,1.14 211 2109 0.9977 1.0 0.864,1.16 199 2011
364.9 Cornea replaced by transplant sense organs Both 0.133 1.17 0.953,1.44 100 1000 0.1807 1.15 0.936,1.42 97 967
365 Glaucoma sense organs Both 0.5408 0.99 0.96,1.02 4408 44136 0.9705 1.0 0.924,1.09 662 6688
365.1 Open-angle glaucoma sense organs Both 0.1321 0.952 0.894,1.01 1032 10346 0.07943 0.943 0.884,1.01 992 9927
365.11 Primary open angle glaucoma sense organs Both 0.1343 0.952 0.894,1.02 1026 10287 0.07943 0.943 0.884,1.01 992 9927
365.2 Primary angle-closure glaucoma sense organs Both 0.8299 1.01 0.933,1.09 698 6996 0.9705 1.0 0.924,1.09 662 6688
366 Cataract sense organs Both 0.6761 0.997 0.982,1.01 19926 168711 0.8974 0.987 0.809,1.2 101 1006
366.1 Nonsenile Cataract sense organs Both 0.7889 1.03 0.811,1.32 69 700 0.778 1.04 0.809,1.33 67 681
366.2 Senile cataract sense organs Both 0.3873 1.01 0.987,1.03 8231 81909 0.5458 1.01 0.984,1.03 7874 78514
366.3 Traumatic cataract sense organs Both 0.8337 0.979 0.802,1.19 102 1019 0.8974 0.987 0.809,1.2 101 1006
367 Disorders of refraction and accommodation; blindness and low vision sense organs Both 0.9333 1.0 0.961,1.04 2408 24092 0.879 1.01 0.931,1.09 695 6950
367.1 Myopia sense organs Both 0.8974 1.0 0.947,1.06 1251 12519 0.861 1.01 0.947,1.07 1202 12023
367.2 Astigmatism sense organs Both 0.3556 0.932 0.803,1.08 190 1899 0.2871 0.92 0.79,1.07 179 1815
367.8 Hypermetropia sense organs Both 0.9016 0.992 0.872,1.13 253 2530 0.9016 1.01 0.886,1.15 248 2414
367.9 Blindness and low vision sense organs Both 0.7482 1.01 0.938,1.09 719 7198 0.879 1.01 0.931,1.09 695 6950
368 Visual disturbances sense organs Both 0.302 1.02 0.982,1.06 2962 29648 0.9528 1.0 0.921,1.09 574 5907
368.1 Amblyopia sense organs Both 0.1164 1.07 0.983,1.17 532 5322 0.08851 1.08 0.989,1.18 512 5093
368.2 Diplopia and disorders of binocular vision sense organs Both 0.9099 0.996 0.922,1.07 727 7288 0.7603 0.988 0.914,1.07 691 7085
368.3 Anisometropia sense organs Both 0.1611 1.12 0.954,1.32 154 1548 0.1442 1.13 0.958,1.34 145 1493
368.4 Visual field defects sense organs Both 0.778 0.984 0.882,1.1 333 3327 0.4753 0.96 0.859,1.07 323 3242
368.9 Subjective visual disturbances sense organs Both 0.4732 1.03 0.949,1.12 612 6115 0.9528 1.0 0.921,1.09 574 5907
369 Infection of the eye sense organs Both 0.14 1.07 0.979,1.17 553 5544 0.1742 1.1 0.957,1.28 205 2046
369.2 Eye infection, viral sense organs Both 0.302 1.1 0.919,1.31 125 1257 0.2234 1.12 0.933,1.35 119 1199
369.5 Conjunctivitis, infectious sense organs Both 0.2286 1.09 0.948,1.25 213 2128 0.1742 1.1 0.957,1.28 205 2046
370 Keratitis sense organs Both 0.9057 1.01 0.895,1.13 286 2855 0.9572 0.995 0.842,1.18 136 1366
370.1 Corneal ulcer sense organs Both 0.9183 0.991 0.841,1.17 141 1408 0.9572 0.995 0.842,1.18 136 1366
371 Inflammation of the eye sense organs Both 0.6223 0.991 0.954,1.03 3045 30480 0.8017 0.994 0.952,1.04 2263 22829
371.1 Uveitis, noninfectious or NOS sense organs Both 0.3266 1.05 0.954,1.15 482 4821 0.2495 1.06 0.962,1.16 467 4670
371.3 Inflammation of eyelids sense organs Both 0.6902 0.991 0.95,1.03 2353 23555 0.8017 0.994 0.952,1.04 2263 22829
372 Disorders of conjunctiva sense organs Both 0.9931 1.0 0.928,1.08 760 7602 0.9016 0.995 0.923,1.07 731 7347
374 Other disorders of eyelids sense organs Both 0.2455 0.984 0.958,1.01 5680 56807 0.1005 0.96 0.914,1.01 1751 17480
374.1 Ectropion or entropion sense organs Both 0.1054 0.949 0.891,1.01 1063 10645 0.1303 0.952 0.893,1.01 1030 10339
374.3 Ptosis of eyelid sense organs Both 0.1786 0.968 0.922,1.02 1825 18232 0.1005 0.96 0.914,1.01 1751 17480
375 Disorders of lacrimal system sense organs Both 0.04943 1.04 1.0,1.09 2204 22031 0.0879 1.06 0.991,1.14 850 8549
375.2 Epiphora sense organs Both 0.02825 1.08 1.01,1.16 898 8969 0.0879 1.06 0.991,1.14 850 8549
376 Disorders of the orbit sense organs Both 0.414 0.914 0.738,1.13 86 859 0.6109 0.945 0.76,1.18 84 831
377 Disorders of optic nerve and visual pathways sense organs Both 0.6622 0.976 0.877,1.09 361 3618 0.2564 1.11 0.926,1.34 118 1202
377.1 Optic atrophy sense organs Both 0.8511 1.03 0.783,1.35 56 570 0.6823 1.06 0.805,1.39 54 557
377.3 Optic neuritis/neuropathy sense organs Both 0.3606 1.09 0.909,1.3 125 1249 0.2564 1.11 0.926,1.34 118 1202
378 Strabismus and other disorders of binocular eye movements sense organs Both 0.5808 1.02 0.962,1.07 1410 14116 0.8072 0.985 0.87,1.11 264 2674
378.1 Strabismus (not specified as paralytic) sense organs Both 0.4955 1.02 0.956,1.1 909 9082 0.6592 1.02 0.948,1.09 877 8789
378.2 Nystagmus and other irregular eye movements sense organs Both 0.8974 1.01 0.88,1.16 213 2138 0.9863 0.999 0.87,1.15 208 2091
378.5 Paralytic strabismus sense organs Both 0.9638 1.0 0.888,1.13 275 2755 0.8072 0.985 0.87,1.11 264 2674
379 Other disorders of eye sense organs Both 0.4446 1.01 0.98,1.05 3703 37063 0.673 1.04 0.882,1.21 158 1636
379.2 Disorders of vitreous body sense organs Both 0.9204 1.0 0.948,1.06 1367 13665 0.5559 0.983 0.928,1.04 1304 13189
379.3 Aphakia and other disorders of lens sense organs Both 0.7534 1.01 0.96,1.06 1813 18134 0.857 0.995 0.947,1.05 1725 17435
379.4 Anomalies of pupillary function sense organs Both 0.8492 1.02 0.8,1.31 71 710 0.6067 1.07 0.829,1.38 66 687
379.5 Disorders of iris and ciliary body sense organs Both 0.04592 1.11 1.0,1.23 400 4028 0.04467 1.11 1.0,1.24 385 3906
379.9 Pain, swelling or discharge of eye sense organs Both 0.4955 1.06 0.903,1.23 169 1690 0.673 1.04 0.882,1.21 158 1636
380 Disorders of external ear sense organs Both 0.3281 0.96 0.886,1.04 642 6413 0.2624 1.06 0.955,1.19 350 3491
380.1 Otitis externa sense organs Both 0.631 1.02 0.934,1.12 509 5107 0.6109 1.02 0.935,1.12 495 4958
380.4 Impacted cerumen sense organs Both 0.2723 1.06 0.954,1.18 362 3614 0.2624 1.06 0.955,1.19 350 3491
381 Otitis media and Eustachian tube disorders sense organs Both 0.861 1.0 0.961,1.05 2150 21493 0.3908 1.06 0.932,1.2 270 2721
381.1 Otitis media sense organs Both 0.9462 0.998 0.951,1.05 1767 17668 0.6501 0.984 0.915,1.06 821 8256
381.11 Suppurative and unspecified otitis media sense organs Both 0.7962 0.991 0.923,1.06 852 8524 0.6501 0.984 0.915,1.06 821 8256
381.2 Eustachian tube disorders sense organs Both 0.1959 1.1 0.952,1.27 193 1929 0.257 1.09 0.94,1.26 184 1867
381.3 Mastoiditis & related conditions sense organs Both 0.08072 0.869 0.742,1.02 171 1709 0.06982 0.861 0.733,1.01 164 1654
381.9 Otorrhea sense organs Both 0.3508 1.06 0.938,1.2 281 2807 0.3908 1.06 0.932,1.2 270 2721
382 Otalgia sense organs Both 0.02911 1.14 1.01,1.28 308 3084 0.03767 1.13 1.01,1.28 285 2967
383 Otosclerosis sense organs Both 0.6998 1.02 0.911,1.15 309 3090 0.7129 1.02 0.909,1.15 298 3002
384 Other disorders of tympanic membrane sense organs Both 0.9506 0.998 0.943,1.06 1299 12991 0.8831 0.995 0.933,1.06 1004 10104
384.4 Perforation of tympanic membrane sense organs Both 0.9931 1.0 0.938,1.06 1043 10432 0.8831 0.995 0.933,1.06 1004 10104
385 Other disorders of middle ear and mastoid sense organs Both 0.1963 1.05 0.976,1.13 783 7837 0.5188 0.958 0.84,1.09 236 2332
385.3 Cholesteatoma sense organs Both 0.04246 1.09 1.0,1.18 607 6078 0.08375 1.08 0.99,1.17 585 5911
385.5 Tympanosclerosis and middle ear disease related to otitis media sense organs Both 0.5309 0.959 0.842,1.09 241 2409 0.5188 0.958 0.84,1.09 236 2332
386 Vertiginous syndromes and other disorders of vestibular system sense organs Both 0.1854 0.967 0.921,1.02 1736 17373 0.6546 1.01 0.976,1.04 4374 44351
386.1 Meniere's disease sense organs Both 0.1327 0.937 0.86,1.02 576 5768 0.1416 0.936 0.857,1.02 542 5534
386.2 Peripheral or central vertigo sense organs Both 0.02716 0.887 0.797,0.987 377 3763 0.01466 0.872 0.782,0.973 360 3615
386.3 Labyrinthitis sense organs Both 0.4519 1.03 0.955,1.11 765 7664 0.4227 1.03 0.956,1.11 741 7417
386.9 Dizziness and giddiness (Light-headedness and vertigo) sense organs Both 0.5 1.01 0.98,1.04 4582 45806 0.6546 1.01 0.976,1.04 4374 44351
388 Other disorders of ear sense organs Both 0.4121 1.06 0.921,1.22 202 2017 0.2999 1.08 0.935,1.25 195 1949
389 Hearing loss sense organs Both 0.3199 1.02 0.985,1.05 4188 41944 0.1076 1.08 0.983,1.18 498 4996
389.1 Sensorineural hearing loss sense organs Both 0.173 1.07 0.972,1.17 456 4553 0.2113 1.06 0.966,1.17 442 4399
389.2 Conductive hearing loss sense organs Both 0.0811 0.918 0.835,1.01 450 4497 0.07396 0.916 0.832,1.01 440 4341
389.4 Tinnitus sense organs Both 0.09016 1.08 0.988,1.19 513 5134 0.1076 1.08 0.983,1.18 498 4996
394 Rheumatic disease of the heart valves circulatory system Both 0.4477 1.01 0.982,1.04 4899 48974 0.2911 0.966 0.906,1.03 1020 10246
394.2 Mitral valve disease circulatory system Both 0.6855 0.992 0.956,1.03 2993 29922 0.7031 0.993 0.956,1.03 2882 29085
394.3 Aortic valve disease circulatory system Both 0.2851 1.03 0.974,1.09 1282 12814 0.1496 1.04 0.985,1.11 1240 12506
394.7 Disease of tricuspid valve circulatory system Both 0.2089 0.96 0.901,1.02 1058 10566 0.2911 0.966 0.906,1.03 1020 10246
395 Heart valve disorders circulatory system Both 0.9817 1.0 0.969,1.03 4223 42219 0.3177 1.03 0.974,1.08 1448 14596
395.1 Nonrheumatic mitral valve disorders circulatory system Both 0.9376 0.999 0.961,1.04 2891 28900 0.9683 0.999 0.961,1.04 2781 28107
395.2 Nonrheumatic aortic valve disorders circulatory system Both 0.4634 0.955 0.845,1.08 276 2766 0.4446 0.953 0.841,1.08 268 2708
395.3 Nonrheumatic tricuspid valve disorders circulatory system Both 0.871 1.02 0.833,1.24 105 1039 0.975 1.0 0.819,1.23 100 1024
395.4 Nonrheumatic pulmonary valve disorders circulatory system Both 0.7295 0.964 0.782,1.19 97 970 0.7943 0.973 0.789,1.2 97 946
395.6 Heart valve replaced circulatory system Both 0.4083 1.02 0.97,1.08 1495 14942 0.3177 1.03 0.974,1.08 1448 14596
396 Abnormal heart sounds circulatory system Both 0.9661 1.0 0.94,1.07 1048 10468 0.6546 0.985 0.922,1.05 974 10029
401 Hypertension circulatory system Both 0.7551 0.999 0.99,1.01 73956 266957 0.3483 0.922 0.777,1.09 138 1401
401.1 Essential hypertension circulatory system Both 0.7656 0.999 0.99,1.01 73731 266739 0.05636 0.992 0.983,1.0 70560 258992
401.2 Hypertensive heart and/or renal disease circulatory system Both 0.7603 0.993 0.947,1.04 1898 19031 0.6109 0.986 0.935,1.04 1484 15097
401.21 Hypertensive heart disease circulatory system Both 0.5998 1.03 0.924,1.15 370 3699 0.6266 1.03 0.922,1.14 362 3632
401.22 Hypertensive chronic kidney disease circulatory system Both 0.5395 0.984 0.934,1.04 1543 15483 0.6109 0.986 0.935,1.04 1484 15097
401.3 Other hypertensive complications circulatory system Both 0.4831 0.942 0.797,1.11 144 1438 0.3483 0.922 0.777,1.09 138 1401
402 Elevated blood pressure reading without diagnosis of hypertension circulatory system Both 0.2344 0.968 0.917,1.02 1479 14786 0.105 0.955 0.904,1.01 1415 14377
411 Ischemic Heart Disease circulatory system Both 0.26 0.993 0.981,1.01 31245 210714 0.3428 0.972 0.916,1.03 1193 11937
411.1 Unstable angina (intermediate coronary syndrome) circulatory system Both 0.191 0.981 0.953,1.01 5152 51498 0.1656 0.98 0.952,1.01 5029 50315
411.2 Myocardial infarction circulatory system Both 0.2864 0.99 0.971,1.01 11950 112699 0.2178 0.988 0.97,1.01 11737 110723
411.3 Angina pectoris circulatory system Both 0.975 1.0 0.983,1.02 15888 143745 0.8166 0.998 0.982,1.01 15474 139847
411.4 Coronary atherosclerosis circulatory system Both 0.208 0.991 0.976,1.01 20171 154621 0.597 1.02 0.946,1.1 681 6839
411.41 Aneurysm and dissection of heart circulatory system Both 0.4613 1.03 0.954,1.11 700 6997 0.597 1.02 0.946,1.1 681 6839
411.8 Other chronic ischemic heart disease, unspecified circulatory system Both 0.4742 0.994 0.977,1.01 15290 131798 0.3917 0.993 0.976,1.01 14926 128684
411.9 Other acute and subacute forms of ischemic heart disease circulatory system Both 0.2864 0.969 0.914,1.03 1218 12166 0.3428 0.972 0.916,1.03 1193 11937
414 Other forms of chronic heart disease circulatory system Both 0.3459 0.977 0.931,1.03 1823 18228 0.4786 1.09 0.853,1.4 69 710
414.2 ASCVD circulatory system Both 0.5248 1.08 0.848,1.38 72 719 0.4786 1.09 0.853,1.4 69 710
415 Pulmonary heart disease circulatory system Both 0.6966 1.01 0.976,1.04 4476 44810 0.6252 1.02 0.929,1.13 433 4320
415.11 Pulmonary embolism and infarction, acute circulatory system Both 0.02582 0.771 0.614,0.969 75 750 0.02748 0.769 0.609,0.971 72 714
415.2 Chronic pulmonary heart disease circulatory system Both 0.9376 0.997 0.917,1.08 601 6002 0.6252 1.02 0.929,1.13 433 4320
415.21 Primary pulmonary hypertension circulatory system Both 0.5675 1.03 0.934,1.13 448 4475 0.6252 1.02 0.929,1.13 433 4320
416 Cardiomegaly circulatory system Both 0.2864 0.979 0.941,1.02 2680 26793 0.4217 0.984 0.945,1.02 2604 26175
418 Nonspecific chest pain circulatory system Both 0.7998 1.0 0.989,1.01 28599 270106 0.8531 1.0 0.969,1.04 3424 34403
418.1 Precordial pain circulatory system Both 0.6442 1.01 0.974,1.04 3551 35541 0.8531 1.0 0.969,1.04 3424 34403
420 Carditis circulatory system Both 0.5808 1.01 0.968,1.06 2106 21053 0.9247 1.0 0.929,1.08 695 7007
420.1 Myocarditis circulatory system Both 0.02799 1.23 1.02,1.47 127 1267 0.01629 1.25 1.04,1.5 125 1241
420.2 Pericarditis circulatory system Both 0.9354 0.998 0.943,1.06 1338 13371 0.4198 0.923 0.758,1.12 109 1103
420.21 Acute pericarditis circulatory system Both 0.5984 0.963 0.837,1.11 223 2227 0.7586 0.978 0.85,1.13 220 2178
420.22 Chronic pericarditis circulatory system Both 0.375 0.916 0.755,1.11 113 1129 0.4198 0.923 0.758,1.12 109 1103
420.3 Endocarditis circulatory system Both 0.9397 1.0 0.929,1.08 719 7194 0.9247 1.0 0.929,1.08 695 7007
425 Cardiomyopathy circulatory system Both 0.526 1.02 0.962,1.08 1271 12699 0.7925 1.04 0.795,1.35 59 598
425.1 Primary/intrinsic cardiomyopathies circulatory system Both 0.6622 1.01 0.955,1.07 1236 12349 0.4634 1.06 0.902,1.25 160 1576
425.11 Hypertrophic obstructive cardiomyopathy circulatory system Both 0.7194 1.03 0.864,1.24 133 1329 0.9616 1.0 0.839,1.2 129 1294
425.12 Other hypertrophic cardiomyopathy circulatory system Both 0.5715 1.05 0.89,1.24 163 1629 0.4634 1.06 0.902,1.25 160 1576
425.8 Other cardiomyopathy circulatory system Both 0.6808 1.06 0.811,1.38 60 600 0.7925 1.04 0.795,1.35 59 598
426 Cardiac conduction disorders circulatory system Both 0.6902 1.01 0.981,1.03 6910 69146 0.8851 1.0 0.96,1.05 2209 22248
426.2 Atrioventricular [AV] block circulatory system Both 0.1361 1.03 0.989,1.08 2114 21162 0.2254 1.12 0.934,1.34 126 1284
426.21 First degree AV block circulatory system Both 0.7015 1.01 0.949,1.08 986 9867 0.811 1.01 0.945,1.08 967 9692
426.23 Second degree AV block circulatory system Both 0.157 1.07 0.974,1.18 452 4515 0.1435 1.07 0.976,1.18 441 4452
426.24 Atrioventricular block, complete circulatory system Both 0.5236 1.03 0.946,1.12 587 5868 0.5598 1.03 0.942,1.12 567 5744
426.25 Other heart block circulatory system Both 0.1334 1.14 0.959,1.37 131 1318 0.2254 1.12 0.934,1.34 126 1284
426.3 Bundle branch block circulatory system Both 0.8472 1.0 0.968,1.04 3336 33359 0.4498 1.02 0.97,1.07 1691 17005
426.31 Right bundle branch block circulatory system Both 0.2535 0.97 0.92,1.02 1494 14933 0.2891 0.971 0.921,1.02 1452 14624
426.32 Left bundle branch block circulatory system Both 0.3266 1.03 0.976,1.08 1750 17503 0.4498 1.02 0.97,1.07 1691 17005
426.4 Anomalous atrioventricular excitation circulatory system Both 0.02938 1.16 1.02,1.33 233 2328 0.05728 1.14 0.996,1.32 223 2279
426.8 Other cardiac conduction disorders circulatory system Both 0.5521 1.08 0.833,1.41 60 600 0.5508 1.08 0.83,1.42 57 578
426.9 Cardiac pacemaker/device in situ circulatory system Both 0.9727 1.0 0.96,1.04 2475 24774 0.8851 1.0 0.96,1.05 2209 22248
426.91 Cardiac pacemaker in situ circulatory system Both 0.7834 1.01 0.964,1.05 2274 22762 0.8851 1.0 0.96,1.05 2209 22248
427 Cardiac dysrhythmias circulatory system Both 0.3565 0.994 0.981,1.01 24207 206016 0.9462 0.999 0.965,1.03 3619 36633
427.1 Paroxysmal tachycardia, unspecified circulatory system Both 0.2877 1.02 0.983,1.06 3199 32017 0.3192 0.966 0.903,1.03 921 9222
427.11 Paroxysmal supraventricular tachycardia circulatory system Both 0.1472 1.03 0.989,1.08 2344 23474 0.2228 1.03 0.984,1.07 2238 22715
427.12 Paroxysmal ventricular tachycardia circulatory system Both 0.4074 0.972 0.908,1.04 936 9365 0.3192 0.966 0.903,1.03 921 9222
427.2 Atrial fibrillation and flutter circulatory system Both 0.4519 0.993 0.977,1.01 14628 133501 0.1656 0.988 0.971,1.01 14182 130160
427.3 Other specified cardiac dysrhythmias circulatory system Both 0.4677 0.987 0.952,1.02 3228 32281 0.1811 0.975 0.94,1.01 3124 31519
427.4 Cardiac arrest and ventricular fibrillation circulatory system Both 0.5309 0.981 0.925,1.04 1193 11915 0.5781 0.982 0.919,1.05 962 9666
427.41 Ventricular fibrillation and flutter circulatory system Both 0.7047 0.979 0.88,1.09 344 3437 0.5998 0.971 0.872,1.08 333 3385
427.42 Cardiac arrest circulatory system Both 0.6252 0.984 0.922,1.05 990 9890 0.5781 0.982 0.919,1.05 962 9666
427.5 Arrhythmia (cardiac) NOS circulatory system Both 0.2046 0.958 0.896,1.02 952 9541 0.1549 0.952 0.889,1.02 910 9269
427.6 Premature beats circulatory system Both 0.4074 0.963 0.881,1.05 535 5358 0.8414 1.02 0.84,1.24 116 1144
427.61 Supraventricular premature beats circulatory system Both 0.9863 0.998 0.823,1.21 117 1168 0.8414 1.02 0.84,1.24 116 1144
427.7 Tachycardia NOS circulatory system Both 0.2301 1.03 0.983,1.07 2185 21865 0.4395 1.02 0.973,1.07 2046 21135
427.8 Sinoatrial node dysfunction (Bradycardia) circulatory system Both 0.9954 1.0 0.904,1.11 402 4029 0.9057 0.994 0.897,1.1 388 3909
427.9 Palpitations circulatory system Both 0.6053 1.01 0.976,1.04 3811 38105 0.9462 0.999 0.965,1.03 3619 36633
428 Congestive heart failure; nonhypertensive circulatory system Both 0.7396 0.995 0.968,1.02 5605 56018 0.4721 1.01 0.98,1.04 4315 43620
428.1 Congestive heart failure (CHF) NOS circulatory system Both 0.257 0.974 0.932,1.02 2111 21108 0.537 0.986 0.942,1.03 2044 20589
428.2 Heart failure NOS circulatory system Both 0.3664 1.01 0.984,1.05 4455 44524 0.4721 1.01 0.98,1.04 4315 43620
429 Ill-defined descriptions and complications of heart disease circulatory system Both 0.673 0.984 0.912,1.06 716 7168 0.5929 0.961 0.829,1.11 186 1903
429.1 Heart transplant/surgery circulatory system Both 0.2529 1.16 0.897,1.51 64 639 0.3311 1.14 0.875,1.49 61 629
429.2 Abnormal function study of cardiovascular system circulatory system Both 0.7568 0.986 0.902,1.08 522 5211 0.9772 0.999 0.913,1.09 512 5079
429.3 Symptoms involving cardiovascular system circulatory system Both 0.6683 0.969 0.84,1.12 196 1978 0.5929 0.961 0.829,1.11 186 1903
430 Intracranial hemorrhage circulatory system Both 0.2366 0.972 0.927,1.02 1883 18825 0.2606 0.929 0.818,1.06 256 2607
430.1 Subarachnoid hemorrhage circulatory system Both 0.2582 0.96 0.895,1.03 836 8353 0.3133 0.964 0.898,1.04 811 8034
430.2 Intracerebral hemorrhage circulatory system Both 0.8035 0.991 0.919,1.07 765 7656 0.6546 0.983 0.911,1.06 740 7448
430.3 Subdural hemorrhage circulatory system Both 0.3206 0.938 0.828,1.06 267 2667 0.2606 0.929 0.818,1.06 256 2607
433 Cerebrovascular disease circulatory system Both 0.2286 0.987 0.965,1.01 8749 87456 0.09099 0.951 0.898,1.01 1236 12427
433.1 Occlusion and stenosis of precerebral arteries circulatory system Both 0.2317 0.964 0.908,1.02 1185 11825 0.9528 0.996 0.868,1.14 220 2191
433.12 Cerebral atherosclerosis circulatory system Both 0.9638 1.0 0.876,1.15 227 2267 0.9528 0.996 0.868,1.14 220 2191
433.2 Occlusion of cerebral arteries circulatory system Both 0.02388 0.964 0.935,0.995 4233 42320 0.06324 0.953 0.906,1.0 1630 16369
433.21 Cerebral artery occlusion, with cerebral infarction circulatory system Both 0.09506 0.958 0.912,1.01 1680 16794 0.06324 0.953 0.906,1.0 1630 16369
433.3 Cerebral ischemia circulatory system Both 0.5534 0.989 0.952,1.03 2895 28989 0.5383 0.986 0.943,1.03 2074 20748
433.31 Transient cerebral ischemia circulatory system Both 0.5117 0.985 0.943,1.03 2135 21379 0.5383 0.986 0.943,1.03 2074 20748
433.5 Cerebral aneurysm circulatory system Both 0.3954 0.955 0.86,1.06 394 3939 0.2099 0.933 0.837,1.04 370 3768
433.8 Late effects of cerebrovascular disease circulatory system Both 0.1169 0.956 0.903,1.01 1279 12783 0.09099 0.951 0.898,1.01 1236 12427
440 Atherosclerosis circulatory system Both 0.09462 1.05 0.992,1.11 1380 13822 0.5321 1.04 0.921,1.17 281 2769
440.1 Atherosclerosis of renal artery circulatory system Both 0.2553 0.895 0.74,1.08 113 1129 0.2723 0.898 0.741,1.09 111 1105
440.2 Atherosclerosis of the extremities circulatory system Both 0.1503 1.05 0.981,1.13 805 8070 0.169 1.05 0.978,1.13 788 7931
440.9 Atherosclerosis of aorta circulatory system Both 0.6194 1.03 0.915,1.16 287 2867 0.5321 1.04 0.921,1.17 281 2769
441 Vascular insufficiency of intestine circulatory system Both 0.2046 0.949 0.875,1.03 614 6154 0.2884 0.935 0.827,1.06 268 2717
441.1 Acute vascular insufficiency of intestine circulatory system Both 0.4581 0.956 0.848,1.08 283 2827 0.2884 0.935 0.827,1.06 268 2717
442 Other aneurysm circulatory system Both 0.8356 1.0 0.959,1.05 1892 18959 0.4285 1.06 0.917,1.23 195 1970
442.1 Aortic aneurysm circulatory system Both 0.9594 0.999 0.947,1.05 1458 14625 0.6442 0.984 0.921,1.05 921 9268
442.11 Abdominal aortic aneurysm circulatory system Both 0.6761 0.986 0.923,1.05 931 9341 0.6442 0.984 0.921,1.05 921 9268
442.2 Aneurysm of iliac artery circulatory system Both 0.1945 0.873 0.711,1.07 102 1019 0.191 0.872 0.711,1.07 102 1012
442.3 Aneurysm of artery of lower extremity circulatory system Both 0.9772 1.0 0.856,1.17 169 1696 0.881 1.01 0.863,1.19 165 1670
442.4 Arterial dissection circulatory system Both 0.3622 0.879 0.667,1.16 54 549 0.3184 0.867 0.654,1.15 53 536
442.8 Aneurysm of other specified artery circulatory system Both 0.3177 1.08 0.932,1.24 203 2028 0.4285 1.06 0.917,1.23 195 1970
443 Peripheral vascular disease circulatory system Both 0.507 0.989 0.957,1.02 3921 39273 0.9162 1.0 0.962,1.04 2522 25320
443.1 Raynaud's syndrome circulatory system Both 0.4677 0.978 0.92,1.04 1145 11438 0.4688 0.977 0.918,1.04 1094 10916
443.7 Peripheral angiopathy in diseases classified elsewhere circulatory system Both 0.04842 0.898 0.808,0.999 384 3878 0.06607 0.905 0.814,1.01 381 3817
443.8 Other specified peripheral vascular diseases circulatory system Both 0.6295 0.992 0.959,1.03 3686 36906 0.778 0.995 0.961,1.03 3582 35877
443.9 Peripheral vascular disease, unspecified circulatory system Both 0.881 0.997 0.957,1.04 2579 25846 0.9162 1.0 0.962,1.04 2522 25320
444 Arterial embolism and thrombosis circulatory system Both 0.9795 0.999 0.934,1.07 922 9251 0.5105 0.971 0.888,1.06 543 5467
444.1 Arterial embolism and thrombosis of lower extremity artery circulatory system Both 0.4539 0.967 0.886,1.06 554 5552 0.5105 0.971 0.888,1.06 543 5467
446 Polyarteritis nodosa and allied conditions circulatory system Both 0.5902 1.02 0.949,1.1 822 8226 0.05395 1.14 0.998,1.3 234 2335
446.4 Wegener's granulomatosis circulatory system Both 0.1954 0.905 0.778,1.05 188 1878 0.2432 0.914 0.785,1.06 186 1826
446.5 Giant cell arteritis circulatory system Both 0.877 1.01 0.908,1.12 388 3879 0.9419 1.0 0.901,1.12 365 3676
446.9 Arteritis NOS circulatory system Both 0.05012 1.14 1.0,1.3 239 2400 0.05395 1.14 0.998,1.3 234 2335
447 Other disorders of arteries and arterioles circulatory system Both 0.1637 1.04 0.984,1.1 1327 13316 0.2559 1.04 0.971,1.12 857 8557
447.1 Stricture of artery circulatory system Both 0.2958 1.04 0.968,1.11 868 8712 0.2559 1.04 0.971,1.12 857 8557
448 Disease of capillaries circulatory system Both 0.9886 0.999 0.845,1.18 142 1420 0.7691 1.03 0.865,1.22 135 1365
450 Noninfectious disorders of lymphatic channels circulatory system Both 1.135E-5 1.19 1.1,1.28 704 7034 0.02958 1.1 1.01,1.2 526 6739
451 Phlebitis and thrombophlebitis circulatory system Both 0.4188 0.987 0.955,1.02 3955 39683 0.1738 0.976 0.943,1.01 3501 35961
451.2 Phlebitis and thrombophlebitis of lower extremities circulatory system Both 0.4018 0.986 0.953,1.02 3683 36977 0.1738 0.976 0.943,1.01 3501 35961
452 Other venous embolism and thrombosis circulatory system Both 0.9638 0.998 0.915,1.09 564 5645 0.9572 0.998 0.912,1.09 519 5468
454 Varicose veins circulatory system Both 0.002618 1.03 1.01,1.05 11180 112047 0.6081 0.978 0.899,1.06 593 6151
454.1 Varicose veins of lower extremity circulatory system Both 4.721E-4 1.03 1.02,1.05 11503 115272 0.6081 0.978 0.899,1.06 593 6151
454.11 Varicose veins of lower extremity, symptomtic circulatory system Both 0.7516 0.987 0.909,1.07 624 6325 0.6081 0.978 0.899,1.06 593 6151
455 Hemorrhoids circulatory system Both 0.6531 1.0 0.99,1.02 23452 234585 0.7015 1.0 0.989,1.02 22689 227493
456 Chronic venous insufficiency [CVI] circulatory system Both 0.8472 0.985 0.847,1.15 184 1868 0.7889 0.979 0.84,1.14 176 1820
457 Encounter for long-term (current) use of anticoagulants, antithrombotics, aspirin circulatory system Both 0.1968 1.14 0.933,1.4 97 967 0.2307 1.13 0.923,1.4 94 938
458 Hypotension circulatory system Both 0.0863 1.02 0.997,1.05 5769 57772 0.7962 0.995 0.96,1.03 3292 33918
458.1 Orthostatic hypotension circulatory system Both 0.04159 1.06 1.0,1.12 1335 13376 0.1153 1.05 0.989,1.11 1279 12991
458.2 Iatrogenic hypotension circulatory system Both 0.9078 1.01 0.883,1.15 235 2348 0.8241 1.02 0.888,1.16 228 2272
458.9 Hypotension NOS circulatory system Both 0.6081 1.01 0.975,1.04 3494 35005 0.7962 0.995 0.96,1.03 3292 33918
459 Other disorders of circulatory system circulatory system Both 0.5598 1.0 0.989,1.02 16268 160790 0.375 0.993 0.976,1.01 15281 154653
459.1 Hemorrhage NOS circulatory system Both 0.1151 1.14 0.968,1.35 142 1420 0.2366 1.11 0.934,1.32 132 1381
459.9 Circulatory disease NEC circulatory system Both 0.8147 1.0 0.986,1.02 16103 159422 0.375 0.993 0.976,1.01 15281 154653
464 Acute sinusitis respiratory Both 0.1622 0.901 0.779,1.04 196 1957 0.1888 0.905 0.781,1.05 187 1877
465 Acute upper respiratory infections of multiple or unspecified sites respiratory Both 0.1596 1.03 0.988,1.08 2283 22827 0.06982 0.861 0.732,1.01 159 1594
465.2 Acute pharyngitis respiratory Both 0.06839 1.07 0.995,1.15 835 8348 0.9226 1.0 0.931,1.08 735 8102
465.4 Acute laryngitis and tracheitis respiratory Both 0.07278 0.865 0.738,1.01 165 1649 0.06982 0.861 0.732,1.01 159 1594
470 Septal Deviations/Turbinate Hypertrophy respiratory Both 0.9247 1.0 0.972,1.03 4654 46553 0.8511 0.997 0.967,1.03 4558 45576
471 Nasal polyps respiratory Both 0.8128 0.996 0.961,1.03 3297 32973 0.9268 0.998 0.963,1.03 3227 32267
472 Chronic pharyngitis and nasopharyngitis respiratory Both 0.7228 1.01 0.947,1.08 960 9594 0.3516 1.03 0.965,1.11 926 9326
473 Diseases of the larynx and vocal cords respiratory Both 0.9727 0.999 0.959,1.04 2554 25548 0.1811 1.04 0.98,1.11 1038 10425
473.1 Chronic laryngitis respiratory Both 0.2864 1.11 0.915,1.35 104 1038 0.3069 1.11 0.91,1.35 103 1009
473.3 Paralysis/spasm of vocal cords or larynx respiratory Both 0.3855 0.946 0.835,1.07 264 2647 0.4831 0.955 0.839,1.09 245 2562
473.4 Voice disturbance respiratory Both 0.1652 1.05 0.982,1.11 1080 10789 0.1811 1.04 0.98,1.11 1038 10425
474 Acute and chronic tonsillitis respiratory Both 0.2133 0.97 0.923,1.02 1772 17710 0.3656 0.972 0.913,1.03 1097 10892
474.1 Acute tonsillitis respiratory Both 0.695 0.983 0.9,1.07 549 5486 0.4819 0.968 0.886,1.06 529 5351
474.2 Chronic tonsillitis and adenoiditis respiratory Both 0.3516 0.971 0.914,1.03 1122 11199 0.3656 0.972 0.913,1.03 1097 10892
475 Chronic sinusitis respiratory Both 0.5284 0.987 0.948,1.03 2589 25882 0.4943 0.986 0.946,1.03 2507 25089
476 Allergic rhinitis respiratory Both 0.6152 1.02 0.954,1.08 1055 10563 0.9036 1.0 0.942,1.07 1016 10228
477 Epistaxis or throat hemorrhage respiratory Both 0.7852 1.01 0.965,1.05 2447 24452 0.7295 1.01 0.966,1.05 2354 23801
478 Throat pain respiratory Both 0.2148 0.935 0.84,1.04 377 3789 0.2958 0.944 0.846,1.05 361 3647
479 Other upper respiratory disease respiratory Both 0.01774 1.04 1.01,1.07 4074 40737 0.02518 1.04 1.0,1.07 3960 39639
480 Pneumonia respiratory Both 0.5212 1.01 0.987,1.03 10336 103397 0.7031 0.986 0.915,1.06 756 7735
480.1 Bacterial pneumonia respiratory Both 0.8337 1.0 0.978,1.03 6637 66410 0.4989 1.08 0.868,1.34 87 904
480.11 Pneumococcal pneumonia respiratory Both 0.7834 1.0 0.977,1.03 5883 58863 0.6237 0.993 0.966,1.02 5576 57104
480.12 Pseudomonal pneumonia respiratory Both 0.4634 1.08 0.877,1.33 93 929 0.4989 1.08 0.868,1.34 87 904
480.2 Viral pneumonia respiratory Both 0.826 1.03 0.808,1.31 72 720 0.8414 1.03 0.802,1.31 69 696
480.3 Pneumonia due to fungus (mycoses) respiratory Both 0.4009 1.09 0.889,1.34 99 989 0.2884 1.12 0.908,1.38 95 965
480.5 Bronchopneumonia and lung abscess respiratory Both 0.8166 0.991 0.922,1.07 794 7951 0.7031 0.986 0.915,1.06 756 7735
481 Influenza respiratory Both 0.3648 0.949 0.848,1.06 328 3278 0.1963 0.927 0.826,1.04 315 3184
483 Acute bronchitis and bronchiolitis respiratory Both 0.4395 1.06 0.916,1.22 193 1930 0.5585 1.05 0.901,1.21 184 1863
495 Asthma respiratory Both 0.166 1.01 0.996,1.02 25689 250406 0.5821 1.04 0.907,1.19 240 2423
495.2 Asthma with exacerbation respiratory Both 0.492 1.05 0.918,1.19 250 2510 0.5821 1.04 0.907,1.19 240 2423
496 Chronic airway obstruction respiratory Both 0.1268 1.02 0.996,1.04 10424 101546 0.4083 1.02 0.972,1.07 1779 18136
496.1 Emphysema respiratory Both 0.7396 0.992 0.944,1.04 1743 17438 0.4074 0.979 0.931,1.03 1660 16988
496.2 Chronic bronchitis respiratory Both 0.1253 1.03 0.992,1.07 2947 29498 0.1169 1.03 0.992,1.07 2596 26267
496.21 Obstructive chronic bronchitis respiratory Both 0.1552 1.03 0.989,1.07 2706 27081 0.1169 1.03 0.992,1.07 2596 26267
496.3 Bronchiectasis respiratory Both 0.2051 1.03 0.983,1.08 1885 18859 0.4083 1.02 0.972,1.07 1779 18136
497 Bronchitis respiratory Both 0.2559 1.05 0.966,1.14 626 6267 0.3155 1.04 0.96,1.13 599 6054
500 Lung disease due to external agents respiratory Both 0.5916 0.973 0.881,1.07 412 4099 0.9183 0.993 0.872,1.13 241 2398
500.1 Extrinsic allergic alveolitis respiratory Both 0.2004 0.864 0.691,1.08 79 784 0.2495 0.877 0.701,1.1 79 758
500.2 Pneumoconiosis respiratory Both 0.9057 0.992 0.871,1.13 243 2409 0.9183 0.993 0.872,1.13 241 2398
501 Pneumonitis due to inhalation of food or vomitus respiratory Both 0.7447 0.987 0.911,1.07 656 6557 0.798 0.989 0.912,1.07 633 6423
502 Postinflammatory pulmonary fibrosis respiratory Both 0.929 0.997 0.931,1.07 917 9193 0.8892 0.995 0.929,1.07 882 8939
503 Pulmonary congestion and hypostasis respiratory Both 0.8204 0.989 0.903,1.08 508 5079 0.826 0.99 0.901,1.09 489 4921
504 Other alveolar and parietoalveolar pneumonopathy respiratory Both 0.7674 0.983 0.877,1.1 328 3280 0.5998 0.97 0.863,1.09 317 3176
505 Other pulmonary inflamation or edema respiratory Both 0.6471 1.06 0.82,1.38 61 610 0.7328 1.05 0.805,1.36 59 586
506 Empyema and pneumothorax respiratory Both 0.3327 0.97 0.912,1.03 1133 11362 0.1324 0.953 0.895,1.01 1075 11107
507 Pleurisy; pleural effusion respiratory Both 0.9016 0.998 0.973,1.02 6419 64252 0.09594 0.978 0.952,1.0 5996 62505
508 Pulmonary collapse; interstitial and compensatory emphysema respiratory Both 0.5572 0.986 0.942,1.03 1996 19947 0.3828 0.979 0.934,1.03 1897 19342
509 Respiratory failure, insufficiency, arrest respiratory Both 0.7603 1.01 0.967,1.05 2599 26031 0.859 0.99 0.891,1.1 380 3743
509.1 Respiratory failure respiratory Both 0.7328 1.01 0.964,1.05 2068 20708 0.9661 1.0 0.956,1.05 1975 20083
509.2 Respiratory insufficiency respiratory Both 0.5662 1.01 0.967,1.06 1806 18106 0.7047 1.01 0.961,1.06 1722 17547
509.5 Respiratory arrest respiratory Both 0.9226 1.01 0.852,1.19 143 1429 0.9036 1.01 0.852,1.2 141 1382
509.8 Dependence on respirator [Ventilator] or supplemental oxygen respiratory Both 0.7396 0.982 0.884,1.09 386 3863 0.859 0.99 0.891,1.1 380 3743
510 Other diseases of lung respiratory Both 0.5984 0.98 0.909,1.06 755 7554 0.1368 0.943 0.872,1.02 703 7327
512 Other symptoms of respiratory system respiratory Both 0.2897 1.01 0.99,1.03 9031 90349 0.7328 1.01 0.944,1.08 879 8878
512.1 Wheezing respiratory Both 0.7112 0.974 0.848,1.12 220 2196 0.4943 0.952 0.825,1.1 211 2129
512.2 Painful respiration respiratory Both 0.2148 0.914 0.793,1.05 207 2075 0.3289 0.929 0.802,1.08 191 1995
512.7 Shortness of breath respiratory Both 0.01726 1.03 1.01,1.06 5842 58498 0.06531 1.03 0.998,1.06 5517 56563
512.8 Cough respiratory Both 0.6887 0.992 0.955,1.03 2866 28642 0.1556 0.972 0.934,1.01 2706 27660
512.9 Other dyspnea respiratory Both 0.5929 1.02 0.952,1.09 914 9124 0.7328 1.01 0.944,1.08 879 8878
513 Respiratory abnormalities respiratory Both 0.6397 0.98 0.9,1.07 611 6112 0.01081 0.799 0.672,0.949 150 1518
513.3 Hypoventilation respiratory Both 0.2377 0.872 0.694,1.09 83 830 0.2472 0.87 0.688,1.1 77 809
513.4 Hyperventilation respiratory Both 0.8091 1.02 0.896,1.15 278 2778 0.8185 1.02 0.894,1.15 265 2680
513.8 Disorders of diaphragm respiratory Both 0.01086 0.8 0.674,0.95 153 1538 0.01081 0.799 0.672,0.949 150 1518
514 Abnormal findings examination of lungs respiratory Both 0.4539 1.02 0.975,1.06 2465 24673 0.8147 0.995 0.953,1.04 2281 23883
516 Abnormal sputum respiratory Both 0.1324 1.03 0.99,1.08 2132 21335 0.4519 1.02 0.972,1.07 1996 20201
516.1 Hemoptysis respiratory Both 0.2618 1.03 0.981,1.07 2073 20745 0.4519 1.02 0.972,1.07 1996 20201
519 Other diseases of respiratory system, not elsewhere classified respiratory Both 0.7925 0.997 0.976,1.02 9366 93681 0.7816 1.02 0.897,1.16 268 2937
519.2 Respiratory complications respiratory Both 0.7015 1.02 0.913,1.15 327 3279 0.9817 0.999 0.888,1.12 304 3159
519.8 Other diseases of respiratory system, NEC respiratory Both 0.811 0.997 0.976,1.02 8853 88522 0.4581 0.992 0.97,1.01 8381 85909
519.9 Symptoms involving respiratory system and other chest symptoms respiratory Both 0.2148 1.08 0.958,1.21 303 3049 0.7816 1.02 0.897,1.16 268 2937
520 Disorders of tooth development digestive Both 0.5333 1.01 0.969,1.06 2038 20354 0.2891 1.02 0.98,1.07 2283 22893
520.1 Hereditary disturbances in tooth structure digestive Both 0.354 1.14 0.866,1.5 53 530 0.3357 1.15 0.867,1.52 51 513
520.2 Disturbances in tooth eruption digestive Both 0.369 1.02 0.977,1.06 2356 23539 0.2891 1.02 0.98,1.07 2283 22893
521 Diseases of hard tissues of teeth digestive Both 0.04667 0.963 0.928,0.999 3016 30245 0.003141 0.945 0.909,0.981 2906 29490
521.1 Dental caries digestive Both 0.01884 0.956 0.921,0.993 3026 30353 0.003141 0.945 0.909,0.981 2906 29490
522 Diseases of pulp and periapical tissues digestive Both 0.5715 1.01 0.966,1.06 1774 17750 0.2559 1.04 0.975,1.1 1120 11356
522.5 Periapical abscess digestive Both 0.1932 1.04 0.98,1.1 1172 11731 0.2559 1.04 0.975,1.1 1120 11356
523 Gingival and periodontal diseases digestive Both 0.6383 1.01 0.962,1.06 1681 16812 0.7745 1.01 0.927,1.11 534 5409
523.1 Gingivitis digestive Both 0.6166 1.05 0.868,1.27 113 1127 0.5572 1.06 0.871,1.29 106 1083
523.3 Periodontitis (acute or chronic) digestive Both 0.8318 1.01 0.948,1.07 1165 11650 0.7745 1.01 0.927,1.11 534 5409
523.31 Acute periodontitis digestive Both 0.8241 0.991 0.915,1.07 666 6667 0.7889 0.989 0.912,1.07 642 6469
523.32 Chronic periodontitis digestive Both 0.6823 1.02 0.933,1.11 560 5594 0.7745 1.01 0.927,1.11 534 5409
524 Dentofacial anomalies, including malocclusion digestive Both 0.6902 1.02 0.915,1.14 331 3307 0.4634 1.04 0.929,1.18 298 2960
524.3 Anomalies of tooth position/malocclusion digestive Both 0.3491 1.06 0.941,1.19 305 3046 0.4634 1.04 0.929,1.18 298 2960
525 Other diseases of the teeth and supporting structures digestive Both 0.6442 1.01 0.97,1.05 2668 26728 0.7762 1.04 0.807,1.33 69 682
525.2 Atrophy of edentulous alveolar ridge digestive Both 0.9528 1.01 0.79,1.29 72 720 0.7762 1.04 0.807,1.33 69 682
526 Diseases of the jaws digestive Both 0.413 0.972 0.909,1.04 928 9279 0.9333 1.01 0.88,1.15 224 2241
526.1 Cysts of the jaws digestive Both 0.3069 0.943 0.843,1.06 329 3289 0.3155 0.943 0.842,1.06 323 3199
526.3 Anomalies of jaw size/symmetry digestive Both 0.05248 0.761 0.578,1.0 61 610 0.00877 0.682 0.513,0.908 57 590
526.4 Temporomandibular joint disorders digestive Both 0.3508 1.06 0.934,1.21 240 2406 0.6412 1.03 0.901,1.18 222 2236
526.41 Temporomandibular joint disorder, unspecified digestive Both 0.4365 1.05 0.923,1.2 233 2336 0.6412 1.03 0.901,1.18 222 2236
526.5 Inflammatory conditions of jaw digestive Both 0.1758 0.875 0.72,1.06 110 1098 0.1483 0.863 0.706,1.05 102 1058
526.9 Jaw disease NOS digestive Both 0.7656 1.02 0.895,1.16 233 2329 0.9333 1.01 0.88,1.15 224 2241
527 Diseases of the salivary glands digestive Both 0.5188 1.03 0.949,1.11 694 6943 0.5117 0.937 0.773,1.14 113 1158
527.1 Hypertrophy of salivary gland digestive Both 0.879 0.983 0.793,1.22 84 838 0.7031 0.958 0.771,1.19 82 806
527.2 Sialoadenitis digestive Both 0.4446 1.04 0.936,1.16 365 3656 0.4121 1.05 0.938,1.17 355 3534
527.7 Disturbance of salivary secretion digestive Both 0.3133 1.14 0.883,1.47 62 619 0.3864 1.12 0.866,1.45 60 595
527.8 Other specified diseases of the salivary glands digestive Both 0.3236 0.909 0.753,1.1 120 1200 0.5117 0.937 0.773,1.14 113 1158
528 Diseases of the oral soft tissues, excluding lesions specific for gingiva and tongue digestive Both 0.2223 1.02 0.988,1.05 3873 38741 0.9594 0.997 0.887,1.12 306 3046
528.1 Stomatitis and mucositis digestive Both 0.01109 1.13 1.03,1.24 468 4675 0.3963 1.1 0.878,1.39 74 818
528.11 Stomatitis and mucositis (ulcerative) digestive Both 0.007798 1.15 1.04,1.27 389 3884 0.05821 1.11 0.996,1.23 345 3746
528.12 Oral aphthae digestive Both 0.6252 1.06 0.85,1.31 84 840 0.3963 1.1 0.878,1.39 74 818
528.3 Cellulitis and abscess of oral soft tissues digestive Both 0.4477 1.06 0.912,1.23 179 1790 0.7762 1.02 0.877,1.19 170 1738
528.4 Cysts of oral soft tissues digestive Both 0.2113 0.89 0.741,1.07 122 1219 0.4989 0.929 0.751,1.15 91 908
528.41 Cyst of the salivary gland digestive Both 0.5768 0.942 0.764,1.16 94 940 0.4989 0.929 0.751,1.15 91 908
528.5 Diseases of lips digestive Both 0.01169 1.1 1.02,1.19 681 6813 0.007889 1.11 1.03,1.2 659 6572
528.6 Leukoplakia of oral mucosa digestive Both 0.8185 0.986 0.877,1.11 308 3079 0.7889 0.984 0.874,1.11 300 2982
528.7 Sialolithiasis digestive Both 0.9908 0.999 0.891,1.12 314 3138 0.9594 0.997 0.887,1.12 306 3046
529 Diseases and other conditions of the tongue digestive Both 0.2275 0.965 0.91,1.02 1232 12312 0.3236 1.06 0.943,1.2 290 2890
529.1 Glossitis digestive Both 0.3221 1.06 0.944,1.19 299 2986 0.3236 1.06 0.943,1.2 290 2890
530 Diseases of esophagus digestive Both 0.5152 1.0 0.992,1.02 33453 279172 0.342 1.02 0.977,1.07 1997 20027
530.1 Esophagitis, GERD and related diseases digestive Both 0.5861 1.0 0.992,1.02 31253 272429 0.4178 0.992 0.972,1.01 10122 101202
530.11 GERD digestive Both 0.415 1.01 0.992,1.02 22633 225879 0.861 1.0 0.987,1.02 21680 218171
530.12 Ulcer of esophagus digestive Both 0.4121 1.01 0.984,1.04 5203 52068 0.4634 1.01 0.982,1.04 5076 50706
530.14 Reflux esophagitis digestive Both 0.3221 0.99 0.97,1.01 10444 104493 0.4178 0.992 0.972,1.01 10122 101202
530.2 Esophageal bleeding (varices/hemorrhage) digestive Both 0.3311 0.975 0.927,1.03 1681 16808 0.2553 0.971 0.922,1.02 1625 16282
530.3 Stricture and stenosis of esophagus digestive Both 0.1127 1.04 0.991,1.09 1869 18684 0.171 1.03 0.986,1.08 1807 18195
530.5 Disorders of esophageal motility digestive Both 0.3516 1.04 0.958,1.13 635 6365 0.5458 1.03 0.944,1.12 606 6136
530.6 Diverticulum of esophagus, acquired digestive Both 0.5433 1.05 0.894,1.24 153 1527 0.7063 1.03 0.876,1.22 149 1470
530.7 Gastroesophageal laceration-hemorrhage syndrome digestive Both 0.2173 0.932 0.833,1.04 341 3416 0.1811 0.925 0.826,1.04 333 3332
530.9 Heartburn digestive Both 0.3664 1.02 0.976,1.07 2087 20881 0.342 1.02 0.977,1.07 1997 20027
531 Peptic ulcer (excl. esophageal) digestive Both 0.1361 0.982 0.958,1.01 7103 71066 0.1435 0.927 0.838,1.03 415 4125
531.1 Hemorrhage from gastrointestinal ulcer digestive Both 0.3565 0.963 0.889,1.04 637 6374 0.3141 0.959 0.884,1.04 614 6250
531.2 Gastric ulcer digestive Both 0.6442 0.992 0.961,1.02 4091 40941 0.6039 0.991 0.96,1.02 3966 39549
531.3 Duodenal ulcer digestive Both 0.3296 0.981 0.945,1.02 2999 30005 0.1849 0.974 0.938,1.01 2902 29284
531.4 Peptic ulcer, site unspecified digestive Both 0.1079 0.921 0.834,1.02 427 4268 0.1435 0.927 0.838,1.03 415 4125
532 Dysphagia digestive Both 0.9162 1.0 0.976,1.03 6427 64329 0.867 0.998 0.972,1.02 6139 62009
535 Gastritis and duodenitis digestive Both 0.06124 0.988 0.976,1.0 28078 261548 0.8299 0.979 0.808,1.19 120 1150
535.1 Acute gastritis digestive Both 0.6776 1.01 0.954,1.07 1183 11833 0.7962 1.01 0.949,1.07 1143 11420
535.2 Atrophic gastritis digestive Both 0.2382 0.938 0.843,1.04 370 3687 0.3926 0.954 0.856,1.06 358 3565
535.6 Duodenitis digestive Both 0.2249 0.985 0.963,1.01 7592 75928 0.1694 0.983 0.96,1.01 7382 73936
535.8 Other specified gastritis digestive Both 0.2576 1.01 0.99,1.04 8071 80763 0.2128 1.01 0.992,1.04 7789 77834
535.9 Gastritis and duodenitis, NOS digestive Both 0.6761 0.96 0.792,1.16 120 1191 0.8299 0.979 0.808,1.19 120 1150
536.8 Dyspepsia and other specified disorders of function of stomach digestive Both 0.3388 0.94 0.828,1.07 259 2576 0.3281 0.937 0.823,1.07 245 2487
537 Other disorders of stomach and duodenum digestive Both 0.5093 0.988 0.954,1.02 3391 33907 0.1923 0.976 0.942,1.01 3259 32749
540 Appendiceal conditions digestive Both 0.9078 1.0 0.966,1.04 3088 30890 0.7379 1.01 0.967,1.05 2537 25288
540.1 Appendicitis digestive Both 0.873 0.997 0.959,1.04 2895 28963 0.7379 1.01 0.967,1.05 2537 25288
540.11 Acute appendicitis digestive Both 0.875 1.0 0.963,1.04 2601 26019 0.7379 1.01 0.967,1.05 2537 25288
550 Abdominal hernia digestive Both 0.955 1.0 0.99,1.01 45429 282640 0.1306 0.973 0.939,1.01 3292 33346
550.1 Inguinal hernia digestive Both 0.4842 0.994 0.978,1.01 15794 123247 0.5559 0.995 0.979,1.01 15711 122486
550.2 Diaphragmatic hernia digestive Both 0.6138 1.0 0.991,1.02 26494 238953 0.8185 1.0 0.989,1.01 25417 230563
550.3 Femoral hernia digestive Both 0.4395 0.969 0.893,1.05 651 6504 0.6081 0.978 0.9,1.06 619 6195
550.4 Umbilical hernia digestive Both 0.1303 0.974 0.942,1.01 3705 37072 0.09462 0.972 0.939,1.01 3647 36517
550.5 Ventral hernia digestive Both 0.3221 0.982 0.949,1.02 3435 34338 0.1306 0.973 0.939,1.01 3292 33346
555 Inflammatory bowel disease and other gastroenteritis and colitis digestive Both 0.2661 1.02 0.987,1.05 4444 44442 0.6592 1.02 0.932,1.12 517 5237
555.1 Regional enteritis digestive Both 0.975 1.0 0.953,1.05 1734 17340 0.9226 1.0 0.953,1.05 1674 16786
555.2 Ulcerative colitis digestive Both 0.4178 1.02 0.979,1.05 3178 31786 0.6592 1.02 0.932,1.12 517 5237
555.21 Ulcerative colitis (chronic) digestive Both 0.6124 1.02 0.936,1.12 538 5382 0.6592 1.02 0.932,1.12 517 5237
556 Ulceration of the lower GI tract digestive Both 0.6339 0.985 0.925,1.05 1055 10592 0.8017 0.99 0.914,1.07 648 6490
556.1 Ulceration of intestine digestive Both 0.787 0.989 0.915,1.07 670 6714 0.8017 0.99 0.914,1.07 648 6490
557 Intestinal malabsorption (non-celiac) digestive Both 0.05508 0.89 0.789,1.0 299 2987 0.3281 0.976 0.929,1.02 1775 17705
557.1 Celiac disease digestive Both 0.5047 0.984 0.937,1.03 1837 18388 0.3281 0.976 0.929,1.02 1775 17705
558 Noninfectious gastroenteritis digestive Both 0.3981 0.993 0.977,1.01 15492 155105 0.0547 0.984 0.967,1.0 14741 149690
559 Ileostomy status digestive Both 0.3365 1.03 0.975,1.08 1656 16541 0.542 1.02 0.965,1.07 1590 16107
560 Intestinal obstruction without mention of hernia digestive Both 0.7998 1.0 0.972,1.04 3936 39337 0.9183 0.998 0.962,1.04 3191 32386
560.1 Paralytic ileus digestive Both 0.7362 1.02 0.929,1.11 523 5231 0.6808 1.02 0.932,1.11 512 5105
560.2 Impaction of intestine digestive Both 0.052 0.882 0.777,1.0 268 2671 0.04111 0.874 0.768,0.995 256 2564
560.3 Peritoneal or intestinal adhesions digestive Both 0.9506 1.0 0.933,1.08 832 8317 0.6339 0.982 0.913,1.06 789 8048
560.4 Other intestinal obstruction digestive Both 0.5929 1.01 0.975,1.05 3358 33550 0.9183 0.998 0.962,1.04 3191 32386
561 Symptoms involving digestive system digestive Both 0.02924 1.02 1.0,1.04 15772 157686 0.1968 1.03 0.983,1.09 1593 16231
561.1 Diarrhea digestive Both 0.6934 0.981 0.893,1.08 466 4653 0.6138 0.975 0.885,1.08 435 4475
561.2 Flatulence digestive Both 0.09247 1.04 0.993,1.1 1687 16859 0.1968 1.03 0.983,1.09 1593 16231
562 Diverticulosis and diverticulitis digestive Both 0.8511 0.999 0.986,1.01 26714 211692 0.3733 0.994 0.981,1.01 25598 204861
562.1 Diverticulosis digestive Both 0.8185 0.998 0.986,1.01 26672 211642 0.3733 0.994 0.981,1.01 25598 204861
563 Constipation digestive Both 0.9727 1.0 0.98,1.02 10314 103140 0.2065 0.987 0.966,1.01 9758 99467
564 Functional digestive disorders digestive Both 0.4667 0.995 0.981,1.01 21639 209949 0.278 0.991 0.974,1.01 14683 147161
564.1 Irritable Bowel Syndrome digestive Both 0.2999 1.01 0.987,1.04 5508 55117 0.618 1.01 0.979,1.04 5226 52742
564.8 Abnormal findings on exam of gastrointestinal tract/ abdominal area digestive Both 0.6223 1.01 0.963,1.07 1645 16457 0.6194 1.01 0.962,1.07 1566 15816
564.9 Personal history of diseases of digestive system digestive Both 0.3802 0.993 0.976,1.01 15186 151648 0.278 0.991 0.974,1.01 14683 147161
565 Anal and rectal conditions digestive Both 0.4009 1.01 0.99,1.02 14744 147535 0.6095 0.994 0.97,1.02 7136 71526
565.1 Anal and rectal polyp digestive Both 0.7345 0.996 0.972,1.02 7351 73533 0.6095 0.994 0.97,1.02 7136 71526
567 Peritonitis and retroperitoneal infections digestive Both 0.1928 0.956 0.894,1.02 929 9293 0.1556 0.951 0.888,1.02 889 9069
568 Other disorders of peritoneum digestive Both 0.826 0.996 0.961,1.03 3262 32602 0.9817 1.0 0.963,1.04 2957 29747
568.1 Peritoneal adhesions (postoperative) (postinfection) digestive Both 0.7161 1.01 0.971,1.04 3101 30987 0.9817 1.0 0.963,1.04 2957 29747
569 Other disorders of intestine digestive Both 0.7047 0.994 0.963,1.03 4192 41922 0.7396 1.02 0.924,1.12 466 4720
569.1 Toxic gastroenteritis and colitis digestive Both 0.9727 1.0 0.847,1.19 148 1479 0.4266 0.928 0.77,1.12 122 1428
569.2 Gastrointestinal complications digestive Both 0.6823 1.02 0.929,1.12 486 4868 0.7396 1.02 0.924,1.12 466 4720
571 Chronic liver disease and cirrhosis digestive Both 0.4688 1.01 0.976,1.05 2957 29628 0.537 1.03 0.941,1.12 515 5185
571.5 Other chronic nonalcoholic liver disease digestive Both 0.861 1.0 0.955,1.06 1689 16917 0.1991 0.88 0.724,1.07 111 1097
571.51 Cirrhosis of liver without mention of alcohol digestive Both 0.1449 0.867 0.715,1.05 113 1139 0.1991 0.88 0.724,1.07 111 1097
571.6 Primary biliary cirrhosis digestive Both 0.5662 1.04 0.913,1.18 257 2568 0.2472 1.08 0.947,1.24 239 2448
571.8 Liver abscess and sequelae of chronic liver disease digestive Both 0.2636 1.04 0.972,1.11 976 9804 0.537 1.03 0.941,1.12 515 5185
571.81 Portal hypertension digestive Both 0.6095 1.02 0.937,1.12 528 5285 0.537 1.03 0.941,1.12 515 5185
572 Ascites (non malignant) digestive Both 0.5943 1.01 0.963,1.07 1544 15454 0.631 0.987 0.934,1.04 1397 14929
573 Other disorders of liver digestive Both 0.7709 0.992 0.941,1.05 1496 14982 0.5741 0.959 0.829,1.11 201 2036
573.2 Liver replaced by transplant digestive Both 0.984 0.998 0.808,1.23 96 960 0.6607 1.05 0.846,1.3 92 945
573.3 Hepatomegaly digestive Both 0.9397 0.995 0.886,1.12 297 2968 0.879 0.991 0.88,1.12 285 2899
573.5 Jaundice (not of newborn) digestive Both 0.8375 1.01 0.94,1.08 896 8955 0.8356 0.993 0.925,1.06 857 8722
573.7 Abnormal results of function study of liver digestive Both 0.2317 1.02 0.986,1.06 3454 34597 0.5284 1.01 0.976,1.05 3286 33501
573.9 Abnormal serum enzyme levels digestive Both 0.6427 0.967 0.838,1.12 209 2089 0.5741 0.959 0.829,1.11 201 2036
574 Cholelithiasis and cholecystitis digestive Both 0.1021 1.01 0.997,1.03 15607 156123 0.342 1.02 0.98,1.06 2614 26422
574.1 Cholelithiasis digestive Both 0.4571 1.01 0.989,1.02 13549 135537 0.6442 0.993 0.965,1.02 5171 51922
574.11 Cholelithiasis with acute cholecystitis digestive Both 0.6637 0.988 0.938,1.04 1506 15072 0.6531 0.988 0.936,1.04 1436 14478
574.12 Cholelithiasis with other cholecystitis digestive Both 0.6095 0.993 0.965,1.02 5429 54289 0.6442 0.993 0.965,1.02 5171 51922
574.2 Calculus of bile duct digestive Both 0.134 1.03 0.991,1.07 2620 26191 0.1194 1.03 0.992,1.08 2497 25146
574.3 Cholecystitis without cholelithiasis digestive Both 0.1535 1.03 0.989,1.07 2748 27523 0.342 1.02 0.98,1.06 2614 26422
575 Other biliary tract disease digestive Both 0.5333 1.01 0.978,1.04 3867 38724 0.08337 1.11 0.987,1.24 321 3366
575.1 Cholangitis digestive Both 0.9616 0.998 0.909,1.09 495 4945 0.9057 0.994 0.905,1.09 481 4815
575.2 Obstruction of bile duct digestive Both 0.05821 0.93 0.862,1.0 774 7756 0.04111 0.923 0.854,0.997 736 7518
575.6 Cholesterolosis of gallbladder digestive Both 0.6252 0.977 0.889,1.07 458 4577 0.7362 0.983 0.892,1.08 429 4380
575.7 Other disorders of gallbladder digestive Both 0.4797 1.02 0.966,1.08 1408 14107 0.8147 1.01 0.952,1.07 1321 13542
575.8 Other disorders of biliary tract digestive Both 0.01531 1.08 1.02,1.15 1036 10367 0.01186 1.09 1.02,1.16 982 9921
575.9 Nonspecific abnormal findings on radiological and other examination of biliary tract digestive Both 0.1614 1.08 0.969,1.21 348 3488 0.08337 1.11 0.987,1.24 321 3366
577 Diseases of pancreas digestive Both 0.3899 1.02 0.978,1.06 2668 26677 0.3436 1.05 0.945,1.17 351 3517
577.1 Acute pancreatitis digestive Both 0.7413 1.01 0.963,1.05 1996 19962 0.9376 1.0 0.956,1.05 1906 19260
577.2 Chronic pancreatitis digestive Both 0.3882 1.04 0.951,1.14 515 5149 0.4539 1.04 0.945,1.13 509 5040
577.3 Cyst and pseudocyst of pancreas digestive Both 0.3589 1.05 0.945,1.17 365 3650 0.3436 1.05 0.945,1.17 351 3517
578 Gastrointestinal hemorrhage digestive Both 0.7244 1.0 0.988,1.02 20626 206278 0.8872 0.998 0.97,1.03 5093 51165
578.1 Hematemesis digestive Both 0.7674 0.993 0.948,1.04 1958 19564 0.3784 0.979 0.934,1.03 1887 19075
578.2 Blood in stool digestive Both 0.2123 0.975 0.936,1.01 2626 26283 0.1972 0.973 0.934,1.01 2526 25535
578.8 Hemorrhage of rectum and anus digestive Both 0.2805 1.01 0.992,1.03 13073 130745 0.3733 1.01 0.99,1.03 12581 126303
578.9 Hemorrhage of gastrointestinal tract digestive Both 0.8453 0.997 0.969,1.03 5275 52787 0.8872 0.998 0.97,1.03 5093 51165
579 Other symptoms involving abdomen and pelvis digestive Both 0.9141 1.0 0.952,1.06 1548 15498 0.4831 1.02 0.968,1.07 1595 15990
579.2 Splenomegaly digestive Both 0.05728 0.908 0.822,1.0 422 4246 0.06152 0.909 0.822,1.0 413 4163
579.8 Nonspecific abnormal findings in stool contents digestive Both 0.375 1.02 0.973,1.08 1654 16540 0.4831 1.02 0.968,1.07 1595 15990
580 Nephritis; nephrosis; renal sclerosis genitourinary Both 0.9057 1.0 0.952,1.06 1531 15350 0.3724 1.06 0.932,1.21 244 2471
580.1 Glomerulonephritis genitourinary Both 0.7534 1.01 0.948,1.08 1052 10544 0.6368 1.02 0.948,1.09 839 8476
580.11 Proliferative glomerulonephritis genitourinary Both 0.4842 1.09 0.859,1.38 74 738 0.4498 1.1 0.864,1.39 73 716
580.12 Non-proliferative glomerulonephritis genitourinary Both 0.1995 0.89 0.745,1.06 135 1360 0.2761 0.905 0.756,1.08 131 1319
580.14 Chronic glomerulonephritis, NOS genitourinary Both 0.7129 1.01 0.945,1.09 876 8769 0.6368 1.02 0.948,1.09 839 8476
580.2 Nephrotic syndrome without mention of glomerulonephritis genitourinary Both 0.7145 0.982 0.893,1.08 468 4697 0.7745 0.986 0.896,1.09 460 4588
580.3 Nephritis and nephropathy without mention of glomerulonephritis genitourinary Both 0.4295 1.05 0.926,1.2 246 2460 0.3724 1.06 0.932,1.21 244 2471
580.32 Nephritis and nephropathy with pathological lesion genitourinary Both 0.5821 1.04 0.912,1.18 253 2529 0.3724 1.06 0.932,1.21 244 2471
585 Renal failure genitourinary Both 0.1186 0.981 0.957,1.01 6967 69751 0.04018 0.905 0.823,0.996 477 4858
585.1 Acute renal failure genitourinary Both 0.2133 0.981 0.951,1.01 4527 45305 0.07047 0.972 0.942,1.0 4323 44204
585.2 Renal failure NOS genitourinary Both 0.7745 0.992 0.94,1.05 1460 14625 0.7499 0.991 0.939,1.05 1409 14280
585.3 Chronic renal failure [CKD] genitourinary Both 0.005035 0.944 0.907,0.983 2644 26484 0.04018 0.905 0.823,0.996 477 4858
585.31 Renal dialysis genitourinary Both 0.07709 0.919 0.837,1.01 496 4955 0.04018 0.905 0.823,0.996 477 4858
586 Other disorders of the kidney and ureters genitourinary Both 0.7447 1.01 0.971,1.04 3355 33580 0.1186 0.946 0.882,1.01 874 8878
586.1 Anatomical abnormatilies of kidney and ureters genitourinary Both 0.05875 0.871 0.755,1.01 208 2089 0.1517 0.892 0.762,1.04 174 1748
586.11 Small kidney genitourinary Both 0.1663 0.897 0.769,1.05 179 1799 0.1517 0.892 0.762,1.04 174 1748
586.2 Cyst of kidney, acquired genitourinary Both 0.9311 0.997 0.941,1.06 1257 12582 0.9078 0.997 0.94,1.06 1220 12241
586.3 Vascular disorders of kidney/hypertrophy genitourinary Both 0.1009 1.2 0.966,1.48 80 799 0.09572 1.2 0.968,1.49 78 787
586.4 Stricture/obstruction of ureter genitourinary Both 0.1208 0.947 0.885,1.01 910 9122 0.1186 0.946 0.882,1.01 874 8878
587 Kidney replaced by transpant genitourinary Both 0.1371 0.923 0.83,1.03 368 3683 0.09099 0.91 0.816,1.02 350 3604
588 Disorders resulting from impaired renal function genitourinary Both 0.3589 0.909 0.74,1.12 99 990 0.4046 0.916 0.746,1.13 98 954
589 Abnormal results of function study of kidney genitourinary Both 0.1002 0.848 0.697,1.03 116 1158 0.1507 0.862 0.705,1.06 109 1119
590 Pyelonephritis genitourinary Both 0.5598 1.02 0.961,1.08 1328 13285 0.871 1.0 0.949,1.06 1260 12753
591 Urinary tract infection genitourinary Both 0.7745 1.0 0.984,1.02 12400 123937 0.4498 0.993 0.974,1.01 11735 119390
592 Cystitis and urethritis genitourinary Both 0.7907 0.995 0.958,1.03 2966 29661 0.6138 0.959 0.816,1.13 162 1619
592.1 Cystitis genitourinary Both 0.955 0.999 0.962,1.04 2904 29035 0.8185 1.02 0.891,1.16 237 2344
592.11 Acute cystitis genitourinary Both 0.5395 0.947 0.797,1.13 138 1372 0.7621 0.974 0.819,1.16 137 1325
592.12 Chronic cystitis genitourinary Both 0.9354 0.997 0.931,1.07 889 8890 0.984 0.999 0.932,1.07 847 8511
592.13 Chronic interstitial cystitis genitourinary Both 0.9162 1.01 0.886,1.14 249 2486 0.8185 1.02 0.891,1.16 237 2344
592.2 Urethritis and urethral syndrome genitourinary Both 0.5164 0.948 0.808,1.11 165 1662 0.6138 0.959 0.816,1.13 162 1619
593 Hematuria genitourinary Both 0.8872 0.999 0.983,1.02 16068 160204 0.7112 0.997 0.981,1.01 15600 155884
594 Urinary calculus genitourinary Both 0.4246 1.01 0.985,1.04 6376 63761 0.7112 1.01 0.964,1.06 2008 20149
594.1 Calculus of kidney genitourinary Both 0.7079 1.01 0.971,1.04 3175 31757 0.7261 1.01 0.97,1.04 3097 31123
594.2 Calculus of lower urinary tract genitourinary Both 0.01476 0.912 0.847,0.982 776 7764 0.01009 0.907 0.842,0.977 764 7686
594.3 Calculus of ureter genitourinary Both 0.1327 1.03 0.99,1.08 2401 24024 0.1086 1.04 0.992,1.08 2367 23720
594.8 Renal colic genitourinary Both 0.7096 1.01 0.964,1.06 2050 20500 0.7112 1.01 0.964,1.06 2008 20149
595 Hydronephrosis genitourinary Both 0.3855 0.979 0.935,1.03 1936 19395 0.2642 0.973 0.928,1.02 1850 18945
596 Other disorders of bladder genitourinary Both 0.1047 0.983 0.963,1.0 9771 97778 0.6792 0.989 0.94,1.04 1601 16007
596.1 Bladder neck obstruction genitourinary Both 0.8147 0.994 0.949,1.04 1969 19690 0.8551 0.996 0.951,1.04 1957 19625
596.5 Functional disorders of bladder genitourinary Both 0.4207 0.979 0.931,1.03 1658 16572 0.6792 0.989 0.94,1.04 1601 16007
597 Other disorders of urethra and urinary tract genitourinary Both 0.5495 0.99 0.958,1.02 3913 39135 0.743 0.961 0.76,1.22 75 749
597.1 Urethral stricture (not specified as infectious) genitourinary Both 0.208 0.977 0.943,1.01 3317 33137 0.1968 0.976 0.942,1.01 3216 32287
597.2 Urinary complications NEC genitourinary Both 0.9462 0.992 0.787,1.25 78 778 0.743 0.961 0.76,1.22 75 749
598 Abnormal findings on examination of urine genitourinary Both 0.08222 1.03 0.996,1.07 3528 35302 0.04764 1.13 1.0,1.27 288 2945
598.9 Other nonspecific findings on examination of urine genitourinary Both 0.01626 1.15 1.03,1.29 304 3035 0.04764 1.13 1.0,1.27 288 2945
599 Other symptoms/disorders or the urinary system genitourinary Both 0.5321 1.0 0.99,1.02 18428 184311 0.2466 1.03 0.981,1.08 1873 18791
599.1 Urinary obstruction genitourinary Both 0.004571 0.797 0.681,0.932 166 1670 0.01081 0.813 0.693,0.953 161 1645
599.2 Retention of urine genitourinary Both 0.4457 0.99 0.966,1.02 6718 67168 0.2404 0.985 0.96,1.01 6564 66108
599.3 Dysuria genitourinary Both 0.5023 0.98 0.923,1.04 1196 11967 0.2858 0.967 0.91,1.03 1148 11610
599.4 Urinary incontinence genitourinary Both 0.5383 1.01 0.985,1.03 8748 87477 0.7328 1.0 0.982,1.03 8270 82937
599.5 Frequency of urination and polyuria genitourinary Both 0.6966 0.994 0.962,1.03 4018 40144 0.5902 0.991 0.959,1.02 3904 39055
599.6 Oliguria and anuria genitourinary Both 0.4266 0.926 0.766,1.12 105 1059 0.3076 0.903 0.743,1.1 99 1020
599.8 Other symptoms involving urinary system genitourinary Both 0.5768 1.08 0.825,1.41 62 620 0.6761 1.06 0.805,1.4 58 602
599.9 Other abnormality of urination genitourinary Both 0.1807 1.03 0.985,1.08 1913 19151 0.2466 1.03 0.981,1.08 1873 18791
600 Hyperplasia of prostate genitourinary Male 0.1811 0.987 0.967,1.01 11093 87892 0.1726 0.986 0.967,1.01 11082 87821
601 Inflammatory diseases of prostate genitourinary Male 0.1932 0.971 0.928,1.02 2081 20818 0.7015 1.02 0.91,1.15 303 3017
601.1 Prostatitis genitourinary Male 0.02858 0.943 0.895,0.994 1563 15644 0.06855 0.939 0.878,1.0 910 9081
601.11 Acute prostatitis genitourinary Male 0.03715 0.867 0.758,0.992 234 2358 0.03707 0.867 0.759,0.992 234 2357
601.12 Chronic prostatitis genitourinary Male 0.06839 0.939 0.878,1.0 910 9089 0.06855 0.939 0.878,1.0 910 9081
601.3 Orchitis and epididymitis genitourinary Male 0.4121 0.892 0.678,1.17 59 588 0.4121 0.892 0.679,1.17 59 588
601.4 Balanoposthitis genitourinary Male 0.3206 1.06 0.943,1.2 287 2864 0.3243 1.06 0.943,1.19 287 2862
601.8 Other inflammatory disorders of male genital organs genitourinary Male 0.7047 1.02 0.91,1.15 303 3019 0.7015 1.02 0.91,1.15 303 3017
602 Other disorders of prostate genitourinary Male 0.8913 1.0 0.949,1.06 1341 13408 0.9204 1.0 0.948,1.06 1338 13394
603 Other disorders of testis genitourinary Male 0.1452 1.03 0.989,1.08 2150 21512 0.03776 1.06 1.0,1.12 1337 13393
603.1 Hydrocele genitourinary Male 0.03715 1.06 1.0,1.12 1339 13402 0.03776 1.06 1.0,1.12 1337 13393
604 Disorders of penis genitourinary Male 0.309 0.982 0.947,1.02 3280 32779 0.7396 0.993 0.955,1.03 2718 27161
604.1 Redundant prepuce and phimosis/BXO genitourinary Male 0.7295 0.993 0.955,1.03 2719 27172 0.7396 0.993 0.955,1.03 2718 27161
605 Erectile dysfunction [ED] genitourinary Male 0.9661 0.997 0.88,1.13 278 2800 0.9683 0.997 0.88,1.13 278 2799
608 Other disorders of male genital organs genitourinary Male 0.5483 1.01 0.974,1.05 2822 28236 0.5458 1.01 0.974,1.05 2820 28217
609 Male infertility and abnormal spermatozoa genitourinary Male 0.08166 0.882 0.765,1.02 214 2138 0.2065 0.904 0.774,1.06 168 1696
609.1 Infertility, male genitourinary Male 0.2786 0.873 0.683,1.12 63 638 0.2786 0.873 0.684,1.12 63 638
609.2 Abnormal spermatozoa genitourinary Male 0.2576 0.914 0.782,1.07 169 1698 0.2065 0.904 0.774,1.06 168 1696
610 Benign mammary dysplasias genitourinary Female 2.188E-19 1.21 1.16,1.26 2482 24809 0.05728 1.09 0.997,1.18 570 6579
610.1 Cystic mastopathy genitourinary Female 2.301E-7 1.19 1.12,1.27 925 9250 0.005546 1.11 1.03,1.2 720 8745
610.2 Fibroadenosis of breast genitourinary Female 8.414E-4 1.22 1.09,1.37 306 3057 0.2972 1.08 0.933,1.26 179 2892
610.3 Fibrosclerosis of breast genitourinary Female 0.0139 1.16 1.03,1.3 302 3018 0.9484 0.995 0.855,1.16 184 2871
610.4 Benign neoplasm of breast genitourinary Female 1.51E-10 1.19 1.13,1.26 1388 13865 2.46E-5 1.14 1.07,1.21 1131 13188
610.8 Other specified benign mammary dysplasias genitourinary Female 0.009141 1.11 1.03,1.19 696 6954 0.05728 1.09 0.997,1.18 570 6579
611 Abnormal findings on mammogram or breast exam genitourinary Both 2.455E-14 1.22 1.16,1.29 1574 15731 0.06516 1.06 0.996,1.13 1062 14482
611.1 Abnormal mammogram genitourinary Both 0.01828 1.37 1.05,1.78 57 569 ,
611.3 Lump or mass in breast genitourinary Both 3.388E-13 1.22 1.15,1.28 1522 15213 0.06516 1.06 0.996,1.13 1062 14482
612 Breast conditions, congenital or relating to hormones genitourinary Both 1.581E-4 1.14 1.07,1.22 887 8871 0.7499 1.04 0.805,1.35 63 688
612.2 Hypertrophy of breast (Gynecomastia) genitourinary Both 2.427E-4 1.14 1.06,1.22 849 8490 0.01161 1.1 1.02,1.19 715 8164
612.3 Congenital anomalies of breast genitourinary Both 0.5929 1.07 0.841,1.35 72 719 0.7499 1.04 0.805,1.35 63 688
613 Other nonmalignant breast conditions genitourinary Both 4.508E-8 1.15 1.09,1.21 1651 16519 0.1026 1.14 0.975,1.33 171 3110
613.1 Inflammatory disease of breast genitourinary Both 6.607E-4 1.14 1.06,1.23 720 7210 0.4853 1.03 0.942,1.13 489 6849
613.5 Mastodynia genitourinary Both 0.7447 1.04 0.821,1.32 77 768 0.4055 0.887 0.67,1.18 52 735
613.7 Other signs and symptoms in breast genitourinary Both 0.008472 1.11 1.03,1.2 702 7013 0.3524 1.04 0.956,1.14 580 6605
613.8 Other specified disorders of breast genitourinary Both 5.916E-5 1.26 1.13,1.41 327 3278 0.1026 1.14 0.975,1.33 171 3110
613.9 Breast disorder NOS genitourinary Both 0.02477 1.18 1.02,1.36 207 2069 ,
614 Inflammatory diseases of female pelvic organs genitourinary Female 0.2979 0.986 0.959,1.01 5711 57118 0.2924 0.933 0.821,1.06 250 2579
614.1 Pelvic peritoneal adhesions, female (postoperative) (postinfection) genitourinary Female 0.04018 0.958 0.92,0.998 2538 25363 0.01614 0.95 0.911,0.991 2404 24133
614.3 Pelvic inflammatory disease (PID) genitourinary Female 0.4581 0.973 0.906,1.05 830 8308 0.2661 0.937 0.835,1.05 328 3345
614.31 Acute inflammatory pelvic disease genitourinary Female 0.826 0.971 0.749,1.26 61 608 0.526 0.916 0.699,1.2 55 571
614.32 Chronic inflammatory pelvic disease genitourinary Female 0.5636 0.971 0.879,1.07 422 4221 0.5212 0.967 0.872,1.07 397 4011
614.33 Pelvic inflammatory disease, NOS genitourinary Female 0.5715 0.969 0.867,1.08 351 3510 0.2661 0.937 0.835,1.05 328 3345
614.4 Inflammatory diseases of uterus, except cervix genitourinary Female 0.4027 1.05 0.933,1.19 277 2775 0.877 1.01 0.89,1.15 250 2642
614.5 Inflammatory disease of cervix, vagina, and vulva genitourinary Female 0.9311 0.998 0.959,1.04 2601 26023 0.2924 0.933 0.821,1.06 250 2579
614.51 Cervicitis and endocervicitis genitourinary Female 0.5821 1.02 0.96,1.07 1318 13189 0.6383 0.986 0.93,1.05 1229 12479
614.52 Vaginitis and vulvovaginitis genitourinary Female 0.1324 0.928 0.841,1.02 428 4273 0.1469 0.928 0.838,1.03 399 4019
614.53 Cyst or abscess of Bartholin's gland genitourinary Female 0.3357 1.04 0.963,1.12 755 7574 0.6546 1.02 0.942,1.1 707 7170
614.54 Abscess or ulceration of vulva genitourinary Female 0.561 0.965 0.854,1.09 274 2737 0.2924 0.933 0.821,1.06 250 2579
615 Endometriosis genitourinary Female 0.7834 1.0 0.973,1.04 4029 40284 0.8241 1.0 0.971,1.04 3799 38316
617 Disorders secondary to childbirth, surgery, trauma genitourinary Female 0.9795 1.0 0.89,1.13 304 3037 0.5546 0.963 0.851,1.09 277 2873
618 Genital prolapse genitourinary Female 0.5834 0.995 0.976,1.01 11689 116878 0.5768 1.02 0.943,1.11 635 6336
618.1 Prolapse of vaginal walls genitourinary Female 0.6823 0.995 0.972,1.02 7392 73940 0.9977 1.0 0.976,1.03 6944 69176
618.2 Uterine/Uterovaginal prolapse genitourinary Female 0.597 0.992 0.965,1.02 5393 53918 0.526 0.991 0.962,1.02 5058 50422
618.5 Prolapse of vaginal vault after hysterectomy genitourinary Female 0.151 0.934 0.852,1.03 512 5125 0.1702 0.936 0.851,1.03 493 4747
618.6 Vaginal enterocele, congenital or acquired genitourinary Female 0.26 1.05 0.967,1.13 680 6794 0.5768 1.02 0.943,1.11 635 6336
619 Noninflammatory female genital disorders genitourinary Female 0.8892 1.0 0.98,1.02 8726 87297 0.08851 1.05 0.993,1.11 1272 12763
619.1 Noninflammatory disorders of ovary, fallopian tube, and broad ligament genitourinary Female 0.7311 1.01 0.938,1.09 729 7284 0.9376 1.0 0.926,1.09 670 6936
619.2 Disorders of uterus, NEC genitourinary Female 0.09099 0.97 0.936,1.0 3324 33273 0.04436 0.962 0.927,0.999 3022 31318
619.3 Noninflammatory disorders of cervix genitourinary Female 0.9594 1.0 0.963,1.04 2860 28608 0.859 0.996 0.957,1.04 2667 27073
619.4 Noninflammatory disorders of vagina genitourinary Female 0.5808 1.01 0.966,1.06 1768 17669 0.857 1.0 0.955,1.06 1639 16655
619.5 Noninflammatory disorders of vulva and perineum genitourinary Female 0.1396 1.04 0.986,1.1 1350 13489 0.08851 1.05 0.993,1.11 1272 12763
620 Dysplasia of female genital organs genitourinary Female 0.5689 0.932 0.733,1.19 72 720 0.3945 0.896 0.695,1.15 65 679
621 Endometrial hyperplasia genitourinary Female 0.04159 1.07 1.0,1.13 1129 11294 0.16 1.05 0.982,1.12 979 10644
622 Polyp of female genital organs genitourinary Female 2.438E-5 1.04 1.02,1.07 10480 104803 0.07244 1.03 0.997,1.07 3160 32418
622.1 Polyp of corpus uteri genitourinary Female 2.0E-4 1.04 1.02,1.07 7857 78601 0.3524 1.01 0.987,1.04 6936 74136
622.2 Mucous polyp of cervix genitourinary Female 0.00975 1.05 1.01,1.08 3442 34387 0.07244 1.03 0.997,1.07 3160 32418
623 Hypertrophy of female genital organs genitourinary Female 0.0114 1.08 1.02,1.14 1268 12684 0.0673 1.06 0.996,1.12 1172 12060
624 Symptoms involving female genital tract genitourinary Female 0.03516 0.924 0.859,0.995 797 7961 0.5702 0.992 0.965,1.02 5521 55090
624.1 Dystrophy of female genital tract genitourinary Female 0.04426 0.874 0.766,0.997 237 2365 0.03199 0.861 0.751,0.987 220 2208
624.2 Atrophy of female genital tract genitourinary Female 0.2133 0.94 0.852,1.04 440 4398 0.1164 0.92 0.829,1.02 397 4080
624.9 stress incontinence, female genitourinary Female 0.6095 0.993 0.967,1.02 5865 58634 0.5702 0.992 0.965,1.02 5521 55090
625 Pain and other symptoms associated with female genital organs genitourinary Female 0.4169 0.984 0.947,1.02 2876 28740 0.52 0.98 0.923,1.04 1130 11313
625.1 Dyspareunia genitourinary Female 0.7464 0.99 0.934,1.05 1188 11891 0.52 0.98 0.923,1.04 1130 11313
626 Disorders of menstruation and other abnormal bleeding from female genital tract genitourinary Female 0.03873 1.02 1.0,1.03 16168 115018 0.8851 0.996 0.941,1.05 1303 13128
626.1 Irregular menstrual cycle/bleeding genitourinary Female 0.06012 1.02 0.999,1.04 14110 109918 0.9057 1.0 0.968,1.04 3612 36268
626.11 Absent or infrequent menstruation genitourinary Female 0.04276 1.23 1.01,1.49 109 1099 0.1816 1.15 0.937,1.41 100 1059
626.12 Excessive or frequent menstruation genitourinary Female 0.105 1.02 0.996,1.04 9727 91749 0.1191 1.02 0.996,1.04 9249 87559
626.13 Irregular menstrual cycle genitourinary Female 0.1285 1.04 0.99,1.09 1985 19829 0.4345 1.02 0.972,1.07 1845 18826
626.14 Irregular menstrual bleeding genitourinary Female 0.8337 1.0 0.971,1.04 3804 38021 0.9057 1.0 0.968,1.04 3612 36268
626.2 Dysmenorrhea genitourinary Female 0.2042 1.03 0.983,1.08 1778 17767 0.1803 1.03 0.984,1.09 1709 17054
626.4 Premenstrual tension syndromes genitourinary Female 0.2089 0.901 0.766,1.06 159 1587 0.207 0.899 0.762,1.06 154 1530
626.8 Infertility, female genitourinary Female 0.8395 0.994 0.94,1.05 1362 13613 0.8851 0.996 0.941,1.05 1303 13128
627 Menopausal and postmenopausal disorders genitourinary Female 0.01368 1.03 1.01,1.05 10392 103948 0.02673 1.14 1.02,1.29 297 2931
627.1 Postmenopausal bleeding genitourinary Female 0.0138 1.03 1.01,1.05 9042 90439 0.5152 0.992 0.97,1.02 7940 84785
627.2 Symptomatic menopause genitourinary Female 0.02642 0.84 0.719,0.98 183 1826 0.02355 0.828 0.704,0.975 166 1711
627.3 Postmenopausal atrophic vaginitis genitourinary Female 0.7063 1.01 0.952,1.08 1111 11115 0.9078 0.996 0.934,1.06 1000 10418
627.4 Premenopausal menorrhagia genitourinary Female 0.05675 1.12 0.997,1.26 310 3097 0.02673 1.14 1.02,1.29 297 2931
628 Ovarian cyst genitourinary Female 0.6209 1.01 0.978,1.04 4747 47482 0.798 1.0 0.974,1.04 4412 45211
634 Miscarriage; stillbirth pregnancy complications Female 0.04943 1.03 1.0,1.06 5218 36422 0.7499 1.02 0.909,1.14 318 3184
634.1 Missed abortion/Hydatidiform mole pregnancy complications Female 0.9016 0.996 0.938,1.06 1136 11300 0.6281 0.985 0.926,1.05 1092 10946
634.3 Ectopic pregnancy pregnancy complications Female 0.7096 1.02 0.914,1.14 331 3305 0.7499 1.02 0.909,1.14 318 3184
635 Hemorrhage during pregnancy; childbirth and postpartum pregnancy complications Female 0.133 1.04 0.989,1.09 1974 17372 0.2023 1.04 0.98,1.1 1228 11979
635.2 Antepartum hemorrhage, abruptio placentae, and placenta previa pregnancy complications Female 0.8954 1.0 0.937,1.08 866 8614 0.9226 1.0 0.935,1.08 841 8372
635.3 Placenta previa and abruptio placenta pregnancy complications Female 0.07925 1.05 0.994,1.12 1270 12306 0.2023 1.04 0.98,1.1 1228 11979
636 Early or threatened labor; hemorrhage in early pregnancy pregnancy complications Female 0.6124 0.989 0.948,1.03 2347 19972 0.8017 0.992 0.931,1.06 1038 10442
636.2 Early onset of delivery pregnancy complications Female 0.7482 0.987 0.909,1.07 617 6144 0.6887 0.983 0.904,1.07 597 5972
636.3 Hemorrhage in early pregnancy pregnancy complications Female 0.7925 0.992 0.932,1.06 1082 10766 0.8017 0.992 0.931,1.06 1038 10442
638 Other high-risk pregnancy pregnancy complications Female 0.8995 1.02 0.802,1.29 70 700 0.8356 1.03 0.809,1.3 69 676
642 Hypertension complicating pregnancy, childbirth, and the puerperium pregnancy complications Female 0.04508 1.07 1.0,1.13 1110 11074 0.7852 1.02 0.903,1.14 301 2970
642.1 Preeclampsia and eclampsia pregnancy complications Female 0.7295 1.02 0.908,1.15 307 3058 0.7852 1.02 0.903,1.14 301 2970
643 Excessive vomiting in pregnancy pregnancy complications Female 0.6902 1.03 0.894,1.18 215 2149 0.9638 0.996 0.845,1.17 152 1484
643.1 Hyperemesis gravidarum pregnancy complications Female 0.9954 1.0 0.848,1.18 153 1525 0.9638 0.996 0.845,1.17 152 1484
645 Late pregnancy and failed induction pregnancy complications Female 0.5943 1.02 0.959,1.08 1250 12450 0.6808 1.01 0.955,1.07 1219 12107
646 Other complications of pregnancy NEC pregnancy complications Female 0.7194 0.992 0.95,1.04 2228 20847 0.4977 0.985 0.942,1.03 2166 20249
647 Infectious and parasitic complications affecting pregnancy pregnancy complications Female 0.4227 1.11 0.862,1.43 68 679 0.7063 0.976 0.863,1.11 271 2665
647.1 Infections of genitourinary tract during pregnancy pregnancy complications Female 0.6067 0.968 0.856,1.09 275 2748 0.7063 0.976 0.863,1.11 271 2665
649 Other conditions or status of the mother complicating pregnancy, childbirth, or the puerperium pregnancy complications Female 0.4055 1.08 0.896,1.31 113 1129 0.3365 1.08 0.927,1.25 185 1870
649.1 Diabetes or abnormal glucose tolerance complicating pregnancy pregnancy complications Female 0.309 1.08 0.933,1.25 193 1922 0.3365 1.08 0.927,1.25 185 1870
650 Normal delivery pregnancy complications Female 0.007096 0.938 0.895,0.983 1922 18973 0.009931 0.939 0.896,0.985 1870 18412
651 Multiple gestation pregnancy complications Female 0.5957 1.03 0.922,1.15 346 3454 0.5495 1.03 0.925,1.16 339 3349
652 Malposition and malpresentation of fetus or obstruction pregnancy complications Female 0.9616 0.999 0.951,1.05 1716 16521 0.826 0.994 0.946,1.05 1670 16087
653 Problems associated with amniotic cavity and membranes pregnancy complications Female 0.8356 0.994 0.941,1.05 1401 13649 0.9683 0.999 0.945,1.06 1361 13271
654 Other and unspecified complications of birth; puerperium affecting management of mother pregnancy complications Female 0.3532 1.12 0.88,1.43 74 739 0.3981 1.11 0.869,1.42 70 723
655 Known or suspected fetal abnormality affecting management of mother pregnancy complications Female 0.3097 1.02 0.985,1.05 4306 29454 0.5534 1.01 0.977,1.04 4175 28574
656 Other perinatal conditions of fetus or newborn pregnancy complications Both 0.3828 0.918 0.757,1.11 109 1080 0.4385 0.927 0.765,1.12 109 1051
661 Fetal distress and abnormal forces of labor pregnancy complications Female 0.1413 1.03 0.989,1.08 2265 18397 0.2393 1.03 0.982,1.07 2195 17883
663 Umbilical cord complications during labor and delivery pregnancy complications Female 0.7656 1.01 0.927,1.11 532 5316 0.8299 1.01 0.923,1.11 521 5167
665 Obstetrical/birth trauma pregnancy complications Female 0.07516 1.03 0.997,1.06 5313 29472 0.07586 1.03 0.997,1.06 5179 28548
669 Complications of labor and delivery NEC pregnancy complications Female 0.01714 1.05 1.01,1.1 2552 21174 0.05623 1.04 0.999,1.09 2469 20539
671 Venous/cerebrovascular complications embolism in pregnancy and the puerperium pregnancy complications Female 0.9772 1.0 0.853,1.18 164 1628 0.9661 1.0 0.851,1.18 157 1577
674 Other complications of the puerperium NEC pregnancy complications Female 0.869 0.99 0.872,1.12 262 2605 0.8091 0.984 0.867,1.12 255 2541
676 Other disorders of the breast associated with childbirth and disorders of lactation pregnancy complications Female 0.6982 1.05 0.816,1.36 63 624 0.9863 1.0 0.772,1.3 60 612
679 Complications of in utero procedures dermatologic Female 0.955 0.992 0.757,1.3 53 530 0.5047 0.91 0.689,1.2 51 513
681 Superficial cellulitis and abscess dermatologic Both 0.1892 1.02 0.992,1.04 7200 72225 0.7638 1.01 0.924,1.11 491 5781
681.1 Cellulitis and abscess of fingers/toes dermatologic Both 0.05715 1.09 0.997,1.18 563 5647 0.1099 1.07 0.984,1.17 535 5478
681.2 Cellulitis and abscess of face/neck dermatologic Both 0.1679 1.06 0.974,1.16 520 5208 0.2388 1.06 0.964,1.16 497 5024
681.3 Cellulitis and abscess of arm/hand dermatologic Both 0.9311 1.0 0.974,1.03 5481 55014 0.3811 0.987 0.96,1.02 5221 53756
681.5 Cellulitis and abscess of leg, except foot dermatologic Both 0.8356 1.0 0.975,1.03 5487 55074 0.4613 0.989 0.962,1.02 5226 53817
681.6 Cellulitis and abscess of foot, toe dermatologic Both 0.8091 1.0 0.976,1.03 5444 54643 0.4688 0.99 0.962,1.02 5186 53387
681.7 Cellulitis and abscess of trunk dermatologic Both 0.1374 1.07 0.98,1.16 597 5987 0.7638 1.01 0.924,1.11 491 5781
686 Other local infections of skin and subcutaneous tissue dermatologic Both 0.1211 1.05 0.988,1.11 1337 13427 0.9528 1.0 0.899,1.12 343 3500
686.1 Carbuncle and furuncle dermatologic Both 0.2951 1.02 0.98,1.07 2284 22925 0.3631 1.02 0.977,1.07 2210 22339
686.3 Pilonidal cyst dermatologic Both 0.787 1.01 0.929,1.1 583 5837 0.8356 1.01 0.926,1.1 572 5762
686.4 Pyogenic granuloma dermatologic Both 0.975 0.998 0.897,1.11 362 3615 0.9528 1.0 0.899,1.12 343 3500
687 Symptoms affecting skin dermatologic Both 0.05212 1.09 0.999,1.19 548 5508 0.003119 0.943 0.907,0.98 2780 27926
687.1 Rash and other nonspecific skin eruption dermatologic Both 0.004111 1.07 1.02,1.12 2146 21470 0.09705 1.04 0.993,1.09 2017 20814
687.2 Localized superficial swelling, mass, or lump dermatologic Both 0.8395 1.01 0.896,1.15 283 2839 0.9268 0.994 0.876,1.13 265 2736
687.3 Changes in skin texture dermatologic Both 0.09099 1.18 0.974,1.42 106 1070 0.1002 1.17 0.969,1.42 104 1035
687.4 Disturbance of skin sensation dermatologic Both 0.003048 0.944 0.909,0.981 2884 28859 0.003119 0.943 0.907,0.98 2780 27926
689 Disorder of skin and subcutaneous tissue NOS dermatologic Both 0.514 0.991 0.964,1.02 5747 57521 0.2421 0.984 0.957,1.01 5459 55556
690 Erythematosquamous dermatosis dermatologic Both 0.826 1.03 0.801,1.32 71 710 0.9638 0.993 0.746,1.32 53 527
690.1 Seborrheic dermatitis dermatologic Both 0.9528 0.992 0.743,1.32 53 530 0.9638 0.993 0.746,1.32 53 527
691 Congenital anomalies of skin dermatologic Both 0.4169 1.08 0.895,1.31 120 1199 0.2851 1.11 0.915,1.35 112 1155
694 Dyschromia and Vitiligo dermatologic Both 0.879 0.995 0.932,1.06 986 9854 0.2004 0.879 0.721,1.07 110 1137
694.1 Vitiligo dermatologic Both 0.4634 1.1 0.849,1.43 60 599 0.3698 1.13 0.864,1.48 58 574
694.2 Other dyschromia dermatologic Both 0.7096 0.986 0.916,1.06 782 7821 0.4074 0.968 0.898,1.04 740 7517
694.3 Vascular disorders of skin dermatologic Both 0.2958 0.903 0.746,1.09 117 1170 0.2004 0.879 0.721,1.07 110 1137
695 Erythematous conditions dermatologic Both 0.9638 1.0 0.96,1.04 2379 23813 0.03273 0.897 0.811,0.991 427 4540
695.1 Toxic erythema dermatologic Both 0.4603 1.08 0.884,1.31 109 1090 0.5129 1.07 0.874,1.31 105 1043
695.2 Bullous dermatoses dermatologic Both 0.3819 1.08 0.907,1.29 137 1365 0.1091 1.22 0.956,1.57 69 697
695.21 Dermatitis herpetiformis dermatologic Both 0.6887 0.947 0.727,1.23 57 569 0.7311 0.953 0.725,1.25 53 552
695.22 Pemphigus and pemphigoid dermatologic Both 0.08166 1.24 0.974,1.57 73 727 0.1091 1.22 0.956,1.57 69 697
695.3 Rosacea dermatologic Both 0.3698 1.05 0.939,1.19 309 3097 0.3882 1.05 0.936,1.19 300 3000
695.4 Lupus (localized and systemic) dermatologic Both 0.1114 1.09 0.981,1.2 411 4114 0.2382 1.07 0.957,1.2 329 3224
695.41 Cutaneous lupus erythematosus dermatologic Both 0.975 0.997 0.831,1.2 130 1295 0.631 1.05 0.87,1.26 125 1238
695.42 Systemic lupus erythematosus dermatologic Both 0.3491 1.05 0.945,1.17 340 3407 0.2382 1.07 0.957,1.2 329 3224
695.7 Prurigo and Lichen dermatologic Both 0.09817 0.94 0.873,1.01 775 7760 0.02723 0.918 0.851,0.99 731 7461
695.8 Other specified erythematous conditions dermatologic Both 0.0875 1.12 0.983,1.28 236 2359 0.4519 1.09 0.871,1.37 71 733
695.81 Erythema nodosum dermatologic Both 0.3243 1.12 0.896,1.39 76 760 0.4519 1.09 0.871,1.37 71 733
695.9 Unspecified erythematous condition dermatologic Both 0.04498 0.906 0.823,0.998 467 4672 0.03273 0.897 0.811,0.991 427 4540
696 Psoriasis and related disorders dermatologic Both 0.7295 1.01 0.965,1.05 2252 22509 0.526 0.975 0.902,1.05 692 6836
696.4 Psoriasis dermatologic Both 0.7534 1.01 0.964,1.05 2198 21969 0.526 0.975 0.902,1.05 692 6836
696.41 Psoriasis vulgaris dermatologic Both 0.4508 1.02 0.97,1.07 1680 16796 0.6683 1.01 0.961,1.06 1604 16325
696.42 Psoriatic arthropathy dermatologic Both 0.369 0.965 0.894,1.04 706 7052 0.526 0.975 0.902,1.05 692 6836
697 Sarcoidosis dermatologic Both 0.1002 0.93 0.853,1.01 539 5373 0.1928 0.943 0.862,1.03 510 5188
698 Pruritus and related conditions dermatologic Both 0.03141 1.08 1.01,1.17 782 7814 0.02673 1.09 1.01,1.17 752 7527
700 Corns and callosities dermatologic Both 0.1435 0.915 0.813,1.03 291 2904 0.2113 0.925 0.819,1.04 278 2763
701 Other hypertrophic and atrophic conditions of skin dermatologic Both 0.005236 1.04 1.01,1.08 4663 46650 0.6166 1.06 0.854,1.3 97 975
701.1 Keratoderma, acquired dermatologic Both 0.7145 1.04 0.834,1.3 87 870 0.6653 1.05 0.837,1.32 83 845
701.2 Scar conditions and fibrosis of skin dermatologic Both 0.008375 1.06 1.01,1.1 2348 23478 0.9863 1.0 0.955,1.05 1969 22605
701.3 Circumscribed scleroderma dermatologic Both 0.9795 1.0 0.771,1.31 61 610 0.9795 0.996 0.764,1.3 59 579
701.4 Keloid scar dermatologic Both 0.1256 1.11 0.971,1.27 216 2159 0.2897 1.08 0.935,1.25 182 2073
701.5 Abnormal granulation tissue dermatologic Both 0.4519 1.04 0.942,1.14 455 4568 0.7656 0.985 0.89,1.09 417 4394
701.6 Acquired acanthosis nigricans dermatologic Both 0.5808 1.06 0.863,1.3 102 1019 0.6166 1.06 0.854,1.3 97 975
702 Degenerative skin conditions and other dermatoses dermatologic Both 0.984 1.0 0.972,1.03 5459 54587 0.8337 0.996 0.959,1.03 2903 29611
702.1 Actinic keratosis dermatologic Both 0.6531 0.991 0.952,1.03 2585 25842 0.4457 0.984 0.944,1.03 2490 24879
702.2 Seborrheic keratosis dermatologic Both 0.7447 1.01 0.97,1.04 3078 30772 0.8337 0.996 0.959,1.03 2903 29611
703 Diseases of nail, NOS dermatologic Both 0.07621 1.1 0.99,1.23 354 3539 0.01114 1.09 1.02,1.17 935 9400
703.1 Ingrowing nail dermatologic Both 0.01377 1.09 1.02,1.16 966 9660 0.01114 1.09 1.02,1.17 935 9400
704 Diseases of hair and hair follicles dermatologic Both 0.6281 1.01 0.979,1.04 5267 52727 0.05559 0.789 0.619,1.01 74 734
704.1 Alopecia dermatologic Both 0.3622 0.921 0.771,1.1 125 1269 0.5636 0.947 0.788,1.14 118 1198
704.8 Other specified diseases of hair and hair follicles dermatologic Both 0.0857 0.811 0.639,1.03 76 759 0.05559 0.789 0.619,1.01 74 734
705 Disorders of sweat glands dermatologic Both 0.8511 1.01 0.884,1.16 228 2287 0.9638 1.0 0.919,1.09 583 5785
705.3 Hidradenitis dermatologic Both 0.6839 1.03 0.888,1.2 186 1868 0.4808 1.06 0.907,1.23 182 1804
705.8 Hyperhidrosis dermatologic Both 0.8892 0.994 0.912,1.08 591 5919 0.9638 1.0 0.919,1.09 583 5785
706 Diseases of sebaceous glands dermatologic Both 0.8831 1.0 0.979,1.02 8317 83195 0.6295 0.995 0.973,1.02 8466 85173
706.1 Acne dermatologic Both 0.4345 1.09 0.875,1.37 78 779 0.5272 1.08 0.857,1.35 75 757
706.2 Sebaceous cyst dermatologic Both 0.8472 0.998 0.976,1.02 8787 87882 0.6295 0.995 0.973,1.02 8466 85173
707 Chronic ulcer of skin dermatologic Both 0.4046 1.02 0.973,1.07 1953 19654 0.6653 1.02 0.946,1.09 861 8851
707.1 Decubitus ulcer dermatologic Both 0.5058 1.02 0.955,1.1 909 9097 0.6653 1.02 0.946,1.09 861 8851
709 Diffuse diseases of connective tissue dermatologic Both 0.2286 0.979 0.945,1.01 3432 34317 0.1795 0.973 0.934,1.01 2577 26058
709.2 Sicca syndrome dermatologic Both 0.2838 0.951 0.869,1.04 508 5073 0.2249 0.943 0.858,1.04 473 4776
709.3 Systemic sclerosis dermatologic Both 0.857 1.01 0.871,1.18 176 1753 0.8933 0.989 0.844,1.16 165 1665
709.6 Other specified diffuse diseases of connective tissue dermatologic Both 0.1901 1.18 0.921,1.51 65 649 0.6808 1.06 0.815,1.37 59 618
709.7 Unspecified diffuse connective tissue disease dermatologic Both 0.2649 0.978 0.94,1.02 2714 27144 0.1795 0.973 0.934,1.01 2577 26058
939 Atopic/contact dermatitis due to other or unspecified dermatologic Both 0.09908 0.963 0.92,1.01 2094 20961 0.052 0.955 0.912,1.0 1984 20324
710 Osteomyelitis, periostitis, and other infections involving bone musculoskeletal Both 0.6887 1.02 0.935,1.11 602 6034 0.9863 0.999 0.899,1.11 386 3903
710.1 Osteomyelitis musculoskeletal Both 0.4395 1.04 0.948,1.13 556 5574 0.9863 0.999 0.899,1.11 386 3903
710.12 Chronic osteomyelitis musculoskeletal Both 0.7798 0.979 0.842,1.14 194 1947 0.6486 0.965 0.829,1.12 187 1899
710.19 Unspecified osteomyelitis musculoskeletal Both 0.7727 1.02 0.915,1.13 398 3997 0.9863 0.999 0.899,1.11 386 3903
711 Arthropathy associated with infections musculoskeletal Both 0.9727 0.998 0.903,1.1 421 4225 0.8851 0.992 0.885,1.11 322 3215
711.1 Pyogenic arthritis musculoskeletal Both 0.811 0.986 0.881,1.1 328 3296 0.8851 0.992 0.885,1.11 322 3215
712 Infective connective tissue disorders musculoskeletal Both 0.7568 1.04 0.828,1.3 81 810 0.865 1.02 0.81,1.29 78 781
713 Arthropathy associated with other disorders classified elsewhere musculoskeletal Both 0.9078 0.99 0.839,1.17 148 1499 0.9683 1.01 0.784,1.29 63 662
713.5 Arthropathy associated with neurological disorders musculoskeletal Both 0.826 1.03 0.804,1.31 65 669 0.9683 1.01 0.784,1.29 63 662
714 Rheumatoid arthritis and other inflammatory polyarthropathies musculoskeletal Both 0.3664 1.01 0.984,1.04 4832 48320 0.3758 1.01 0.983,1.05 4161 41863
714.1 Rheumatoid arthritis musculoskeletal Both 0.3459 1.02 0.984,1.05 4372 43714 0.3758 1.01 0.983,1.05 4161 41863
715 Other inflammatory spondylopathies musculoskeletal Both 0.7638 1.01 0.958,1.06 1659 16588 0.6577 1.02 0.937,1.11 600 6049
715.1 Sacroiliitis NEC musculoskeletal Both 0.3048 0.903 0.743,1.1 113 1129 0.4656 0.928 0.76,1.13 110 1078
715.2 Ankylosing spondylitis musculoskeletal Both 0.875 1.01 0.927,1.09 618 6177 0.6577 1.02 0.937,1.11 600 6049
716 Other arthropathies musculoskeletal Both 0.0547 0.989 0.979,1.0 37478 265375 0.002275 0.982 0.971,0.994 34200 253946
716.1 Unspecified polyarthropathy or polyarthritis musculoskeletal Both 0.6823 0.993 0.959,1.03 3505 35090 0.3243 0.982 0.947,1.02 3306 33554
716.2 Unspecified monoarthritis musculoskeletal Both 0.02931 0.982 0.966,0.998 15522 155339 0.01675 0.98 0.963,0.996 14915 150303
716.9 Arthropathy NOS musculoskeletal Both 0.02917 0.988 0.977,0.999 35944 262308 0.002275 0.982 0.971,0.994 34200 253946
717 Polymyalgia Rheumatica musculoskeletal Both 0.7311 0.989 0.931,1.05 1145 11480 0.6887 0.987 0.928,1.05 1094 10903
720 Spinal stenosis musculoskeletal Both 0.9078 0.998 0.965,1.03 3705 37091 0.865 0.997 0.963,1.03 3562 35801
721 Spondylosis and allied disorders musculoskeletal Both 0.2891 1.01 0.989,1.04 7832 78318 0.369 0.949 0.847,1.06 331 3386
721.1 Spondylosis without myelopathy musculoskeletal Both 0.6934 1.01 0.977,1.04 5045 50451 0.7178 1.01 0.976,1.04 4798 48447
721.2 Spondylosis with myelopathy musculoskeletal Both 0.8933 1.01 0.873,1.17 189 1899 0.867 1.01 0.872,1.18 178 1852
721.8 Other allied disorders of spine musculoskeletal Both 0.863 0.99 0.888,1.11 352 3519 0.369 0.949 0.847,1.06 331 3386
722 Intervertebral disc disorders musculoskeletal Both 0.1803 1.01 0.993,1.04 8978 89848 0.1191 1.03 0.994,1.06 4254 42786
722.1 Displacement of intervertebral disc musculoskeletal Both 0.2518 0.949 0.867,1.04 512 5116 0.3945 0.961 0.877,1.05 497 4983
722.6 Degeneration of intervertebral disc musculoskeletal Both 0.8035 0.995 0.957,1.03 2831 28328 0.7499 0.994 0.955,1.03 2718 27318
722.8 Postlaminectomy syndrome musculoskeletal Both 0.9419 1.01 0.785,1.3 67 669 0.9506 0.992 0.765,1.29 63 655
722.9 Other and unspecified disc disorder musculoskeletal Both 0.09908 1.03 0.995,1.06 4407 44127 0.1191 1.03 0.994,1.06 4254 42786
723 Other disorders of cervical region musculoskeletal Both 0.4831 1.03 0.944,1.13 517 5173 0.7228 0.964 0.789,1.18 102 1025
723.1 Torticollis musculoskeletal Both 0.8892 0.986 0.81,1.2 107 1068 0.7228 0.964 0.789,1.18 102 1025
724 Other and unspecified disorders of back musculoskeletal Both 0.263 1.03 0.981,1.07 2052 20514 0.4699 1.02 0.968,1.07 1549 15689
724.1 Disorders of sacrum musculoskeletal Both 0.5875 0.972 0.879,1.08 403 4024 0.7396 0.983 0.885,1.09 383 3844
724.2 Disorders of coccyx musculoskeletal Both 0.7998 0.987 0.892,1.09 406 4054 0.9506 0.997 0.898,1.11 386 3876
724.8 Other symptoms referable to back musculoskeletal Both 0.5508 0.926 0.72,1.19 63 630 0.5 0.914 0.702,1.19 58 600
724.9 Other unspecified back disorders musculoskeletal Both 0.2489 1.03 0.979,1.08 1614 16139 0.4699 1.02 0.968,1.07 1549 15689
726 Peripheral enthesopathies and allied syndromes musculoskeletal Both 0.6039 0.996 0.979,1.01 14663 146691 0.7112 0.987 0.92,1.06 844 8454
726.1 Enthesopathy musculoskeletal Both 0.5675 0.994 0.973,1.01 9589 95900 0.6053 0.994 0.973,1.02 9269 92496
726.2 Synoviopathy musculoskeletal Both 0.7499 0.982 0.88,1.1 334 3336 0.4842 0.961 0.859,1.07 318 3214
726.3 Bursitis musculoskeletal Both 0.6966 0.986 0.919,1.06 854 8573 0.7112 0.987 0.92,1.06 844 8454
727 Other disorders of synovium, tendon, and bursa musculoskeletal Both 0.3141 0.988 0.964,1.01 7331 73332 0.7499 0.972 0.816,1.16 138 1384
727.1 Synovitis and tenosynovitis musculoskeletal Both 0.6039 0.99 0.951,1.03 2737 27406 0.492 0.986 0.947,1.03 2643 26427
727.2 Bursitis disorders musculoskeletal Both 0.9506 0.993 0.807,1.22 103 1029 0.9977 1.0 0.811,1.23 102 1006
727.4 Ganglion and cyst of synovium, tendon, and bursa musculoskeletal Both 0.1274 0.972 0.937,1.01 3109 31085 0.07261 0.966 0.93,1.0 2979 29838
727.5 Rupture of synovium musculoskeletal Both 0.6855 1.02 0.935,1.11 586 5854 0.857 1.01 0.925,1.1 560 5641
727.6 Rupture of tendon, nontraumatic musculoskeletal Both 0.2911 0.942 0.844,1.05 353 3527 0.07656 0.903 0.806,1.01 336 3416
727.7 Contracture of tendon (sheath) musculoskeletal Both 0.6934 0.966 0.813,1.15 143 1429 0.7499 0.972 0.816,1.16 138 1384
728 Disorders of muscle, ligament, and fascia musculoskeletal Both 0.5297 0.989 0.956,1.02 3677 36788 0.7015 0.993 0.959,1.03 3407 34185
728.2 Laxity of ligament or hypermobility syndrome musculoskeletal Both 0.867 1.01 0.913,1.11 412 4115 0.7691 1.02 0.918,1.12 402 4004
728.7 Fasciitis musculoskeletal Both 0.7551 0.995 0.962,1.03 3803 38045 0.7015 0.993 0.959,1.03 3407 34185
728.71 Contracture of palmar fascia [Dupuytren's disease] musculoskeletal Both 0.7145 0.994 0.96,1.03 3477 34788 0.7015 0.993 0.959,1.03 3407 34185
729 Other disorders of soft tissues musculoskeletal Both 0.9397 1.0 0.975,1.03 6014 60309 0.7464 0.967 0.788,1.19 97 982
729.1 Rheumatism, unspecified and fibrositis musculoskeletal Both 0.9268 0.997 0.934,1.06 1005 10063 1.0 1.0 0.935,1.07 945 9546
729.3 Panniculitis musculoskeletal Both 0.929 0.991 0.811,1.21 101 1009 0.7464 0.967 0.788,1.19 97 982
731 Osteitis deformans and osteopathies associated with other disorders classified elsewhere musculoskeletal Both 0.8892 1.01 0.893,1.14 276 2758 0.9376 0.995 0.874,1.13 243 2511
731.1 Osteitis deformans [Paget's disease of bone] musculoskeletal Both 0.863 0.989 0.873,1.12 261 2609 0.9376 0.995 0.874,1.13 243 2511
732 Osteochondropathies musculoskeletal Both 0.2 0.94 0.855,1.03 467 4679 0.1222 0.803 0.609,1.06 56 564
732.1 Juvenile osteochondrosis musculoskeletal Both 0.3882 0.939 0.814,1.08 207 2068 0.4266 0.943 0.815,1.09 198 2014
732.7 Osteochondritis dissecans musculoskeletal Both 0.0875 0.786 0.596,1.04 57 570 0.1222 0.803 0.609,1.06 56 564
733 Other disorders of bone and cartilage musculoskeletal Both 0.06808 1.05 0.997,1.1 1777 17814 0.3811 0.92 0.762,1.11 116 1173
733.2 Cyst of bone musculoskeletal Both 7.345E-6 1.31 1.16,1.47 311 3115 0.06138 1.15 0.994,1.32 211 2962
733.4 Aseptic necrosis of bone musculoskeletal Both 0.867 0.993 0.909,1.08 540 5393 0.8913 0.994 0.908,1.09 507 5206
733.6 Costochondritis musculoskeletal Both 0.5047 0.941 0.788,1.12 128 1276 0.3926 0.924 0.77,1.11 124 1220
733.8 Malunion and nonunion of fracture musculoskeletal Both 0.1409 0.957 0.903,1.01 1231 12313 0.1038 0.952 0.897,1.01 1181 11924
733.9 Chondromalacia musculoskeletal Both 0.4667 0.934 0.779,1.12 121 1206 0.3811 0.92 0.762,1.11 116 1173
735 Acquired foot deformities musculoskeletal Both 0.1059 1.02 0.996,1.04 9603 96090 0.492 1.01 0.983,1.04 6255 62528
735.1 Flat foot musculoskeletal Both 0.881 1.01 0.872,1.17 189 1910 0.9204 1.01 0.864,1.18 175 1848
735.2 Acquired toe deformities musculoskeletal Both 0.3105 1.02 0.986,1.04 5070 50712 0.1442 1.04 0.986,1.1 1461 14783
735.21 Hammer toe (acquired) musculoskeletal Both 0.3873 0.98 0.935,1.03 1929 19324 0.4385 0.981 0.935,1.03 1825 18237
735.23 Hallux rigidus musculoskeletal Both 0.05058 1.05 1.0,1.11 1555 15527 0.1442 1.04 0.986,1.1 1461 14783
735.3 Hallux valgus (Bunion) musculoskeletal Both 0.4603 1.01 0.984,1.04 6643 66463 0.492 1.01 0.983,1.04 6255 62528
736 Other acquired deformities of limbs musculoskeletal Both 0.4246 1.02 0.97,1.07 1627 16282 0.3451 1.07 0.934,1.22 243 2397
736.2 Acquired deformities of finger musculoskeletal Both 0.4943 1.05 0.919,1.19 248 2476 0.3451 1.07 0.934,1.22 243 2397
737 Curvature of spine musculoskeletal Both 0.5559 1.02 0.958,1.08 1128 11300 0.4571 1.03 0.96,1.09 994 10087
737.3 Kyphoscoliosis and scoliosis musculoskeletal Both 0.5781 1.02 0.956,1.08 1061 10632 0.4571 1.03 0.96,1.09 994 10087
738 Other acquired musculoskeletal deformity musculoskeletal Both 0.9162 1.0 0.956,1.05 1904 19058 0.6966 1.01 0.957,1.07 1441 14441
738.4 Acquired spondylolisthesis musculoskeletal Both 0.9528 1.0 0.95,1.06 1513 15147 0.6966 1.01 0.957,1.07 1441 14441
739 Contracture of joint musculoskeletal Both 0.2805 1.05 0.96,1.15 488 4884 0.4217 1.04 0.947,1.14 471 4698
740 Osteoarthrosis musculoskeletal Both 0.01567 0.985 0.973,0.997 27707 231603 0.03192 0.979 0.961,0.998 11561 117767
740.1 Osteoarthritis; localized musculoskeletal Both 0.01202 0.98 0.965,0.996 17412 169419 0.6637 0.975 0.871,1.09 334 3350
740.11 Osteoarthrosis, localized, primary musculoskeletal Both 0.06026 0.979 0.958,1.0 8974 89750 0.0399 0.977 0.956,0.999 8604 86448
740.12 Osteoarthrosis, localized, secondary musculoskeletal Both 0.8433 0.989 0.885,1.1 348 3474 0.6637 0.975 0.871,1.09 334 3350
740.2 Osteoarthrosis, generalized musculoskeletal Both 0.1897 0.945 0.869,1.03 598 5969 0.1021 0.93 0.853,1.01 569 5700
740.9 Osteoarthrosis NOS musculoskeletal Both 0.2594 0.989 0.971,1.01 12270 122792 0.03192 0.979 0.961,0.998 11561 117767
741 Symptoms and disorders of the joints musculoskeletal Both 0.05212 0.967 0.934,1.0 3563 35648 0.4083 1.13 0.85,1.49 51 515
741.1 Ankylosis of joint musculoskeletal Both 0.6471 0.952 0.773,1.17 102 1019 0.5998 0.945 0.763,1.17 98 982
741.2 Stiffness of joint musculoskeletal Both 0.2655 0.955 0.879,1.04 614 6146 0.3281 0.959 0.883,1.04 595 5934
741.3 Difficulty in walking musculoskeletal Both 0.3556 0.925 0.784,1.09 154 1540 0.2917 0.912 0.769,1.08 145 1486
741.4 Joint effusions musculoskeletal Both 0.5715 0.985 0.933,1.04 1418 14197 0.5585 0.984 0.931,1.04 1363 13791
741.5 Hemarthrosis musculoskeletal Both 0.5395 0.942 0.779,1.14 110 1100 0.4295 0.924 0.76,1.12 104 1065
741.6 Villonodular synovitis musculoskeletal Both 0.3388 1.14 0.868,1.51 54 535 0.4083 1.13 0.85,1.49 51 515
742 Derangement of joint, non-traumatic musculoskeletal Both 0.7015 0.992 0.955,1.03 2843 28441 0.7691 1.01 0.961,1.06 1956 19390
742.1 Loose body in joint musculoskeletal Both 0.9886 0.999 0.894,1.12 333 3337 0.826 0.987 0.882,1.11 322 3262
742.2 Pathological, developmental or recurrent dislocation musculoskeletal Both 0.5902 1.06 0.859,1.31 95 960 0.5508 1.07 0.864,1.32 94 941
742.8 Articular cartilage disorder musculoskeletal Both 0.3251 0.955 0.871,1.05 500 4996 0.2489 0.946 0.862,1.04 481 4844
742.9 Other derangement of joint musculoskeletal Both 0.9795 1.0 0.955,1.05 1993 19926 0.7691 1.01 0.961,1.06 1956 19390
743 Osteoporosis, osteopenia and pathological fracture musculoskeletal Both 0.3381 1.01 0.988,1.04 7563 75729 0.5023 1.03 0.953,1.1 772 7831
743.1 Osteoporosis musculoskeletal Both 0.3404 1.01 0.987,1.04 6400 64107 0.7568 0.986 0.9,1.08 498 5118
743.11 Osteoporosis NOS musculoskeletal Both 0.195 1.02 0.991,1.05 5549 55604 0.6501 0.993 0.965,1.02 5003 52449
743.13 Other specified osteoporosis musculoskeletal Both 0.7345 1.02 0.93,1.11 529 5283 0.7568 0.986 0.9,1.08 498 5118
743.2 Pathologic fracture musculoskeletal Both 0.8091 0.989 0.904,1.08 516 5179 0.415 0.962 0.875,1.06 475 4972
743.9 Osteopenia or other disorder of bone and cartilage musculoskeletal Both 0.4036 1.03 0.96,1.11 815 8144 0.5023 1.03 0.953,1.1 772 7831
745 Pain in joint musculoskeletal Both 0.3733 1.01 0.988,1.03 7975 79789 0.7278 1.0 0.981,1.03 7627 76938
747 Cardiac and circulatory congenital anomalies congenital anomalies Both 0.1062 0.969 0.932,1.01 2802 28058 0.3855 0.932 0.795,1.09 160 1618
747.1 Cardiac congenital anomalies congenital anomalies Both 0.1384 0.97 0.932,1.01 2628 26323 0.3388 0.977 0.93,1.03 1748 17745
747.11 Cardiac shunt/ heart septal defect congenital anomalies Both 0.1641 0.941 0.865,1.02 584 5838 0.2723 0.953 0.874,1.04 563 5643
747.12 Valvular heart disease/ heart chambers congenital anomalies Both 0.227 0.922 0.809,1.05 235 2358 0.2692 0.927 0.811,1.06 225 2307
747.13 Congenital anomalies of great vessels congenital anomalies Both 0.3048 0.975 0.93,1.02 1816 18200 0.3388 0.977 0.93,1.03 1748 17745
747.2 Congenital anomalies of peripheral vascular system congenital anomalies Both 0.5 0.949 0.813,1.11 167 1680 0.3855 0.932 0.795,1.09 160 1618
748 Anomalies of respiratory system, congenital congenital anomalies Both 0.7925 0.964 0.731,1.27 51 510 ,
749 Congenital anomalies of face and neck congenital anomalies Both 0.7031 1.02 0.911,1.15 303 3029 0.7295 1.02 0.908,1.15 297 2949
750 Digestive congenital anomalies congenital anomalies Both 0.9727 0.999 0.924,1.08 686 6870 0.4385 0.924 0.756,1.13 109 1130
750.1 Upper gastrointestinal congenital anomalies congenital anomalies Both 0.7943 0.985 0.88,1.1 327 3263 0.6531 0.966 0.829,1.12 187 1861
750.13 Congenital anomalies of mouth/tongue congenital anomalies Both 0.5675 0.957 0.823,1.11 191 1909 0.6531 0.966 0.829,1.12 187 1861
750.2 Lower gastrointestinal congenital anomalies congenital anomalies Both 0.8851 1.01 0.905,1.12 356 3574 0.4385 0.924 0.756,1.13 109 1130
750.21 Congenital anomalies of intestine congenital anomalies Both 0.8204 1.02 0.889,1.16 225 2256 0.8128 0.984 0.858,1.13 212 2193
750.22 Congenital anomaly of gallbladder, bile ducts, liver, pancreas congenital anomalies Both 0.4943 0.935 0.77,1.13 117 1179 0.4385 0.924 0.756,1.13 109 1130
751 Genitourinary congenital anomalies congenital anomalies Both 0.5248 0.983 0.934,1.04 1527 15286 0.9397 1.0 0.897,1.12 320 3228
751.1 Congenital anomalies of genital organs congenital anomalies Both 0.3945 0.967 0.894,1.05 694 6932 0.5957 1.04 0.903,1.19 220 2214
751.11 Congenital anomalies of female genital organs congenital anomalies Female 0.1396 0.93 0.845,1.02 455 4546 0.173 0.934 0.846,1.03 429 4309
751.12 Congenital anomalies of male genital organs congenital anomalies Male 0.5117 1.05 0.912,1.2 222 2217 0.5957 1.04 0.903,1.19 220 2214
751.2 Congenital anomalies of urinary system congenital anomalies Both 0.9727 1.0 0.933,1.07 836 8385 0.9397 1.0 0.897,1.12 320 3228
751.21 Cystic kidney disease congenital anomalies Both 0.5585 0.971 0.879,1.07 424 4246 0.4236 0.959 0.867,1.06 407 4153
751.22 Other specified congenital anomalies of kidney congenital anomalies Both 0.9528 0.997 0.893,1.11 333 3346 0.9397 1.0 0.897,1.12 320 3228
752 Nervous system congenital anomalies congenital anomalies Both 0.3206 1.06 0.946,1.19 328 3307 0.9397 0.991 0.789,1.25 73 760
752.1 Neural tube defects congenital anomalies Both 0.4519 1.05 0.924,1.19 253 2557 0.1175 1.12 0.972,1.29 203 2041
752.11 Spina bifida congenital anomalies Both 0.2014 1.1 0.952,1.26 208 2108 0.1175 1.12 0.972,1.29 203 2041
752.2 Other specified congenital anomalies of nervous system congenital anomalies Both 0.9268 1.01 0.81,1.26 78 780 0.9397 0.991 0.789,1.25 73 760
753 Congenital anomalies of the eye congenital anomalies Both 0.1633 0.879 0.733,1.05 127 1270 0.1419 0.833 0.653,1.06 73 734
753.1 Congenital cataract and lens anomalies congenital anomalies Both 0.302 0.882 0.695,1.12 76 760 0.1419 0.833 0.653,1.06 73 734
754 Congenital musculoskeletal deformities of spine congenital anomalies Both 0.6471 1.05 0.865,1.26 109 1099 0.9016 0.988 0.811,1.2 99 1051
755 Congenital anomalies of limbs congenital anomalies Both 0.2541 1.06 0.959,1.17 425 4276 0.1517 1.15 0.949,1.4 104 1012
755.1 Congenital deformities of feet congenital anomalies Both 0.2805 1.08 0.936,1.26 208 2086 0.2805 1.09 0.935,1.26 204 1991
755.6 Other congenital anomalies of lower limb, including pelvic girdle congenital anomalies Both 0.04831 1.18 1.0,1.38 160 1620 0.1517 1.15 0.949,1.4 104 1012
755.61 Congenital hip dysplasia and deformity congenital anomalies Both 0.2089 1.13 0.933,1.37 106 1070 0.1517 1.15 0.949,1.4 104 1012
756 Other congenital musculoskeletal anomalies congenital anomalies Both 0.1409 0.939 0.863,1.02 587 5872 0.1449 0.929 0.842,1.03 419 4195
756.3 Congenital anomalies of muscle, tendon, fascia, and connective tissue congenital anomalies Both 0.7047 0.957 0.761,1.2 81 810 0.4634 0.917 0.727,1.16 79 778
756.5 Congenital osteodystrophies congenital anomalies Both 0.0873 0.919 0.833,1.01 435 4356 0.1449 0.929 0.842,1.03 419 4195
758 Chromosomal anomalies and genetic disorders congenital anomalies Both 0.5188 1.06 0.894,1.25 148 1708 0.3945 1.13 0.856,1.48 51 801
758.1 Chromosomal anomalies congenital anomalies Both 0.3105 1.14 0.885,1.47 60 830 0.3945 1.13 0.856,1.48 51 801
759 Other and unspecified congenital anomalies congenital anomalies Both 0.4325 0.948 0.829,1.08 216 2159 0.0984 0.841 0.686,1.03 94 920
759.1 Anomalies of endocrine glands, congenital congenital anomalies Both 0.08072 0.836 0.684,1.02 96 959 0.0984 0.841 0.686,1.03 94 920
760 Back pain symptoms Both 0.7015 1.0 0.984,1.02 11126 111353 0.9616 1.0 0.98,1.02 10641 107485
761 Cervicalgia symptoms Both 0.5585 0.986 0.939,1.03 1791 17901 0.5585 0.985 0.937,1.04 1714 17304
764 Sciatica symptoms Both 0.3311 1.02 0.979,1.07 2372 23732 0.3811 1.02 0.976,1.06 2278 22854
766 Neuralgia, neuritis, and radiculitis NOS symptoms Both 0.8128 1.01 0.949,1.07 1172 11738 0.8492 1.01 0.946,1.07 1116 11313
770 Myalgia and myositis unspecified symptoms Both 0.7328 1.01 0.936,1.1 631 6311 0.7691 1.01 0.932,1.1 601 6105
771 Musculoskeletal symptoms referable to limbs symptoms Both 0.7244 0.988 0.922,1.06 870 8687 0.8395 1.0 0.973,1.03 4374 44747
771.1 Swelling of limb symptoms Both 0.5675 1.01 0.979,1.04 4617 46330 0.8395 1.0 0.973,1.03 4374 44747
772 Symptoms of the muscles symptoms Both 0.7852 0.989 0.913,1.07 659 6581 0.7096 0.985 0.907,1.07 632 6387
773 Pain in limb symptoms Both 0.542 1.01 0.982,1.03 6209 62203 0.7464 1.0 0.978,1.03 5930 59940
780 Hypothermia/Chills symptoms Both 0.4989 1.05 0.904,1.23 171 1719 0.7568 1.03 0.874,1.2 158 1659
781 Symptoms involving nervous and musculoskeletal systems symptoms Both 0.955 1.0 0.955,1.05 1870 18715 0.6266 0.988 0.942,1.04 1785 18158
782.3 Edema symptoms Both 0.3673 1.02 0.973,1.08 1642 16450 0.9419 1.0 0.952,1.06 1544 15897
782.6 Pallor and flushing symptoms Both 0.8492 0.985 0.846,1.15 175 1748 0.7674 0.976 0.834,1.14 162 1697
783 Fever of unknown origin symptoms Both 0.2218 1.02 0.988,1.05 3911 39105 0.2636 0.98 0.947,1.02 3475 37922
785 Abdominal pain symptoms Both 0.3467 1.01 0.995,1.02 40080 301686 0.3681 1.0 0.994,1.02 38482 292262
788 Syncope and collapse symptoms Both 0.673 0.995 0.974,1.02 9069 90813 0.4416 0.991 0.97,1.01 8729 88191
789 Nausea and vomiting symptoms Both 0.7656 1.0 0.984,1.02 11577 115807 0.2317 0.988 0.969,1.01 10790 111496
790 Nonspecific findings on examination of blood symptoms Both 0.414 1.07 0.908,1.26 150 1500 0.7925 0.997 0.971,1.02 6184 62714
790.1 Elevated sedimentation rate symptoms Both 0.3141 1.12 0.898,1.4 84 840 0.4667 1.09 0.865,1.37 77 802
790.6 Other abnormal blood chemistry symptoms Both 0.7638 1.0 0.978,1.03 6357 63635 0.7925 0.997 0.971,1.02 6184 62714
791 Gangrene symptoms Both 0.05483 0.917 0.839,1.0 549 5501 0.01361 0.892 0.814,0.977 520 5379
792 Abnormal Papanicolaou smear of cervix and cervical HPV symptoms Female 0.1119 1.18 0.962,1.45 98 966 0.2415 1.13 0.92,1.39 95 966
793 Nonspecific abnormal findings on radiological and other examination of musculoskeletal system symptoms Both 0.8299 0.981 0.82,1.17 134 1340 0.8974 0.994 0.908,1.09 516 5456
793.2 Nonspecific abnormal findings on radiological and other examination of other intrathoracic organs (echocardiogram, etc) symptoms Both 0.8892 1.01 0.922,1.1 565 5647 0.8974 0.994 0.908,1.09 516 5456
794 Abnormal results of other function studies (bladder, pancreas, placenta, spleen, etc) symptoms Both 0.2466 1.12 0.927,1.34 120 1198 0.2415 1.12 0.928,1.35 117 1173
797 Shock symptoms Both 0.5272 1.06 0.893,1.25 156 1559 0.4732 1.08 0.88,1.32 102 1005
797.1 Cardiogenic shock symptoms Both 0.5117 1.07 0.875,1.31 102 1020 0.4732 1.08 0.88,1.32 102 1005
798 Malaise and fatigue symptoms Both 0.5715 0.99 0.956,1.03 3408 34103 0.4508 0.967 0.887,1.05 561 5663
798.1 Chronic fatigue syndrome symptoms Both 0.6887 0.983 0.903,1.07 591 5913 0.4508 0.967 0.887,1.05 561 5663
800 Fracture of lower limb injuries & poisonings Both 0.9727 1.0 0.975,1.02 7035 70329 0.3614 1.04 0.961,1.12 745 7459
800.1 Fracture of neck of femur injuries & poisonings Both 0.4819 0.983 0.937,1.03 1815 18152 0.1875 0.967 0.921,1.02 1720 17359
800.2 Fracture of unspecified part of femur injuries & poisonings Both 0.4355 1.07 0.909,1.25 170 1693 0.6808 1.03 0.879,1.22 162 1630
800.3 Fracture of tibia and fibula injuries & poisonings Both 0.5284 0.986 0.943,1.03 2158 21577 0.5546 0.987 0.943,1.03 2081 20930
800.4 Fracture of patella injuries & poisonings Both 0.3681 1.03 0.961,1.11 766 7661 0.3614 1.04 0.961,1.12 745 7459
801 Fracture of ankle and foot injuries & poisonings Both 0.9268 1.0 0.959,1.05 2205 22041 0.9886 1.0 0.952,1.05 1757 17698
801.1 Fracture of foot injuries & poisonings Both 0.7079 1.01 0.962,1.06 1835 18346 0.9886 1.0 0.952,1.05 1757 17698
802 Fracture of pelvis injuries & poisonings Both 0.8375 1.01 0.934,1.09 718 7185 0.9484 1.0 0.928,1.08 691 6939
803 Fracture of upper limb injuries & poisonings Both 0.3573 1.01 0.988,1.03 8288 82880 0.5188 1.02 0.965,1.07 1473 14930
803.1 Fracture of humerus injuries & poisonings Both 0.561 1.01 0.966,1.07 1691 16883 0.955 0.999 0.949,1.05 1610 16201
803.2 Fracture of radius and ulna injuries & poisonings Both 0.9931 1.0 0.972,1.03 5215 52171 0.7603 0.995 0.967,1.03 4932 49662
803.3 Fracture of clavicle or scapula injuries & poisonings Both 0.3281 1.03 0.974,1.08 1518 15186 0.5188 1.02 0.965,1.07 1473 14930
804 Fracture of hand or wrist injuries & poisonings Both 0.5546 0.989 0.955,1.03 3339 33384 0.4519 0.986 0.951,1.02 3234 32439
805 Fracture of vertebral column without mention of spinal cord injury injuries & poisonings Both 0.8375 0.994 0.94,1.05 1358 13565 0.6871 0.988 0.934,1.05 1292 13198
807 Fracture of ribs injuries & poisonings Both 0.9162 0.996 0.924,1.07 776 7752 0.9528 0.998 0.925,1.08 760 7589
809 Fracture of unspecified bones injuries & poisonings Both 0.9594 0.998 0.943,1.06 1300 12998 0.9931 1.0 0.944,1.06 1263 12641
817 Concussion injuries & poisonings Both 0.1282 0.904 0.793,1.03 243 2428 0.1459 0.907 0.795,1.03 235 2367
818 Intracranial hemorrhage (injury) injuries & poisonings Both 0.5105 1.03 0.942,1.13 522 5213 0.6902 1.02 0.93,1.12 506 5089
819 Skull and face fracture and other intercranial injury injuries & poisonings Both 0.02818 1.04 1.0,1.08 2957 29596 0.02223 1.05 1.01,1.09 2897 29043
823 Torus fracture injuries & poisonings Both 0.859 0.995 0.947,1.05 1673 16710 0.8091 0.994 0.944,1.05 1615 16204
830 Dislocation injuries & poisonings Both 0.2193 1.03 0.983,1.08 2088 20872 0.1429 1.03 0.989,1.08 2040 20395
835 Internal derangement of knee injuries & poisonings Both 0.3258 0.992 0.975,1.01 15221 152247 0.3508 0.992 0.975,1.01 14824 148273
836 Traumatic arthropathy injuries & poisonings Both 0.5495 1.03 0.939,1.12 526 5267 0.8414 1.01 0.921,1.11 505 5132
840 Sprains and strains injuries & poisonings Both 0.1294 0.928 0.843,1.02 470 4697 0.1291 0.928 0.842,1.02 461 4600
850 Hemorrhage or hematoma complicating a procedure injuries & poisonings Both 0.00241 1.04 1.02,1.07 5259 52626 0.9204 1.0 0.972,1.03 4604 50976
851 Complications of transplants and reattached limbs injuries & poisonings Both 0.6427 1.04 0.882,1.23 157 1567 0.354 0.918 0.767,1.1 130 1516
853 Complication of colostomy or enterostomy injuries & poisonings Both 0.4436 0.965 0.881,1.06 501 5010 0.4111 0.962 0.876,1.06 473 4889
854 Complications of cardiac/vascular device, implant, and graft injuries & poisonings Both 0.9931 1.0 0.953,1.05 1826 18238 0.6486 0.989 0.941,1.04 1738 17885
857 Mechanical complication of unspecified genitourinary device, implant, and graft injuries & poisonings Both 0.2799 0.968 0.914,1.03 1241 12418 0.2692 0.967 0.912,1.03 1200 12086
858 Complication of internal orthopedic device injuries & poisonings Both 0.03828 0.962 0.927,0.998 3158 31607 0.02065 0.956 0.921,0.993 3028 30471
859 Complication due to other implant and internal device injuries & poisonings Both 0.0673 1.03 0.998,1.07 3259 32599 0.3802 0.983 0.947,1.02 2914 31400
870 Open wounds of head; neck; and trunk injuries & poisonings Both 0.871 1.0 0.969,1.04 3502 35062 0.7161 0.956 0.75,1.22 68 666
870.1 Open wound or laceration of eye or eyelid injuries & poisonings Both 0.597 0.967 0.855,1.09 272 2713 0.3917 0.946 0.833,1.07 258 2655
870.2 Open wound of ear injuries & poisonings Both 0.2831 0.924 0.8,1.07 196 1949 0.2851 0.924 0.799,1.07 191 1911
870.3 Other open wound of head and face injuries & poisonings Both 0.3365 1.02 0.981,1.06 2904 29085 0.3491 1.02 0.98,1.06 2825 28437
870.4 Open wound of nose and sinus injuries & poisonings Both 0.1054 0.891 0.775,1.02 220 2199 0.05408 0.871 0.756,1.0 213 2163
870.6 Open wound of neck injuries & poisonings Both 0.6637 0.947 0.743,1.21 68 678 0.7161 0.956 0.75,1.22 68 666
871 Open wounds of extremities injuries & poisonings Both 0.4977 0.989 0.957,1.02 4063 40648 0.2404 0.911 0.781,1.06 170 1731
871.1 Open wound of hand except finger(s) injuries & poisonings Both 0.1167 1.24 0.948,1.61 53 530 0.1279 1.23 0.942,1.61 53 526
871.2 Open wound of finger(s) injuries & poisonings Both 0.2223 0.873 0.703,1.09 91 900 0.2541 0.879 0.705,1.1 88 877
871.3 Open wound of foot except toe(s) alone injuries & poisonings Both 0.3258 0.927 0.797,1.08 178 1785 0.2404 0.911 0.781,1.06 170 1731
872 Traumatic amputation injuries & poisonings Both 0.1875 0.938 0.852,1.03 475 4742 0.2198 0.942 0.856,1.04 472 4688
873 Broken tooth injuries & poisonings Both 0.002818 1.22 1.07,1.4 229 2289 0.004285 1.22 1.06,1.4 222 2211
874 Complication of amputation stump injuries & poisonings Both 0.3917 1.07 0.917,1.25 169 1710 0.3516 1.08 0.923,1.25 167 1689
905 Late effects of musculoskeletal and connective tissue injuries injuries & poisonings Both 0.9099 0.991 0.849,1.16 157 1567 0.6902 0.968 0.827,1.13 149 1536
907 Injuries to the nervous system injuries & poisonings Both 0.06281 1.06 0.997,1.12 1314 13140 0.05012 1.06 1.0,1.12 1282 12839
915 Superficial injury without mention of infection injuries & poisonings Both 0.3999 1.01 0.982,1.05 4260 42663 0.5358 1.01 0.978,1.04 4096 41482
916 Contusion injuries & poisonings Both 0.04677 0.946 0.896,0.999 1450 14506 0.02393 0.938 0.887,0.992 1401 14081
930 Allergic reaction to food injuries & poisonings Both 0.5649 0.957 0.822,1.11 179 1807 0.6683 0.967 0.828,1.13 171 1728
938 Dermatitis due to solar radiation injuries & poisonings Both 0.4477 0.961 0.868,1.06 389 3899 0.6855 0.974 0.856,1.11 246 2457
938.2 Chronic dermatitis due to solar radiation injuries & poisonings Both 0.5272 0.96 0.845,1.09 252 2530 0.6855 0.974 0.856,1.11 246 2457
941 Adverse reaction to serum or vaccine injuries & poisonings Both 0.3664 1.06 0.929,1.22 225 2249 0.5176 1.05 0.909,1.21 206 2167
942 Infusion and transfusion reaction injuries & poisonings Both 0.151 1.16 0.949,1.41 104 1038 0.2523 1.13 0.917,1.39 92 1006
946 Anaphylactic shock NOS injuries & poisonings Both 0.06383 1.09 0.995,1.18 550 5509 0.1321 1.07 0.979,1.17 520 5321
947 Urticaria injuries & poisonings Both 0.8492 1.01 0.91,1.12 371 3707 0.8318 0.989 0.888,1.1 354 3563
949 Allergies, other injuries & poisonings Both 0.5598 1.03 0.93,1.14 397 3989 0.4345 1.04 0.938,1.16 384 3852
952 Spinal cord injury without evidence of spinal bone injury injuries & poisonings Both 0.8995 1.01 0.912,1.11 423 4224 0.798 0.987 0.893,1.09 409 4114
957 Injury to other and unspecified nerves injuries & poisonings Both 0.1581 1.1 0.965,1.24 269 2698 0.1972 1.09 0.957,1.24 259 2585
958 Certain early complications of trauma or procedure injuries & poisonings Both 0.7096 0.982 0.895,1.08 491 4926 0.1854 0.853 0.674,1.08 73 731
958.1 Postoperative shock injuries & poisonings Both 0.2958 1.16 0.88,1.52 55 555 0.1919 1.2 0.911,1.59 54 543
958.2 Traumatic and surgical subcutaneous emphysema injuries & poisonings Both 0.1816 0.852 0.673,1.08 74 740 0.1854 0.853 0.674,1.08 73 731
960 Poisoning by antibiotics injuries & poisonings Both 0.002904 1.02 1.01,1.04 18100 181147 0.5023 1.01 0.989,1.02 14859 152759
960.2 Allergy/adverse effect of penicillin injuries & poisonings Both 0.02198 1.02 1.0,1.04 15846 158623 0.5023 1.01 0.989,1.02 14859 152759
961 Poisoning by other anti-infectives injuries & poisonings Both 0.4395 1.04 0.941,1.15 420 4195 0.7129 1.01 0.942,1.09 781 8254
961.1 Poisoning/allergy of sulfonamides injuries & poisonings Both 0.2761 1.04 0.97,1.11 869 8703 0.7129 1.01 0.942,1.09 781 8254
962 Poisoning by hormones and synthetic substitutes injuries & poisonings Both 0.5754 1.03 0.927,1.15 371 3707 0.8433 1.01 0.904,1.13 335 3501
962.3 Hormones and synthetic substitutes causing adverse effects in therapeutic use injuries & poisonings Both 0.6683 1.02 0.919,1.14 364 3638 0.8433 1.01 0.904,1.13 335 3501
963 Poisoning by primarily systemic agents injuries & poisonings Both 0.3999 1.06 0.925,1.22 223 2228 0.4529 1.06 0.916,1.22 204 2160
964 Poisoning by agents primarily affecting blood constituents injuries & poisonings Both 0.1968 0.923 0.818,1.04 282 2830 0.4111 0.949 0.837,1.08 260 2715
964.1 Anticoagulants causing adverse effects injuries & poisonings Both 0.4018 0.949 0.841,1.07 276 2770 0.4111 0.949 0.837,1.08 260 2715
965 Poisoning by analgesics, antipyretics, and antirheumatics injuries & poisonings Both 0.278 0.986 0.96,1.01 6082 60875 0.2128 1.07 0.963,1.18 394 3949
965.1 Opiates and related narcotics causing adverse effects in therapeutic use injuries & poisonings Both 0.5781 0.983 0.925,1.04 1144 11447 0.2208 0.961 0.901,1.02 1031 10931
965.2 Antirheumatics causing adverse effects in therapeutic use injuries & poisonings Both 0.9376 1.0 0.914,1.1 476 4767 0.8892 1.01 0.916,1.11 458 4644
965.3 Salicylates causing adverse effects in therapeutic use injuries & poisonings Both 0.2051 1.07 0.965,1.18 403 4045 0.2128 1.07 0.963,1.18 394 3949
966 Poisoning by anticonvulsants and anti-Parkinsonism drugs injuries & poisonings Both 0.2786 0.952 0.87,1.04 512 5123 0.2259 0.945 0.863,1.04 497 4957
967 Adverse effects of sedatives or other central nervous system depressants and anesthetics injuries & poisonings Both 0.8222 0.99 0.909,1.08 583 5843 0.7096 0.983 0.9,1.07 541 5637
969 Poisoning by psychotropic agents injuries & poisonings Both 0.5358 1.01 0.969,1.06 1950 19519 0.7709 1.01 0.961,1.06 1884 18988
971 Poisoning by drugs primarily affecting the autonomic nervous system injuries & poisonings Both 0.3631 1.07 0.922,1.25 190 1908 0.4036 1.07 0.916,1.24 186 1863
972 Poisoning by agents primarily affecting the cardiovascular system injuries & poisonings Both 0.9226 0.994 0.877,1.13 271 2717 0.4315 0.914 0.731,1.14 82 836
972.6 Antihypertensive agents causing adverse effects injuries & poisonings Both 0.5521 0.935 0.749,1.17 84 849 0.4315 0.914 0.731,1.14 82 836
973 Poisoning by agents primarily affecting the gastrointestinal system injuries & poisonings Both 0.7396 0.968 0.798,1.17 108 1080 0.6516 0.956 0.788,1.16 106 1053
974 Poisoning by water, mineral, and uric acid metabolism drugs injuries & poisonings Both 0.1837 1.15 0.936,1.41 101 1018 0.182 1.15 0.935,1.42 98 996
975 Poisoning by agents primarily acting on the smooth and skeletal muscles and respiratory system injuries & poisonings Both 0.7638 1.04 0.813,1.33 64 640 0.695 1.05 0.816,1.36 61 612
976 Poisoning by agents primarily affecting skin & mucous membrane, ophthalmological, otorhinolaryngological, & dental drugs injuries & poisonings Both 0.0492 1.31 1.0,1.72 58 580 0.01683 1.41 1.06,1.88 53 561
977 Personal history of allergy to medicinal agents injuries & poisonings Both 0.2037 1.09 0.954,1.24 234 2337 0.1854 1.1 0.956,1.26 215 2258
979 Adverse drug events and drug allergies injuries & poisonings Both 0.08337 1.07 0.991,1.16 698 6966 0.09908 1.07 0.988,1.16 668 6752
981 Toxic effect of (non-ethyl) alcohol and petroleum and other solvents injuries & poisonings Both 0.5888 1.04 0.901,1.2 200 1999 0.6531 1.03 0.893,1.2 195 1937
986 Toxic effect of carbon monoxide injuries & poisonings Both 0.7907 0.966 0.747,1.25 62 620 0.8913 0.982 0.758,1.27 61 606
987 Toxic effect of other gases, fumes, or vapors injuries & poisonings Both 0.7943 1.03 0.838,1.26 105 1049 0.7907 1.03 0.839,1.26 104 1030
988 Toxic effect of noxious substances eaten as food injuries & poisonings Both 0.2138 0.885 0.731,1.07 111 1128 0.2541 0.893 0.734,1.09 106 1086
989 Toxic effect of other substances, chiefly nonmedicinal as to source injuries & poisonings Both 0.8147 1.03 0.831,1.27 89 890 0.8933 0.985 0.793,1.22 85 867
990 Effects radiation NOS injuries & poisonings Both 4.467E-12 1.14 1.1,1.18 3113 31140 0.2265 0.973 0.931,1.02 2105 30165
994 Sepsis and SIRS injuries & poisonings Both 0.02037 1.04 1.01,1.08 3028 30268 0.7603 0.994 0.955,1.03 2553 29336
994.2 Sepsis injuries & poisonings Both 0.02037 1.04 1.01,1.08 3028 30268 0.7603 0.994 0.955,1.03 2553 29336
1000 Burns injuries & poisonings Both 0.1355 0.937 0.86,1.02 578 5796 0.1225 0.934 0.857,1.02 565 5660
1001 Foreign body injury injuries & poisonings Both 0.4603 0.978 0.921,1.04 1199 12007 0.3327 0.971 0.914,1.03 1164 11686
1002 Symptoms concerning nutrition, metabolism, and development injuries & poisonings Both 0.4699 1.01 0.983,1.04 5480 54819 0.6871 1.01 0.978,1.03 5240 52778
1004 Other signs and symptoms involving emotional state injuries & poisonings Both 0.4786 1.04 0.927,1.18 300 2997 0.5188 1.04 0.923,1.17 292 2920
1005 Other symptoms injuries & poisonings Both 0.4159 1.02 0.969,1.08 1444 14422 0.9594 1.0 0.946,1.06 1318 13963
1006 Crushing injury injuries & poisonings Both 0.2366 0.925 0.812,1.05 256 2558 0.3069 0.935 0.821,1.06 256 2525
1007 Injury to blood vessels injuries & poisonings Both 0.1977 1.09 0.957,1.24 256 2559 0.228 1.08 0.952,1.23 252 2521
1008 Crushing or internal injury to organs injuries & poisonings Both 0.1023 1.05 0.989,1.12 1013 10132 0.1175 1.05 0.987,1.12 993 9977
1009 Injury, NOS injuries & poisonings Both 0.15 1.02 0.994,1.04 8482 84911 0.1384 1.02 0.994,1.04 8273 82852
1010 Other tests injuries & poisonings Both 0.302 0.986 0.96,1.01 5945 59512 0.1832 0.982 0.955,1.01 5636 57417
1011 Complications of surgical and medical procedures injuries & poisonings Both 0.7015 1.0 0.983,1.03 9152 91588 0.0787 0.98 0.959,1.0 8521 88559
1012 Late effect injuries & poisonings Both 0.9931 1.0 0.822,1.22 105 1057 0.8995 1.01 0.829,1.24 103 1023
1013 Asphyxia and hypoxemia injuries & poisonings Both 0.863 1.01 0.902,1.13 316 3168 0.8166 1.01 0.903,1.14 300 3081
1014 Effects of heat, cold and air pressure injuries & poisonings Both 0.3467 0.887 0.691,1.14 66 659 0.3556 0.889 0.693,1.14 66 649
1015 Effects of other external causes injuries & poisonings Both 0.5082 1.01 0.979,1.04 4226 42294 0.5741 0.991 0.959,1.02 3947 40919
1019 Other ill-defined and unknown causes of morbidity and mortality injuries & poisonings Both 0.003597 1.02 1.01,1.04 15895 159019 0.07621 1.02 0.998,1.03 15111 153823
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LEGENDS

Figure 1: PheWAS results
P-values correspond to associations between the polygenic risk score (PRS) and the electronic health record-derived phenotype obtained using Firth’s logistic regression and also adjusting for age, gender, genotyping array, and the first four genotype principal components.
Upward (downward)-pointing triangles indicate a positive (negative) association.
Additional details are available by hovering the cursor over a particular triangle and by clicking the triangle. The horizontal dashed line indicates phenome-wide significance. Results are color-coded by disease category.

Figure 2: Exclusion PheWAS results
Results from a PheWAS performed using only subjects who never had the primary cancer diagnosis. The results are obtained as in Figure 1 but using the reduced dataset.

Figure 3: Associations between PRS and Selected Phenotype
This figure shows results for the selected phenotype in Figure 1.
This figure provides the beta estimate for the adjusted association between the PRS and the selected phenotype from Firth-corrected logistic regression. The corresponding confidence intervals are also shown. Results are presented for models using either a continuous or a categorical version of the PRS.
Q1 through Q4 represent the four quartiles of the PRS.

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